| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiachan Long, Yuanhang Xu, Xuerong Zhang, Bingxing Wu, Caiyan Wan. Role of FXR in the development of NAFLD and intervention strategies of small molecules. Archives of biochemistry and biophysics. 2024-05-04. PMID:38703803. |
the cardinal features that characterize nafld are insulin resistance, lipogenesis, oxidative stress and inflammation, extracellular matrix deposition and fibrosis. |
2024-05-04 |
2024-05-07 |
Not clear |
| Shao-Jie Pang, Ting-Ting Liu, Jian-Cun Pan, Qing-Qing Man, Shuang Song, Jian Zhan. The Association between the Plasma Phospholipid Profile and Insulin Resistance: A Population-Based Cross-Section Study from the China Adult Chronic Disease and Nutrition Surveillance. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674894. |
the associations of the phospholipid matrix, clusters, and molecular species with insulin resistance were investigated. |
2024-04-27 |
2024-04-29 |
human |
| Shao-Jie Pang, Ting-Ting Liu, Jian-Cun Pan, Qing-Qing Man, Shuang Song, Jian Zhan. The Association between the Plasma Phospholipid Profile and Insulin Resistance: A Population-Based Cross-Section Study from the China Adult Chronic Disease and Nutrition Surveillance. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674894. |
a significant association was confirmed between the phospholipid matrix and the homeostatic-model assessment of insulin resistance (homa-ir) by a distance-based linear model. |
2024-04-27 |
2024-04-29 |
human |
| Max C Petersen, Gordon I Smith, Hector H Palacios, Sarah S Farabi, Mihoko Yoshino, Jun Yoshino, Kevin Cho, Victor G Davila-Roman, Mahalakshmi Shankaran, Ruteja A Barve, Jinsheng Yu, Jennifer H Stern, Bruce W Patterson, Marc K Hellerstein, Gerald I Shulman, Gary J Patti, Samuel Klei. Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity. Cell metabolism. vol 36. issue 4. 2024-04-03. PMID:38569471. |
compared with muo, people with mho had (1) altered skeletal muscle biology (decreased ceramide content and increased expression of genes involved in bcaa catabolism and mitochondrial structure/function); (2) altered adipose tissue biology (decreased expression of genes involved in inflammation and extracellular matrix remodeling and increased expression of genes involved in lipogenesis); (3) lower 24-h plasma glucose, insulin, non-esterified fatty acids, and triglycerides; (4) higher plasma adiponectin and lower plasma pai-1 concentrations; and (5) decreased oxidative stress. |
2024-04-03 |
2024-04-06 |
Not clear |
| Yen-Chun Huang, Monika Renuka Sanotra, Chi-Chang Huang, Yi-Ju Hsu, Chen-Chung Lia. Aerobic Exercise Modulates Proteomic Profiles in Gastrocnemius Muscle of Life (Basel, Switzerland). vol 14. issue 3. 2024-03-28. PMID:38541736. |
aerobic exercise modulates proteomic profiles in gastrocnemius muscle of type-2 diabetes mellitus (t2dm)-induced sarcopenia is intertwined with diminished insulin sensitivity and extracellular matrix (ecm) remodeling in skeletal muscle and other organs. |
2024-03-28 |
2024-03-30 |
Not clear |
| Aaron L Slusher, Jessica Nouws, Fuyuze Tokoglu, Alla Vash-Margita, Marcy D Matthews, Mark Fitch, Mahalakshmi Shankaran, Marc K Hellerstein, Sonia Capri. Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. Obesity (Silver Spring, Md.). vol 32. issue 3. 2024-02-28. PMID:38410080. |
altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. |
2024-02-28 |
2024-03-01 |
Not clear |
| Jing Yang, Glenn R Gourley, Adam Gilbertsen, Chi Chen, Lei Wang, Karen Smith, Marion Namenwirth, Libang Yan. High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81. Cells. vol 13. issue 3. 2024-02-09. PMID:38334628. |
hyperglycemia, lipotoxicity, and insulin resistance are known to increase the secretion of extracellular matrix from cardiac fibroblasts as well as the activation of paracrine signaling from cardiomyocytes, immune cells, and vascular cells, which release fibroblast-activating mediators. |
2024-02-09 |
2024-02-11 |
mouse |
| Helena Hrušková, Christine Olsen, Roman Řemínek, Chencheng Wang, Aleksandra Aizenshtadt, Stefan Krauss, Hanne Scholz, Hanne Røberg-Larsen, František Foret, Steven Ray Wilso. Preparative agarose gel electrophoresis for reducing matrix interferences of organoid cell medium prior to LC-MS analysis of insulin. Journal of chromatography. A. vol 1717. 2024-01-26. PMID:38278130. |
preparative agarose gel electrophoresis for reducing matrix interferences of organoid cell medium prior to lc-ms analysis of insulin. |
2024-01-26 |
2024-01-29 |
human |
| Anindya Ghosh, Yat Hei Leung, Jeffrey Yu, Robert Sladek, Isabelle Chénier, Abel K Oppong, Marie-Line Peyot, S R Murthy Madiraju, Irina Al-Khairi, Thangavel Alphonse Thanaraj, Jehad Abubaker, Fahd Al-Mulla, Marc Prentki, Mohamed Abu-Farh. Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2024-01-25. PMID:38272177. |
rna-seq analysis of angptl8 sirna or control sirna transfected sc preadipocytes on days 0, 2, 4 and 7 of differentiation showed that angptl8 knockdown impeded the early (day 2) expression of adipogenic and insulin signaling genes, pparγ, as well as genes related to extracellular matrix and nf-κb signaling. |
2024-01-25 |
2024-01-28 |
mouse |
| Andreas Thomas, Katja Walpurgis, Mario Thevi. Chromatographic-mass spectrometric analysis of peptidic analytes (2-10 kDa) in doping control urine samples. Journal of mass spectrometry : JMS. vol 59. issue 1. 2024-01-10. PMID:38197510. |
