| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pablo Berríos-Cárcamo, Sarah Núñez, Justine Castañeda, Javiera Gallardo, María Rosa Bono, Fernando Ezque. Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673763. |
we found a significant increase in mcp1 mrna levels in the cerebellum of mice that consumed ethanol compared to controls, whereas no significant changes were observed in the prefrontal cortex, hippocampus, or striatum or in microglia isolated from the hippocampus and striatum. |
2024-04-27 |
2024-04-29 |
mouse |
| Mingjie Zhang, Congyan Duan, Weifang Lin, Honghua Wu, Lu Chen, Hong Guo, Minyu Yu, Qi Liu, Yaling Nie, Hong Wang, Shaoxia Wan. Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease. Molecules (Basel, Switzerland). vol 29. issue 4. 2024-02-24. PMID:38398662. |
in vivo experiments further corroborated these findings, demonstrating that la mitigated the death of th-positive dopaminergic neurons and reduced microglia activation in the ventral snpc brain region of the midbrain and the striatum. |
2024-02-24 |
2024-02-26 |
Not clear |
| Rikang Wang, Zhi Liang, Xiaoyan Xue, Hua Mei, Lianru Ji, Bocheng Wang, Wenjin Chen, Chao Gao, Shun Yuan, Tao Wu, Hui Qi, Suifa Hu, Li Yi, Yonggui Song, Rifang Liao, Baodong Che. Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1. Journal of cellular and molecular medicine. vol 28. issue 1. 2024-01-24. PMID:37890842. |
furthermore, the microglia activation in the striatum showed significant along with a high expression level of foxo3a in the ich mice. |
2024-01-24 |
2024-01-26 |
mouse |
| Rikang Wang, Zhi Liang, Xiaoyan Xue, Hua Mei, Lianru Ji, Bocheng Wang, Wenjin Chen, Chao Gao, Shun Yuan, Tao Wu, Hui Qi, Suifa Hu, Li Yi, Yonggui Song, Rifang Liao, Baodong Che. Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1. Journal of cellular and molecular medicine. vol 28. issue 1. 2024-01-24. PMID:37890842. |
we found that conditional knockout of foxo3a in microglia in mice alleviated neurological deficits and microglia activation as well as ferroptosis-induced striatum injury in the autologous blood-induced ich model. |
2024-01-24 |
2024-01-26 |
mouse |
| Max Gentenaar, Fleur L Meulmeester, Ximaine R van der Burg, Anna T Hoekstra, Hazel Hunt, Jan Kroon, Willeke M C van Roon-Mom, Onno C Meije. Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice. Experimental neurology. 2024-01-12. PMID:38216109. |
it also restored hd-related parameters including astrocyte markers in both the dorsolateral striatum and the hippocampus, and microglia markers in the hippocampus. |
2024-01-12 |
2024-01-15 |
mouse |
| Maria João Nunes, Andreia Neves Carvalho, Alexandra I Rosa, Paula A Videira, Maria João Gama, Elsa Rodrigues, Margarida Castro-Calda. Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease. Journal of molecular medicine (Berlin, Germany). 2024-01-10. PMID:38197965. |
importantly, our results show that mptp triggers the presentation of more proteins decorated with slex in mouse cortex and striatum in a time-dependent manner, as well as increased mrna expression of its rate-limiting enzyme fucosyltransferase 7. slex is expressed in neurons, including dopaminergic neurons, and microglia. |
2024-01-10 |
2024-01-13 |
mouse |
| Ge Shi, Chunhui Zhang, Xinghua Bai, Jian Sun, KaiDong Wang, Qi Meng, Yang Li, Guiling Hu, Rong Hu, Qian Cai, Min Huan. A potential mechanism clue to the periodic storm from microglia activation and progressive neuron damage induced by paraquat exposure. Environmental toxicology. 2024-01-08. PMID:38189626. |
