| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shannon L Kelleher, Serena Burkinshaw, Seun Elizabeth Kuyoor. Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues. Molecular nutrition & food research. 2024-04-27. PMID:38676329. |
limited information delineating effects of polyphenols on the molecular pathways that affect lactation are found, although available information suggests modulation of stat5 signaling/differentiation, stat3 signaling/remodeling, mtor and insulin signaling/energy production, and nuclear factor kappa beta (nfκβ) signaling/oxidative stress and inflammation may play roles. |
2024-04-27 |
2024-04-29 |
Not clear |
| Ying Fu, Yu Xiang, Jie Zha, Guochun Chen, Zheng Don. Enhanced STAT3/PIK3R1/mTOR Signaling Triggers Tubular Cell Inflammation and Apoptosis in Septic-Induced Acute Kidney Injury: Implications for Therapeutic Intervention. Clinical science (London, England : 1979). 2024-02-27. PMID:38411015. |
pharmacological inhibition of either mtor or stat3 significantly improved renal function and reduced apoptosis and inflammation. |
2024-02-27 |
2024-03-02 |
mouse |
| Ying Fu, Yu Xiang, Jie Zha, Guochun Chen, Zheng Don. Enhanced STAT3/PIK3R1/mTOR Signaling Triggers Tubular Cell Inflammation and Apoptosis in Septic-Induced Acute Kidney Injury: Implications for Therapeutic Intervention. Clinical science (London, England : 1979). 2024-02-27. PMID:38411015. |
in these models, renal inflammation and tubular cell apoptosis were accompanied by the aberrant activation of the mechanistic target of rapamycin (mtor) and the signal transducer and activator of transcription 3 (stat3) signaling pathways. |
2024-02-27 |
2024-03-02 |
mouse |
| Shupeng Zhang, Yongpei Lu, Yanling Liu, Mei Wang, Shaoqi Xu, Ya Li, Hongwei Wu, Qaolin Pei, Lei Yang, Lu Lu, Yixiao Xiong, Youlian Liu, Shuhuang Chen, Qin Yao, Qin Kang, Yingzi Li, Defang Chen, Xin Zhang, Ni Tang, Zhiqiong L. Neglected function of gastrin to reduce feeding in Siberian sturgeon (Acipenser baerii) via cholecystokinin receptor B. Fish physiology and biochemistry. 2024-02-21. PMID:38381278. |
in addition, gastrin 17 treatment significantly affected the expression of appetite signaling pathways in the hypothalamus, such that the mrna expression of ampkα1 was significantly reduced, whereas the mrna abundance of stat3, mtor and s6k was significantly increased. |
2024-02-21 |
2024-02-23 |
Not clear |
| Xuanhong Jin, Liangkun You, Jincheng Qiao, Weidong Han, Hongming Pa. Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development. Autophagy. vol 20. issue 2. 2024-01-25. PMID:37723664. |
a. muciniphila: akkermansia muciniphila; aiec: adherent invasive escherichia coli; aom/dss: azoxymethane-dextran sodium sulfate; atg: autophagy related; becn1: beclin1, autophagy related; cac: colitis-associated colon cancer; ccdc50: coiled-coil domain containing 50; cldn2: claudin 2; copec: colibactin-producing escherichia coli; crc: colorectal cancer; damps: danger/damage-associated molecular patterns; dc: dendritic cell; dss: dextran sulfate sodium; dtp: drug-resistant persistent; er: endoplasmic reticulum; ern1/ire1α: endoplasmic reticulum to nucleus signaling 1; ibd: inflammatory bowel disease; iecs: intestinal epithelial cells; ikk: ikappab kinase; il: interleukin; irgm1: immunity-related gtpase family m member 1; isc: intestinal stem cell; lps: lipopolysaccharide; map1lc3/lc3: microtubule-associated protein 1 light chain 3; mapk: mitogen-activated protein kinase; mdp: muramyl dipeptide; melk: maternal embryonic leucine zipper kinase; mhc: major histocompatibility complex; mirna: microrna; mtor: mechanistic target of rapamycin kinase; nlrp3: nlr family, pyrin domain containing 3; nod2: nucleotide-binding oligomerization domain containing 2; nrbf2: nuclear receptor binding factor 2; pamps: pathogen-associated molecular patterns; pi3k: class i phosphoinositide 3-kinase; ptdins3k: class iii phosphatidylinositol 3-kinase; pycard/asc: pyd and card domain containing; ralgapa2/ralgapα2: ral gtpase activating protein protein, alpha subunit 2 (catalytic); ripk2/card3: receptor (tnfrsf)-interacting serine-threonine kinase 2; ripk3: receptor-interacting serine-threonine kinase 3; ros: reactive oxygen species; scrc: sporadic colorectal cancer; smarca4/brg1: swi/snf related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; sqstm1: sequestosome 1; stat3: signal transducer and activator of transcription 3; tnf/tnfa: tumor necrosis factor; ulk1: unc-51 like autophagy activating kinase 1; upr: unfolded protein response; wt: wild-type. |
