| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shannon L Kelleher, Serena Burkinshaw, Seun Elizabeth Kuyoor. Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues. Molecular nutrition & food research. 2024-04-27. PMID:38676329. |
limited information delineating effects of polyphenols on the molecular pathways that affect lactation are found, although available information suggests modulation of stat5 signaling/differentiation, stat3 signaling/remodeling, mtor and insulin signaling/energy production, and nuclear factor kappa beta (nfκβ) signaling/oxidative stress and inflammation may play roles. |
2024-04-27 |
2024-04-29 |
Not clear |
| Antonio Paoli, Grant M Tinsley, Mark P Mattson, Immaculata De Vivo, Ravi Dhawan, Tatiana Mor. Common and divergent molecular mechanisms of fasting and ketogenic diets. Trends in endocrinology and metabolism: TEM. vol 35. issue 2. 2024-04-05. PMID:38577754. |
mechanisms of action of istf include stimulation of autophagy, increased insulin and leptin sensitivity, activation of amp-activated protein kinase (ampk), inhibition of the mechanistic target of rapamycin (mtor) pathway, bolstering mitochondrial resilience, and suppression of oxidative stress and inflammation. |
2024-04-05 |
2024-04-07 |
Not clear |
| Stavros P Papadakos, Alexandra Argyrou, Vasileios Lekakis, Konstantinos Arvanitakis, Polyxeni Kalisperati, Ioanna E Stergiou, Ippokratis Konstantinidis, Dimitrios Schizas, Theocharis Koufakis, Georgios Germanidis, Stamatios Theochari. Metformin in Esophageal Carcinoma: Exploring Molecular Mechanisms and Therapeutic Insights. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474224. |
key focus areas include its impact on insulin signaling, amp-activated protein kinase (ampk) activation, and the mtor pathway, which collectively contribute to its role in mitigating esophageal cancer progression. |
2024-03-13 |
2024-03-15 |
Not clear |
| Liyue Zhang, Xin Yu, Nan Hong, Yutong Xia, Xuhong Zhang, Liyin Wang, Chen Xie, Feng Dong, Jianping Tong, Ye She. CircRNA expression profiles and regulatory networks in the vitreous humor of people with high myopia. Experimental eye research. 2024-02-14. PMID:38354945. |
kegg analysis showed that the target genes of circrnas were enriched in the mtor, insulin, camp, and vegf signaling pathways. |
2024-02-14 |
2024-02-17 |
mouse |
| Jiahui Gong, Xilong Gao, Shaoyang Ge, Hongliang Li, Ran Wang, Liang Zha. The Role of cGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention. International journal of biological sciences. vol 20. issue 1. 2024-01-02. PMID:38164186. |
the interaction of cgas-sting with other pathways, such as the nuclear factor-kappa b (nf-κb), jun n-terminal kinase (jnk), amp-activated protein kinase (ampk), mammalian target of rapamycin (mtor), autophagy, pyroptosis and insulin signalling pathways, is considered an important mechanism by which cgas-sting regulates inflammation and metabolism. |
2024-01-02 |
2024-01-05 |
Not clear |
| Zhen Yu, Junyong Han, Lisha Li, Qiufeng Zhang, Ayun Chen, Jinyan Chen, Kun Wang, Jingjun Jin, Huangyuan Li, Gang Che. Chronic triclosan exposure induce impaired glucose tolerance by altering the gut microbiota. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-12-05. PMID:38052405. |
western blot and immunostaining results further confirmed that elevated bcaas stimulated mtor, a nutrient-sensing complex, and following irs-1 serine phosphorylation, resulted in insulin resistance and glucose intolerance. |
2023-12-05 |
2023-12-10 |
human |
