| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raymond J Pickles, Gang Chen, Scott H Randel. Enhanced susceptibility of pediatric airway epithelium to respiratory syncytial virus infection. The Journal of clinical investigation. vol 134. issue 21. 2024-11-01. PMID:39484717. |
bolstering stat3 activation and treatment of neonatal mice with apoptosis inhibitors suppressed virus spread, suggesting that enhancing stat3 activation may provide therapeutic benefit. |
2024-11-01 |
2024-11-03 |
mouse |
| Nimra Irshad, Hammad Naeem, Muhammad Shahbaz, Muhammad Imran, Ahmed Mujtaba, Muzzamal Hussain, Waleed Al Abdulmonem, Suliman A Alsagaby, Tadesse Fenta Yehuala, Mohamed A Abdelgawad, Mohammed M Ghoneim, Ehab M Mostafa, Samy Selim, Soad K Al Jaoun. Mangiferin: An effective agent against human malignancies. Food science & nutrition. vol 12. issue 10. 2024-10-31. PMID:39479608. |
it can control/regulate multiple key signaling pathways, such as signal transducer and activator of transcription 3 (stat3), second mitochondria-derived activator of caspases/direct inhibitor of apoptosis (iap)-binding protein with low propidium iodide (pl) (smac/diablo) nuclear factor kappa b (nf-κb), phosphatidylinositol 3 kinase/protein 3 kinase (pi3k/akt), transforming growth factor beta/suppressor of mothers against decapentaplegic (tgf-β/smad), c-jun n-terminal kinase/p38 mitogen-activated protein kinase (jnk/p38-mapk), and phosphor-i kappa b kinase (p-iκb), which are crucial to the development of cancers. |
2024-10-31 |
2024-11-02 |
human |
| Muhammad Suleman, Safir Ullah Khan, Shahid Ali, Abdullah Alghamdi, Mohammed Alissa, Rayan Y Mushtaq, Sergio Crovell. Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis. Current gene therapy. 2024-10-30. PMID:39473261. |
numerous studies have demonstrated that the abnormal hyperactivation of stat3 in crc tissues enhances cell proliferation, suppresses apoptosis, promotes angiogenesis, and facilitates tumor invasion and metastasis. |
2024-10-30 |
2024-11-02 |
Not clear |
| Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |
| Rui Li, Renfa Liu, Yunxue Xu, Shuhao Zhang, Peipei Yang, Wenlong Zeng, Huiyang Wang, Yijia Liu, Huajing Yang, Xiuli Yue, Zhifei Da. Suppressing Pancreatic Cancer Survival and Immune Escape via Nanoparticle-Modulated STING/STAT3 Axis Regulation. Bioconjugate chemistry. 2024-10-18. PMID:39420541. |
we observed that inhibiting stat3 signaling post-sting activation effectively suppressed tumor growth through signal transducer and activator of transcription 1 (stat1)-mediated apoptosis but led to a potential risk of immune-related adverse events (iraes). |
2024-10-18 |
2024-10-20 |
Not clear |
| Ming Zhou, Yaqi Zhang, Qiong Zhang, Yanchu Ton. METTL14-mediated m6A modification upregulated SOCS3 expression alleviates thyroid cancer progression by regulating the JAK2/STAT3 pathway. Molecular and cellular probes. 2024-10-16. PMID:39413935. |
in addition, mettl14-mediated m6a modification of socs3 inactivated the janus kinase 2 (jak2)-signal transducer and activator of transcription 3 (stat3) pathway, and in the mettl14-overexpressing tc cells, silencing socs3-induced upregulation of cell proliferation, emt and suppression of apoptosis was reversed by jak2/stat3 inhibitor ag490 and wp1066. |
2024-10-16 |
2024-10-19 |
Not clear |
| Tianjun Xing, Zhu Wang, Xiaojie Hao, Jingjun Mu, Bin Wan. Copper Nanoparticles Green-Formulated by Curcuma longa Extract Induce Apoptosis via P53 and STAT3 Signaling Pathways in Bladder Carcinoma Cell. Biological trace element research. 2024-10-13. PMID:39397139. |
