| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingshu Hong, Yue Li, Lei Chen, Dengyang Han, Yitong Li, Xinning Mi, Kaixi Liu, Qian Wang, Yanan Song, Taotao Liu, Ning Yang, Yajie Liu, Zhengqian Li, Xiangyang Gu. A53T α-synuclein mutation increases susceptibility to postoperative delayed neurocognitive recovery via hippocampal Ang-(1-7)/MasR axis. Biochemical pharmacology. 2024-05-05. PMID:38705534. |
we respectively examined molecular changes at 6 h, 1 day, and 2 days after partial hepatectomy and observed that cognitive changes were accompanied by weakened angiotensin-(1-7)/mas receptor [ang-(1-7)/masr] axis, increased alpha-synuclein (α-syn) expression and phosphorylation, decreased methylated protein phosphatase-2a (me-pp2a), and prompted microglia m1 polarization and neuronal apoptosis in the hippocampus at 1 day after surgery. |
2024-05-05 |
2024-05-08 |
mouse |
| Valeria Cogut, Maaike Goris, Aukje Jansma, Marrit van der Staaij, Robert H Hennin. Hippocampal neuroimmune response in mice undergoing serial daily torpor induced by calorie restriction. Frontiers in neuroanatomy. vol 18. 2024-05-01. PMID:38686173. |
concurrently, the ca1 region of the hippocampus showed persistent morphological changes in microglia, characterized by reduced cell branching, decreased cell complexity and altered shape. |
2024-05-01 |
2024-05-03 |
mouse |
| Pablo Berríos-Cárcamo, Sarah Núñez, Justine Castañeda, Javiera Gallardo, María Rosa Bono, Fernando Ezque. Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673763. |
we found a significant increase in mcp1 mrna levels in the cerebellum of mice that consumed ethanol compared to controls, whereas no significant changes were observed in the prefrontal cortex, hippocampus, or striatum or in microglia isolated from the hippocampus and striatum. |
2024-04-27 |
2024-04-29 |
mouse |
| Bilal El-Mansoury, Kamal Smimih, Abdelaati El Khiat, Ahmed Draoui, Abdelmohcine Aimrane, Redouane Chatoui, Abdesslam Ferssiwi, Abdelali Bitar, Halima Gamrani, Arumugam R Jayakumar, Omar El Hib. Short Working Memory Impairment Associated with Hippocampal Microglia Activation in Chronic Hepatic Encephalopathy. Metabolites. vol 14. issue 4. 2024-04-26. PMID:38668321. |
short working memory impairment associated with hippocampal microglia activation in chronic hepatic encephalopathy. |
2024-04-26 |
2024-04-28 |
rat |
| Bilal El-Mansoury, Kamal Smimih, Abdelaati El Khiat, Ahmed Draoui, Abdelmohcine Aimrane, Redouane Chatoui, Abdesslam Ferssiwi, Abdelali Bitar, Halima Gamrani, Arumugam R Jayakumar, Omar El Hib. Short Working Memory Impairment Associated with Hippocampal Microglia Activation in Chronic Hepatic Encephalopathy. Metabolites. vol 14. issue 4. 2024-04-26. PMID:38668321. |
swm function was assessed through y-maze, t-maze, and novel object recognition (nor) tests, together with an immunofluorescence study of microglia activation within the hippocampal areas. |
2024-04-26 |
2024-04-28 |
rat |
| Feng Liu, Yaping Wang, Dongbo Li, Tao Yan. Atractylodin ameliorates lipopolysaccharide-induced depressive-like behaviors in mice through reducing neuroinflammation and neuronal damage. Journal of neuroimmunology. vol 390. 2024-04-26. PMID:38669915. |
further study showed atractylodin reduced the oxidative stress and the activation of microglia in mouse hippocampus, also inhibited the level of cytokine release, especially il-1β. |
2024-04-26 |
2024-04-29 |
mouse |
| Josephin Wagner, Lauren M Park, Partha Mukhopadhyay, Csaba Matyas, Eszter Trojnar, Ruslan Damadzic, Jeesun Jung, Andrew S Bell, Lucas A Mavromatis, Ali M Hamandi, Daniel B Rosoff, Leandro F Vendruscolo, George F Koob, Pal Pacher, Falk W Lohof. PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury. Brain, behavior, and immunity. vol 119. 2024-04-25. PMID:38657842. |
alirocumab also mitigated ethanol-induced microglia recruitment in the cortex and hippocampus (iba1). |
2024-04-25 |
2024-04-28 |
rat |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
we also observe abnormal activation of microglia characterized by enhanced release of the nlrp3 inflammasome, casepase-1 and pro-inflammatory cytokines il-1β, in the hippocampus of mice and bv2 cells. |
2024-04-24 |
2024-04-28 |
mouse |
| Jeremy M Shea, Saul A Villed. Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645176. |
microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline. |
2024-04-22 |
2024-04-24 |
mouse |
| Jeremy M Shea, Saul A Villed. Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645176. |
to bridge this gap in knowledge, we undertook complementary cellular and molecular analyses of microglia in the mouse hippocampus across the adult lifespan and in the experimental aging model of heterochronic parabiosis. |
2024-04-22 |
2024-04-24 |
mouse |