| Md Torikul Islam, Shelby A Hall, Tavia Dutson, Samuel I Bloom, R Colton Bramwell, John Kim, Jordan R Tucker, Daniel R Machin, Anthony J Donato, Lisa A Lesniewsk. Endothelial cell-specific reduction in mTOR ameliorates age-related arterial and metabolic dysfunction. Aging cell. 2023-12-01. PMID:38017701. |
the reduction in endothelial mtor also improved glucose tolerance in old mice, and this was associated with attenuated hepatic gluconeogenesis and improved lipid tolerance, but was independent of alterations in peripheral insulin sensitivity, pancreatic beta cell function, or fasted plasma lipids in old mice. |
2023-12-01 |
2023-12-07 |
mouse |
| Md Torikul Islam, Shelby A Hall, Tavia Dutson, Samuel I Bloom, R Colton Bramwell, John Kim, Jordan R Tucker, Daniel R Machin, Anthony J Donato, Lisa A Lesniewsk. Endothelial cell-specific reduction in mTOR ameliorates age-related arterial and metabolic dysfunction. Aging cell. 2023-12-01. PMID:38017701. |
the reduction in endothelial mtor also improved glucose tolerance in old mice, and this was associated with attenuated hepatic gluconeogenesis and improved lipid tolerance, but was independent of alterations in peripheral insulin sensitivity, pancreatic beta cell function, or fasted plasma lipids in old mice. |
2023-11-29 |
2023-12-07 |
mouse |
| Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Han. Endometrial protein expression and phosphorylation landscape decipher aberrant insulin and mTOR signalling in patients with recurrent pregnancy loss. Reproductive biomedicine online. vol 48. issue 1. 2023-11-28. PMID:38016376. |
endometrial protein expression and phosphorylation landscape decipher aberrant insulin and mtor signalling in patients with recurrent pregnancy loss. |
2023-11-28 |
2023-12-07 |
Not clear |
| Alex J T Yang, Ahmad Mohammad, Michael S Finch, Evangelia Tsiani, Gaynor Spencer, Aleksandar Necakov, Rebecca E K MacPherso. Influence of metabolic stress and metformin on synaptic protein profile in SH-SY5Y-derived neurons. Physiological reports. vol 11. issue 22. 2023-11-28. PMID:38010200. |
ins and ins/met groups saw impairments in markers of insulin signaling (akt s473, mtor s2448, p70s6k t389, and irs-1s636) demonstrating ir was not recovered with met treatment. |
2023-11-28 |
2023-11-29 |
Not clear |
| Joana Santiago, Joana V Silva, Manuel A S Santos, Margarida Fardilh. Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001924. |
targets of dems were involved in signaling pathways previously associated with the ageing process, including cellular senescence, autophagy, insulin, and mtor pathways. |
2023-11-25 |
2023-11-28 |
human |
| Don Vu, Tariq Shah, Prashant Sakharkar, David I Mi. Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation. Transplant immunology. 2023-11-02. PMID:37918578. |
genetic variations in sestrin2/sestrin3/ mtor axis may cause obesity-associated metabolic syndrome, including lipid accumulation and insulin resistance thereby increasing individual's risk of diabetes. |
2023-11-02 |
2023-11-08 |
Not clear |
| Sumit Saha, Xianjun Fang, Christopher D Green, Anindita Da. mTORC1 and SGLT2 Inhibitors-A Therapeutic Perspective for Diabetic Cardiomyopathy. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894760. |
several studies have indicated hyperactivation of the mammalian target of rapamycin (mtor), specifically complex 1 (mtorc1), as a critical mediator of t2d pathophysiology by promoting insulin resistance, hyperlipidemia, inflammation, vasoconstriction, and stress. |
2023-10-30 |
2023-11-08 |
Not clear |
| Megan Beetch, Brian Akhaphong, Alicia Wong, Briana Clifton, Seokwon Jo, Ramkumar Mohan, Juan E Abrahante Llorens, Emilyn U Alejandr. Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring. Journal of molecular endocrinology. vol 71. issue 4. 2023-10-21. PMID:37855320. |
