| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pablo Berríos-Cárcamo, Sarah Núñez, Justine Castañeda, Javiera Gallardo, María Rosa Bono, Fernando Ezque. Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673763. |
we found a significant increase in mcp1 mrna levels in the cerebellum of mice that consumed ethanol compared to controls, whereas no significant changes were observed in the prefrontal cortex, hippocampus, or striatum or in microglia isolated from the hippocampus and striatum. |
2024-04-27 |
2024-04-29 |
mouse |
| Fulton T Crews, Victoria Macht, Ryan P Vetren. Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD. Advances in drug and alcohol research. vol 4. 2024-03-25. PMID:38524847. |
epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (aie) exposure and in human aud. |
2024-03-25 |
2024-03-27 |
human |
| Fulton T Crews, Victoria Macht, Ryan P Vetren. Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD. Advances in drug and alcohol research. vol 4. 2024-03-25. PMID:38524847. |
microglia are monocyte-like cells that provide trophic and synaptic functions, that ethanol proinflammatory signals sensitize or "prime" during repeated drinking cycles, impacting neurocircuitry. |
2024-03-25 |
2024-03-27 |
human |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
developmental ethanol exposure impacts purkinje cells but not microglia in the young adult cerebellum. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
to determine how developmental ethanol exposure affects adult cerebellar microglia and purkinje cells, we used a human third-trimester binge exposure model in which mice received ethanol or saline from postnatal (p) days 4-9. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
ethanol had no effect on microglia density, morphology, dynamics, or injury response. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
overall, developmental ethanol exposure had few effects on cerebellar microglia in young adulthood and purkinje cells appeared to be more susceptible to its effects. |
2024-03-13 |
2024-03-15 |
mouse |
| Paige E Anton, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. NF-κB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464118. |
our group, and others, have implicated hippocampal-resident microglia as key producers of inflammatory mediators, yet the link between inflammation and neurodegeneration has not been established in models of binge ethanol exposure and advanced age. |
2024-03-11 |
2024-03-14 |
Not clear |
| Paige E Anton, Lauren N Rutt, Michael L Kaufman, Nicolas Busquet, Elizabeth J Kovacs, Rebecca L McCulloug. Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice. Brain, behavior, and immunity. 2023-12-27. PMID:38151165. |
binge ethanol exposure also increased measures of senescence, the nod like receptor pyrin domain containing 3 (nlrp3) inflammasome, and microglia reactivity in the brains of aged mice compared to young. |
2023-12-27 |
2023-12-30 |
mouse |
| Tori R Sides, James C Nelson, Kala N Nwachukwu, Jhana Boston, S Alex Marshal. The Influence of Arsenic Co-Exposure in a Model of Alcohol-Induced Neurodegeneration in C57BL/6J Mice. Brain sciences. vol 13. issue 12. 2023-12-23. PMID:38137081. |
the following were examined after the last dose of ethanol: (1) microglia activation assessed via immunohistochemical detection of iba-1, (2) reactive oxygen and nitrogen species (ros/rns) using a colorimetric assay, (3) neurodegeneration using fluoro-jade |
2023-12-23 |
2023-12-25 |
mouse |
| Douglas B Matthews, Samantha Scaletty, Sarah Trapp, Areonna Schreiber, Gillian Rossmann, Bailey Imhoff, Quinn Petersilka, Abigail Kastner, Jim Pauly, Kimberly Nixo. Chronic intermittent ethanol exposure during adolescence produces sex- and age-dependent changes in anxiety and cognition without changes in microglia reactivity late in life. Frontiers in behavioral neuroscience. vol 17. 2023-08-17. PMID:37589035. |
chronic intermittent ethanol exposure during adolescence produces sex- and age-dependent changes in anxiety and cognition without changes in microglia reactivity late in life. |
2023-08-17 |
2023-09-07 |
rat |