| Jeremy M Shea, Saul A Villed. Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645176. |
single-cell rna-seq and pseudotime analysis revealed age-related transcriptional heterogeneity in hippocampal microglia and identified intermediate states of microglial aging that also emerge following heterochronic parabiosis. |
2024-04-22 |
2024-04-24 |
mouse |
| Jit Poddar, Suresh B Rangasamy, Kalipada Paha. Therapeutic efficacy of cinnamein, a component of balsam of Tolu/Peru, in controlled cortical impact mouse model of TBI. Neurochemistry international. 2024-04-19. PMID:38641028. |
oral delivery of cinnamein through gavage brought down the activation of microglia and astrocytes to decrease the expression of inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap) and ionized calcium binding adaptor molecule 1 (iba1) in hippocampus and cortex of tbi mice. |
2024-04-19 |
2024-04-22 |
mouse |
| Giusy Pizzirusso, Efthalia Preka, Julen Goikolea, Celia Aguilar-Ruiz, Patricia Rodriguez Rodriguez, Guillermo Vazquez Cabrera, Simona Laterza, Maria Latorre Leal, Francesca Eroli, Klas Blomgren, Silvia Maioli, Per Nilsson, Adamantia Fragkopoulou, André Fisahn, Luis Enrique Arroyo-Garcí. Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression. Brain, behavior, and immunity. 2024-04-12. PMID:38608739. |
dynamic microglia alterations associate with hippocampal network impairments: a turning point in amyloid pathology progression. |
2024-04-12 |
2024-04-15 |
Not clear |
| Xiuting Yao, Chenxi Yang, Xirui Jia, Zhehao Yu, Conghui Wang, Jingyi Zhao, Yuxi Chen, Bingjie Xie, Hong Zhuang, Congli Sun, Qian Li, Xiaomin Kang, Yu Xiao, Lijie Li. High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration. Brain, behavior, and immunity. 2024-04-11. PMID:38604269. |
additionally, we showed that hippocampal microglia in hfd-fed mice assumed a hyperactive state concomitant with increased psd95-positive and myelin basic protein (mbp)-positive inclusions, implicating microglia in hippocampal structural alterations induced by hfd consumption. |
2024-04-11 |
2024-04-14 |
mouse |
| Xiuting Yao, Chenxi Yang, Xirui Jia, Zhehao Yu, Conghui Wang, Jingyi Zhao, Yuxi Chen, Bingjie Xie, Hong Zhuang, Congli Sun, Qian Li, Xiaomin Kang, Yu Xiao, Lijie Li. High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration. Brain, behavior, and immunity. 2024-04-11. PMID:38604269. |
along with increased levels of serum free fatty acids (ffas), abnormal deposition of lipid droplets and increased levels of hif-1α protein (a transcription factor that has been reported to facilitate cellular lipid accumulation) within hippocampal microglia were observed in hfd-fed mice. |
2024-04-11 |
2024-04-14 |
mouse |
| Xiuting Yao, Chenxi Yang, Xirui Jia, Zhehao Yu, Conghui Wang, Jingyi Zhao, Yuxi Chen, Bingjie Xie, Hong Zhuang, Congli Sun, Qian Li, Xiaomin Kang, Yu Xiao, Lijie Li. High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration. Brain, behavior, and immunity. 2024-04-11. PMID:38604269. |
the use of minocycline, a pharmacological suppressor of microglial overactivation, effectively attenuated neurobehavioral abnormalities and hippocampal structural alterations but barely altered lipid droplet accumulation in the hippocampal microglia of hfd-fed mice. |
2024-04-11 |
2024-04-14 |
mouse |
| Yizhen Zhu, Xue Zhao, Ruojing Liu, Dan Yang, Guo G. Effect of Oxygen-Glucose Deprivation of Microglia-Derived Exosomes on Hippocampal Neurons: A Study on miR-124 and Inflammatory Cytokines. Journal of molecular histology. 2024-04-10. PMID:38598045. |
we incubated hippocampal neurons with exosomes secreted by oxygen-glucose deprivation/ reoxygenation (ogd/r) microglia. |
2024-04-10 |
2024-04-12 |
human |
| Michael Surala, Luna Soso-Zdravkovic, David Munro, Ali Rifat, Koliane Ouk, Imre Vida, Josef Priller, Christian Madr. Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density. EMBO reports. 2024-04-08. PMID:38589666. |
lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density. |
2024-04-08 |
2024-04-11 |
mouse |
| Bin Fan, Junbin Lin, Qihang Luo, Weijing Liao, Chizi Ha. Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats. Neurotoxicity research. vol 42. issue 2. 2024-04-02. PMID:38564082. |
immunofluorescence was used to detect glutamatergic synapses, neurotoxic reactive astrocytes, and reactive microglia, as well as the expression of p-stat3 in astrocytes in the hippocampus. |
2024-04-02 |
2024-04-04 |
rat |
| Shunfeng Liu, Bei Zhang, Haowei Guo, Zhanghua Ding, Wenhui Hou, Xiaoli Hu, Yuchu Wang, Wupeng Tan, Shouhong Zho. The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation. Neurochemistry international. 2024-04-01. PMID:38561150. |
hippocampal microglia and prmt2 were stained using immunofluorescence techniques. |
2024-04-01 |
2024-04-04 |
rat |