impact of placental mtor deficiency on peripheral insulin signaling in adult mice offspring. |
2023-10-21 |
2023-11-08 |
mouse |
| Megan Beetch, Brian Akhaphong, Alicia Wong, Briana Clifton, Seokwon Jo, Ramkumar Mohan, Juan E Abrahante Llorens, Emilyn U Alejandr. Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring. Journal of molecular endocrinology. vol 71. issue 4. 2023-10-21. PMID:37855320. |
upon insulin stimulation, insulin signaling via phosphorylation of akt and nutrient sensing via phosphorylation of mtor target ribosomal s6 were evaluated in the offspring liver, white adipose tissue, and skeletal muscle. |
2023-10-21 |
2023-11-08 |
mouse |
| Megan Beetch, Brian Akhaphong, Alicia Wong, Briana Clifton, Seokwon Jo, Ramkumar Mohan, Juan E Abrahante Llorens, Emilyn U Alejandr. Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring. Journal of molecular endocrinology. vol 71. issue 4. 2023-10-21. PMID:37855320. |
in summary, deletion of placental mtor nutrient sensing in utero programs hepatic response to insulin action in a sexually dimorphic manner. |
2023-10-21 |
2023-11-08 |
mouse |
| Daisuke Sawada, Hisaya Kato, Hiyori Kaneko, Daisuke Kinoshita, Shinichiro Funayama, Takuya Minamizuka, Atsushi Takasaki, Katsushi Igarashi, Masaya Koshizaka, Aki Takada-Watanabe, Rito Nakamura, Kazuto Aono, Ayano Yamaguchi, Naoya Teramoto, Yukari Maeda, Tomohiro Ohno, Aiko Hayashi, Kana Ide, Shintaro Ide, Mayumi Shoji, Takumi Kitamoto, Yusuke Endo, Hideyuki Ogata, Yoshitaka Kubota, Nobuyuki Mitsukawa, Atsushi Iwama, Yasuo Ouchi, Naoya Takayama, Koji Eto, Katsunori Fujii, Tomozumi Takatani, Tadashi Shiohama, Hiromichi Hamada, Yoshiro Maezawa, Koutaro Yokot. Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome. Aging. vol 15. 2023-10-04. PMID:37793000. |
rapamycin, an inhibitor of the mammalian target of rapamycin (mtor), alleviated premature cellular senescence, rescued the decrease in insulin signaling, and extended the lifespan of ws model of |
2023-10-04 |
2023-10-07 |
Not clear |
| Vivek Panwar, Aishwarya Singh, Manini Bhatt, Rajiv K Tonk, Shavkatjon Azizov, Agha Saquib Raza, Shinjinee Sengupta, Deepak Kumar, Manoj Gar. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-01. PMID:37779156. |
mtor catalyzes the phosphorylation of several critical proteins like akt, protein kinase c, insulin growth factor receptor (igf-1r), 4e binding protein 1 (4e-bp1), ribosomal protein s6 kinase (s6k), transcription factor eb (tfeb), sterol-responsive element-binding proteins (srebps), lipin-1, and unc-51-like autophagy-activating kinases. |
2023-10-01 |
2023-10-07 |
human |
| Megan Beetch, Brian Akhaphong, Alicia Wong, Briana Clifton, Seokwon Jo, Ramkumar Mohan, Juan E Abrahante Llorens, Emilyn Alejandr. Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring. Journal of molecular endocrinology. 2023-09-29. PMID:37772736. |
impact of placental mtor deficiency on peripheral insulin signaling in adult mice offspring. |
2023-09-29 |
2023-10-07 |
mouse |
| Megan Beetch, Brian Akhaphong, Alicia Wong, Briana Clifton, Seokwon Jo, Ramkumar Mohan, Juan E Abrahante Llorens, Emilyn Alejandr. Impact of placental mTOR deficiency on peripheral insulin signaling in adult mice offspring. Journal of molecular endocrinology. 2023-09-29. PMID:37772736. |
upon insulin stimulation, insulin signaling via phosphorylation of akt and nutrient sensing via phosphorylation of mtor target ribosomal s6 were evaluated in the offspring liver, white adipose tissue, and skeletal muscle. |
2023-09-29 |
2023-10-07 |
mouse |