| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Hossein Fatemi, Elysabeth D Otte, Timothy D Folsom, Arthur C Eschenlauer, Randall J Roper, Justin W Aman, Paul D Thura. Early Chronic Fluoxetine Treatment of Ts65Dn Mice Rescues Synaptic Vesicular Deficits and Prevents Aberrant Proteomic Alterations. Genes. vol 15. issue 4. 2024-04-27. PMID:38674386. |
proteomic analysis of trisomic synaptic fractions revealed significant downregulation of proteins involved in synaptic vesicular traffic, including vesicular endocytosis (clta, cltb, cltc), synaptic assembly and maturation (exoc1, exoc3, exoc8), anterograde axonal transport (exoc1), neurotransmitter transport to psd (sacm1l), endosomal-lysosomal acidification (rogdi, dmxl2), and synaptic signaling (nrxn1, hip1, itsn1, ywhag). |
2024-04-27 |
2024-04-29 |
mouse |
| Takeshi Kaizuka, Toru Takum. Alteration of synaptic protein composition during developmental synapse maturation. The European journal of neuroscience. 2024-04-04. PMID:38571321. |
the psd proteome comprises ~1000 proteins, including neurotransmitter receptors, scaffolding proteins and signalling enzymes. |
2024-04-04 |
2024-04-06 |
Not clear |
| Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Li. Inflammatory Pathogenesis of Post-stroke Depression. Aging and disease. 2024-02-20. PMID:38377025. |
emerging evidence suggests that microglial activation, astrocyte responses, nuclear factor κb(nf-κb) signaling, dysregulation of the hypothalamic pituitary adrenal (hpa) axis, alterations in brain-derived neurotrophic factor (bdnf) expression, neurotransmitter imbalances, adenosine triphosphate (atp) and its receptors and oxidative stress are intricately linked to the pathogenesis of psd. |
2024-02-20 |
2024-02-23 |
Not clear |
| Yanjuan Bai, Rubo Sui, Lei Zhang, Bing Bai, Yue Zhu, Hongxin Jian. Resveratrol improves cognitive function in post-stroke depression rats by repressing inflammatory reactions and oxidative stress via the Nrf2/HO-1 pathway. Neuroscience. 2024-01-26. PMID:38278473. |
psd rats exhibited depressive behaviors, disrupted neurotransmitter levels, and oxidative stress markers. |
2024-01-26 |
2024-01-29 |
rat |
| Daniel Woike, Debora Tibbe, Fatemeh Hassani Nia, Victoria Martens, Emily Wang, Igor Barsukov, Hans-Jürgen Kreienkam. The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling. Molecular neurobiology. 2023-09-01. PMID:37656313. |
members of the shank family of postsynaptic scaffold proteins (shank1-3) link neurotransmitter receptors to the actin cytoskeleton in dendritic spines through establishing numerous interactions within the postsynaptic density (psd) of excitatory synapses. |
2023-09-01 |
2023-09-07 |
mouse |
| Yutong Zhang, Yuehua Yang, Hao Li, Qian Feng, Wei Ge, Xingshun X. Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression. Molecular neurobiology. 2023-08-17. PMID:37592185. |
these cytokines contribute to psd through various mechanisms, including hypothalamic-pituitary-adrenal (hpa) axis dysfunction, neurotransmitter alterations, neurotrophic factor changes, gut microbiota imbalances, and genetic predispositions. |
2023-08-17 |
2023-09-07 |
Not clear |
| Jiaen Yang, Guangjin Zhou, Zixuan Ou, Ning Jia, Dong Wan. The Effect and Mechanism of Exercise Training on Rats with Poststroke Depression Based on the Intestinal Flora. Computational and mathematical methods in medicine. vol 2021. 2022-01-03. PMID:34976105. |
the pathogenesis of psd mainly involves neurotransmitter inflammatory factors, hpa and bdnf. |
2022-01-03 |
2023-08-13 |
rat |
| Christian G Spech. Fractional occupancy of synaptic binding sites and the molecular plasticity of inhibitory synapses. Neuropharmacology. vol 169. 2021-06-03. PMID:30648560. |
the postsynaptic density (psd) at inhibitory synapses is a complex molecular assembly that serves as a platform for the interaction of neurotransmitter receptors, scaffold and adapter proteins, cytoskeletal elements and signalling molecules. |
2021-06-03 |
2023-08-13 |
Not clear |
| L Cai, W T Li, L L Zhang, X Q Lu, M Chen, Y Li. Long noncoding RNA GAS5 enhanced by curcumin relieves poststroke depression by targeting miR-10b/BDNF in rats. Journal of biological regulators and homeostatic agents. vol 34. issue 3. 2020-11-03. PMID:32627518. |
in the present study, the therapeutic effect of curcumin on rats with psd was detected by open field tests and tail suspension tests, as well as the examination of corticosterone and corticotropin-releasing hormone (crh) levels in the serum and neurotransmitter 5-hydroxytryptamine (5-ht), 5-hydroxyindoleacetic acid (5-hiaa) and dopamine (da) levels in the hippocampus. |
2020-11-03 |
2023-08-13 |
rat |
| Mary B Kenned. The Protein Biochemistry of the Postsynaptic Density in Glutamatergic Synapses Mediates Learning in Neural Networks. Biochemistry. vol 57. issue 27. 2019-03-26. PMID:29913061. |
the psd is attached to the postsynaptic membrane just underneath the concentrated plaque of neurotransmitter receptors. |
2019-03-26 |
2023-08-13 |
Not clear |
| Waja Wegner, Alexander C Mott, Seth G N Grant, Heinz Steffens, Katrin I Willi. In vivo STED microscopy visualizes PSD95 sub-structures and morphological changes over several hours in the mouse visual cortex. Scientific reports. vol 8. issue 1. 2018-11-15. PMID:29317733. |
