| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bayan El Amine, Joey Fournier, Mélanie Minoves, Sébastien Baillieul, Frédéric Roche, Nathalie Perek, Jean-Louis Pépin, Renaud Tamisier, Charles Khouri, Claire Rome, Anne Briançon-Marjolle. Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data. European respiratory review : an official journal of the European Respiratory Society. vol 33. issue 174. 2024-12-18. PMID:39694586. |
hence, we conducted a systematic review and meta-analysis to evaluate the impact of ih on rodent brain oxidative stress, inflammation, apoptosis and the expression of brain-derived neurotrophic factor (bdnf) and hypoxia-inducible factor 1 (hif-1). |
2024-12-18 |
2024-12-21 |
Not clear |
| Bayan El Amine, Joey Fournier, Mélanie Minoves, Sébastien Baillieul, Frédéric Roche, Nathalie Perek, Jean-Louis Pépin, Renaud Tamisier, Charles Khouri, Claire Rome, Anne Briançon-Marjolle. Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data. European respiratory review : an official journal of the European Respiratory Society. vol 33. issue 174. 2024-12-18. PMID:39694586. |
the examined outcomes were oxidative stress, inflammation, apoptosis, hif-1 or bdnf in brains. |
2024-12-18 |
2024-12-21 |
Not clear |
| Xin Gong, Zhijian Tan, Henghui Xu, Xu Jiang, Lei Che. Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis. The American journal of Chinese medicine. vol 52. issue 7. 2024-12-11. PMID:39663263. |
pf dose-dependently reduced rgma expression, ros, mda, tnf-α, il-2, and il-6 levels; mitigated apoptosis; and lowered cleaved-caspase 3, cleaved-caspase 8, cox-2, and inos expression while improving cell viability; increasing [formula: see text]m, gap-43, and bdnf expression; and raising sod, gsh-px, cat, and il-10 levels in pff-induced sh-sy5y cells. |
2024-12-11 |
2024-12-14 |
mouse |
| Xin Gong, Zhijian Tan, Henghui Xu, Xu Jiang, Lei Che. Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis. The American journal of Chinese medicine. vol 52. issue 7. 2024-12-11. PMID:39663263. |
apoptosis; cleaved-caspase 3, cleaved-caspase 8, repulsive guidance molecule a (rgma), gap-43, and brain-derived neurotrophic factor (bdnf) expression; and superoxide dismutase (sod), malondialdehyde (mda), glutathione peroxidase (gsh-px), catalase (cat), tumor necrosis factor (tnf)-α, interleukin (il)-2, il-6, and il-10 levels were determined in mice and cells. |
2024-12-11 |
2024-12-14 |
mouse |
| Noha Aladdin, Salah A Gharei. Vitamin D3 Exerts a Neuroprotective Effect in Metabolic Syndrome Rats: Role of BDNF/TRKB/Akt/GS3Kβ Pathway. Journal of biochemical and molecular toxicology. vol 38. issue 12. 2024-12-09. PMID:39651608. |
the advanced glycation end products (ages), and markers of inflammation (tnf-α and nf-κb), oxidative stress (malondialdehyde), and apoptosis (caspase3), as well as bdnf, trkb, pi3k, akt, gsk3β, phosphorylated tau, and amyloid beta (aβ) were assessed in the cerebral cortex. |
2024-12-09 |
2024-12-12 |
rat |
| Noha Aladdin, Salah A Gharei. Vitamin D3 Exerts a Neuroprotective Effect in Metabolic Syndrome Rats: Role of BDNF/TRKB/Akt/GS3Kβ Pathway. Journal of biochemical and molecular toxicology. vol 38. issue 12. 2024-12-09. PMID:39651608. |
mets rats had deteriorated glycemic and lipid profiles, higher ages, reduced levels of bdnf, trkb, pi3k, and active akt, along with increased gsk3β levels, inflammation, oxidative stress, and apoptosis. |
2024-12-09 |
2024-12-12 |
rat |
| Pallavi Singh, Priyanka Agrawal, K P Sing. Neurocognitive impairments in rat offspring after maternal exposure to Vortioxetine: Involvement of BDNF, apoptosis and cholinergic mediated signaling pathways. Reproductive toxicology (Elmsford, N.Y.). 2024-11-18. PMID:39557222. |
neurocognitive impairments in rat offspring after maternal exposure to vortioxetine: involvement of bdnf, apoptosis and cholinergic mediated signaling pathways. |
2024-11-18 |
2024-11-22 |
rat |
| Wenyan Shi, Xingyan Wu, Chengdong Yuan, Tao Kuang, Xiangfan Xie, Wenlu Gong, Fujia Li, Lechen Shen, Yi Zhang, Xiaoli Lian. Effect of remimazolam toluene sulfonate on the cognitive function of juveniles and its mechanism of action. European journal of medical research. vol 29. issue 1. 2024-11-13. PMID:39533344. |
concurrently, the extent of caspase-3 upregulation, the number of neuronal apoptosis in ca1 and ca3 regions, a downward trend of psd95 and bdnf in the hippocampus, and the inhibition of ltp were highly consistent with the behavior of short-term memory impairment. |
2024-11-13 |
2024-11-17 |
mouse |
| Cong-Ya Chen, Yu-Fei Wang, Lan Lei, Yi Zhan. MicroRNA-specific targets for neuronal plasticity, neurotransmitters, neurotrophic factors, and gut microbes in the pathogenesis and therapeutics of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 136. 2024-11-12. PMID:39521033. |
