| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rokeya Akter, Rackhyun Park, Soo Kyung Lee, Eun Ju Han, Kyu-Sang Park, Junsoo Park, Mee-Yon Ch. Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673975. |
jak2/stat3 inhibition decreased the levels of emr1, jak2, stat1, and stat3, significantly impeded the proliferation, migration, and mobility of cells, and increased the apoptosis of emr1 |
2024-04-27 |
2024-04-29 |
Not clear |
| Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yan. Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3. Archives of toxicology. 2023-07-03. PMID:37395757. |
apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating stat1 and stat3. |
2023-07-03 |
2023-08-14 |
mouse |
| Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yan. Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3. Archives of toxicology. 2023-07-03. PMID:37395757. |
in conclusion, our results indicate that apelin-13 could be a potential otoprotective agent to prevent cisplatin-induced ototoxicity by inhibiting apoptosis, ros production, tnf-α and il-6 expression, and regulating phosphorylation of stat1 and stat3 transcription factors. |
2023-07-03 |
2023-08-14 |
mouse |
| Valeri V Mossine, James K Waters, Grace Y Sun, Zezong Gu, Thomas P Mawhinne. Microglia Signaling Pathway Reporters Unveiled Manganese Activation of the Interferon/STAT1 Pathway and Its Mitigation by Flavonoids. Molecular neurobiology. 2023-05-04. PMID:37140843. |
using an in vitro neuroinflammation model based on the insulated signaling pathway reporter transposon constructs stably transfected into a murine bv-2 microglia line, we tested effects of manganese (ii) together with a set of 12 metal salts on the transcriptional activities of the nf-κb, activator protein-1 (ap-1), signal transducer and activator of transcription 1 (stat1), stat1/stat2, stat3, nrf2, and metal-responsive transcription factor-1 (mtf-1) via luciferase assay, while concatenated destabilized green fluorescent protein expression provided for simultaneous evaluation of cellular viability. |
2023-05-04 |
2023-08-14 |
Not clear |
| Anima Kumari, Anugya Srivastava, Pankaj Jagdale, Anjaneya Ayanur, Vinay Kumar Khann. Lambda-cyhalothrin Enhances Inflammation in Nigrostriatal Region in Rats:Regulatory Role of NF-κβ and JAK-STAT Signaling. Neurotoxicology. 2023-04-15. PMID:37060950. |
exposure of rats to lct also caused alteration in the levelsof heat shock protein 60 (hsp60) and mrna expression of toll-like receptors(tlr2 and tlr4) in the substantia nigra and corpus striatum.an increase in the phosphorylation of key proteins involved in nf-kβ (p65, iκβ, ikkα, ikkβ)signalingand stat1 and stat3 and alteration in the protein levels of jak1 and jak2 were prominent in lct-treated rats.histological studies revealed damage of dopaminergic neurons and reactive gliosis as evidenced by the presence of darkly stained pyknotic neurons anddecrease in nisslsubstance and an increase in infiltration of immune cells both in substantia nigra and corpus striatum of lct-treated rats. |
2023-04-15 |
2023-08-14 |
rat |
| Min Zhou, Ping Zhang, Mengting Da, Rui Yang, Yulian Ma, Jiuda Zhao, Tao Ma, Jiazeng Xia, Guoshuang Shen, Yu Chen, Daozhen Che. A pan-cancer analysis of the expression of STAT family genes in tumors and their relationship to the tumor microenvironment. Frontiers in oncology. vol 12. 2022-09-30. PMID:36176415. |