2024-01-25 |
2024-01-27 |
Not clear |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
this study investigated the effect and mechanism of morin in inducing autophagy and apoptosis in hepatocellular carcinoma cells through the protein kinase b(akt)/mammalian target of rapamycin(mtor)/signal transducer and activator of transcription protein 3(stat3) pathway. |
2023-10-06 |
2023-10-15 |
human |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
compared with the control group, the morin groups showed decreased viability of sk-hep-1 cells in a time-and concentration-dependent manner, increased number of apoptotic cells, up-regulated expression level of apoptosis marker parp, up-regulated phosphorylation level of apoptosis-regulating protein h2ax, decreased number of positive cells and the colony formation rate, an upward trend of expression levels of autophagy-related proteins lc3-Ⅱ, atg5, and atg7, and decreased phosphorylation levels of akt, mtor, and stat3. |
2023-10-06 |
2023-10-15 |
human |
| Wei Li, Tao Huang, Shenghan Xu, Bangwei Che, Ying Yu, Wenjun Zhang, Kaifa Tan. Molecular Mechanism of Tanshinone against Prostate Cancer. Molecules (Basel, Switzerland). vol 27. issue 17. 2022-09-09. PMID:36080361. |
several studies have shown that tanshinone can target various molecular pathways of pca, including the signal transducer and activator of transcription 3 (stat3) pathway, androgen receptor (ar) pathway, phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) pathway, and mitogen-activated protein kinase (mapk) pathway, which will affect the release of pro-inflammatory cytokines and affect cell proliferation, apoptosis, tumor metabolism, genomic stability, and tumor drug resistance. |
2022-09-09 |
2023-08-14 |
Not clear |
| Sisi Li, Xuyun Hua, Mouxiong Zheng, Jiajia Wu, Zhenzhen Ma, Xiangxin Xing, Jie Ma, Junpeng Zhang, Chunlei Shan, Jianguang X. PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury. Experimental neurology. vol 346. 2021-10-04. PMID:34474008. |
in addition, plxna2 knockdown restrained proinflammatory cytokine release and promoted anti-inflammatory cytokine release, and the mammalian target of rapamycin (mtor)/signal transducer and activator of transcription 3 (stat3) pathway was involved in plxna2 regulated microglia polarization. |
2021-10-04 |
2023-08-13 |
rat |
| Jeong-Hun Lee, Kyung-Sook Chung, Hwi-Ho Lee, Dohyeong Ko, Minji Kang, Ho Yoo, JooHoon Ahn, Jae Yeol Lee, Kyung-Tae Le. Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34329824. |
moreover, our findings showed that mechanistic target of rapamycin (mtor), ribosomal protein s6 kinase (p70s6k), and signal transducer and activator of transcription (stat3) inactivation was required for apoptosis induced by the combination of oz-001 and cisplatin in in vitro and in vivo experiments. |
2021-09-22 |
2023-08-13 |
mouse |
| Ying Liu, ShiJi Deng, Zhi Zhang, Yue Gu, ShengNan Xia, XinYu Bao, Xiang Cao, Yun X. 6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway. European journal of pharmacology. vol 883. 2021-05-18. PMID:32681941. |
in terms of mechanism, 6-gingerol potently suppressed phosphorylation of serine-threonine protein kinase (akt) - mammalian target of rapamycin (mtor) - signal transducer and activator of transcription 3 (stat3) in lps-treated microglia. |
2021-05-18 |
2023-08-13 |
Not clear |
| Jing-Hui Feng, Su-Min Sim, Jung-Seok Park, Jae-Seung Hong, Hong-Won Su. The changes of nociception and the signal molecules expression in the dorsal root ganglia and the spinal cord after cold water swimming stress in mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 25. issue 3. 2021-05-02. PMID:33859061. |
our results suggest that the antinociception induced by cwss may be mediated by several molecules, such as erk, jnk, creb, ampkα1, ampkα2, mtor, tyk2, and stat3 located in the spinal cord and drg. |
2021-05-02 |
2023-08-13 |
mouse |
| Ritika Ramani, Gail Megason, Jason Schallheim, Cynthia Karlson, Vani Vijayakumar, Srinivasan Vijayakumar, Chindo Hick. Integrative Analysis of MicroRNA-Mediated Gene Signatures and Pathways Modulating White Blood Cell Count in Childhood Acute Lymphoblastic Leukemia. Biomarker insights. vol 12. 2020-10-01. PMID:28469402. |
in addition, we identified molecular networks and biological pathways, among them pi3/akt, jak/stat, il-17, tgf-β, apoptosis, il-15, stat3, igf-1, fgf, mtor, vegf, nf-kb, and p53 signaling pathways, enriched for or targeted by mirnas. |
2020-10-01 |
2023-08-13 |
Not clear |