with urine samples representing still the most frequently collected doping control specimens, efficient extraction of peptidic analytes from this matrix was a major goal of this method, as demonstrated for the included compounds such as insulins (human, lispro, aspart, glulisine, tresiba, glargine metabolite, bovine insulin, porcine insulin), growth hormone-releasing hormones (sermorelin, cjc-1295, tesamorelin) incl. |
2024-01-10 |
2024-01-13 |
human |
| Jing Yi Zhao, Li Juan Zhou, Kai Le Ma, Rui Hao, Min L. MHO or MUO? White adipose tissue remodeling. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2024-01-08. PMID:38186200. |
in individuals with mho, wat remodeling is beneficial, reducing ectopic fat deposition and insulin resistance (ir) through mechanisms like increased adipocyte hyperplasia, anti-inflammatory microenvironment, appropriate extracellular matrix (ecm) remodeling, appropriate vascularization, enhanced wat browning, and subcutaneous adipose tissue (swat) deposition. |
2024-01-08 |
2024-01-10 |
Not clear |
| Vishal Musale, Colin E Murdoch, Ayman K Banah, Annie Hasib, Chandani K Hennayake, Bo Dong, Chim C Lang, David H Wasserman, Li Kan. Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014154. |
extracellular matrix abnormalities contribute to cardiac insulin resistance and associated dysfunction in diet-induced obese mice. |
2023-11-28 |
2023-11-29 |
mouse |
| Vishal Musale, Colin E Murdoch, Ayman K Banah, Annie Hasib, Chandani K Hennayake, Bo Dong, Chim C Lang, David H Wasserman, Li Kan. Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014154. |
increased deposition of extracellular matrix (ecm) components such as collagens and hyaluronan contributes to the pathogenesis of obesity-associated insulin resistance in muscle, liver, and adipose tissue. |
2023-11-28 |
2023-11-29 |
mouse |
| Vishal Musale, Colin E Murdoch, Ayman K Banah, Annie Hasib, Chandani K Hennayake, Bo Dong, Chim C Lang, David H Wasserman, Li Kan. Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014154. |
increased collagen deposition by genetic deletion of matrix metalloproteinase 9 (mmp9) exacerbated cardiac insulin resistance and decreased hyaluronan deposition by treatment with pegylated human recombinant hyaluronidase ph20 (pegph20) improved cardiac insulin resistance in obese mice. |
2023-11-28 |
2023-11-29 |
mouse |
| Kung-Hsien Ho, Guoqiang Gu, Irina Kaverin. Preparation of Whole-mount Mouse Islets on Vascular Extracellular Matrix for Live Islet Cell Microscopy. Bio-protocol. vol 13. issue 21. 2023-11-16. PMID:37969764. |
pancreatic islet β cells preferentially secrete insulin toward the plasma membrane, making contact with the capillary extracellular matrix (ecm). |
2023-11-16 |
2023-11-20 |
mouse |
| Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraj. Glucose-Responsive Self-Regulated Injectable Silk Fibroin Hydrogel for Controlled Insulin Delivery. ACS applied materials & interfaces. 2023-10-17. PMID:37847862. |
under hyperglycemic conditions, the hydrogen peroxide generated from the sensing element induces hydrogel matrix degradation by oxidative cleavage, enabling insulin release. |
2023-10-17 |
2023-11-08 |
Not clear |
| Jackie Fule Liu, Amin GhavamiNejad, Brian Lu, Sako Mirzaie, Melisa Samarikhalaj, Adria Giacca, Xiao Yu W. "Smart" Matrix Microneedle Patch Made of Self-Crosslinkable and Multifunctional Polymers for Delivering Insulin On-Demand. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-09-18. PMID:37718654. |
"smart" matrix microneedle patch made of self-crosslinkable and multifunctional polymers for delivering insulin on-demand. |
2023-09-18 |
2023-10-07 |
Not clear |
| Jackie Fule Liu, Amin GhavamiNejad, Brian Lu, Sako Mirzaie, Melisa Samarikhalaj, Adria Giacca, Xiao Yu W. "Smart" Matrix Microneedle Patch Made of Self-Crosslinkable and Multifunctional Polymers for Delivering Insulin On-Demand. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-09-18. PMID:37718654. |
the simplicity in the design and fabrication process, and glucose-responsiveness in insulin delivery impart the matrix microneedle (mmn) patch great potential for clinical translation. |
2023-09-18 |
2023-10-07 |
Not clear |
| Hannah Reich, Cathy Savage-Dun. Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode American journal of physiology. Cell physiology. 2023-09-18. PMID:37721005. |
signaling circuits and the apical extracellular matrix in aging: connections identified in the nematode numerous conserved signaling pathways play critical roles in aging, including insulin, tgf-β, wnt, and autophagy pathways. |
2023-09-18 |
2023-10-07 |
Not clear |
| Bo Zhi Chen, Wen Xuan Li, Yun Hao Feng, Xiao Peng Zhang, Jie Jiao, Zhuo Lin Li, Vahideh Nosrati-Siahmazgi, Mohammad-Ali Shahbazi, Xin Dong Gu. Functional insulin aspart/insulin degludec-based microneedles for promoting postprandial glycemic control. Acta biomaterialia. 2023-09-14. PMID:37708925. |
molecular dynamics simulations were utilized to study the interactions between the insulin and microneedle matrix materials, providing a strategy for theoretically understanding drug stability as well as the release mechanism of drug-loaded microneedles. |
2023-09-14 |
2023-10-07 |
rat |