| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Byung Hak Kim, Yun Sook Min, Jung Sook Choi, Gyeong Hun Baeg, Young Soo Kim, Jong Wook Shin, Tae Yoon Kim, Sang Kyu Y. Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Experimental & molecular medicine. vol 43. issue 5. 2011-10-03. PMID:21499010. |
in addition, bot-4-one-treated hodgkin's lymphoma cells showed decreased cell survival and proliferation by inducing apoptosis through down-regulation of stat3 downstream target anti-apoptotic gene expression. |
2011-10-03 |
2023-08-12 |
human |
| Golla Jaya Prakash, Pankaj Suman, Diana M Morales Prieto, Udo R Markert, Satish K Gupt. Leukaemia inhibitory factor mediated proliferation of HTR-8/SVneo trophoblast cells is dependent on activation of extracellular signal-regulated kinase 1/2. Reproduction, fertility, and development. vol 23. issue 5. 2011-09-30. PMID:21635820. |
although stat3 silencing had no effect on lif-dependent proliferation of htr-8/svneo cells, it did result in an increase in cell apoptosis, which increased further upon inhibition of erk1/2 activation irrespective of lif stimulation. |
2011-09-30 |
2023-08-12 |
Not clear |
| Yi Jiang, Ze-Hong Miao, Lei Xu, Bing Yu, Jing-Xu Gong, Lin-Jiang Tong, Yi Chen, Zhao-Li Zhou, Hong-Chun Liu, Yi Wang, Yue-Wei Guo, Jian Din. Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction. The Journal of biological chemistry. vol 286. issue 30. 2011-09-28. PMID:21659517. |
in contrast, mesp potently induced apoptosis via activation of a proapoptotic caspase cascade and relief of the suppression of antiapoptotic signal transducers and activators of transcription 3 (stat3) signaling. |
2011-09-28 |
2023-08-12 |
Not clear |
| Yi Jiang, Ze-Hong Miao, Lei Xu, Bing Yu, Jing-Xu Gong, Lin-Jiang Tong, Yi Chen, Zhao-Li Zhou, Hong-Chun Liu, Yi Wang, Yue-Wei Guo, Jian Din. Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction. The Journal of biological chemistry. vol 286. issue 30. 2011-09-28. PMID:21659517. |
mesp inhibited the phosphorylation of stat3, a critical survival signaling factor that reduced the expression of the antiapoptotic protein x-linked inhibitor of apoptosis protein but enhanced the expression of the proapoptotic protein bax, thus promoting caspase-dependent apoptosis. |
2011-09-28 |
2023-08-12 |
Not clear |
| Jeffrey A Poynter, Jeremy L Herrmann, Mariuxi C Manukyan, Yue Wang, Aaron M Abarbanell, Brent R Weil, Benjamin D Brewster, Daniel R Meldru. Intracoronary mesenchymal stem cells promote postischemic myocardial functional recovery, decrease inflammation, and reduce apoptosis via a signal transducer and activator of transcription 3 mechanism. Journal of the American College of Surgeons. vol 213. issue 2. 2011-09-27. PMID:21546276. |
signal transducer and activator of transcription 3 (stat3) regulates myocardial apoptosis, cellular proliferation, and the immune response after ischemia/reperfusion (i/r). |
2011-09-27 |
2023-08-12 |
Not clear |
| Lucy Liu, Sangkil Nam, Yan Tian, Fan Yang, Jun Wu, Yan Wang, Anna Scuto, Panos Polychronopoulos, Prokopios Magiatis, Leandros Skaltsounis, Richard Jov. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer research. vol 71. issue 11. 2011-09-20. PMID:21610112. |
apoptosis of human melanoma cells induced by 6bio was associated with reduced phosphorylation of jaks and stat3 in both dose- and time-dependent manners. |
2011-09-20 |
2023-08-12 |
mouse |
| Lucy Liu, Sangkil Nam, Yan Tian, Fan Yang, Jun Wu, Yan Wang, Anna Scuto, Panos Polychronopoulos, Prokopios Magiatis, Leandros Skaltsounis, Richard Jov. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer research. vol 71. issue 11. 2011-09-20. PMID:21610112. |
taken together, these results show that 6bio is a novel pan-jak inhibitor that can selectively inhibit stat3 signaling and induces tumor cell apoptosis. |
2011-09-20 |
2023-08-12 |
mouse |
| W Okamoto, I Okamoto, T Arao, K Yanagihara, K Nishio, K Nakagaw. Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells. British journal of cancer. vol 105. issue 3. 2011-09-16. PMID:21730976. |
signal transducer and activator of transcription 3 (stat3) is a transcription factor that is activated in response to growth factors and cytokines, and which contributes to the regulation of cell proliferation, apoptosis, and motility in many human tumour types. |
2011-09-16 |
2023-08-12 |
human |
| Ralf Buettner, Renzo Corzano, Rumana Rashid, Jianping Lin, Maheswari Senthil, Michael Hedvat, Anne Schroeder, Allen Mao, Andreas Herrmann, John Yim, Hongzhi Li, Yate-Ching Yuan, Kenichi Yakushijin, Fumiko Yakushijin, Nagarajan Vaidehi, Roger Moore, Gabriel Gugiu, Terry D Lee, Richard Yip, Yuan Chen, Richard Jove, David Horne, John C William. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS chemical biology. vol 6. issue 5. 2011-09-06. PMID:21226522. |
inhibition of stat3 signaling pathways suppresses cell survival signals and leads to apoptosis in cancer cells, suggesting direct inhibition of stat3 function is a viable therapeutic approach. |