copper nanoparticles green-formulated by curcuma longa extract induce apoptosis via p53 and stat3 signaling pathways in bladder carcinoma cell. |
2024-10-13 |
2024-10-16 |
Not clear |
| Tianjun Xing, Zhu Wang, Xiaojie Hao, Jingjun Mu, Bin Wan. Copper Nanoparticles Green-Formulated by Curcuma longa Extract Induce Apoptosis via P53 and STAT3 Signaling Pathways in Bladder Carcinoma Cell. Biological trace element research. 2024-10-13. PMID:39397139. |
the study outlines the production of new copper nanoparticles infused with curcuma longa extract to trigger apoptosis through p53 and signal transducer and activator of transcription 3 (stat3) signaling pathways in bladder carcinoma cells. |
2024-10-13 |
2024-10-16 |
Not clear |
| Liliana Cortés-Ballinas, Tania V López-Pérez, Leticia Rocha-Zavalet. STAT3 and the STAT3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review). Biomedical reports. vol 21. issue 6. 2024-10-02. PMID:39355529. |
stat3 and the stat3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (review). |
2024-10-02 |
2024-10-04 |
Not clear |
| Liliana Cortés-Ballinas, Tania V López-Pérez, Leticia Rocha-Zavalet. STAT3 and the STAT3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review). Biomedical reports. vol 21. issue 6. 2024-10-02. PMID:39355529. |
in crc, stat3 is activated by il-6, among other pro-inflammatory cytokines, inducing the expression of target genes that stimulate proliferation, angiogenesis and the inhibition of apoptosis. |
2024-10-02 |
2024-10-04 |
Not clear |
| Chenhui Zhao, Zeyu Wu, Zhipeng Yao, Fan Zhang, Rui Zhao, Xiaoxiang Cao, Shizhang Ling, Xiaochun Jian. The tumorigenic effect of the high expression of ABRACL in glioma and its potential as a therapeutic target. Heliyon. vol 10. issue 17. 2024-09-17. PMID:39286126. |
knockdown of abracl inhibited the proliferation, cell migration, invasion and cytodynamics behaviors in glioma cell lines via activating stat3 signaling, which also induced apoptosis and cell cycle arrest. |
2024-09-17 |
2024-09-19 |
human |
| Surya P Singh, Gopal Pathuri, Adam S Asch, Chinthalapally V Rao, Venkateshwar Madk. Stat3 Inhibitors TTI-101 and SH5-07 Suppress Bladder Cancer Cell Survival in 3D Tumor Models. Cells. vol 13. issue 17. 2024-09-14. PMID:39273033. |
western blot analysis was performed to evaluate the pharmacodynamic markers involved in cell proliferation, apoptosis, cancer stem cells (cscs), and stat3 signaling in bca. |
2024-09-14 |
2024-09-16 |
mouse |
| Zhiwei Zhang, Bo Li, Shuqin Wu, Yuxin Yang, Binkang Wu, Qi Lai, Fuchong Lai, Fengbo Mo, Yufei Zhong, Song Wang, Runsheng Guo, Bin Zhan. Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing osteoclastogenesis. Scientific reports. vol 14. issue 1. 2024-08-31. PMID:39217193. |
ber suppressed il-1β-induced chondrocyte apoptosis and extracellular matrix catabolism by inhibiting the stat3, nf-κb and jun signalling pathway in vitro. |
2024-08-31 |
2024-09-04 |
mouse |
| Samarpana Chakraborty, Claudia Morganti, Bianca Rivera Pena, Hui Zhang, Divij Verma, Kimberly Zaldana, Nadege Gitego, Feiyang Ma, Srinivas Aluri, Kith Pradhan, Shanisha Gordon, Ioannis Mantzaris, Mendel Goldfinger, Eric Feldman, Kira Gritsman, Yang Shi, Stefan Hubner, Yi Hua Qiu, Brandon D Brown, Anna Skwarska, Amit Verma, Marina Konopleva, Yoko Tabe, Evripidis Gavathiotis, Simona Colla, Jared Gollob, Joyoti Dey, Steven M Kornblau, Sergei B Koralov, Keisuke Ito, Aditi Shastr. A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211137. |
