| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linjun Wu, Shijie Ye, Xiangfei Deng, Zhengwei Fu, Jinjun Li, Chunlei Yan. Conjugated Linoleic Acid Ameliorates High Fat-Induced Insulin Resistance via Regulating Gut Microbiota-Host Metabolic and Immunomodulatory Interactions. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674824. |
histomorphology, gene and protein expression analysis revealed that cla reduced fat deposition and inflammation, and enhanced fatty acid oxidation, insulin signaling and glucose transport in adipose tissue or liver. |
2024-04-27 |
2024-04-29 |
mouse |
| Linjun Wu, Shijie Ye, Xiangfei Deng, Zhengwei Fu, Jinjun Li, Chunlei Yan. Conjugated Linoleic Acid Ameliorates High Fat-Induced Insulin Resistance via Regulating Gut Microbiota-Host Metabolic and Immunomodulatory Interactions. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674824. |
hepatic transcriptome analysis confirmed that cla inhibited inflammatory signaling pathways and promoted insulin, pi3k-akt and ampk signaling pathways, as well as linoleic acid, arachidonic acid, arginine and proline metabolism. |
2024-04-27 |
2024-04-29 |
mouse |
| Zuzanna Flis, Piotr Szatkowski, Kinga Pielichowska, Edyta Moli. The Potential of Sheep or Camel Milk Constituents to Contribute to Novel Dressings for Diabetic Wounds. International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139380. |
sheep and camel milk is gaining importance due to the content of many bioactive substances with health-promoting effects, such as insulin, lf, proline, or cla. |
2023-12-23 |
2023-12-25 |
human |
| Sara Badawy, Yanan Liu, Mingyue Guo, Zhenli Liu, Changqing Xie, Marawan A Marawan, Irma Ares, Bernardo Lopez-Torres, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Xu Wang, Arturo Anadón, María-Aránzazu Martíne. Conjugated linoleic acid (CLA) as a functional food: Is it beneficial or not? Food research international (Ottawa, Ont.). vol 172. 2023-09-10. PMID:37689911. |
in contrast, adverse effects of cla have been also reported, such as glucose homeostasis, insulin resistance, hepatic steatosis and induction of colon carcinogenesis in humans, as well as milk fat inhibition in ruminants, lowering chicken productivity, influencing egg quality and altering growth performance in fish. |
2023-09-10 |
2023-10-07 |
chicken |
| Wenbang Li, Xinyan Fu, Dai Lin, Tong Li, Nan Zhang, Yanzi Huo, Pingping Zhu, Fuchuan Guo, Fang Huan. Conjugated linoleic acid alleviates glycolipid metabolic disorders by modulating intestinal microbiota and short-chain fatty acids in obese rats. Food & function. 2023-01-24. PMID:36692407. |
the results of blood biochemical indices showed that cla significantly reduced the levels of total cholesterol, triglycerides, fasting blood glucose and insulin. |
2023-01-24 |
2023-08-14 |
rat |
| Bahram Rahbar, Akbar Taghizadeh, Hamid Paya, Hossein Daghigh Ki. Conjugated linoleic acid (CLA) supplementation effects on performance, metabolic parameters and reproductive traits in lactating Holstein dairy cows. Veterinary research forum : an international quarterly journal. vol 12. issue 3. 2021-11-25. PMID:34815840. |
serum concentrations of glucose, cholesterol, triglyceride (tg), insulin, insulin-like growth factor-1(igf-1), estradiol and progesterone were higher in cla treated cows when compared to cows fed on the control diet. |
2021-11-25 |
2023-08-13 |
Not clear |
| Haoyu Li, Pan Zhuang, Yu Zhang, Qiyang Shou, Yanhua Lu, Guangfa Wang, Jieni Qiu, Jun Wang, Lilin He, Jingnan Chen, Jingjing Jia. Mixed conjugated linoleic acid sex-dependently reverses high-fat diet-induced insulin resistance via the gut-adipose axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 4. 2021-07-15. PMID:33734496. |
