| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gergely Keszler, Bálint Vékony, Zsuzsanna Elek, Zsófia Nemoda, Nóra Angyal, Zsófia Bánlaki, Réka Kovács-Nagy, Zsolt Rónai, János M Réthely. MicroRNA-Mediated Suppression of Glial Cell Line-Derived Neurotrophic Factor Expression Is Modulated by a Schizophrenia-Associated Non-Coding Polymorphism. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674063. |
plasma levels of glial cell line-derived neurotrophic factor (gdnf), a pivotal regulator of differentiation and survival of dopaminergic neurons, are reportedly decreased in schizophrenia. |
2024-04-27 |
2024-04-29 |
human |
| Guo Ge, Barath P Sivasubramanian, Bill D Geng, Shujie Zhao, Qing Zhou, Gang Huang, Jason C O'Connor, Robert A Clark, Senlin L. Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease. Gene therapy. 2024-04-16. PMID:38627469. |
glial cell line-derived neurotrophic factor (gdnf) protects dopaminergic neurons in various models of parkinson's disease (pd). |
2024-04-16 |
2024-04-19 |
mouse |
| Chun Cui, Yun Shi, Hui Hong, Yu Zhou, Chenmeng Qiao, Liping Zhao, Xuebing Jia, Weijiang Zhao, Yanqin She. 5-HT4 Receptor is Protective for MPTP-induced Parkinson's Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-10-02. PMID:37782386. |
in addition, gr 125487 pretreatment exacerbated the loss of dopaminergic neurons probably by suppressing jak2/pka/creb signaling pathway and increased reactive glia and neuroinflammation in the striatum. |
2023-10-02 |
2023-10-07 |
mouse |
| Laoise Casserly, Daniel R Garton, Ana Montaño-Rodriguez, Jaan-Olle Andresso. Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759827. |
glial cell line-derived neurotrophic factor (gdnf) is a strong dopaminergic factor, that recently was shown to correlate with scz in human csf and in striatal tissue. |
2023-09-28 |
2023-10-07 |
mouse |
| Valerio Ricci, Domenico de Berardis, Giovanni Martinotti, Giuseppe Main. Neurotrophic Factors In Cannabis-Induced Psychosis: An Update. Current topics in medicinal chemistry. 2023-08-30. PMID:37644743. |
glial cell derived neurotrophic factor (gdnf) promotes the survival of midbrain dopaminergic neurons and neuregulin 1 (nrg-1) contributes to glutamatergic signals regulating the n-methyl-d-aspartate (nmda). |
2023-08-30 |
2023-09-07 |
Not clear |
| Marika Alborghetti, Edoardo Bianchini, Lanfranco De Carolis, Silvia Galli, Francesco E Pontieri, Domiziana Rinald. Type-B monoamine oxidase inhibitors in neurological diseases: clinical applications based on preclinical findings. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488838. |
preclinical studies indicate that type-b monoamine oxidase inhibitors hold a strong neuroprotective potential in parkinson's disease and other neurodegenerative diseases for reducing oxidative stress and stimulating the production and release of neurotrophic factors, particularly glial cell line-derived neurotrophic factor, which support dopaminergic neurons. |
2023-07-25 |
2023-08-14 |
Not clear |
| Tathagata Mahintamani, Debasish Basu, Abhishek Ghosh, Manni Luthra-Guptasarm. The toll of opioid dependence: A research report on the possible role of Toll-like receptor-4 and related immune markers in opioid dependence. Indian journal of psychiatry. vol 65. issue 6. 2023-07-24. PMID:37485408. |
xenobiotics-associated molecular pattern of opioids interacts with toll-like receptor-4 (tlr-4) on the glial cell surface and increases dopaminergic activity in the nucleus accumbens in preclinical studies. |
2023-07-24 |
2023-08-14 |
Not clear |
| Pepin Marshal. Finding an Optimal Level of GDNF Overexpression: Insights from Dopamine Cycling. Cellular and molecular neurobiology. 2023-07-06. PMID:37410316. |
the application of glial cell line-derive neurotrophic factor (gdnf) to cell cultures and animal models has demonstrated positive effects upon dopaminergic neuronal survival and development, function, restoration, and protection. |
2023-07-06 |
2023-08-14 |
human |
| Peter Riederer, Toshiharu Nagatsu, Moussa B H Youdim, Max Wulf, Johannes M Dijkstra, Jeswinder Sian-Huelsman. Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-04-16. PMID:37062012. |
however, more recent pd research demonstrates that (i) lbs are detected not only in dopaminergic neurons and glia but in various neurotransmitter systems, (ii) sympathetic nerve fibres degenerate first, and (iii) at least in "brain-first" cases dopaminergic deficiency is evident before pathology induced by iron and nm. |
2023-04-16 |
2023-08-14 |
Not clear |
| Shu-Yan Tong, Rui-Wen Wang, Qian Li, Yi Liu, Xiao-Yan Yao, De-Qin Geng, Dian-Shuai Gao, Chao Re. Serum glial cell line-derived neurotrophic factor (GDNF) a potential biomarker of executive function in Parkinson's disease. Frontiers in neuroscience. vol 17. 2023-03-13. PMID:36908789. |
glial cell line-derived neurotrophic factor (gdnf), as the strongest protective neurotrophic factor for dopaminergic neurons (dans), may play a role in ef to some extent. |
