| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
compared to monotherapy, combined treatment of glioma cells with plk1 and stat3 inhibitors, bi2536 and stattic, respectively, showed lower expression of myc, synergistic induction of cell invasion and apoptosis in vitro, and tumor inhibition in xenografts. |
2021-03-18 |
2023-08-13 |
Not clear |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
plk1 and stat3 were able to directly regulate the expression of myc and induce apoptosis of glioma cells through the regulation of myc. |
2021-03-18 |
2023-08-13 |
Not clear |
| Antonella Di Sotto, Silvia Di Giacomo, Elisabetta Rubini, Alberto Macone, Marco Gulli, Caterina Loredana Mammola, Margherita Eufemi, Romina Mancinelli, Gabriela Mazzant. Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention. Cells. vol 9. issue 4. 2021-03-15. PMID:32252311. |
the modulation of stat3 signaling, oxidative stress, dna damage response, cell cycle progression and apoptosis was investigated as possible mechanisms of action. |
2021-03-15 |
2023-08-13 |
Not clear |
| Fengchang Zhu, Xi Zhao, Junping Li, Lianhong Guo, Liping Bai, Xiaoqiang Q. A new compound Trichomicin exerts antitumor activity through STAT3 signaling inhibition. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 121. 2021-03-11. PMID:31707338. |
trichomicin can significantly induce cancer cell apoptosis and reduced il-6 expression and phosphorylation of stat3 were found in response to trichomicin treatment. |
2021-03-11 |
2023-08-13 |
human |
| Milad Ashrafizadeh, Mohammad Hossein Gholami, Sepideh Mirzaei, Amirhossein Zabolian, Amirabbas Haddadi, Mahdi Vasheghani Farahani, Sharareh Hosseinzadeh Kashani, Kiavash Hushmandi, Masoud Najafi, Ali Zarrabi, Kwang Seok Ahn, Haroon Kha. Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis. Life sciences. vol 270. 2021-03-11. PMID:33421521. |
stat3 is a tumor-promoting factors in cancers due to its role in cancer proliferation (cell cycle progression and apoptosis inhibition) and metastasis (emt induction). |
2021-03-11 |
2023-08-13 |
Not clear |
| Mohammad Rahmati, Behrooz Johari, Mehdi Kadivar, Elham Rismani, Yousef Mortazav. Suppressing the metastatic properties of the breast cancer cells using STAT3 decoy oligodeoxynucleotides: A promising approach for eradication of cancer cells by differentiation therapy. Journal of cellular physiology. vol 235. issue 6. 2021-03-09. PMID:31912904. |
stat3 decoy odns treatment showed cell growth inhibition by decreasing cell viability (17%), increasing the percentage of arrested cells in g0/g1 phases (18%), and triggering apoptosis (29%). |
2021-03-09 |
2023-08-13 |
Not clear |
| Carmen Tse, Ashleigh Warner, Rufaik Farook, James G Croni. Phytochemical Targeting of STAT3 Orchestrated Lipid Metabolism in Therapy-Resistant Cancers. Biomolecules. vol 10. issue 8. 2021-03-09. PMID:32731620. |
signal transducer and activator of transcription 3 (stat3) plays a key role in cellular processes such as cell growth, apoptosis and lipid metabolism. |
2021-03-09 |
2023-08-13 |
human |
| Xueming Cao, Na Zhu, Yuwei Zhang, Yan Chen, Jing Zhang, Jiang Li, Peiyuan Hao, Chuanyu Gao, Li L. Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation. Journal of cellular physiology. vol 235. issue 11. 2021-03-08. PMID:31967332. |
y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via shp-1-dependent stat3 inactivation. |
2021-03-08 |
2023-08-13 |
Not clear |
| Xueming Cao, Na Zhu, Yuwei Zhang, Yan Chen, Jing Zhang, Jiang Li, Peiyuan Hao, Chuanyu Gao, Li L. Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation. Journal of cellular physiology. vol 235. issue 11. 2021-03-08. PMID:31967332. |
in vitro, h/r treatment upregulated the yb1 expression in h9c2 cells, whereas yb1 knockdown inhibited h/r-induced cardiomyocyte apoptosis and induced h9c2 cell proliferation via src homology region 2 domain-containing phosphatase 1 (shp-1)-mediated activation of signal transducer and activator of transcription 3 (stat3). |
2021-03-08 |
2023-08-13 |
Not clear |
| Xueming Cao, Na Zhu, Yuwei Zhang, Yan Chen, Jing Zhang, Jiang Li, Peiyuan Hao, Chuanyu Gao, Li L. Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation. Journal of cellular physiology. vol 235. issue 11. 2021-03-08. PMID:31967332. |
in vivo, yb1 knockdown ameliorated ami, reducing infarct size, cardiomyocyte apoptosis, and oxidative stress, via shp-1-mediated inactivation of stat3. |
2021-03-08 |
2023-08-13 |
Not clear |
