| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaobing Zhang, Xian Shao, Qingquan Bao, Lingyan He, Xuchen Q. Baicalein inhibits cell proliferation and induces apoptosis in brain glioma cells by downregulating the LGR4-EGFR pathway. Cancer gene therapy. 2024-10-29. PMID:39468312. |
lgr4 knockdown repressed the proliferation and egfr phosphorylation but induced apoptosis in brain glioma cells. |
2024-10-29 |
2024-10-31 |
human |
| Zhigang Yi, Tao Ma, Jia Liu, Wenting Tie, Yanhong Li, Jun Bai, Lijuan Li, Liansheng Zhan. LGR4 promotes tumorigenesis by activating TGF-β1/Smad signaling pathway in multiple myeloma. Cellular signalling. 2023-07-20. PMID:37473901. |
in vitro and in vivo experiments showed that knockdown of lgr4 significantly inhibited proliferation of mm cells, promoted apoptosis and arrested cell cycle in g1. |
2023-07-20 |
2023-08-14 |
Not clear |
| Xiaofeng Zhou, Yingting He, Nian Li, Guofeng Bai, Xiangchun Pan, Zhe Zhang, Hao Zhang, Jiaqi Li, Xiaolong Yua. DNA methylation mediated RSPO2 to promote follicular development in mammals. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34175894. |
in addition, rspo2 knockdown promoted the apoptosis of gcs, blocked the development of follicles, and delayed the onset of puberty with decreasing the expression level of wnt signaling pathway-related genes (lgr4 and ctnnb1) in vivo. |
2021-09-20 |
2023-08-13 |
Not clear |
| Tao Chen, Xiangrui Qiao, Lele Cheng, Mengping Liu, Yangyang Deng, Xiaozhen Zhu. LGR4 silence aggravates ischemic injury by modulating mitochondrial function and oxidative stress via ERK signaling pathway in H9c2 cells. Journal of molecular histology. vol 52. issue 2. 2021-04-01. PMID:33559814. |
knockdown of lgr4 increased the apoptosis rate of h9c2 cells and led to excessed oxidant stress and impaired mitochondrial function by increasing the levels of ros, mda, ldh, ck and cyt c and inhibiting sod activity, atp production. |
2021-04-01 |
2023-08-13 |
Not clear |
| Fang Liang, Hao Zhang, Duo Cheng, Hui Gao, Junyong Wang, Junmin Yue, Nan Zhang, Jingjing Wang, Zhaoyang Wang, Beibei Zha. Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells. Life sciences. vol 265. 2021-02-02. PMID:33171177. |
our previous study has shown that leucine-rich repeat containing gpcr-4 (lgr4, or gpr48) lgr4 plays a role in cell migration, invasion, proliferation and apoptosis of prostate cancer (pca). |
2021-02-02 |
2023-08-13 |
Not clear |
| Peng Sun, Kunhang Jia, Chunbing Zheng, Xinlei Zhu, Jing Li, Liang He, Stefan Siwko, Feng Xue, Mingyao Liu, Jian Lu. Loss of Lgr4 inhibits differentiation, migration and apoptosis, and promotes proliferation in bone mesenchymal stem cells. Journal of cellular physiology. vol 234. issue 7. 2020-05-11. PMID:30536377. |
loss of lgr4 inhibits differentiation, migration and apoptosis, and promotes proliferation in bone mesenchymal stem cells. |
2020-05-11 |
2023-08-13 |
mouse |
| Mohammed Ashrafi, Anil Sebastian, Barbara Shih, Nicholas Greaves, Teresa Alonso-Rasgado, Mohamed Baguneid, Ardeshir Baya. Whole genome microarray data of chronic wound debridement prior to application of dermal skin substitutes. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 24. issue 5. 2019-11-20. PMID:27365116. |
microarray analysis identified significant differences (p < 0.05) related to proliferation (hipk2, lgr4, fgfr1, srrt), migration (rhoc, prpf40a, fgfr1), differentiation (tcf4, col13a1, gnptab, huwe1, fgfr1), angiogenesis (hipk2, casp8), extracellular matrix organization (vwa1), and apoptosis (bbc3, hipk2, klf11, psme3, msfd10, top2a, mlh1, casp8, pdia3, xaf1) when comparing untreated chronic wounds to chronic wounds treated with dss, with similar expression levels compared to untreated acute wounds. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yuchen Dong, Yajuan Zheng, Jun Xiao, Chao Zhu, Meisheng Zha. MicroRNA let-7b induces lens epithelial cell apoptosis by targeting leucine-rich repeat containing G protein-coupled receptor 4 (Lgr4) in age-related cataract. Experimental eye research. vol 147. 2017-05-25. PMID:27179410. |
microrna let-7b induces lens epithelial cell apoptosis by targeting leucine-rich repeat containing g protein-coupled receptor 4 (lgr4) in age-related cataract. |
2017-05-25 |
2023-08-13 |
Not clear |
| Yuchen Dong, Yajuan Zheng, Jun Xiao, Chao Zhu, Meisheng Zha. MicroRNA let-7b induces lens epithelial cell apoptosis by targeting leucine-rich repeat containing G protein-coupled receptor 4 (Lgr4) in age-related cataract. Experimental eye research. vol 147. 2017-05-25. PMID:27179410. |
furthermore, we showed that leucine-rich repeat containing g protein-coupled receptor 4 (lgr4) was a direct target of let-7b, and let-7b modulated lens epithelial cell apoptosis by directly targeting lgr4. |
2017-05-25 |
2023-08-13 |
Not clear |
| Jianwei Zhang, Qi Li, Shaojin Zhang, Quanquan Xu, Tianen Wan. Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway. Experimental cell research. vol 349. issue 1. 2017-05-15. PMID:27743893. |
next, we found that lgr4 overexpression promoted jmjd2a mrna expression, reduced cell apoptosis and arrested cell cycle in the s phase, these effects were reversed by jmjd2a silencing. |
2017-05-15 |
2023-08-13 |
Not clear |
| Jianwei Zhang, Qi Li, Shaojin Zhang, Quanquan Xu, Tianen Wan. Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway. Experimental cell research. vol 349. issue 1. 2017-05-15. PMID:27743893. |
lgr4 activates jmjd2a/ar signaling pathway to promote interaction ar with psa promoter, causing reduction of pca apoptosis and cell cycle arrest. |
2017-05-15 |
2023-08-13 |
Not clear |
| Jianwei Zhang, Qi Li, Shaojin Zhang, Quanquan Xu, Tianen Wan. Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway. Experimental cell research. vol 349. issue 1. 2017-05-15. PMID:27743893. |
furthermore, interaction ar with psa promoter (containing an ar response element) was obviously improved by lgr4 overexpression, and psa silencing reduced lgr4-induced cell apoptosis and cell cycle arrest in pca cells. |
2017-05-15 |
2023-08-13 |
Not clear |
| J T Zhang, W L Zhou, C He, T Liu, C Y Li, L Wan. 5-Fluorouracil induces apoptosis of colorectal cancer cells. Genetics and molecular research : GMR. vol 15. issue 1. 2016-12-13. PMID:26985934. |
the specific gene silence or over-expression of lgr4 in hct116 cells increased and decreased the levels of apoptosis in hct116, respectively. |
2016-12-13 |
2023-08-13 |
Not clear |
| J T Zhang, W L Zhou, C He, T Liu, C Y Li, L Wan. 5-Fluorouracil induces apoptosis of colorectal cancer cells. Genetics and molecular research : GMR. vol 15. issue 1. 2016-12-13. PMID:26985934. |
small interference rna or over-expression techniques were used to manipulate lgr4 expression in hct116 cells and describe the proliferation and apoptosis of hct116 treated with 5-fu. |
2016-12-13 |
2023-08-13 |
Not clear |
| J T Zhang, W L Zhou, C He, T Liu, C Y Li, L Wan. 5-Fluorouracil induces apoptosis of colorectal cancer cells. Genetics and molecular research : GMR. vol 15. issue 1. 2016-12-13. PMID:26985934. |
5-fu induces apoptosis of colorectal cancer cells and inhibits proliferation by suppressing lgr4 proteins. |
2016-12-13 |
2023-08-13 |
Not clear |
| J T Zhang, W L Zhou, C He, T Liu, C Y Li, L Wan. 5-Fluorouracil induces apoptosis of colorectal cancer cells. Genetics and molecular research : GMR. vol 15. issue 1. 2016-12-13. PMID:26985934. |
a dosage of 20 μg/ml 5-fu resulted in a significant decrease in the proliferation and apoptosis of hct116 cells and significantly decreased expression levels of lgr4. |
2016-12-13 |
2023-08-13 |
Not clear |
| Tingfang Yi, Jinsheng Weng, Stefan Siwko, Jian Luo, Dali Li, Mingyao Li. LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects. The Journal of biological chemistry. vol 289. issue 13. 2014-05-21. PMID:24519938. |
furthermore, lgr4 inactivation significantly increased cell apoptosis and decreased the expression of multiple important genes involved in the development of wagr syndrome related organs. |
2014-05-21 |
2023-08-12 |
mouse |
| Yu Qian, Shijie Liu, Yuting Guan, Hongjie Pan, Xin Guan, Zhongwei Qiu, Liang Li, Na Gao, Yongxiang Zhao, Xiaoying Li, Yan Lu, Mingyao Liu, Dali L. Lgr4-mediated Wnt/β-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development (Cambridge, England). vol 140. issue 8. 2013-06-07. PMID:23533175. |
here we report that lgr4 is selectively expressed in mouse pmcs in the testes, and loss of lgr4 leads to germ cells arresting at meiosis i and then undergoing apoptosis. |
2013-06-07 |
2023-08-12 |
mouse |
| Shijie Liu, Yu Qian, Liang Li, Gaigai Wei, Yuting Guan, Hongjie Pan, Xin Guan, Long Zhang, Xiaoling Lu, Yongxiang Zhao, Mingyao Liu, Dali L. Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice. The Journal of biological chemistry. vol 288. issue 13. 2013-05-30. PMID:23393138. |
during the intestinal regeneration process, cell proliferation but not apoptosis of intestinal epithelial cells was significantly impaired in lgr4(-/-) mice. |
2013-05-30 |
2023-08-12 |
mouse |
| Yasuaki Mohri, Kazunori Oyama, Mizuki Sone, Atsushi Akamatsu, Katsuhiko Nishimor. LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis. Bioscience, biotechnology, and biochemistry. vol 76. issue 5. 2012-10-26. PMID:22738954. |
we found that the lgr4 defect caused an increase in apoptosis in the peripheral mesenchyme during kidney development. |
2012-10-26 |
2023-08-12 |
mouse |