2011-09-06 |
2023-08-12 |
mouse |
| Aiguo Liu, Yan Liu, Zhenghu Xu, Wenying Yu, Hong Wang, Chenglong Li, Jiayuh Li. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer science. vol 102. issue 7. 2011-08-26. PMID:21435102. |
we also demonstrated that inhibition of the stat3 pathway led to apoptosis in human rhabdomyosarcoma cells. |
2011-08-26 |
2023-08-12 |
human |
| Aiguo Liu, Yan Liu, Zhenghu Xu, Wenying Yu, Hong Wang, Chenglong Li, Jiayuh Li. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer science. vol 102. issue 7. 2011-08-26. PMID:21435102. |
the inhibition of stat3 by xzh-5 was confirmed by the inhibition of stat3 dna binding ability and the downregulation of stat3 downstream genes, such as bcl-2, bcl-xl, cyclin d1 and survivin; we also demonstrated that blockade of stat3 phosphorylation in human rhabdomyosarcoma cells with xzh-5 caused apoptosis and suppressed colony-forming ability and cell migration. |
2011-08-26 |
2023-08-12 |
human |
| Haili Lü, Qiuhang Zhang, Bo Ya. [Stat3 antisense oligodeoxynucleotide induces apoptosis in laryngeal carcinoma cells by regulating apoptosis-related factors]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 24. issue 4. 2011-08-25. PMID:20422978. |
[stat3 antisense oligodeoxynucleotide induces apoptosis in laryngeal carcinoma cells by regulating apoptosis-related factors]. |
2011-08-25 |
2023-08-12 |
Not clear |
| Haili Lü, Qiuhang Zhang, Bo Ya. [Stat3 antisense oligodeoxynucleotide induces apoptosis in laryngeal carcinoma cells by regulating apoptosis-related factors]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 24. issue 4. 2011-08-25. PMID:20422978. |
to study the mechanism of apoptosis in laryngeal carcinoma cell induced by stat3 antisense oligodeoxynucleotide (asodn). |
2011-08-25 |
2023-08-12 |
Not clear |
| Jang Choon Lee, Kwang Seok Ahn, Soo-Jin Jeong, Ji Hoon Jung, Tae-Rin Kwon, Yun-Hee Rhee, Sun-Hee Kim, Si-Young Kim, Hwi-Joong Yoon, Shudong Zhu, Chang-Yan Chen, Sung-Hoon Ki. Signal transducer and activator of transcription 3 pathway mediates genipin-induced apoptosis in U266 multiple myeloma cells. Journal of cellular biochemistry. vol 112. issue 6. 2011-08-25. PMID:21344490. |
using several myelogenous cell lines, the effect of genipin (an active compound of gardenia fruit) on the stat3 pathway and apoptosis was investigated. |
2011-08-25 |
2023-08-12 |
Not clear |
| Jang Choon Lee, Kwang Seok Ahn, Soo-Jin Jeong, Ji Hoon Jung, Tae-Rin Kwon, Yun-Hee Rhee, Sun-Hee Kim, Si-Young Kim, Hwi-Joong Yoon, Shudong Zhu, Chang-Yan Chen, Sung-Hoon Ki. Signal transducer and activator of transcription 3 pathway mediates genipin-induced apoptosis in U266 multiple myeloma cells. Journal of cellular biochemistry. vol 112. issue 6. 2011-08-25. PMID:21344490. |
our data suggest that through regulation of src and shp-1, genipin antagonizes stat3 for the induction of apoptosis in myeloma cells. |
2011-08-25 |
2023-08-12 |
Not clear |
| Michele S Redell, Marcos J Ruiz, Todd A Alonzo, Robert B Gerbing, David J Tweard. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. vol 117. issue 21. 2011-08-23. PMID:21447830. |
stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule stat3 inhibitor. |
2011-08-23 |
2023-08-12 |
Not clear |
| Michele S Redell, Marcos J Ruiz, Todd A Alonzo, Robert B Gerbing, David J Tweard. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. vol 117. issue 21. 2011-08-23. PMID:21447830. |
the objectives of this study were: (1) to characterize stat3 signaling patterns in aml cells lines and primary pediatric samples; and (2) to test the efficacy and potency of a novel stat3 inhibitor in inducing apoptosis in aml cells. |
2011-08-23 |
2023-08-12 |
Not clear |
| Michele S Redell, Marcos J Ruiz, Todd A Alonzo, Robert B Gerbing, David J Tweard. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. vol 117. issue 21. 2011-08-23. PMID:21447830. |
our novel small-molecule stat3 inhibitor, c188-9, inhibited g-csf-induced stat3 phosphorylation, induced apoptosis in aml cell lines and primary samples, and inhibited aml blast colony formation with potencies in the low micromolar range. |
2011-08-23 |
2023-08-12 |
Not clear |
| Yu-Cai Wang, Lian-He Zheng, Bao-An Ma, Yong Zhou, Ming-Hua Zhang, Dian-Zhong Zhang, Qing-Yu Fa. Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma. Acta histochemica. vol 113. issue 4. 2011-08-22. PMID:20546860. |
mtt and flow cytometric assays were performed to analyze the effect of stat3 inhibition on proliferation and apoptosis of osteosarcoma cells. |
2011-08-22 |
2023-08-12 |
human |
| Yu-Cai Wang, Lian-He Zheng, Bao-An Ma, Yong Zhou, Ming-Hua Zhang, Dian-Zhong Zhang, Qing-Yu Fa. Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma. Acta histochemica. vol 113. issue 4. 2011-08-22. PMID:20546860. |
rnai-mediated stat3 inhibition could induce proliferation inhibition and apoptosis enhancement in osteosarcoma cells, which might be associated with inhibition of some anti-apoptosis genes. |
2011-08-22 |
2023-08-12 |
human |