| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joan S Baize. Neuroanatomy of autism: what is the role of the cerebellum? Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 13. 2024-05-02. PMID:38696597. |
both neuropathological and imaging studies found differences in the cerebellum in autism spectrum disorder, the most widely documented being a decreased density of purkinje cells in the cerebellar cortex. |
2024-05-02 |
2024-05-05 |
Not clear |
| Anna Niewiadomska-Cimicka, Lorraine Fievet, Magdalena Surdyka, Ewelina Jesion, Céline Keime, Elisabeth Singer, Aurélie Eisenmann, Zaneta Kalinowska-Poska, Hoa Huu Phuc Nguyen, Agnieszka Fiszer, Maciej Figiel, Yvon Trottie. AAV-Mediated CAG-Targeting Selectively Reduces Polyglutamine-Expanded Protein and Attenuates Disease Phenotypes in a Spinocerebellar Ataxia Mouse Model. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673939. |
polyq-expanded sca proteins are toxic for cerebellar neurons, with purkinje cells (pcs) being the most vulnerable. |
2024-04-27 |
2024-04-29 |
mouse |
| Ke Zhang, Zhen Yang, Michael A Gaffield, Garrett G Gross, Don B Arnold, Jason M Christi. Molecular layer disinhibition unlocks climbing-fiber-instructed motor learning in the cerebellum. bioRxiv : the preprint server for biology. 2024-04-26. PMID:38654827. |
climbing fibers supervise cerebellar learning by providing signals to purkinje cells (pcs) that instruct adaptive changes to mistakenly performed movements. |
2024-04-26 |
2024-04-28 |
mouse |
| Jay S Pi, Mohammad Amin Fakharian, Paul Hage, Ehsan Sedaghat-Nejad, Salomon Z Muller, Reza Shadmeh. The olivary input to the cerebellum dissociates sensory events from movement plans. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 17. 2024-04-17. PMID:38630714. |
neurons in the inferior olive are thought to anatomically organize the purkinje cells (p-cells) of the cerebellum into computational modules, but what is computed by each module? |
2024-04-17 |
2024-04-20 |
human |
| C'iana P Cooper, Liam H Cheng, Jafar A Bhatti, Edward L Rivera, Derek Huell, Cristina Banuelos, Evelyn J Perez, Jeffrey M Long, Peter R Rap. Cerebellum Purkinje cell vulnerability in aged rats with memory impairment. The Journal of comparative neurology. vol 532. issue 4. 2024-04-12. PMID:38605461. |
to interrogate potential substrates of the relationship between cerebellar structure and memory in aging, here we target the purkinje cells (pcs). |
2024-04-12 |
2024-04-14 |
rat |
| Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M Youn. Development of adenoviral vectors that transduce Purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. Molecular therapy. Methods & clinical development. vol 32. issue 2. 2024-04-12. PMID:38605812. |
development of adenoviral vectors that transduce purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. |
2024-04-12 |
2024-04-14 |
mouse |
| Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M Youn. Development of adenoviral vectors that transduce Purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. Molecular therapy. Methods & clinical development. vol 32. issue 2. 2024-04-12. PMID:38605812. |
using a "humanized" hcd46 mouse model, we demonstrate these ad vectors transduce cerebellar cell types, including purkinje cells, that are refractory to ad5 transduction. |
2024-04-12 |
2024-04-14 |
mouse |
| Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehran. A disintegrin and Metalloprotease 10 expression within the murine central nervous system. Brain research. 2024-03-28. PMID:38548249. |
we observed adam10 expression through the whole cns, with a strong expression in the hippocampus, in the hypothalamus and in the cerebral and piriform cortex in the brain, in the purkinje and in granular cell layers in the cerebellum and in the spinal cord to a lower extent. |
2024-03-28 |
2024-03-31 |
mouse |
| Tariq Zaman, Daniel Vogt, Jeremy Prokop, Qusai Abdulkhaliq Alsabia, Gabriel Simms, April Stafford, Bryan W Luikart, Michael R William. Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells. eLife. vol 12. 2024-03-27. PMID:38536959. |