in addition, we observed the fluorescence intensity enhancement of iba-1 activated microglia with released pro-inflammatory, all ahead of both the damage of dopaminergic neurons in the substantia nigra and corpus striatum of the brain. |
2024-01-08 |
2024-01-10 |
mouse |
| Anna M Fiorito, Eric Fakra, Guillaume Sescousse, El Chérif Ibrahim, Romain Re. Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia. Translational psychiatry. vol 13. issue 1. 2023-12-13. PMID:38092734. |
we report evidence of a widespread transcriptional alteration of microglia genes both in brain tissues (we observed a decreased expression in the cerebellum, associative striatum, hippocampus, and parietal cortex of individuals with schizophrenia compared with healthy controls) and whole blood (characterized by a mixed altered expression pattern). |
2023-12-13 |
2023-12-17 |
human |
| Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, Hidetsugu Fujigaki, Tatsuya Ando, Hiroki Kimura, Itaru Kushima, Yuko Arioka, Youta Torii, Akihiro Mouri, Norio Ozaki, Toshitaka Nabeshima, Kuniaki Sait. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. The FEBS journal. 2023-12-01. PMID:38037233. |
furthermore, decreased abundance of ramified-type microglia resulted in increased dendritic spine density in the striatum of ido2 ko mice. |
2023-12-01 |
2023-12-10 |
mouse |
| Peggy Rentsch, Timothy Egan, Andrea Kuriakose, Sandy Stayte, Bryce Visse. The ratio of M1 to M2 microglia in the striatum determines the severity of L-Dopa-induced dyskinesias. Journal of neurochemistry. 2023-11-02. PMID:37916541. |
the ratio of m1 to m2 microglia in the striatum determines the severity of l-dopa-induced dyskinesias. |
2023-11-02 |
2023-11-08 |
mouse |
| Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Jacyln B Fahey, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Yejin A Kim, Richard L M Faull, Suman Jayadev, Ted Yednock, X William Yang, Beth Steven. Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nature medicine. 2023-10-09. PMID:37814059. |
inhibition of this complement-dependent elimination mechanism through administration of a therapeutically relevant c1q function-blocking antibody or genetic ablation of a complement receptor on microglia prevented synapse loss, increased excitatory input to the striatum and rescued the early development of visual discrimination learning and cognitive flexibility deficits in these models. |
2023-10-09 |
2023-10-15 |
Not clear |
| David N King'uyu, Lily Nti-Kyemereh, Jesse L Bonin, Paul J Feustel, Michelle Tram, Katherine C MacNamara, Ashley M Kope. The effect of morphine on rat microglial phagocytic activity: An in vitro study of brain region-, plating density-, sex-, morphine concentration-, and receptor-dependency. Journal of neuroimmunology. vol 384. 2023-09-29. PMID:37774553. |
to examine how morphine impacts microglial phagocytosis, we isolated microglia from adult male and female rat cortex and striatum and plated them in vitro at 10,000 (10k) or 50,000 cells/well densities. |
2023-09-29 |
2023-10-07 |
rat |
| Taisuke Murata, Sho Ishiwa, Xin Lin, Yosuke Nakazawa, Kenji Tago, Megumi Funakoshi-Tag. The citrus flavonoid, nobiletin inhibits neuronal inflammation by preventing the activation of NF-κB. Neurochemistry international. 2023-09-29. PMID:37774798. |
furthermore, the administration of nobiletin significantly suppressed the accumulation of microglia and induction of the mrna expression of ccl2, cxcl1, il-6, and tnfα in the murine brain induced by injecting lps into the striatum. |
2023-09-29 |
2023-10-07 |
mouse |
| Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. |
