| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Giansante, Luca Di Angelo, Chiara Calabrese, Paolo De Sanctis, Paolo Regi, Filippo Maria Martelli, Gianmarco Stati, Rossano Lattanzio, Saverio Alberti, Emanuela Guerra, Roberta Di Pietr. Novel Ultrastructural Insights into the Clear-Cell Carcinoma of the Pancreas: A Case Report. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673897. |
immunohistochemistry staining for nadh dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (ndufa4l2) proved specifically negative for the clear-cell tumor. |
2024-04-27 |
2024-04-29 |
Not clear |
| Qingbu Mei, Ping Chen, Ying Lv, Lihong Zheng, Dan Liu, Minglong Zhang, Wanquan Liu, Penghui L. Elevated of NDUFA4L2 expression in colon adenocarcinoma is correlated with an unfavorable prognosis and increased immune cell infiltration. Heliyon. vol 10. issue 3. 2024-02-14. PMID:38352787. |
previous studies have suggested that nadh dehydrogenase 1 alpha subcomplex subunit 4-like 2 (ndufa4l2) may affect tumor progression across various cancers. |
2024-02-14 |
2024-02-16 |
Not clear |
| Nianyuan Ye, Yibo Wang, Peng Jiang, Huaji Jiang, Wei Ding, Zheng Zhang, Cheng X. Hypoxia-induced the upregulation of NDUFA4L2 promoted colon adenocarcinoma progression through ROS-mediated PI3K/AKT pathway. Cytotechnology. vol 75. issue 6. 2023-10-16. PMID:37841958. |
the nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 (ndufa4l2) gene has been reported to be upregulated in colorectal cancer (crc) and is associated with worse prognosis. |
2023-10-16 |
2023-11-08 |
Not clear |
| Zhenzhong Liu, Li Wang, Yue Wang, Siya Wu, Caiting Peng, Yu Wang, Ming Huang, Li Che, Rongjing Sun, Xi Zhao, Zuo Du, Wenhu Li. Quantitative Proteomics Reveals the Neurotoxicity of Trimethyltin Chloride on Mitochondria in the Hippocampus of Mice. Neurotoxicology. 2023-10-14. PMID:37838251. |
some proteins, including succinate-coa ligase subunit (suclg1), nadh dehydrogenase subunit 5 (nd5), nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (ndufa4l2) and cytochrome c oxidase assembly factor 7 (coa7), which were closely related to mitochondrial respiratory electron transport, showed tmt dose and time dependent changes in the hippocampus of mice. |
2023-10-14 |
2023-11-08 |
mouse |
| Jaclyn M Kubala, Kristian B Laursen, Ryan Schreiner, Ryan M Williams, Johannes C van der Mijn, Michael J Crowley, Nigel P Mongan, David M Nanus, Daniel A Heller, Lorraine J Guda. NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma. Cancer biology & therapy. vol 24. issue 1. 2023-02-01. PMID:36722045. |
in clear cell renal cell carcinoma (ccrcc), activation of hypoxic signaling induces nadh dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (ndufa4l2) expression. |
2023-02-01 |
2023-08-14 |
human |
| Zhengye Liu, Thomas Chaillou, Estela Santos Alves, Theresa Mader, Baptiste Jude, Duarte M S Ferreira, Heidi Hynynen, Arthur J Cheng, William O Jonsson, Gianluigi Pironti, Daniel C Andersson, Ellinor Kenne, Jorge L Ruas, Pasi Tavi, Johanna T Lanne. Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 12. 2021-12-02. PMID:34724256. |
the hypoxia-inducible nuclear-encoded mitochondrial protein nadh dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (ndufa4l2) has been demonstrated to decrease oxidative phosphorylation and production of reactive oxygen species in neonatal cardiomyocytes, brain tissue and hypoxic domains of cancer cells. |
2021-12-02 |
2023-08-13 |
mouse |
| Zheng Chen, Xiangyu Wei, Xueyi Wang, Xuan Zheng, Bowen Chang, Lin Shen, Hanshuo Zhu, Min Yang, Shiting Li, Xuesheng Zhen. NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib. Cell death & disease. vol 12. issue 4. 2021-10-12. PMID:33828084. |
nadh dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (ndufa4l2) is a subunit of complex i of the mitochondrial respiratory chain, which is important in metabolic reprogramming and oxidative stress in multiple cancers. |
2021-10-12 |
2023-08-13 |
Not clear |
| Yun Liu, Xiaowei Nie, Jinquan Zhu, Tianyan Wang, Yanli Li, Qian Wang, Zengxian Su. NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension. Journal of cellular and molecular medicine. vol 25. issue 2. 2021-09-14. PMID:33340241. |
