| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqiang Yu, Qi Zhao, Fangqi Duan, Yan Dong, Li Zhang, Jie Gao, Dongyan Che. Dexmedetomidine alleviates sevoflurane-induced neurotoxicity during late pregnancy by modulating apoptotic pathways and BDNF receptor expression. Experimental brain research. vol 243. issue 4. 2025-03-21. PMID:40116959. |
to investigate the associations between the neurotoxicity of sevoflurane and the neuroprotection provided by dexmedetomidine, we measured apoptotic gene and protein expression, brain-derived neurotrophic factor (bdnf) levels, and receptor expression, and neuronal apoptosis. |
2025-03-21 |
2025-03-24 |
rat |
| Zhiqiang Yu, Qi Zhao, Fangqi Duan, Yan Dong, Li Zhang, Jie Gao, Dongyan Che. Dexmedetomidine alleviates sevoflurane-induced neurotoxicity during late pregnancy by modulating apoptotic pathways and BDNF receptor expression. Experimental brain research. vol 243. issue 4. 2025-03-21. PMID:40116959. |
the apoptotic genes and proteins expression, bdnf and receptor expression, and neuronal apoptosis were assessed in offspring hippocampi on postnatal day 1 (p1) and p41. |
2025-03-21 |
2025-03-24 |
rat |
| Zhiqiang Yu, Qi Zhao, Fangqi Duan, Yan Dong, Li Zhang, Jie Gao, Dongyan Che. Dexmedetomidine alleviates sevoflurane-induced neurotoxicity during late pregnancy by modulating apoptotic pathways and BDNF receptor expression. Experimental brain research. vol 243. issue 4. 2025-03-21. PMID:40116959. |
maternal sevoflurane exposure increased bax mrna and protein expression, decreased bcl-2 mrna and protein expression, enhanced neuronal apoptosis, decreased the ratio of mature bdnf (mbdnf) to probdnf, reduced mbdnf and tropomyosin receptor kinase b (trkb) protein expression, and increased p75 neurotrophin receptor (p75ntr) protein expression in the hippocampi of neonatal rats. |
2025-03-21 |
2025-03-24 |
rat |
| Min Chen, Min Li, Liwei Ma, Huiling Hou, Meiling Tang, Qiang L. Saikosaponins alleviate depression-like behaviors of chronic unpredictable mild stress exposed mice through ERK signaling pathway. Experimental brain research. vol 243. issue 3. 2025-02-12. PMID:39937248. |
tunel staining of brain tissues and protein levels of brain-derived neurotrophic factor (bdnf) and caspase-3 were combined to evaluate cell apoptosis. |
2025-02-12 |
2025-02-14 |
mouse |
| Min Chen, Min Li, Liwei Ma, Huiling Hou, Meiling Tang, Qiang L. Saikosaponins alleviate depression-like behaviors of chronic unpredictable mild stress exposed mice through ERK signaling pathway. Experimental brain research. vol 243. issue 3. 2025-02-12. PMID:39937248. |
ss also inhibited apoptosis of hippocampal neurons by down-regulating caspase-3 protein and up-regulating bdnf protein levels. |
2025-02-12 |
2025-02-14 |
mouse |
| Rui Zhang, Yongkai Yang, Yijun Li. Edaravone Mitigates Hippocampal Neuronal Death and Cognitive Dysfunction by Upregulating BDNF Expression in Neonatal Hypoxic-Ischemic Rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 85. issue 1. 2025-01-20. PMID:39831776. |
results demonstrated that eda significantly reduced hippocampal neuronal apoptosis and death, increased neuronal survival, and enhanced bdnf expression compared to the control group. |
2025-01-20 |
2025-01-23 |
rat |
| Bo Yang, Feiqing Wang, Xu Yang, Xiaoshuang Yuan, Yuting Yang, Xiaoxu Chen, Tingting Tian, Fa Chen, Dongxin Tang, Zhixu He, Yang Liu, Yanju L. The Role of SIRT1-BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells. Biological trace element research. 2025-01-17. PMID:39825065. |