2023-03-13 |
2023-08-14 |
Not clear |
| Xinguo Zhang, Ruiqi Zhang, Maher Un Nisa Awan, Jie Ba. The Mechanism and Function of Glia in Parkinson's Disease. Frontiers in cellular neuroscience. vol 16. 2022-06-20. PMID:35722618. |
pd is thought to be the loss of midbrain dopaminergic neurons, but it has recently been discovered that glia also affects brain tissue homeostasis, defense, and repair in pd. |
2022-06-20 |
2023-08-14 |
Not clear |
| Irena Hlushchuk, Justyna Barut, Mikko Airavaara, Kelvin Luk, Andrii Domanskyi, Piotr Chmielar. Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons. Biomolecules. vol 12. issue 4. 2022-04-23. PMID:35454152. |
we found that modifying insulin signaling through (1) insulin receptor inhibitor gsk1904529a, (2) ship2 inhibitor as1949490 or (3) pten inhibitor vo-ohpic failed to significantly affect α-synuclein aggregation in dopaminergic neurons, in contrast to the aggregation-reducing effects observed after the addition of glial cell line-derived neurotrophic factor. |
2022-04-23 |
2023-08-13 |
Not clear |
| V Mesa-Infante, D Afonso-Oramas, J Salas-Hernández, J Rodríguez-Núñez, P Barroso-Chine. Long-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease. Molecular and cellular neurosciences. vol 118. 2021-12-07. PMID:34826608. |
glial cell line-derived neurotrophic factor (gdnf) promotes differentiation, proliferation, and survival in different cell types, including dopaminergic neurons. |
2021-12-07 |
2023-08-13 |
rat |
| Dzhirgala V Shamadykova, Dmitry Y Panteleev, Nadezhda N Kust, Ekaterina A Savchenko, Ekaterina Y Rybalkina, Alexander V Revishchin, Galina V Pavlov. Neuroinductive properties of mGDNF depend on the producer, E. Coli or human cells. PloS one. vol 16. issue 10. 2021-11-25. PMID:34634077. |
the glial cell line-derived neurotrophic factor (gdnf) is involved in the survival of dopaminergic neurons. |
2021-11-25 |
2023-08-13 |
mouse |
| Monika Sharma, Jaswinder Kaur, Siddhi Rakshe, Nishant Sharma, Dignesh Khunt, Amit Khairna. Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons. Neurotoxicity research. 2021-11-24. PMID:34817799. |
conversely, after 16 weeks of washout period, rotenone treated mice showed both olfactory and motor impairment, along with α-syn accumulation in the ob and striatum without glial cell activation and loss of dopaminergic neurons. |
2021-11-24 |
2023-08-13 |
mouse |
| Jin Gao, Deng-Li Qin, Chuan-Xi Tang, Xiao-Yu Kang, Cheng-Jie Song, Can-Tang Zhan. Smarcd1 antagonizes the apoptosis of injured MES23.5 DA cells by enhancing the effect of Six2 on GDNF expression. Neuroscience letters. vol 760. 2021-08-17. PMID:34233203. |
glial cell line-derived neurotrophic factor (gdnf) played critical roles in the survival and repair of dopaminergic (da) neurons. |
2021-08-17 |
2023-08-13 |
Not clear |
| Anastasiia Kotliarova, Yulia A Sidorov. Glial Cell Line-Derived Neurotrophic Factor Family Ligands, Players at the Interface of Neuroinflammation and Neuroprotection: Focus Onto the Glia. Frontiers in cellular neuroscience. vol 15. 2021-07-06. PMID:34220453. |
this article summarizes available data on the effects of glial cell line derived neurotrophic factor (gdnf) family ligands (gfls), proteins providing trophic support to dopaminergic, sensory, motor and many other neuronal populations, in non-neuronal cells contributing to the development and maintenance of neuropathic pain. |
2021-07-06 |
2023-08-13 |
rat |
| Alberto F Cintrón-Colón, Gabriel Almeida-Alves, Alicia M Boynton, John M Spitsberge. GDNF synthesis, signaling, and retrograde transport in motor neurons. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32897420. |
gdnf was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons. |
2021-06-23 |
2023-08-13 |
rat |
| Ming-Yu Shi, Cheng-Cheng Ma, Fang-Fang Chen, Xiao-Yu Zhou, Xue Li, Chuan-Xi Tang, Lin Zhang, Dian-Shuai Ga. Possible role of glial cell line-derived neurotrophic factor for predicting cognitive impairment in Parkinson's disease: a case-control study. Neural regeneration research. vol 16. issue 5. 2021-06-23. PMID:33229724. |
glial cell line-derived neurotrophic factor (gdnf) plays an important role in the protection of dopaminergic neurons, but there are few reports of the relationship between gdnf and its precursors (α-pro-gdnf and β-pro-gdnf) and cognitive impairment in parkinson's disease. |
2021-06-23 |
2023-08-13 |
human |
| Nagahide Takahashi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Damee Choi, Toshiki Iwabuchi, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Jeffrey H Newcorn, Nori Takei, Kenji J Tsuchiy. Polygenic risk score analysis revealed shared genetic background in attention deficit hyperactivity disorder and narcolepsy. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32801330. |
gene-set enrichment analyses revealed that pathways related to dopaminergic signaling, immune systems, iron metabolism, and glial cell function involved in both adhd and narcolepsy. |
2021-06-18 |
2023-08-13 |
Not clear |