we have previously demonstrated that the transcription factor stat3 is upregulated in aml hematopoietic stem and progenitor cells (hspcs) and can be effectively targeted to induce apoptosis of these aberrant cells. |
2024-08-30 |
2024-09-04 |
Not clear |
| Samarpana Chakraborty, Claudia Morganti, Bianca Rivera Pena, Hui Zhang, Divij Verma, Kimberly Zaldana, Nadege Gitego, Feiyang Ma, Srinivas Aluri, Kith Pradhan, Shanisha Gordon, Ioannis Mantzaris, Mendel Goldfinger, Eric Feldman, Kira Gritsman, Yang Shi, Stefan Hubner, Yi Hua Qiu, Brandon D Brown, Anna Skwarska, Amit Verma, Marina Konopleva, Yoko Tabe, Evripidis Gavathiotis, Simona Colla, Jared Gollob, Joyoti Dey, Steven M Kornblau, Sergei B Koralov, Keisuke Ito, Aditi Shastr. A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211137. |
treatment with the stat3 degrader induced apoptosis in parental and ven-res aml cell lines and decreased mitochondrial depolarisation, and thereby dependency on mcl1 in ven-res aml cell line, as observed by bh3 profiling assay. |
2024-08-30 |
2024-09-04 |
Not clear |
| Muhammad Farooq Rai, Xin Duan, Mingming Yan, Robert H Brophy, Lei Ca. Loss of periostin function impairs ligament fibroblast activity and facilitates ROS-mediated cellular senescence. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 16. 2024-08-20. PMID:39162681. |
moreover, periostin deficiency triggered apoptosis through stat3 |
2024-08-20 |
2024-08-22 |
Not clear |
| Xiyue Wen, Jinyue H. Targeting STAT3 signaling pathway in the treatment of Alzheimer's disease with compounds from natural products. International immunopharmacology. vol 141. 2024-08-20. PMID:39163684. |
stat3, a multifunctional transcription factor, is involved in various cellular processes including inflammation, cell growth, and apoptosis. |
2024-08-20 |
2024-08-23 |
Not clear |
| Dongmei Qin, Chang Han, Yuefeng Gao, Hong Li, Liping Zh. Lactucin reverses liver fibrosis by inhibiting TGF-β1/STAT3 signaling pathway and regulating short-chain fatty acids metabolism. Scientific reports. vol 14. issue 1. 2024-08-20. PMID:39164375. |
we found that lactucin induced apoptosis in hsc-t6 cells, and inhibition of nuclear translocation of stat3 and p-stat3. |
2024-08-20 |
2024-08-23 |
mouse |
| Hualong Mo, JieYing Liu, Zhengxi Su, Deng-Gao Zhao, Yan-Yan Ma, Kun Zhang, Qi Wang, Chun Fu, Yao Wang, Meiwan Chen, Burong H. Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy. European journal of medicinal chemistry. vol 277. 2024-08-15. PMID:39146833. |
compound 18 is identified as a highly potent dual signal transducer and activator of transcription 3 (stat3)/histone deacetylases (hdac) inhibitor and induces autophagy and apoptosis. |
2024-08-15 |
2024-08-18 |
Not clear |
| Jinxia Wu, Ailu Feng, Chunyang Liu, Wenxiu Zhou, Kexue Li, Yan Liu, Yue Shi, Joseph Adu-Amankwaah, Hongli Yu, Xiuhua Pan, Hong Su. Genistein alleviates doxorubicin-induced cardiomyocyte autophagy and apoptosis via ERK/STAT3/c-Myc signaling pathway in rat model. Phytotherapy research : PTR. vol 38. issue 8. 2024-08-13. PMID:38818771. |
gen inhibited extracellular signal-regulated kinase1/2 (erk1/2)'s phosphorylation, increased the protein levels of stat3 and c-myc, and decreased the autophagy and apoptosis of cardiomyocytes. |
2024-08-13 |
2024-08-16 |
rat |