in this study, we demonstrated that nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 4 like 2 (ndufa4l2) was a proliferation factor and increased in vivo and in vitro through various molecular biology experiments. |
2021-09-14 |
2023-08-13 |
human |
| Lei Wang, Zhiqiang Peng, Kaizhen Wang, Yijun Qi, Ying Yang, Yue Zhang, Xinyuan An, Shudong Luo, Junfang Zhen. NDUFA4L2 is associated with clear cell renal cell carcinoma malignancy and is regulated by ELK1. PeerJ. vol 5. 2020-09-29. PMID:29158991. |
nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 (ndufa4l2) was found to be upregulated and play an important role in ccrcc. |
2020-09-29 |
2023-08-13 |
Not clear |
| Giuseppe Lucarelli, Monica Rutigliano, Fabio Sallustio, Domenico Ribatti, Andrea Giglio, Martina Lepore Signorile, Valentina Grossi, Paola Sanese, Anna Napoli, Eugenio Maiorano, Cristina Bianchi, Roberto A Perego, Matteo Ferro, Elena Ranieri, Grazia Serino, Lauren N Bell, Pasquale Ditonno, Cristiano Simone, Michele Battagli. Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma. Aging. vol 10. issue 12. 2019-12-19. PMID:30538212. |
we identified nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 (ndufa4l2) as the most highly expressed gene in renal cancer cells and evaluated its role in sustaining angiogenesis, chemoresistance, and mitochondrial dysfunction. |
2019-12-19 |
2023-08-13 |
human |
| Yun Lv, Shao-Lin Nie, Ju-Mei Zhou, Feng Liu, Ying-Bin Hu, Jia-Rui Jiang, Ni Li, Jing-Shi Li. Overexpression of NDUFA4L2 is associated with poor prognosis in patients with colorectal cancer. ANZ journal of surgery. vol 87. issue 12. 2018-08-20. PMID:27226356. |
ndufa4l2 (nadh dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2, also called nadh-ubiquinone oxidoreductase mlrq subunit homologue) was clearly enriched in the mitochondrial fraction under hypoxic conditions, and immunofluorescence showed a clear colocalization of ndufa4l2 and cytochrome c in some tumour cells. |
2018-08-20 |
2023-08-13 |
Not clear |
| Jianhua Li, Caiyan Bai, Junxia Guo, Wanqian Liang, Jingning Lon. NDUFA4L2 protects against ischaemia/reperfusion-induced cardiomyocyte apoptosis and mitochondrial dysfunction by inhibiting complex I. Clinical and experimental pharmacology & physiology. vol 44. issue 7. 2018-03-21. PMID:28429857. |
the aims of the present study were to investigate whether nadh dehydrogenase 1 alpha subcomplex subunit 4-like 2 (ndufa4l2) on myocardial ischaemia-reperfusion (i/r) injury and the underlying molecular mechanism. |
2018-03-21 |
2023-08-13 |
Not clear |
| Denise R Minton, Leiping Fu, Nigel P Mongan, Maria M Shevchuk, David M Nanus, Lorraine J Guda. Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 22. issue 11. 2018-01-22. PMID:26783287. |
we delineated the functions of the hypoxia-inducible factor-1α (hif1α) target nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 (ndufa4l2) in clear cell renal cell carcinoma (ccrcc) and characterized ndufa4l2 as a novel molecular target for ccrcc treatment. |
2018-01-22 |
2023-08-13 |
Not clear |
| Esmeralda Castelblanco, Pilar Gallel, Susana Ros, Sonia Gatius, Joan Valls, Aguirre A De-Cubas, Agnieszka Maliszewska, M Teresa Yebra-Pimentel, Javier Menarguez, Carlos Gamallo, Giuseppe Opocher, Mercedes Robledo, Xavier Matias-Gui. Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results. Human pathology. vol 43. issue 7. 2012-09-14. PMID:22209341. |
seven biomarkers showing differential expression were selected (nicotinamide adenine dinucleotide dehydrogenase 1 alpha subcomplex, 4-like 2, ndufa4l2; cytochrome c oxidase subunit iv isoform 2; vesicular monoamine transporter 2; calcitonin gene-related protein/calcitonin; carcinoembryonic antigen; and thyroid transcription factor 1) for immunohistochemical analysis. |
2012-09-14 |
2023-08-12 |
Not clear |
| Daniel Tello, Eduardo Balsa, Bárbara Acosta-Iborra, Esther Fuertes-Yebra, Ainara Elorza, Ángel Ordóñez, María Corral-Escariz, Inés Soro, Elia López-Bernardo, Ester Perales-Clemente, Antonio Martínez-Ruiz, José Antonio Enríquez, Julián Aragonés, Susana Cadenas, Manuel O Landázur. Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity. Cell metabolism. vol 14. issue 6. 2012-04-16. PMID:22100406. |
we have identified a hif-1 target gene, the mitochondrial ndufa4l2 (nadh dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2). |
2012-04-16 |
2023-08-12 |
Not clear |