to further characterize the effects of cocaine on microglia and neuroimmune signaling in vivo, we utilized the brains from both sexes of outbred rats with cocaine self-administration to explore the activation status of microglia, nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome activity, corticotropin-releasing factor (crf) signaling, and nf-κb levels in the striatum and hippocampus (hp). |
2023-07-29 |
2023-08-14 |
mouse |
| Qian Zhao, Yan Hao, Xiaoqian Yang, Jie Mao, Fengjie Tian, Yi Gao, Xiaolin Tian, Xiaoyan Yan, Yulan Qi. Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: Role of microbiota-gut-brain axis. Journal of hazardous materials. vol 457. 2023-06-12. PMID:37307732. |
in prenatal as-challenged offspring after maternal fmt treatment, remarkably, suppressed expression of inflammatory cytokines in tissues (colon, serum, and striatum) were observed along with reversed mrna and protein expression of tight junction related molecules in intestinal barrier and blood-brain barrier (bbb); further, expression of serum lipopolysaccharide (lps), toll-like receptor 4 (tlr4), myeloid differentiation factor 88 (myd88) and nuclear transcription factor-κb (nf-κb) in colonic and striatal tissues were repressed with activation of astrocytes and microglia inhibited. |
2023-06-12 |
2023-08-14 |
rat |
| Chen-Meng Qiao, Wei Quan, Yu Zhou, Gu-Yu Niu, Hui Hong, Jian Wu, Li-Ping Zhao, Ting Li, Chun Cui, Wei-Jiang Zhao, Yan-Qin She. Orally Induced High Serum Level of Trimethylamine N-oxide Worsened Glial Reaction and Neuroinflammation on MPTP-Induced Acute Parkinson's Disease Model Mice. Molecular neurobiology. 2023-06-02. PMID:37266763. |
moreover, high serum tmao significantly increased activation of microglia and astrocytes both in striatum and in substantia nigra. |
2023-06-02 |
2023-08-14 |
mouse |
| Cláudia Saraiva, Jéssica Lopes-Nunes, Marta Esteves, Tiago Santos, Ana Vale, Ana Clara Cristóvão, Raquel Ferreira, Liliana Bernardin. CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival. Molecular neurobiology. 2023-04-15. PMID:37060501. |
herein, we showed that ctbp1 and ctbp2 are expressed in neurons, dopaminergic neurons, astrocytes, and microglia in the substantia nigra (sn) and striatum of adult mice. |
2023-04-15 |
2023-08-14 |
mouse |
| Naveen Nagarajan, Mario R Capecch. Optogenetic stimulation of mouse Hoxb8 microglia in specific regions of the brain induces anxiety, grooming, or both. Molecular psychiatry. 2023-04-10. PMID:37037872. |
optogenetic stimulation of hoxb8 microglia within the dorsomedial striatum (dms) or the medial prefrontal cortex (mpfc) induces grooming, whereas stimulation of hoxb8 microglia in the basolateral amygdala (bla) or central amygdala (cea) produces elevated anxiety. |
2023-04-10 |
2023-08-14 |
mouse |
| Minhee Jang, Jong Hee Choi, Dae Sik Jang, Ik-Hyun Ch. Micrandilactone C, a Nortriterpenoid Isolated from Roots of Cells. vol 12. issue 5. 2023-03-11. PMID:36899922. |
mc also inhibited the activation of the signal transducer and activator of transcription 3 (stat3) in the striatum and microglia after 3-npa treatment. |
2023-03-11 |
2023-08-14 |
Not clear |
| Jogen Atone, Karen Wagner, Shinichiro Koike, Jun Yang, Sung Hee Hwang, Bruce D Hammoc. Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents. Environmental toxicology and pharmacology. 2023-01-22. PMID:36682504. |
thus, this study attempts to observe changes in inflammatory and endoplasmic reticulum stress markers in mouse striatum following chronic paraquat administration to determine whether inhibiting soluble epoxide hydrolase mitigates paraquat-induced neurotoxicity and whether it can reduce tlr4-mediated inflammation in primary astrocytes and microglia. |
2023-01-22 |
2023-08-14 |
mouse |