| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shannon L Kelleher, Serena Burkinshaw, Seun Elizabeth Kuyoor. Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues. Molecular nutrition & food research. 2024-04-27. PMID:38676329. |
limited information delineating effects of polyphenols on the molecular pathways that affect lactation are found, although available information suggests modulation of stat5 signaling/differentiation, stat3 signaling/remodeling, mtor and insulin signaling/energy production, and nuclear factor kappa beta (nfκβ) signaling/oxidative stress and inflammation may play roles. |
2024-04-27 |
2024-04-29 |
Not clear |
| Nanyu Cao, Heyang Wan. Insulin augments angiotensin II-induced myocardial fibrosis via the MEK/STAT3 pathway. Heliyon. vol 9. issue 12. 2023-12-21. PMID:38125490. |
total stat3 expression, but not activation was stimulated by insulin; the effect of insulin on ang ii-induced fibrosis disappeared when stat3 was blocked and could be entirely suppressed by the mek inhibitor pd0325901. |
2023-12-21 |
2023-12-23 |
Not clear |
| Amene Saghazade. Exploring the pharmacological versatility of ficus carica: Modulating classical immunometabolism and beyond. Pharmacological research. vol 198. 2023-11-26. PMID:37995897. |
it reveals a variety of cellular and molecular targets for fcdp: cytokines (tnf-α, il-1β, il-6, il-10, il-12, il-18, ifn-γ), chemokines (ccl2), other inflammatory mediators (crp, pge2), immune receptors (tlr-2, tlr-4, fcεri), oxidative stress-related markers (sod, gsh, mda, gpx, catalase, ros, no, protein carbonyls), kinases (mapks, hexokinase, g6pase, fbpase, pepck, akt, ampk, gsk3, cdks), other enzymes (cox-2, inos, mmps, caspases), growth factors/receptors (vegf, egfr), hormones (dheas, prolactin, gnrh, fsh, lh, estradiol, dht, insulin), cell death-related markers (bcl-2, bax, bak, fasl, gasdermins, cytochrome c), glucose transporter protein (glut4), and transcription factors (nf-κb, hnf-4α, foxo, pgc-1α, ppar-γ, c/ebp-α, creb, nfatc1, stat3). |
2023-11-26 |
2023-11-28 |
Not clear |
| Gokul Sudhakaran, P Snega Priya, Kannan Jagan, B Haridevamuthu, Ramu Meenatchi, Jesu Arockiara. Osteoporosis in polycystic ovary syndrome (PCOS) and involved mechanisms. Life sciences. 2023-11-19. PMID:37981226. |
key genes such as ins, igf1, ctnnb1, akt1, and stat3 play pivotal roles in the complex interplay between pcos and osteoporosis, influencing insulin signaling, oxidative stress, and inflammatory pathways. |
2023-11-19 |
2023-11-29 |
Not clear |
| Xiaoting Hou, Yangshan Chen, Bo Zhou, Wanze Tang, Zhen Ding, Litong Chen, Yun Wu, Hongyu Yang, Changzheng Du, Dazhi Yang, Guixing Ma, Huiling Ca. Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice. Cell death & disease. vol 14. issue 10. 2023-10-31. PMID:37903776. |
furthermore, haploinsufficiency of talin-1 and stat3 genes, but not that of either gene, in β-cell in mice significantly impairs glucose tolerance and insulin expression, indicating that both factors indeed function in the same genetic pathway. |
2023-10-31 |
2023-11-08 |
mouse |
| Lauren Bodilly, Lauren Williamson, Kendra Howell, Matthew Alder, Jennifer Kapla. Obese Mice with Pneumonia Have Hyperleptinemia and Increased Pulmonary Signal Transducer and Activator of Transcription 3 Activation. Shock (Augusta, Ga.). 2023-01-04. PMID:36597767. |
leptin and insulin levels were higher in obese mice compared to non-obese mice, and obese mice with pneumonia had higher pulmonary stat3 activation compared to non-obese mice. |
2023-01-04 |
2023-08-14 |
mouse |
| Zixuan Gao, Gui Wang, Xiaochen Ma, Huihui Tan, Chu Zhang, Xin Yin, Feng Suo, Ruiqin Yao, Xiaonan Ya. Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats. American journal of physiology. Endocrinology and metabolism. vol 323. issue 5. 2022-10-24. PMID:36103628. |