conclusively, mirnas are involved in the pathology of depression by causing structural and functional changes in synapses, mediating neuronal regeneration, differentiation, and apoptosis, regulating the gut microbes and the expression of various neurotransmitters and bdnf, and mediating inflammatory and immune responses. |
2024-11-12 |
2024-11-17 |
Not clear |
| Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |
| Jiapeng Huang, Chuncha Bao, Chunlan Yang, Yun Q. Dual-tDCS Ameliorates Cerebral Injury and Promotes Motor Function Recovery via cGAS-STING Signaling Pathway in a Rat Model of Ischemic Stroke. Molecular neurobiology. 2024-10-25. PMID:39455539. |
dual-tdcs improved motor function and infarct volume, inhibited neuronal apoptosis, promoted the expression of neurotrophins (bdnf and ngf), cd31, and vegf, and suppressed inflammation reaction after mcao via the cgas-sting pathway. |
2024-10-25 |
2024-10-29 |
rat |
| Thibaut Gellé, Théodore Vinais, Aurélie Lacroix, Brigitte Plansont, Philippe Nubukpo, Murielle Girar. Serum BDNF and pro-BDNF levels in alcohol use disorders according to depression status: An exploratory study of their evolution two months after withdrawal. Heliyon. vol 10. issue 19. 2024-10-21. PMID:39430530. |
the bdnf precursor, pro-bdnf, has different effects, as it mainly promotes neuronal apoptosis. |
2024-10-21 |
2024-10-23 |
Not clear |
| Yi-Cheng Tsai, Chih-Hui Chang, Yoon Bin Chong, Chieh-Hsin Wu, Hung-Pei Tsai, Tian-Lu Cheng, Chih-Lung Li. MicroRNA-195-5p Inhibits Intracerebral Hemorrhage-Induced Inflammatory Response and Neuron Cell Apoptosis. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408651. |
the mir-195-5p treatment significantly improved neurological function; modulated macrophage polarization by promoting anti-inflammatory marker (cd206 and arg1) production and inhibiting pro-inflammatory marker (cd68 and inos) production; enhanced akt signalling, reduced oxidative stress by increasing sirt1 and nrf2 levels, and attenuated inflammation by decreasing nf-κb activation; inhibited apoptosis via increased bcl-2 and decreased cleaved caspase-3 levels; and regulated synaptic plasticity by modulating nmdar2a, nmdar2b, bdnf, and trkb expression and erk and creb phosphorylation. |
2024-10-16 |
2024-10-18 |
rat |
| Jun He, Peng Xie, Xiao-Qiong An, Dong-Fen Guo, Bin Bi, Gang Wu, Wen-Feng Yu, Zhen-Kui Ren, Li Zu. LncRNA NPTN-IT1-201 Ameliorates Depressive-like Behavior by Targeting miR-142-5p and Regulating Inflammation and Apoptosis via BDNF. Current medical science. 2024-08-15. PMID:39145838. |
lncrna nptn-it1-201 ameliorates depressive-like behavior by targeting mir-142-5p and regulating inflammation and apoptosis via bdnf. |
2024-08-15 |
2024-08-17 |
Not clear |
| Dan Hou, Jialing Zhong, Yujie Hu, Guoshuai Yan. The effect of miR‑155‑5p on long‑term memory of sleep‑deprived mice through the BDNF/NF‑κB pathway. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087835. |
the upregulation of bdnf effectively mitigated hippocampal damage by attenuating cell apoptosis and reducing inflammation levels in sd mice. |
2024-08-01 |
2024-08-03 |
mouse |
| Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
the aim of the present study was to evaluate the effect of rosiglitazone (rsg) or pioglitazone (pog) on the synaptic plasticity, neuronal apoptosis, brain-derived neurotrophic factor (bdnf), and nitric oxide (no) metabolites in the hippocampus of juvenile hypothyroid rats. |
2024-08-01 |
2024-08-03 |
rat |
| Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
then, the hippocampal tissues were collected to determine bdnf and no levels and the degree of apoptosis. |
2024-08-01 |
2024-08-03 |
rat |
| Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
this study's results revealed that pog or rsg normalized ltp impairment, neuronal apoptosis, and improved bdnf content in the hippocampal tissue of juvenile hypothyroid rats. |
2024-08-01 |
2024-08-03 |
rat |
| Xin Zhang, Wen Ma, Huanyi Liu, Yuanchu Liu, Yaling Zhang, Sitong He, Xiaoli Ding, Baolin Li, Yaping Ya. Daphnetin protects neurons in an Alzheimer disease mouse model and normal rat neurons by inhibiting BACE1 activity and activating the Nrf2/HO-1 pathway. Journal of neuropathology and experimental neurology. vol 83. issue 8. 2024-07-19. PMID:38819094. |
furthermore, in vitro experiments utilizing isolated rat neurons assessing rna expression profiling, immunofluorescence, tunel assay, and western-blot analysis, suggested the potential of daph for regulating bdnf and gm-csf expression and mitigating aβ1-42-induced cortical injury, synaptic loss, and apoptosis. |
2024-07-19 |
2024-07-21 |
mouse |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |