| Meng Lou, Lian Zou, Liying Zhang, Yongquan Lu, Jia Chen, Beige Zon. MECOM and the PRDM gene family in uterine endometrial cancer: bioinformatics and experimental insights into pathogenesis and therapeutic potentials. Molecular medicine (Cambridge, Mass.). vol 30. issue 1. 2024-10-29. PMID:39468462. |
techniques included crispr-cas9 for gene editing and various cellular assays (cck-8, flow cytometry, transwell) to evaluate the effects of mecom on cell proliferation, migration, and apoptosis, alongside western blot analysis for protein regulation in the tgf-beta pathway. |
2024-10-29 |
2024-10-31 |
Not clear |
| David G Covel. Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PloS one. vol 16. issue 4. 2021-09-13. PMID:33909629. |
the results of this analysis find a relatively small set of defective genes, inclusive of abl1, axl, braf, cdc25a, cdkn2a, igf1r, kras, mecom, mmp1, myc, notch1, nras, pik3cg, ptk2, rptor, sptbn1, stat2, tnks and zhx2, as possible candidates for roles in chemosensitivity for compound moas that target primarily, but not exclusively, kinases, nucleic acid synthesis, protein synthesis, apoptosis and tubulin. |
2021-09-13 |
2023-08-13 |
Not clear |
| Eun Ji Choi, Min Sung Kim, Sang Yong Song, Nam Jin Yoo, Sug Hyung Le. Intratumoral Heterogeneity of Frameshift Mutations in MECOM Gene is Frequent in Colorectal Cancers with High Microsatellite Instability. Pathology oncology research : POR. vol 23. issue 1. 2017-03-22. PMID:27620344. |
mecom gene, also known as evi, encodes a transcriptional regulator involved in hematopoiesis, apoptosis, development and proliferation. |
2017-03-22 |
2023-08-13 |
Not clear |