kit is enriched in molecular layer interneurons (mlis) of the cerebellar cortex (i.e., stellate and basket cells), while cerebellar kit ligand is selectively expressed by a target of their inhibition, purkinje cells (pcs). |
2024-03-27 |
2024-03-30 |
mouse |
| Spencer T Brown, Mauricio Medina-Pizarro, Meghana Holla, Christopher E Vaaga, Indira M Rama. Simple spike patterns and synaptic mechanisms encoding sensory and motor signals in Purkinje cells and the cerebellar nuclei. Neuron. 2024-03-16. PMID:38492575. |
synchrony thus allows the cbn to high-pass filter purkinje inputs, facilitating sensory-evoked cerebellar outputs that can drive movements. |
2024-03-16 |
2024-03-19 |
mouse |
| Aalok Varma, Sathvik Udupa, Mohini Sengupta, Prasanta Kumar Ghosh, Vatsala Thirumala. A machine-learning tool to identify bistable states from calcium imaging data. The Journal of physiology. 2024-03-14. PMID:38482722. |
purkinje neurons in the larval zebrafish cerebellum exhibit membrane potential bistability, firing either tonically or in bursts. |
2024-03-14 |
2024-03-16 |
mouse |
| Aalok Varma, Sathvik Udupa, Mohini Sengupta, Prasanta Kumar Ghosh, Vatsala Thirumala. A machine-learning tool to identify bistable states from calcium imaging data. The Journal of physiology. 2024-03-14. PMID:38482722. |
key points: calcium imaging, compriising the gold standard of inferring neuronal activity, does not report cellular state in neurons that are bistable, such as purkinje neurons in the cerebellum of larval zebrafish. |
2024-03-14 |
2024-03-16 |
mouse |
| Le Gui, Vasiliki Tellios, Yun-Yan Xiang, Qingping Feng, Wataru Inoue, Wei-Yang L. Neuronal Nitric Oxide Synthase Regulates Cerebellar Parallel Fiber Slow EPSC in Purkinje Neurons by Modulating STIM1-Gated TRPC3-Containing Channels. Cerebellum (London, England). 2024-03-13. PMID:38472628. |
neuronal nitric oxide synthase regulates cerebellar parallel fiber slow epsc in purkinje neurons by modulating stim1-gated trpc3-containing channels. |
2024-03-13 |
2024-03-15 |
Not clear |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
developmental ethanol exposure impacts purkinje cells but not microglia in the young adult cerebellum. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
to determine how developmental ethanol exposure affects adult cerebellar microglia and purkinje cells, we used a human third-trimester binge exposure model in which mice received ethanol or saline from postnatal (p) days 4-9. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
in adolescence, cerebellar cranial windows were implanted and mice were aged to young adulthood for examination of microglia and purkinje cells in vivo with two-photon imaging or in fixed tissue. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
overall, developmental ethanol exposure had few effects on cerebellar microglia in young adulthood and purkinje cells appeared to be more susceptible to its effects. |
2024-03-13 |
2024-03-15 |
mouse |
| Tsubasa Itoh, Mari Uehara, Shinnosuke Yura, Jui Chun Wang, Yukimi Fujii, Akiko Nakanishi, Takashi Shimizu, Masahiko Hib. Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 2024-03-08. PMID:38456494. |
cerebellar neurons, such as gabaergic purkinje cells (pcs), interneurons (ins), and glutamatergic granule cells (gcs) are differentiated from neural progenitors expressing proneural genes including ptf1a, neurogenin1, and atoh1a/b/c. |
2024-03-08 |
2024-03-10 |
zebrafish |
| Mauliza Mauliza, Herlina Dimiati, Muslim Akmal, Imran Imra. Role of forkhead box protein 2 (FOXP2) in oral-motor abilities of preterm infants: A brief literature review. Narra J. vol 3. issue 2. 2024-03-07. PMID:38450264. |
the oral feeding development involves forkhead box protein 2 (foxp2)-expressing neurons that are found in the deep layers of the cortex, basal ganglia, parts of the thalamus and purkinje cells of the cerebellum. |
2024-03-07 |
2024-03-09 |
Not clear |
| Qiong Wu, Qing-Yun Huang, Guo-He Ta. [Abnormalities in signal transduction of Purkinje cells in spinocerebellar ataxias: a review]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 1. 2024-03-06. PMID:38444133. |
purkinje neuronal degeneration and cerebellar atrophy are common pathological features among most sca subtypes. |
2024-03-06 |
2024-03-08 |
Not clear |