cla favored anti-inflammatory microbiota in male mice, mediating increased short-chain fatty acids and decreased lipopolysaccharide (lps) production, which alleviated global inflammation and improved insulin sensitivity via inhibition of the tlr4-nf-κb pathway in adipose tissue. |
2021-07-15 |
2023-08-13 |
mouse |
| Haoyu Li, Pan Zhuang, Yu Zhang, Qiyang Shou, Yanhua Lu, Guangfa Wang, Jieni Qiu, Jun Wang, Lilin He, Jingnan Chen, Jingjing Jia. Mixed conjugated linoleic acid sex-dependently reverses high-fat diet-induced insulin resistance via the gut-adipose axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 4. 2021-07-15. PMID:33734496. |
cla promoted the growth of hydrogen sulfide-producing desulfovibrio and the release of lps in female mice, which aggravated adipose inflammation and insulin resistance. |
2021-07-15 |
2023-08-13 |
mouse |
| Haoyu Li, Pan Zhuang, Yu Zhang, Qiyang Shou, Yanhua Lu, Guangfa Wang, Jieni Qiu, Jun Wang, Lilin He, Jingnan Chen, Jingjing Jia. Mixed conjugated linoleic acid sex-dependently reverses high-fat diet-induced insulin resistance via the gut-adipose axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 4. 2021-07-15. PMID:33734496. |
in conclusion, cla decreased body weight and increased energy expenditure but sex-dependently modulated insulin resistance via the gut-adipose axis. |
2021-07-15 |
2023-08-13 |
mouse |
| L Vogel, M Gnott, C Kröger-Koch, S Görs, J M Weitzel, E Kanitz, A Hoeflich, A Tuchscherer, A Tröscher, J J Gross, R M Bruckmaier, A Starke, L Bachmann, H M Hammo. Glucose metabolism and the somatotropic axis in dairy cows after abomasal infusion of essential fatty acids together with conjugated linoleic acid during late gestation and early lactation. Journal of dairy science. vol 104. issue 3. 2021-04-14. PMID:33455762. |
in the present study, the hypothesis that combined cla and efa treatment supports glucose metabolism around the time of calving and stimulates insulin action and the somatotropic axis in cows in an additive manner was tested. |
2021-04-14 |
2023-08-13 |
Not clear |
| L Vogel, M Gnott, C Kröger-Koch, S Görs, J M Weitzel, E Kanitz, A Hoeflich, A Tuchscherer, A Tröscher, J J Gross, R M Bruckmaier, A Starke, L Bachmann, H M Hammo. Glucose metabolism and the somatotropic axis in dairy cows after abomasal infusion of essential fatty acids together with conjugated linoleic acid during late gestation and early lactation. Journal of dairy science. vol 104. issue 3. 2021-04-14. PMID:33455762. |
the plasma insulin concentration decreased after calving in all groups and was higher in cla than in non-cla cows at several time points. |
2021-04-14 |
2023-08-13 |
Not clear |
| L Vogel, M Gnott, C Kröger-Koch, S Görs, J M Weitzel, E Kanitz, A Hoeflich, A Tuchscherer, A Tröscher, J J Gross, R M Bruckmaier, A Starke, L Bachmann, H M Hammo. Glucose metabolism and the somatotropic axis in dairy cows after abomasal infusion of essential fatty acids together with conjugated linoleic acid during late gestation and early lactation. Journal of dairy science. vol 104. issue 3. 2021-04-14. PMID:33455762. |
results indicated elevated concentrations of plasma glucose and insulin along with the stimulation of the somatotropic axis in cows treated with cla, whereas efa treatment stimulated egp but not mrna abundance related to egp pp. |
2021-04-14 |
2023-08-13 |
Not clear |
| E Dirandeh, M Ghorbanalinia, A R Roodbari, M G Colaz. Effects of dietary conjugated linoleic acid on metabolic status, BW and expression of genes related to lipid metabolism in adipose tissue of dairy cows during peripartum. Animal : an international journal of animal bioscience. vol 15. issue 2. 2021-03-16. PMID:33579649. |