srt1720 mitigated the harmful effects of naf, stimulated cell proliferation and cell cycle progression, decreased apoptosis, reduced oxidative stress and inflammatory factors, elevated sirt1, bdnf, trkb, pi3k, akt, and mapk protein levels, and suppressed foxo1a protein expression. |
2025-01-17 |
2025-01-21 |
Not clear |
| Lailatuz Zaidah, Soetrisno Soetrisno, Bambang Purwanto, Agus Kristiyanto, Brian Wasita, Vitri Widyaningsi. Aerobic exercise improves spatial memory in a rat model of meningitis. Narra J. vol 4. issue 3. 2025-01-16. PMID:39816058. |
the aim of this study was to evaluate the effect of aerobic exercise on malondialdehyde (mda), nuclear factor-kappa b (nf-κb), insulin-like growth factor 1 (igf-1), endothelial nitric oxide synthase (enos), brain-derived neurotrophic factor (bdnf), apoptosis, and spatial memory. |
2025-01-16 |
2025-01-19 |
rat |
| Baoyu Shen, Zhenling Wu, Mengran Lv, Genmeng Yang, Yuanyuan Cao, Yuan Zhang, Junjie Shu, Wenjuan Dong, Zhenping Hou, Di Jing, Xinjie Zhang, Yuhan Hou, Jing Xu, Shijun Hong, Lihua L. Methamphetamine inhibits huntingtin-associated protein 1-mediated tyrosine receptor kinase B endocytosis resulting the neuroprotective dysfunction of brain-derived neurotrophic factor. Toxicology. 2025-01-12. PMID:39800156. |
in the current study, excessive apoptosis, elevated bdnf and reduced huntingtin-associated protein 1 (hap1) expression were observed in the hippocampus of meth users. |
2025-01-12 |
2025-01-16 |
mouse |
| Yingying Sun, Dandan Zhou, Anlan Liu, Yu Zhou, Yang Zhao, Yuan Yuan, Weifeng Guo, Jianxiang L. Liangxue Tongyu Prescription Exerts Neuroprotection by Regulating the Microbiota-Gut-Brain Axis of Rats with Acute Intracerebral Hemorrhage. Brain research bulletin. 2025-01-02. PMID:39746523. |
analysis via western blot, quantitative real-time pcr, immunohistochemistry (ihc) and tunel staining indicated that ltp upregulated the expression of brain-derived neurotrophic factor (bdnf) and nerve growth factor(ngf) and reduced neuronal cell apoptosis. |
2025-01-02 |
2025-01-05 |
rat |
| Bayan El Amine, Joey Fournier, Mélanie Minoves, Sébastien Baillieul, Frédéric Roche, Nathalie Perek, Jean-Louis Pépin, Renaud Tamisier, Charles Khouri, Claire Rome, Anne Briançon-Marjolle. Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data. European respiratory review : an official journal of the European Respiratory Society. vol 33. issue 174. 2024-12-18. PMID:39694586. |
hence, we conducted a systematic review and meta-analysis to evaluate the impact of ih on rodent brain oxidative stress, inflammation, apoptosis and the expression of brain-derived neurotrophic factor (bdnf) and hypoxia-inducible factor 1 (hif-1). |
2024-12-18 |
2024-12-21 |
Not clear |
| Bayan El Amine, Joey Fournier, Mélanie Minoves, Sébastien Baillieul, Frédéric Roche, Nathalie Perek, Jean-Louis Pépin, Renaud Tamisier, Charles Khouri, Claire Rome, Anne Briançon-Marjolle. Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data. European respiratory review : an official journal of the European Respiratory Society. vol 33. issue 174. 2024-12-18. PMID:39694586. |
the examined outcomes were oxidative stress, inflammation, apoptosis, hif-1 or bdnf in brains. |
2024-12-18 |
2024-12-21 |
Not clear |
| Xin Gong, Zhijian Tan, Henghui Xu, Xu Jiang, Lei Che. Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis. The American journal of Chinese medicine. vol 52. issue 7. 2024-12-11. PMID:39663263. |
pf dose-dependently reduced rgma expression, ros, mda, tnf-α, il-2, and il-6 levels; mitigated apoptosis; and lowered cleaved-caspase 3, cleaved-caspase 8, cox-2, and inos expression while improving cell viability; increasing [formula: see text]m, gap-43, and bdnf expression; and raising sod, gsh-px, cat, and il-10 levels in pff-induced sh-sy5y cells. |