| Jinya Takahashi, Mai Yamamoto, Hideo Yasukawa, Shoichiro Nohara, Takanobu Nagata, Koutatsu Shimozono, Toshiyuki Yanai, Tomoko Sasaki, Kota Okabe, Tatsuhiro Shibata, Kazutoshi Mawatari, Tatsuyuki Kakuma, Hiroki Aoki, Yoshihiro Fukumot. Interleukin-22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription-3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury. Journal of the American Heart Association. vol 9. issue 8. 2021-03-08. PMID:32301368. |
following ischemia reperfusion, compared with pbs-treated mice, il-22-treated mice exhibited a significantly reduced infarct size, significantly reduced myocardial apoptosis, and significantly enhanced phosphorylated stat3 expression. |
2021-03-08 |
2023-08-13 |
mouse |
| Qiaoyu Wang, Qiongjun Zhu, Qiaofang Ye, Jiajun Wang, Qianqian Dong, Youran Chen, Minna Wang, Yu Fu, Rongzhou Wu, Tingting W. STAT3 Suppresses Cardiomyocytes Apoptosis in CVB3-Induced Myocarditis Via Survivin. Frontiers in pharmacology. vol 11. 2021-03-05. PMID:33658937. |
stat3 suppresses cardiomyocytes apoptosis in cvb3-induced myocarditis via survivin. |
2021-03-05 |
2023-08-13 |
Not clear |
| Silke D Werle, Julian D Schwab, Marina Tatura, Sandra Kirchhoff, Robin Szekely, Ramona Diels, Nensi Ikonomi, Bence Sipos, Jan Sperveslage, Thomas M Gress, Malte Buchholz, Hans A Kestle. Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer. Cancers. vol 13. issue 4. 2021-03-03. PMID:33578795. |
moreover, we could predict that cfl1 impacts proliferation and apoptosis via the signal transducer and activator of transcription 3 (stat3). |
2021-03-03 |
2023-08-13 |
human |
| Sha Yang, Xiaoning Wang, Cancan Duan, Jianyong Zhan. A novel approach combining metabolomics and molecular pharmacology to study the effect of Gei Herba on mouse hematopoietic function. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-02-26. PMID:32768939. |
lbz activates pi3k/akt signaling pathways and granulocyte-colony-stimulating-factor (g-csf)-mediated janus kinase 2 (jak2)/transcription 3 (stat3), resulting in inhibiting the release of cytochrome c. further, lbz inhibits caspase-mediated mitochondrial-dependent apoptosis mediated by caspase-9 and caspase-3. |
2021-02-26 |
2023-08-13 |
mouse |
| Sepideh Mirzaei, Mohammad Hossein Gholami, Mahmood Khaksary Mahabady, Noushin Nabavi, Amirhossein Zabolian, Seyed Mohammad Banihashemi, Amirabbas Haddadi, Maliheh Entezari, Kiavash Hushmandi, Pooyan Makvandi, Saeed Samarghandian, Ali Zarrabi, Milad Ashrafizadeh, Haroon Kha. Pre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 133. 2021-02-24. PMID:33378975. |
in respect to its tumor-promoting role, stat3 is able to enhance the growth of bc cells via inhibiting apoptosis and cell cycle arrest. |
2021-02-24 |
2023-08-13 |
Not clear |
| Chun-Chia Cheng, Bi-Ling Yang, Wen-Chao Chen, Ai-Sheng Ho, Zong-Lin Sie, Hsin-Chi Lin, Chun-Chao Chan. STAT3 Mediated miR-30a-5p Inhibition Enhances Proliferation and Inhibits Apoptosis in Colorectal Cancer Cells. International journal of molecular sciences. vol 21. issue 19. 2021-02-23. PMID:33023006. |
stat3 mediated mir-30a-5p inhibition enhances proliferation and inhibits apoptosis in colorectal cancer cells. |
2021-02-23 |
2023-08-13 |
Not clear |
| Xue Li, Yuquan Wei, Xiawei We. Napabucasin, a novel inhibitor of STAT3, inhibits growth and synergises with doxorubicin in diffuse large B-cell lymphoma. Cancer letters. vol 491. 2021-02-22. PMID:32798587. |
mechanistic studies demonstrated that napabucasin induced intrinsic and extrinsic cell apoptosis, downregulated the expression of stat3 target genes, including the antiapoptotic protein mcl-1, and regulated the ros-mediated mitogen-activated protein kinase (mapk) pathway. |
2021-02-22 |
2023-08-13 |
Not clear |
| Xiaoxu Ma, Kai Wu, Aiguo Xu, Pengfei Jiao, Huiling Li, Lihua Xin. The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling. Environmental toxicology and pharmacology. vol 81. 2021-02-22. PMID:33091599. |
the sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing stat3 signaling. |
2021-02-22 |
2023-08-13 |
mouse |
| Xiaoxu Ma, Kai Wu, Aiguo Xu, Pengfei Jiao, Huiling Li, Lihua Xin. The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling. Environmental toxicology and pharmacology. vol 81. 2021-02-22. PMID:33091599. |
furthermore, eupatolide induced apoptosis by suppressing the activation of stat3 in nsclc cells. |
2021-02-22 |
2023-08-13 |
mouse |
| Yuan Liang, Tiehua Zhang, Li Ren, Siyuan Jing, Zhuolin Li, Peng Zuo, Tiezhu Li, Yongjun Wang, Jie Zhang, Zhengyi We. Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway. Environmental toxicology and pharmacology. vol 81. 2021-02-22. PMID:33161110. |
cuiib induced apoptosis via stat3 pathway, which was mitochondria-mediated and caspase-dependent. |
2021-02-22 |
2023-08-13 |
Not clear |