here, glucose tolerance tests (gtts), insulin tolerance tests (itts), and homeostatic model assessment of insulin resistance (homa-ir) analyses revealed that troxerutin treatment in dht-treated rats also significantly improved insulin resistance and enhanced serum il-22 levels, which thereby activated il-22r1/janus kinase 1 (jak1)/signal transducer and activator of transcription-3 (stat3) signaling pathway in pancreatic islet. |
2022-10-24 |
2023-12-17 |
mouse |
| Youchao Qi, Guozhen Duan, Dengbang Wei, Chengzhou Zhao, Yonggui M. The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe? Molecules (Basel, Switzerland). vol 27. issue 16. 2022-08-26. PMID:36014536. |
a series of evidence shows that tgr5 induces protein kinase b (akt), nuclear factor kappa-b (nf-κb), extracellular regulated protein kinases (erk1/2), signal transducer and activator of transcription 3 (stat3), cyclic adenosine monophosphate (camp), ras homolog family member a (rhoa), exchange protein activated by camp (epac), and transient receptor potential ankyrin subtype 1 protein (trpa1) signaling pathways, thereby regulating proliferation, inflammation, adhesion, migration, insulin release, muscle relaxation, and cancer development. |
2022-08-26 |
2023-08-14 |
Not clear |
| Sandra Aparecida Benite-Ribeiro, Valkíria Alves de Lima Rodrigues, Mônica Rodrigues Ferreira Machad. Food intake in early life and epigenetic modifications of pro-opiomelanocortin expression in arcuate nucleus. Molecular biology reports. vol 48. issue 4. 2021-06-09. PMID:33877530. |
insulin, uses inositol 1,4,5-trisphosphate/serine-threonine kinase (ip3/akt) pathways and stimulates the exclusion of (forkhead box protein o1) foxo1 from the nucleus and thereby does the inactivation of the inhibition of pomc expression, while leptin stimulates signal transducer and activator of transcription 3 (stat3) phosphorylation and pomc expression. |
2021-06-09 |
2023-08-13 |
Not clear |
| Akira Mizoguchi, Ryoichi Banno, Runan Sun, Hiroshi Yaginuma, Keigo Taki, Tomoko Kobayashi, Mariko Sugiyama, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Hiroshi Arim. High-fat Feeding Causes Inflammation and Insulin Resistance in the Ventral Tegmental Area in Mice. Neuroscience. vol 461. 2021-05-14. PMID:33609637. |
in experiments using these mice, akt phosphorylation in the vta was significantly decreased after intracerebroventricular injection of insulin, whereas no change in stat3 phosphorylation was found with leptin. |
2021-05-14 |
2023-08-13 |
mouse |
| Shih-Yi Lin, Ching-Ping Yang, Ya-Yu Wang, Chiao-Wan Hsiao, Wen-Ying Chen, Su-Lan Liao, Yu-Li Lo, Yih-Hsin Chang, Chen-Jee Hong, Chun-Jung Che. Interleukin-4 Improves Metabolic Abnormalities in Leptin-Deficient and High-Fat Diet Mice. International journal of molecular sciences. vol 21. issue 12. 2021-03-22. PMID:32585823. |
145e and hfd mice showed a number of abnormalities: obesity, hyperglycemia, hyperinsulinemia, insulin resistance, dyslipidemia, liver injury, and adiposity with concurrent inflammation, decreases in akt, signal transducer and activator of transcription 3 (stat3), and stat6 phosphorylation in the hypothalamus, liver, and epididymal fat. |
2021-03-22 |
2023-08-13 |
mouse |
| T V Iakovleva, N E Kostina, E N Makarova, N M Bazha. Effect of gonadectomy and estradiol on the expression of insulin signaling cascade genes in female and male mice. Vavilovskii zhurnal genetiki i selektsii. vol 24. issue 4. 2021-03-04. PMID:33659826. |