| Soheila Rezapour-Firouzi, Fatemeh Kheradmand, Sharam Shahabi, Ali Asghar Tehrani, Ebrahim Mazloomi, Adel Mohammadzade. Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3 Research in pharmaceutical sciences. vol 14. issue 2. 2020-09-30. PMID:31620191. |
signal transducer and activator of transcription factor3 (stat3) is required for th-cell pathogenicity and its activation in the brain has been demonstrated during the acute phase of experimental autoimmune encephalomyelitis (eae) through the mammalian target of rapamycin (mtor) signaling. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Fang, Xinggang Wang, Qingzhu Sun, Eleni Papakonstantinou, Chongteck S'ng, Michael Tamm, Daiana Stolz, Michael Rot. IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling. International journal of molecular sciences. vol 20. issue 4. 2019-05-31. PMID:30781615. |
non-immune ige activated two signaling pathways: (i) signal transducer and activator of transcription 3 (stat3)→mir-21-5p→downregulating phosphatase and tensin homolog (pten) expression, and (ii) phosphatidylinositol 3-kinases (pi3k)→protein kinase b (akt)→mammalian target of rapamycin (mtor)→ribosomal protein s6 kinase beta-1 (p70s6k)→peroxisome proliferator-activated receptor gamma coactivator 1-α (pgc1-α)→peroxisome proliferator-activated receptor-γ (ppar-γ)→cyclooxygenase-2 (cox-2)→mitochondrial activity, proliferation, migration, and extracellular matrix deposition. |
2019-05-31 |
2023-08-13 |
human |
| Gerwyn Morris, Michael Berk, Michael Maes, Basant K Pur. Could Alzheimer's Disease Originate in the Periphery and If So How So? Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29705945. |
in particular, as a result of increased activity of triggering receptor expressed on myeloid cells 2 (trem-2), the presence of the apolipoprotein e4 (apoe4) isoform, and changes in ank1 expression, with subsequent changes in mir-486 leading to altered levels of protein kinase b (akt), mechanistic (previously mammalian) target of rapamycin (mtor) and signal transducer and activator of transcription 3 (stat3), all of which play major roles in microglial activation, proliferation and survival, there is activation of microglia, leading to the subsequent (further) production of cytokines, chemokines, nitric oxide, prostaglandins, reactive oxygen species, inducible nitric oxide synthase and cyclooxygenase-2, and other mediators of inflammation and neurotoxicity. |
2019-04-01 |
2023-08-13 |
Not clear |
| Chenlin Pei, Qun He, Shuai Liang, Xuejun Gon. Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30273298. |
mahanimbine exerts anticancer effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of akt/mammalian target of rapamycin (mtor) and signal transducer and activator of transcription 3 (stat3) signalling pathways. |
2018-12-12 |
2023-08-13 |
human |
| Ke-Yan Cheng, Min Ha. Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β1 (TGF-β1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-22. PMID:28446743. |
cell migration was detected by wound-healing assay; apoptosis was analyzed by flow cytometry; mtor inhibitors inhibited mtor pathway to assess the expression of e-cadherin, vimentin stat3, snail2, p-p70s6k, and pkm2 expression. |
2018-03-22 |
2023-08-13 |
Not clear |
| Andrey V Markov, Marina A Zenkova, Evgeniya B Logashenk. Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives. Current medicinal chemistry. vol 24. issue 13. 2017-09-08. PMID:28078994. |
among the most relevant mechanisms involved are cell cycle arrest, apoptosis and autophagy triggered by the effect of triterpenoids on tgf-β and her cell surface receptors and the downstream pi3kakt- mtor and ikk/nf-kb signaling axis, stat3 pathway and mapk cascades. |
2017-09-08 |
2023-08-13 |
Not clear |
| Jerome Cros, Emilie Moati, Jerome Raffenne, Olivia Hentic, Magali Svrcek, Louis de Mestier, Emilie Sbidian, Nathalie Guedj, Pierre Bedossa, Valerie Paradis, Alain Sauvanet, Yves Panis, Philippe Ruszniewski, Anne Couvelard, Pascal Hamme. Gly388Arg FGFR4 Polymorphism Is Not Predictive of Everolimus Efficacy in Well-Differentiated Digestive Neuroendocrine Tumors. Neuroendocrinology. vol 103. issue 5. 2017-05-16. PMID:26335532. |
preclinical data suggest that the single nucleotide polymorphism substituting a glycine for an arginine in codon 388 of the fgfr4 transmembrane domain may increase the proliferation of xenografted neuroendocrine cell lines and decrease their sensitivity to everolimus by modulating stat3 signaling and the mtor pathway. |
2017-05-16 |
2023-08-13 |
Not clear |