2024-12-11 |
2024-12-14 |
mouse |
| Xin Gong, Zhijian Tan, Henghui Xu, Xu Jiang, Lei Che. Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis. The American journal of Chinese medicine. vol 52. issue 7. 2024-12-11. PMID:39663263. |
apoptosis; cleaved-caspase 3, cleaved-caspase 8, repulsive guidance molecule a (rgma), gap-43, and brain-derived neurotrophic factor (bdnf) expression; and superoxide dismutase (sod), malondialdehyde (mda), glutathione peroxidase (gsh-px), catalase (cat), tumor necrosis factor (tnf)-α, interleukin (il)-2, il-6, and il-10 levels were determined in mice and cells. |
2024-12-11 |
2024-12-14 |
mouse |
| Noha Aladdin, Salah A Gharei. Vitamin D3 Exerts a Neuroprotective Effect in Metabolic Syndrome Rats: Role of BDNF/TRKB/Akt/GS3Kβ Pathway. Journal of biochemical and molecular toxicology. vol 38. issue 12. 2024-12-09. PMID:39651608. |
the advanced glycation end products (ages), and markers of inflammation (tnf-α and nf-κb), oxidative stress (malondialdehyde), and apoptosis (caspase3), as well as bdnf, trkb, pi3k, akt, gsk3β, phosphorylated tau, and amyloid beta (aβ) were assessed in the cerebral cortex. |
2024-12-09 |
2024-12-12 |
rat |
| Noha Aladdin, Salah A Gharei. Vitamin D3 Exerts a Neuroprotective Effect in Metabolic Syndrome Rats: Role of BDNF/TRKB/Akt/GS3Kβ Pathway. Journal of biochemical and molecular toxicology. vol 38. issue 12. 2024-12-09. PMID:39651608. |
mets rats had deteriorated glycemic and lipid profiles, higher ages, reduced levels of bdnf, trkb, pi3k, and active akt, along with increased gsk3β levels, inflammation, oxidative stress, and apoptosis. |
2024-12-09 |
2024-12-12 |
rat |
| Pallavi Singh, Priyanka Agrawal, K P Sing. Neurocognitive impairments in rat offspring after maternal exposure to Vortioxetine: Involvement of BDNF, apoptosis and cholinergic mediated signaling pathways. Reproductive toxicology (Elmsford, N.Y.). 2024-11-18. PMID:39557222. |
neurocognitive impairments in rat offspring after maternal exposure to vortioxetine: involvement of bdnf, apoptosis and cholinergic mediated signaling pathways. |
2024-11-18 |
2024-11-22 |
rat |
| Wenyan Shi, Xingyan Wu, Chengdong Yuan, Tao Kuang, Xiangfan Xie, Wenlu Gong, Fujia Li, Lechen Shen, Yi Zhang, Xiaoli Lian. Effect of remimazolam toluene sulfonate on the cognitive function of juveniles and its mechanism of action. European journal of medical research. vol 29. issue 1. 2024-11-13. PMID:39533344. |
concurrently, the extent of caspase-3 upregulation, the number of neuronal apoptosis in ca1 and ca3 regions, a downward trend of psd95 and bdnf in the hippocampus, and the inhibition of ltp were highly consistent with the behavior of short-term memory impairment. |
2024-11-13 |
2024-11-17 |
mouse |
| Cong-Ya Chen, Yu-Fei Wang, Lan Lei, Yi Zhan. MicroRNA-specific targets for neuronal plasticity, neurotransmitters, neurotrophic factors, and gut microbes in the pathogenesis and therapeutics of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 136. 2024-11-12. PMID:39521033. |
conclusively, mirnas are involved in the pathology of depression by causing structural and functional changes in synapses, mediating neuronal regeneration, differentiation, and apoptosis, regulating the gut microbes and the expression of various neurotransmitters and bdnf, and mediating inflammatory and immune responses. |
2024-11-12 |
2024-11-17 |
Not clear |
| Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |