| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benneth Ben-Azu, Adaeze Adebesin, Goodes E Moke, Vivian O Ojiokor, Adebayo Olusegun, Thiophilus A Jarikre, Elizabeth T Akinluyi, Opajobi A Olukemi, Noah A Omeiza, Paul Nkenchor, Avwenayeri R Niemogha, Ejaita D Ewere, Chioma Igwoku, Favour Omamogh. Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: attenuation by geraniol. Neurochemistry international. 2024-05-04. PMID:38703789. |
in line with this, geraniol increased the levels of dopamine, serotonin, and glutamic-acid decarboxylase enzyme, accompanied by reduced monoamine oxidase-b and acetylcholinesterase activities in the prefrontal-cortex, hippocampus, and striatum. |
2024-05-04 |
2024-05-07 |
mouse |
| Stefano Maddalena, Carlo Magistri, Cristiano Mellini, Giuseppe Sarl. Aripiprazole for treating delirium: A systematic review-Is it a valid yet understudied treatment? Journal of psychopharmacology (Oxford, England). 2024-04-30. PMID:38686649. |
unfortunately, its adverse effects can be severe, and psychiatrists are considering the use of alternative drugs targeting dopamine and serotonin domains (atypical antipsychotics). |
2024-04-30 |
2024-05-03 |
Not clear |
| Alina Díez-Solinska, Olatz Goñi-Balentziaga, Garikoitz Beitia-Oyarzabal, Maider Muñoz-Culla, Oscar Vegas, Garikoitz Azkon. Chronic defeat stress induces monoamine level dysregulation in the prefrontal cortex but not in the hippocampus of OF1 male mice. Behavioural brain research. 2024-04-30. PMID:38688411. |
in addition, stressed mice showed lower levels of tyrosine, dopamine, dopac, mhpg, kynurenine, kynurenic acid, and 5-hiaa levels but higher serotonin levels in the prefrontal cortex, not in the hippocampus. |
2024-04-30 |
2024-05-03 |
mouse |
| Shan Gao, Ling Fan, Zhigang Yu, Xingxing Xi. Efficacy and safety of lurasidone for schizophrenia: A systematic review and meta‑analysis of eight short‑term, randomized, double‑blind, placebo‑controlled clinical trials. Biomedical reports. vol 20. issue 6. 2024-04-29. PMID:38682090. |
it is mainly used to treat schizophrenia in adults through its antagonistic action on dopamine and 5-hydroxytryptamine receptors. |
2024-04-29 |
2024-05-01 |
Not clear |
| Toufik Abdul-Rahman, Ranferi Eduardo Herrera-Calderón, Nicholas Aderinto, Mrinmoy Kundu, Andrew Awuah Wireko, Favour Tope Adebusoye, Olabode Ekerin, Lukman Lawal, Nikitina Iryna Mykolaivna, Athanasios Alexiou, Majed N Almashjary, Asma Perveen, Ghulam Md Ashra. Clearing the Fog: A Review of Antipsychotics for Parkinson's-Related Hallucinations: A Focus on Pimavanserin, Quetiapine and Clozapine. Journal of integrative neuroscience. vol 23. issue 4. 2024-04-29. PMID:38682215. |
the broad mechanisms of action of aaps, involving dopamine and serotonin receptors, provide improved outcomes and fewer side effects than typical antipsychotics. |
2024-04-29 |
2024-05-01 |
Not clear |
| Al-Sayeda Al-Sayed Newairy, Fatma Ahmad Hamaad, Mayssaa Moharm Wahby, Mamdooh Ghoneum, Heba Mohamed Abdo. Neurotherapeutic effects of quercetin-loaded nanoparticles and Biochanin-A extracted from Trifolium alexandrinum on PI3K/Akt/GSK-3β signaling in the cerebral cortex of male diabetic rats. PloS one. vol 19. issue 4. 2024-04-29. PMID:38683825. |
in addition, these treatments improved neurochemical levels, including acetylcholine, dopamine, and serotonin levels as well acetylcholinesterase and monoamine oxidase activities. |
2024-04-29 |
2024-05-03 |
rat |
| Hoa Quynh Do, Elham Pirayesh, Garren Ferreira, Akash Pandhare, Zackary Ryan Gallardo, Michaela Janse. A bupropion modulatory site in Gloeobacter violaceus ligand-gated ion channel. Biophysical journal. 2024-04-28. PMID:38678367. |
bupropion inhibits dopamine and norepinephrine reuptake transporters and eukaryotic cation-conducting pentameric ligand-gated ion channels (plgics), such as nicotinic acetylcholine (nach) and serotonin type 3a (5-ht3a) receptors, at clinically relevant concentrations. |
2024-04-28 |
2024-04-30 |
Not clear |
| Elena Predescu, Tudor Vaidean, Andreea-Marlena Rapciuc, Roxana Sipo. Metabolomic Markers in Attention-Deficit/Hyperactivity Disorder (ADHD) among Children and Adolescents-A Systematic Review. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673970. |
synthesis revealed intricate links between adhd and altered amino acid metabolism, neurotransmitter dysregulation (especially dopamine and serotonin), oxidative stress, and the kynurenine pathway impacting neurotransmitter homeostasis. |
2024-04-27 |
2024-04-29 |
human |
| Ming Liu, Ping Deng, Guangyu Li, Haoling Liu, Junli Zuo, Wenwen Cui, Huixian Zhang, Xin Chen, Jingjing Yao, Xitian Peng, Lijun Peng, Jiao Liu, Wenting Zheng, Wei Yan, Ning Lua. Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ( Toxics. vol 12. issue 4. 2024-04-26. PMID:38668505. |
to elucidate the underlying mechanisms, we examined changes in acetylcholinesterase (ache) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, hpi axis-related hormone (cortisol and epinephrine) contents and neurodevelopment-related gene expression in zebrafish brain. |