cows fed cla had lower plasma nefa and bhba and greater glucose and insulin concentrations (p < 0.05). |
2021-03-16 |
2023-08-13 |
Not clear |
| Miguel Z Martín-González, Héctor Palacios, Miguel A Rodríguez, Lluís Arola, Gerard Aragonès, Begoña Muguerz. Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats. Nutrients. vol 12. issue 2. 2020-11-23. PMID:32033223. |
however, some authors have associated high doses of cla supplementation with liver impairment and insulin resistance. |
2020-11-23 |
2023-08-13 |
rat |
| Jose Cordoba-Chacon, Dhavamani Sugasini, Poorna C R Yalagala, Apoorva Tummala, Zachary C White, Toshihiro Nagao, Rhonda D Kineman, Papasani V Subbaia. Tissue-dependent effects of cis-9,trans-11- and trans-10,cis-12-CLA isomers on glucose and lipid metabolism in adult male mice. The Journal of nutritional biochemistry. vol 67. 2020-11-04. PMID:30856468. |
because of the reported adverse effects of cla on insulin sensitivity in some mouse studies, we sought to compare the impact of dietary t10c12-cla and c9t11-cla on liver, adipose tissue, and systemic metabolism of adult lean mice. |
2020-11-04 |
2023-08-13 |
mouse |
| Jianyang Tan, Liping Wan, Xiaofang Chen, Xiaolei Li, Xiaoxu Hao, Xiaofei Li, Jian Li, Hong Din. Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway. Molecular nutrition & food research. vol 63. issue 12. 2020-03-26. PMID:30913372. |
conjugated linoleic acid (cla), a bioactive substance predominantly found in ruminant products, improves insulin resistance and exhibits anti-inflammatory activity. |
2020-03-26 |
2023-08-13 |
rat |
| Kun Pang, Zhongke Zhu, Songbo Zhu, Liqiang Ha. A high dose of conjugated linoleic acid increases fatty liver and insulin resistance in lactating mice. PloS one. vol 14. issue 8. 2020-02-27. PMID:31390361. |
moreover, high-dose cla resulted in insulin resistance, possibly affecting the red blood cell (rbc) and hemoglobin (hcb) levels in the plasma. |
2020-02-27 |
2023-08-13 |
mouse |
| Kun Pang, Zhongke Zhu, Songbo Zhu, Liqiang Ha. A high dose of conjugated linoleic acid increases fatty liver and insulin resistance in lactating mice. PloS one. vol 14. issue 8. 2020-02-27. PMID:31390361. |
in conclusion, lactating mice receiving a high dose of cla exhibited fatty liver, insulin resistance, and impaired lactation performance. |
2020-02-27 |
2023-08-13 |
mouse |
| Adriana Roura-Guiberna, Judith Hernandez-Aranda, Carlos Jorge Ramirez-Flores, Ricardo Mondragon-Flores, Nayely Garibay-Nieto, Gloria Queipo-Garcia, Estibalitz Laresgoiti-Servitje, Jae-Won Soh, Jesus Alberto Olivares-Reye. Isomers of conjugated linoleic acid induce insulin resistance through a mechanism involving activation of protein kinase Cε in liver cells. Cellular signalling. vol 53. 2020-02-26. PMID:30352252. |
thus, in the present study, we evaluated the effect of two of the major isomers of cla, cis-9, trans-11-cla and trans-10, cis-12-cla, in the regulation of insulin signaling in a hepatic cell model, clone 9 (c9). |
2020-02-26 |
2023-08-13 |
human |
| I Fernández-Fígares, M Lachica, M Martínez-Pérez, T G Ramsa. Conjugated linoleic acid and betaine affect lipolysis in pig adipose tissue explants. Animal : an international journal of animal bioscience. vol 13. issue 12. 2020-02-18. PMID:31148536. |
to examine the ability of betaine or cla to inhibit insulin's suppression of isoproterenol-stimulated lipolysis, test medium was amended with 1 µm isoproterenol ±10 nm insulin. |
2020-02-18 |
2023-08-13 |
Not clear |