| Douglas B Matthews, Samantha Scaletty, Sarah Trapp, Areonna Schreiber, Gillian Rossmann, Bailey Imhoff, Quinn Petersilka, Abigail Kastner, Jim Pauly, Kimberly Nixo. Chronic intermittent ethanol exposure during adolescence produces sex- and age-dependent changes in anxiety and cognition without changes in microglia reactivity late in life. Frontiers in behavioral neuroscience. vol 17. 2023-08-17. PMID:37589035. |
finally, it is yet to be determined if binge-like ethanol exposure during adolescence alters microglia activation in relevant brain regions late in life. |
2023-08-17 |
2023-09-07 |
rat |
| Kala N Nwachukwu, Hassan E Mohammed, DaQuan R Mebane, Andrew W Barber, H Scott Swartzwelder, S Alex Marshal. Acute and Chronic Ethanol Effects during Adolescence on Neuroimmune Responses: Consequences and Potential Pharmacologic Interventions. Cells. vol 12. issue 10. 2023-07-06. PMID:37408257. |
this review synthesizes the most recent findings of the effects of adolescent alcohol use on toll-like receptors, cytokines, and chemokines, as well as the activation of astrocytes and microglia with an emphasis on differences associated with the duration of ethanol exposure (acute vs. chronic), the amount of exposure (e.g., dose or blood ethanol concentrations), sex differences, and the timing of the neuroimmune observation (immediate vs. persistent). |
2023-07-06 |
2023-08-14 |
Not clear |
| MaKenna Y Cealie, James C Douglas, Linh H D Le, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence. Frontiers in neuroscience. vol 17. 2023-05-23. PMID:37214408. |
while ethanol administered in adulthood can acutely depress the dynamics of the microglial process arbor, it is unknown how developmental ethanol exposure impacts microglia dynamics and their interactions with purkinje cells in the long term. |
2023-05-23 |
2023-08-14 |
Not clear |
| Lei Gao, Daryl L Davies, Liana Asatrya. Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555338. |
additionally, sb supplementation prevented changes in microglia, i.e., increase in iba-1 positive cell number and morphology, and in astrocytes, i.e., decrease in gfap-positive cell number, induced by combination of ethanol and abx treatments. |
2022-12-23 |
2023-08-14 |
mouse |
| Yanxia Guo, Min Yan, Li Li, Li Zhao, Yan L. Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499029. |
treadmill exercise prevents cognitive impairments in adolescent intermittent ethanol rats by reducing the excessive activation of microglia cell in the hippocampus. |
2022-12-11 |
2023-08-14 |
rat |
| Yanxia Guo, Min Yan, Li Li, Li Zhao, Yan L. Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499029. |
the excessive activation of microglia cell induced by adolescent intermittent ethanol (aie) leads to neuroinflammation in the hippocampus. |
2022-12-11 |
2023-08-14 |
rat |
| Kanza M Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E Dailey, Catherine A Marcinkiewc. Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood. Brain, behavior, and immunity. 2022-07-30. PMID:35907582. |
here we report that mice exposed to adolescent intermittent access to ethanol (aie) exhibit increased pain sensitivity and depressive-like behaviors that persist for several weeks after alcohol cessation and are accompanied by elevated cd68 expression in microglia and reduced numbers of serotonin (5-ht)-expressing neurons in the dorsal raphe nucleus (drn). |
2022-07-30 |
2023-08-14 |
mouse |
| Chanin Sillapachaiyaporn, Siriporn Chuchawankul, Sunita Nilkhet, Nuntanat Moungkote, Tewarit Sarachana, Alison T Ung, Seung Joon Baek, Tewin Tencomna. Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation. Food research international (Ottawa, Ont.). vol 157. 2022-06-28. PMID:35761673. |
hexane (aph) and ethanol (ape) extracts of ap inhibited bpa-induced neuroinflammation in bv2 microglia by reducing microglial activation and the expression of pro-inflammatory cytokines. |
2022-06-28 |
2023-08-14 |
Not clear |
| Jian Zou, T Jordan Walter, Alexandra Barnett, Aaron Rohlman, Fulton T Crews, Leon G Colema. Ethanol Induces Secretion of Proinflammatory Extracellular Vesicles That Inhibit Adult Hippocampal Neurogenesis Through G9a/GLP-Epigenetic Signaling. Frontiers in immunology. vol 13. 2022-05-31. PMID:35634322. |
microglia in the neurogenic niche are important regulators of ahn, and ethanol promotes proinflammatory microglia activation. |
2022-05-31 |
2023-08-13 |
Not clear |