psd95 is an abundant scaffolding protein in the psd and assembles a family of supercomplexes comprised of neurotransmitter receptors, ion channels, as well as signalling and structural proteins. |
2018-11-15 |
2023-08-13 |
mouse |
| Andrea de Bartolomeis, Gianmarco Latte, Carmine Tomasetti, Felice Iasevol. Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23999870. |
the psd is a thickness, detectable at electronic microscopy, localized at the postsynaptic membrane of glutamatergic synapses, and made by scaffolding proteins, receptors, and effector proteins; it is considered a structural and functional crossroad where multiple neurotransmitter systems converge, including the dopaminergic, serotonergic, and glutamatergic ones, which are all implicated in the pathophysiology of psychosis. |
2014-10-27 |
2023-08-12 |
mouse |
| Joan M Jasien, Caitlin M Daimon, Rui Wang, Bruce K Shapiro, Bronwen Martin, Stuart Maudsle. The effects of aging on the BTBR mouse model of autism spectrum disorder. Frontiers in aging neuroscience. vol 6. 2014-09-16. PMID:25225482. |
unbiased proteomic analysis of hippocampal and cortical tissue of btbr mice compared to age-matched wild-type controls revealed a significant decrease in brain derived neurotrophic factor and significant increases in multiple synaptic markers (spinophilin, synapsin i, psd 95, neun), as well as distinct changes in functional pathways related to these proteins, including "neural synaptic plasticity regulation" and "neurotransmitter secretion regulation." |
2014-09-16 |
2023-08-13 |
mouse |
| Felice Iasevoli, Carmine Tomasetti, Elisabetta F Buonaguro, Andrea de Bartolomei. The glutamatergic aspects of schizophrenia molecular pathophysiology: role of the postsynaptic density, and implications for treatment. Current neuropharmacology. vol 12. issue 3. 2014-05-22. PMID:24851087. |
being implicated in the postsynaptic signaling of multiple neurotransmitter systems, mostly dopamine and glutamate, the psd constitutes an ideal candidate for studying dopamine-glutamate disturbances in schizophrenia. |
2014-05-22 |
2023-08-13 |
human |
| Yuan Hu, Ming Liu, Ping Liu, Juan-Juan Yan, Ming-Yue Liu, Gang-Qiang Zhang, Xiao-Jiang Zhou, Bing-Ying Y. Effect of kai xin san on learning and memory in a rat model of paradoxical sleep deprivation. Journal of medicinal food. vol 16. issue 4. 2013-09-17. PMID:23514232. |
this study indicates that the effect of kxs on learning and memory in a rat model of psd could be associated with the modulation of neurotransmitter levels and the expression of some genes in the brain that contribute to memory functions. |
2013-09-17 |
2023-08-12 |
rat |
| Isabelle Loubinoux, Golo Kronenberg, Matthias Endres, Pascale Schumann-Bard, Thomas Freret, Robert K Filipkowski, Leszek Kaczmarek, Aurel Popa-Wagne. Post-stroke depression: mechanisms, translation and therapy. Journal of cellular and molecular medicine. vol 16. issue 9. 2013-01-07. PMID:22348642. |
this review therefore presents animal models of psd and summarizes potential underlying mechanisms including genomic signatures, neurotransmitter and neurotrophin signalling, hippocampal neurogenesis, cellular plasticity in the ischaemic lesion, secondary degenerative changes, activation of the hypothalamo-pituitary-adrenal (hpa) axis and neuroinflammation. |
2013-01-07 |
2023-08-12 |
Not clear |
| Haitham S Mohammed, Heba S Aboul Ezz, Yasser A Khadrawy, Neveen A Noo. Neurochemical and electrophysiological changes induced by paradoxical sleep deprivation in rats. Behavioural brain research. vol 225. issue 1. 2012-01-18. PMID:21729722. |
both the waking eeg and neurotransmitter analyses suggest that psd induced neurochemical and electrophysiological changes that may affect brain proper functionality. |
2012-01-18 |
2023-08-12 |
rat |
| Adi Taflia, David Holcma. Estimating the synaptic current in a multiconductance AMPA receptor model. Biophysical journal. vol 101. issue 4. 2011-12-07. PMID:21843468. |
despite intense experimental and theoretical research, it is still unclear how factors such as the synaptic cleft geometry, the organization, the number and the multiconductance state of receptors, the geometry of postsynaptic density (psd), and the neurotransmitter release location, shape the mean and the variance of the postsynaptic current and its plastic changes. |
2011-12-07 |
2023-08-12 |
Not clear |
| Fernanda Ledd. Ligand-induced cell adhesion as a new mechanism to promote synapse formation. Cell adhesion & migration. vol 1. issue 3. 2009-06-09. PMID:19262133. |
the formation of neuronal synapses is a finely organized process that involves the presynaptic assembly of the machinery responsible for neurotransmitter release and the postsynaptic recruitment of neurotransmitter receptors and scaffold proteins to the postsynaptic density (psd). |
2009-06-09 |
2023-08-12 |
Not clear |
| Paul C Bressloff, Berton A Earnsha. A dynamic corral model of receptor trafficking at a synapse. Biophysical journal. vol 96. issue 5. 2009-05-18. PMID:19254538. |
the postsynaptic density (psd) is a cytoskeletal specialization within the postsynaptic membrane of a neuron that helps to concentrate and organize neurotransmitter receptors at a chemical synapse. |
2009-05-18 |
2023-08-12 |
Not clear |