the effect of gonadectomy and estradiol (1 μg/animal, three days) on the expression of insulin signaling cascade genes in muscle, adipose tissue, and liver, as well as on the expression of fgf21, estradiol receptors (esr1/2), and transcription factor stat3 in the liver in female and male mice was investigated. |
2021-03-04 |
2023-08-13 |
mouse |
| Yonghao Cai, Xiaobi Zhang, Xuegu Xu, Yinfei Y. Effects of puerarin on the retina and STAT3 expression in diabetic rats. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285079. |
an electroretinogram and serum and tissue levels of glucose, insulin, superoxide dismutase (sod), malondialdehyde (mda) and total antioxidant capacity (t-aoc) were measured; real-time pcr and elisa were used to determine stat3 mrna and protein expression, respectively, from the retina. |
2020-10-01 |
2023-08-13 |
rat |
| Liping Zhang, Zihong Chen, Ying Wang, David J Tweardy, William E Mitc. Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40. American journal of physiology. Endocrinology and metabolism. vol 318. issue 5. 2020-07-29. PMID:32101031. |
stat3 activation induces insulin resistance via a muscle-specific e3 ubiquitin ligase fbxo40. |
2020-07-29 |
2023-08-13 |
mouse |
| Yu Cheng Lu, Pu Wang, Jie Wang, Ronald Ma, Shao Chin Le. PCNA and JNK1-Stat3 pathways respectively promotes and inhibits diabetes-associated centrosome amplification by targeting at the ROCK1/14-3-3σ complex in human colon cancer HCT116 cells. Journal of cellular physiology. vol 234. issue 7. 2020-05-12. PMID:30478982. |
high glucose, insulin, and palmitic acid also increased the expressions of c-jun n-terminal kinase-1 (jnk1) and signal transducer and activator of transcription 3 (stat3), individual knockdown of which upregulated the treatment-increased expression of 14-3-3σ and promoted the centrosome amplification. |
2020-05-12 |
2023-08-13 |
human |
| Kira Derkach, Irina Zakharova, Inna Zorina, Andrey Bakhtyukov, Irina Romanova, Liubov Bayunova, Alexander Shpako. The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect. PloS one. vol 14. issue 3. 2019-12-12. PMID:30870482. |
in the hypothalamus of mf-treated agouti-mice (10 days, 600 mg/kg/day), the leptin and insulin content was restored, akt-kinase activity was increased, and the activities of ampk and stat3 were reduced and did not differ from control mice. |
2019-12-12 |
2023-08-13 |
mouse |
| Mina Thon, Toru Hosoi, Koichiro Ozaw. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78. Scientific reports. vol 6. 2019-11-20. PMID:27677243. |
insulin enhanced leptin-induced stat3 signaling by inducing grp78. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mina Thon, Toru Hosoi, Koichiro Ozaw. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78. Scientific reports. vol 6. 2019-11-20. PMID:27677243. |
we found that insulin enhanced leptin-induced stat3 phosphorylation and this effect was ameliorated by the knockdown of grp78. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mina Thon, Toru Hosoi, Koichiro Ozaw. Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78. Scientific reports. vol 6. 2019-11-20. PMID:27677243. |
furthermore, insulin may enhance the leptin-induced activation of stat3 by inducing grp78, which may provide an important connection between insulin and leptin in the cns. |
2019-11-20 |
2023-08-13 |
Not clear |
| Weizhou Zhang, Cong S Zong, Ulrich Hermanto, Pablo Lopez-Bergami, Ze'ev Ronai, Lu-Hai Wan. Correction for Zhang et al., RACK1 Recruits STAT3 Specifically to Insulin and Insulin-Like Growth Factor 1 Receptors for Activation, Which Is Important for Regulating Anchorage-Independent Growth. Molecular and cellular biology. vol 37. issue 6. 2019-11-20. PMID:28250086. |
correction for zhang et al., rack1 recruits stat3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth. |
2019-11-20 |
2023-08-13 |
Not clear |