| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongbo Li, Sara Jane War. Paclitaxel-Associated Mechanical Sensitivity and Neuroinflammation Are Sex-, Time-, and Site-Specific and Prevented through Cannabigerol Administration in C57Bl/6 Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673862. |
the overall goals of the present study were to determine (1) paclitaxel-associated changes in markers of inflammation in the pag and drg in male and female c57bl6 mice and (2) determine the effect of prophylactic administration of an anti-inflammatory cannabinoid, cannabigerol (cbg). |
2024-04-27 |
2024-04-29 |
mouse |
| Mohammad-Reza Ghovanloo, Philip R Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxma. Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications biology. vol 7. issue 1. 2024-01-24. PMID:38263462. |
the inhibitory effects of cbn on nav currents and on drg neuron excitability add a new dimension to its actions and suggest that this cannabinoid may be useful for neuropathic pain. |
2024-01-24 |
2024-01-26 |
Not clear |
| Erick Orozco Morato, Brittany Knight, Lakshmi S Nai. Transcriptional profiling of neuronal ion channels in dorsal root ganglion-derived immortal cell line (F-11) under different culture conditions. In vitro models. vol 1. issue 4-5. 2023-12-19. PMID:38107764. |
using a customized gene array of more than eighty neuronal ion channels and receptors including voltage-gated ion channels, transient receptor potential channels, and cannabinoid receptors, we assessed the following groups: control f-11 cells; f-11 cells cultured under different culture conditions, and murine drg tissue. |
2023-12-19 |
2023-12-21 |
mouse |
| Hai Tran, Yin Feng, Dongman Chao, Qing-Song Liu, Quinn H Hogan, Bin Pa. Descending mechanism by which medial prefrontal cortex endocannabinoid signaling controls the development of neuropathic pain and neuronal activity of dorsal root ganglion. Pain. 2023-07-18. PMID:37463226. |
descending mechanism by which medial prefrontal cortex endocannabinoid signaling controls the development of neuropathic pain and neuronal activity of dorsal root ganglion. |
2023-07-18 |
2023-08-14 |
rat |
| Sara Martinez-Torres, Francina Mesquida-Veny, José Antonio Del Rio, Arnau Herver. Injury-induced activation of the endocannabinoid system promotes axon regeneration. iScience. vol 26. issue 6. 2023-05-26. PMID:37235048. |
we also enhanced the regenerative capacity of dorsal root ganglia (drg) neurons through the inhibition of endocannabinoid degradative enzyme magl or a cb1r agonist. |
2023-05-26 |
2023-08-14 |
Not clear |
| Uma Anand, Barbara Pacchetti, Praveen Anand, Mikael Hans Sodergre. The Endocannabinoid Analgesic Entourage Effect: Investigations in Cultured DRG Neurons. Journal of pain research. vol 15. 2022-11-17. PMID:36394060. |
the endocannabinoid analgesic entourage effect: investigations in cultured drg neurons. |
2022-11-17 |
2023-08-14 |
Not clear |
| Yang Yu, Quentin K Tsang, Josue Jaramillo-Polanco, Alan E Lomax, Stephen J Vanner, David E Ree. Cannabinoid 1 and mu-opioid receptor agonists synergistically inhibit abdominal pain and lack side effects in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-07-05. PMID:35790401. |
conversely, cannabinoid 2 receptor (cb2r) agonists did not attenuate vmr, afferent nerve mechanosensitivity or drg neuron excitability. |
2022-07-05 |
2023-08-14 |
mouse |
| Lubin Chen, Philip R Effraim, Jennifer Carrara, Peng Zhao, Fadia B Dib-Hajj, Sulayman D Dib-Hajj, Stephen G Waxma. Pharmacological characterization of a rat Nav1.7 loss-of-function model with insensitivity to pain. Pain. vol 161. issue 6. 2021-05-14. PMID:31977939. |
our data indicate that complete loss of dorsal root ganglion neuron excitability is not required for insensitivity to pain and suggest that endogenous opioid and cannabinoid systems are not required for insensitivity to pain in the absence of nav1.7 channels in this rat nav1.7 loss-of-function model. |
2021-05-14 |
2023-08-13 |
rat |
| Rong Tan, Lijun Ca. Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29786105. |
with or without knockdown of p38 mitogen-activated protein kinase (mapk), drg neurons were treated with tnf-α in the presence or absence of synthetic cannabinoid win-55,212-2 mesylate (win-55) and selective cannabinoid receptor (cb) antagonists. |
2018-10-09 |
2023-08-13 |
Not clear |
| Rong Tan, Lijun Ca. Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29786105. |
cannabinoid win-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. |
2018-10-09 |
2023-08-13 |
Not clear |
| Rong Tan, Lijun Ca. Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29786105. |