the signal transducer and activator of transcription (stat) protein family, a group of seven members (stat1, stat2, stat3, stat4, stat5a, stat5b, and stat6), has been widely used to investigate numerous biological functions including cell proliferation, differentiation, apoptosis, and immune regulation. |
2022-09-30 |
2023-08-14 |
Not clear |
| Carsten Geiß, Elvira Salas, Jose Guevara-Coto, Anne Régnier-Vigouroux, Rodrigo A Mora-Rodrígue. Multistability in Macrophage Activation Pathways and Metabolic Implications. Cells. vol 11. issue 3. 2022-02-15. PMID:35159214. |
first, a decision-making module in signal transduction includes mutual inhibitory interactions between m1 (stat1, nf-kb/p50-p65) and m2 (stat3, nf-kb/p50-p50) signaling pathways. |
2022-02-15 |
2023-08-13 |
Not clear |
| Sony Maharjan, Mijeong Kang, Jinsoo Kim, Dongbum Kim, Sangkyu Park, Minyoung Kim, Kyeongbin Baek, Younghee Lee, Hyung-Joo Kwo. Apoptosis Enhances the Replication of Human Coronavirus OC43. Viruses. vol 13. issue 11. 2021-12-01. PMID:34835005. |
dephosphorylation of stat1 and stat3, induced by hcov-oc43 infection, was also associated with hcov-oc43-mediated apoptosis. |
2021-12-01 |
2023-08-13 |
human |
| Soheil Najafi, Payam Saadat, Nahid Beladi Moghadam, Ali Manoucherinia, Zahra Aghazadeh, Anita Vali Mohammadi, Seyyedeh Masoomeh Noorbakhsh, Monireh Movahedi, Mohammad Reza Nikouei Moghaddam, Hossein Pashaiefar, Abbas Mirshafie. The effects of mannuronic acid on IL-1β, IL-17A, STAT1 and STAT3 gene expression and TLR2 and TLR4 molecules in multiple sclerosis. Journal of clinical pharmacology. 2021-11-26. PMID:34825387. |
the effects of mannuronic acid on il-1β, il-17a, stat1 and stat3 gene expression and tlr2 and tlr4 molecules in multiple sclerosis. |
2021-11-26 |
2023-08-13 |
human |
| Jonggul Lee, Donggu Lee, Yangjin Ki. Mathematical model of STAT signalling pathways in cancer development and optimal control approaches. Royal Society open science. vol 8. issue 9. 2021-10-12. PMID:34631119. |
in this study, we investigate how an intracellular signalling network (stat1, stat3, bcl-2 and bax) regulates important cellular states, either anti-apoptosis or apoptosis of cancer cells. |
2021-10-12 |
2023-08-13 |
Not clear |
| Dandan Chen, Yaoyu Liu, Junqi Chen, Hua Lin, Huijuan Guo, Yifan Wu, Yuan Xu, Yuan Zhou, Wei Zhou, Ruirui Lu, Jiuyao Zhou, Junbiao W. JAK/STAT pathway promotes the progression of diabetic kidney disease via autophagy in podocytes. European journal of pharmacology. vol 902. 2021-09-27. PMID:33901462. |
further, a lower number of autophagosomes, reduced expression of map1lc3 (lc3) in glomeruli, and increased expression of jak/stat pathway-related proteins, namely jak1, jak2, stat1, stat3, stat5, and stat6, were observed in dkd mice. |
2021-09-27 |
2023-08-13 |
mouse |
| Hang Liu, Run-Hong Zhou, Yu Liu, Le Guo, Xu Wang, Wen-Hui Hu, Wen-Zhe H. HIV infection suppresses TLR3 activation-mediated antiviral immunity in microglia and macrophages. Immunology. vol 160. issue 3. 2021-05-26. PMID:32053234. |
mechanistically, hiv infection inhibited the phosphorylation of ifn regulatory factors (irf3 and irf7) and signal transducer and activator of transcription proteins (stat1 and stat3) in both hiv latently infected microglia and acutely infected macrophages. |
2021-05-26 |
2023-08-13 |
human |
| Byoung Kwon Park, Dongbum Kim, Sangkyu Park, Sony Maharjan, Jinsoo Kim, Jun-Kyu Choi, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwo. Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33504682. |
sars-cov-2 infection induced dephosphorylation of stat1 and stat3, high virus production, and apoptosis in vero cells. |