2024-04-26 |
2024-04-28 |
zebrafish |
| Ming Liu, Ping Deng, Guangyu Li, Haoling Liu, Junli Zuo, Wenwen Cui, Huixian Zhang, Xin Chen, Jingjing Yao, Xitian Peng, Lijun Peng, Jiao Liu, Wenting Zheng, Wei Yan, Ning Lua. Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ( Toxics. vol 12. issue 4. 2024-04-26. PMID:38668505. |
the observations suggest that combined exposure to pb and as can cause abnormalities in swimming behavior and ultimately exacerbate neurotoxicity in zebrafish by interfering with the cholinergic system, dopamine and 5-hydroxytryptamine signaling, hpi axis function as well as neuronal development. |
2024-04-26 |
2024-04-28 |
zebrafish |
| Alison G P Wakeford, Jonathon A Nye, Elyse L Morin, Jiyoung Mun, Jerrold S Meyer, Mark Goodman, Leonard L Howell, Mar M Sanche. Alterations in adolescent brain serotonin (5HT) Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-26. PMID:38671147. |
alterations in adolescent brain serotonin (5ht) stress affects brain serotonin (5ht) and dopamine (da) function, and the effectiveness of 5ht and da to regulate stress and emotional responses. |
2024-04-26 |
2024-04-29 |
Not clear |
| Abhinav Goyal, Jason Yuen, Stephen Sinicrope, Bailey Winter, Lindsey Randall, Aaron E Rusheen, Charles D Blaha, Kevin E Bennet, Kendall H Lee, Hojin Shin, Yoonbae O. Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning. Molecular psychiatry. 2024-04-25. PMID:38664492. |
discrimnet is also shown to accurately predict the expected changes in dopamine and serotonin after cocaine and oxycodone administration in anesthetized rats in vivo. |
2024-04-25 |
2024-04-28 |
rat |
| Sixiang Chen, Xingyu Huang, Xintong Zhang, Chan Li, Yuan-Wei Zhan. A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612840. |
the monoamine transporters, including the serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net), are the therapeutic targets for the treatment of many neuropsychiatric disorders. |
2024-04-13 |
2024-04-15 |
Not clear |
| Rajagopal Kalirajan, Khare Rishabh, Jupudi Srikanth, Modi Niharika, Negi Preeya, Islam Rezau. Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants. Archives of Razi Institute. vol 78. issue 5. 2024-04-09. PMID:38590677. |
according to the monoamine-deficiency hypothesis, the underlying pathophysiology of depression is a deficiency of some neurotransmitters (serotonin, norepinephrine, or dopamine) in the central nervous system. |
2024-04-09 |
2024-04-11 |
Not clear |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. |
2024-04-08 |
2024-04-11 |
rat |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
the lateral habenula (lhb) projects to the ventral tegmental area (vta) and dorsal raphe nuclei (drn) that deliver dopamine (da) and serotonin (5-ht) to cortical and limbic regions such as the medial prefrontal cortex (mpfc), hippocampus and basolateral amygdala (bla). |
2024-04-08 |
2024-04-11 |
rat |
| Alexis N Jameson, Justin K Siemann, Carrie A Grueter, BradA Grueter, Douglas G McMaho. Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood. Neurobiology of sleep and circadian rhythms. vol 16. 2024-04-08. PMID:38585223. |
using periadolescent and young adult male and female mice, here we assessed photoperiod's effect on serotonin and dopamine tissue content in the nucleus accumbens core, as well as on accumbal synaptic dopamine release and uptake. |
2024-04-08 |
2024-04-10 |
mouse |
| Alexis N Jameson, Justin K Siemann, Carrie A Grueter, BradA Grueter, Douglas G McMaho. Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood. Neurobiology of sleep and circadian rhythms. vol 16. 2024-04-08. PMID:38585223. |
we found greater serotonin and dopamine tissue content in the nucleus accumbens from young adult mice raised in a short winter-like photoperiod. |
2024-04-08 |
2024-04-10 |
mouse |
| Zhiwei Huang, Junhao Wu, Yihui Guan, Yumei Wei, Fang Xie, Yifeng She. PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans. European journal of nuclear medicine and molecular imaging. 2024-04-08. PMID:38587645. |
despite the in vitro evidence that toludesvenlafaxine inhibits the reuptake of serotonin (5-ht), norepinephrine (ne) and dopamine (da), there is no in vivo evidence that toludesvenlafaxine binds to dat and increases da level, a mechanism thought to contribute to its favorable clinical performance. |
2024-04-08 |
2024-04-10 |
rat |
| Joseph S Lonstein, Taryn A Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. vol 165. 2024-04-03. PMID:38569396. |
the results revealed that, even without pregnancy stress, hn001 reduced postpartum anxiety-related behavior, increased variability in behavioral fragmentation when dams interacted with pups, increased time away from pups, and decreased prefrontal cortex norepinephrine (ne), dopamine (da) and serotonin (5-ht). |
2024-04-03 |
2024-04-06 |
rat |