by linking the functions of tnf-α, nos and cannabinoid in drg neurons, this study adds new insights into the molecular mechanisms underlying the pharmacologic effects of cannabinoids on neuropathic pain as well as into the pathophysiology of neuropathic pain. |
2018-10-09 |
2023-08-13 |
Not clear |
| Rong Tan, Lijun Ca. Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29786105. |
in this study, we explored the effects and the underlying mechanisms of crosstalk between tnf-α and cannabinoid on the expression/activity of nos in drg neurons. |
2018-10-09 |
2023-08-13 |
Not clear |
| Natalia Malek, Magdalena Kostrzewa, Wioletta Makuch, Agnieszka Pajak, Mateusz Kucharczyk, Fabiana Piscitelli, Barbara Przewlocka, Vincenzo Di Marzo, Katarzyna Starowic. The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. Pharmacological research. vol 111. 2018-01-05. PMID:27326920. |
among the possible targets of these mediators, only the mrna levels of cb2, gpr18 and gpr55, which are believed to be novel cannabinoid receptors, were upregulated in the spinal cord and/or drg of cci rats. |
2018-01-05 |
2023-08-13 |
rat |
| Mohammad Alsalem, Paul Millns, Ahmad Altarifi, Khalid El-Salem, Victoria Chapman, David A Kendal. Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat. BMC pharmacology & toxicology. vol 17. issue 1. 2017-10-23. PMID:27439609. |
here we report the inhibitory effects of olvanil on nociceptive processing using cultured dorsal root ganglion (drg) neurons and compare the effects of capsaicin and olvanil on thermal nociceptive processing in vivo; potential contributions of the cannabinoid cb1 receptor to olvanil's anti-hyperalgesic effects were also investigated. |
2017-10-23 |
2023-08-13 |
rat |
| Gen Zheng, Shuangsong Hong, John M Hayes, John W Wile. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. Experimental neurology. vol 273. 2016-02-18. PMID:26408049. |
we found that chronic stress induced reciprocal changes in the endocannabinoid 2-ag (increased) and endocannabinoid degradation enzymes cox-2 and faah (decreased), associated with down-regulation of cb1 and up-regulation of trpv1 receptors in l6-s2 drg but not l4-l5 drg neurons. |
2016-02-18 |
2023-08-13 |
rat |
| Gen Zheng, Shuangsong Hong, John M Hayes, John W Wile. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. Experimental neurology. vol 273. 2016-02-18. PMID:26408049. |
previous studies reported that stress-induced visceral hyperalgesia is associated with reciprocal alterations of endovanilloid and endocannabinoid pain pathways in drg neurons innervating the pelvic viscera. |
2016-02-18 |
2023-08-13 |
rat |
| Yu-Qiang Liu, Fang Qiu, Chun-Yu Qiu, Qi Cai, Pengcheng Zou, Heming Wu, Wang-Ping H. Cannabinoids inhibit acid-sensing ion channel currents in rat dorsal root ganglion neurons. PloS one. vol 7. issue 9. 2013-03-06. PMID:23029075. |
cannabinoids inhibit acid-sensing ion channel currents in rat dorsal root ganglion neurons. |
2013-03-06 |
2023-08-12 |
rat |
| Jenny L Wilkerson, Katherine R Gentry, Ellen C Dengler, James A Wallace, Audra A Kerwin, Leisha M Armijo, Megan N Kuhn, Ganesh A Thakur, Alexandros Makriyannis, Erin D Milliga. Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels. Pain. vol 153. issue 5. 2012-08-13. PMID:22425445. |
in cci animals, lumbar dorsal spinal cord and corresponding dorsal root ganglia (drg) were evaluated by immunohistochemistry for expression of il-10, il-1β, phosphorylated p38-mitogen-activated-kinase (p-p38mapk), a pathway associated with proinflammatory cytokine production, glial cell markers, and degradative endocannabinoid enzymes, including monoacylglycerol lipase (magl). |
2012-08-13 |
2023-08-12 |
human |
| Kelsey C Duggan, Daniel J Hermanson, Joel Musee, Jeffery J Prusakiewicz, Jami L Scheib, Bruce D Carter, Surajit Banerjee, J A Oates, Lawrence J Marnet. (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. Nature chemical biology. vol 7. issue 11. 2011-12-22. PMID:22053353. |
(r)-profens selectively inhibited endocannabinoid oxygenation by lipopolysaccharide-stimulated dorsal root ganglion (drg) cells. |
2011-12-22 |
2023-08-12 |
Not clear |
| Yihong Fan, Bradley A Hooker, Tiffany Runyan Garrison, Odile F El-Kouhen, Kenneth B Idler, Rhonda R Holley-Shanks, Michael D Meyer, Betty Bei Ya. Pharmacological and molecular characterization of a dorsal root ganglion cell line expressing cannabinoid CB(1) and CB(2) receptors. European journal of pharmacology. vol 659. issue 2-3. 2011-09-09. PMID:21458448. |
in the current study, we report the molecular and pharmacological characterization of the f-11 cell line, a hybridoma of rat dorsal root ganglion neurons and mouse neuroblastoma (n18tg2) cells, reported to endogenously express both cannabinoid receptors. |
2011-09-09 |
2023-08-12 |
mouse |