2021-05-07 |
2023-08-13 |
Not clear |
| Byoung Kwon Park, Dongbum Kim, Sangkyu Park, Sony Maharjan, Jinsoo Kim, Jun-Kyu Choi, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwo. Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33504682. |
however, in calu-3 cells, sars-cov-2 infection induced long-lasting phosphorylation of stat1 and stat3, low virus production, and no prominent apoptosis. |
2021-05-07 |
2023-08-13 |
Not clear |
| Jeremy J McGuire, Jeremy S Frieling, Chen Hao Lo, Tao Li, Ayaz Muhammad, Harshani R Lawrence, Nicholas J Lawrence, Leah M Cook, Conor C Lync. Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer. Nature communications. vol 12. issue 1. 2021-02-19. PMID:33526787. |
acquired resistance to apoptosis is pca cell intrinsic, and is associated with a shift in il-28rα signaling via stat1 to stat3. |
2021-02-19 |
2023-08-13 |
Not clear |
| Hua Fang, Fang-Xiang Zhang, Hua-Feng Li, Miao Yang, Ren Liao, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Jian-Ping Zhan. PRR34-AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1-dependent JAK-STAT signaling pathway. Journal of cellular physiology. vol 235. issue 3. 2020-12-17. PMID:31556112. |
upregulated prr34-as1 diminished expression of jak1, stat1, jak2, and stat3 as well as cell apoptosis, while enhancing cell proliferation in vitro. |
2020-12-17 |
2023-08-13 |
mouse |
| Adetola Shodeinde, Kalyani Ginjupalli, H Dan Lewis, Sheraz Riaz, Beverly E Barto. STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2. Journal of molecular biochemistry. vol 2. issue 1. 2020-10-01. PMID:25364701. |
stat3 inhibition induces apoptosis in cancer cells independent of stat1 or stat2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiangyong Feng, Wei Xiong, Mingqiong Yuan, Jian Zhan, Xiankun Zhu, Zhijie Wei, Xidong Chen, Xianbing Chen. Down-regulated microRNA-183 mediates the Jak/Stat signaling pathway to attenuate hippocampal neuron injury in epilepsy rats by targeting Foxp1. Cell cycle (Georgetown, Tex.). vol 18. issue 22. 2020-09-16. PMID:31571517. |
expression of mir-183, foxp1, jak1, stat1, and stat3 in rats' hippocampal tissues was determined by reverse transcription quantitative polymerase chain reaction (rt-qpcr) and western blot analysis. |
2020-09-16 |
2023-08-13 |
rat |
| Xiangyong Feng, Wei Xiong, Mingqiong Yuan, Jian Zhan, Xiankun Zhu, Zhijie Wei, Xidong Chen, Xianbing Chen. Down-regulated microRNA-183 mediates the Jak/Stat signaling pathway to attenuate hippocampal neuron injury in epilepsy rats by targeting Foxp1. Cell cycle (Georgetown, Tex.). vol 18. issue 22. 2020-09-16. PMID:31571517. |
the levels of mir-183, jak1, stat1, and stat3 were elevated, and the expression of foxp1 was declined in ep rats' hippocampal tissues. |
2020-09-16 |
2023-08-13 |
rat |
| Vianney Delplace, Arturo Ortin-Martinez, En Leh S Tsai, Alan N Amin, Valerie Wallace, Molly S Shoiche. Controlled release strategy designed for intravitreal protein delivery to the retina. Journal of controlled release : official journal of the Controlled Release Society. vol 293. 2020-03-19. PMID:30419267. |
intravitreal injections of the bioengineered thermogel showed successful delivery of cntf-sh3 to the mouse retina, with expected transient downregulation of phototransduction genes (e.g., rhodopsin, s-opsin, m-opsin, gnat 1 and 2), upregulation of stat1 and stat3 expression, and upregulation of stat3 phosphorylation. |
2020-03-19 |
2023-08-13 |
mouse |