| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. |
the results showed that the spatial learning and memory of the db/db group were significantly declined, the neurons in the hippocampus were damaged, the protein levels of psd93, psd95, bdnf, cd206, arg1, trem2 and the ratio of p-creb/creb were significantly down-regulated, the mrna and protein expression levels of il-6, il-1β and tnf-α were significantly up-regulated, and the protein levels of inos, iba-1, nf-κb and the ratio of p-stat3/stat3 were significantly increased compared with the con group. |
2024-10-29 |
2024-10-31 |
mouse |
| Peng Li, Fucheng Zhang, Chengyi Huang, Cai Zhang, Zhiyou Yang, Yongping Zhang, Cai Son. Exosomes Derived from DPA-treated UCMSCs Attenuated Depression-like Behaviors and Neuroinflammation in a Model of Depression Induced by Chronic Stress. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-10-21. PMID:39432176. |
molecularly, cums increased the concentrations of the microglial m1 markers iba1, inos, and il-1β, while reducing the m2 markers arg1, cd206, and il-10 in the prefrontal cortex and hippocampus. |
2024-10-21 |
2024-10-23 |
human |
| Maria V Zakharova, Anna A Kovalenko, Olga E Zubareva, Alexander P Schwarz, Tatiana Y Postnikova, Alina M Trofimova, Aleksey V Zaitse. Pentylenetetrazole-Induced Seizures Cause Short-Term Changes in the Phenotype of Microglial and Astroglial Cells in the Hippocampus and Temporal Cortex of Young Male Wistar Rats. Journal of neuroscience research. vol 102. issue 9. 2024-09-21. PMID:39305083. |
however, in contrast to the changes observed in the cortex, the changes in the hippocampus were opposite for the il1rn, bdnf, tgfb, and arg1 genes. |
2024-09-21 |
2024-09-24 |
rat |
| Shunfeng Liu, Bei Zhang, Haowei Guo, Zhanghua Ding, Wenhui Hou, Xiaoli Hu, Yuchu Wang, Wupeng Tan, Shouhong Zho. The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation. Neurochemistry international. 2024-04-01. PMID:38561150. |
western blotting was used to determine protein expression levels of prmt2, histone h3r8 asymmetric dimethylation (h3r8me2a), inducible nitric oxide synthase (inos), and arginase 1 (arg1) in rat hippocampal tissues. |
2024-04-01 |
2024-04-04 |
rat |
| Shunfeng Liu, Bei Zhang, Haowei Guo, Zhanghua Ding, Wenhui Hou, Xiaoli Hu, Yuchu Wang, Wupeng Tan, Shouhong Zho. The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation. Neurochemistry international. 2024-04-01. PMID:38561150. |
prmt2 overexpression in the hippocampus reduced the proportion of activated microglia in the hippocampus, upregulated arg1 and h3r8me2a expression, and downregulated inos expression. |
2024-04-01 |
2024-04-04 |
rat |
| Juan F Duarte-Campos, C Noé Vázquez-Moreno, Mónica Martínez-Marcial, Anahí Chavarría, Ricardo Jair Ramírez-Carreto, Marco A Velasco Velázquez, Marisol De La Fuente-Granada, Aliesha González-Arena. Changes in neuroinflammatory markers and microglial density in the hippocampus and prefrontal cortex of the C58/J mouse model of autism. The European journal of neuroscience. 2023-12-07. PMID:38057955. |
we discovered elevated levels of interferon gamma (ifn-γ) and monocyte chemoattractant protein 1 (mcp-1) in the hippocampus, suggesting increased inflammation, alongside a reduction in the anti-inflammatory enzyme arginase 1 (arg1). |
2023-12-07 |
2023-12-10 |
mouse |
| Jie Wu, Ziwen Hao, Ying Wang, Dongying Yan, Jia Meng, Honglin M. Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-12-25. PMID:36566971. |
besides obvious hippocampal neuron damage, increased microglial activation and pro-inflammatory markers (cd86, tnfα, and il-1β), meanwhile, decreased anti-inflammatory molecules (cd206, il-10, and arg1) were induced by bde-209. |
2022-12-25 |
2023-08-14 |
rat |
| Jie Luo, Jing-Qiong Wang, Li-Na Xie, An-Na Meng, Si-Si Zheng, Shou-Hong Zho. [Voluntary wheel running exercise regulates microglia polarization in hippocampus through STAT3 signal pathway to inhibit depression-like behavior induced by chronic stress in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503065. |
the results showed that, compared with stress group, stress + exercise group exhibited improved depression-like behavior, decreased interleukin-1β (il-1β) and il-6 levels, increased il-4 and il-10 levels, down-regulated iba-1 and inos protein expression levels, up-regulated arg1 protein expression level, and decreased p-stat3/t-stat3 ratio in hippocampal tissue. |
2022-05-03 |
2023-08-13 |
rat |
| Bohyun Yang, Jae-Sang Ryu, Chan Rim, Jung U Shin, Min-Soo Kwo. Possible role of arginase 1 positive microglia on depressive/anxiety-like behaviors in atopic dermatitis mouse model. Archives of pharmacal research. 2022-01-21. PMID:35060088. |
ad mice showed an increased mrna expression of interleukin-4 (il-4) in lymph nodes but decreased arginase 1 (arg1) mrna expression without a change of il-4 in the hippocampus. |
2022-01-21 |
2023-08-13 |
mouse |
| Yan-Ling Liao, Xiao-Yan Zhou, Mu-Huo Ji, Liang-Cheng Qiu, Xiao-Hui Chen, Can-Sheng Gong, Ying Lin, Yan-Hua Guo, Jian-Jun Yan. S100A9 Upregulation Contributes to Learning and Memory Impairments by Promoting Microglia M1 Polarization in Sepsis Survivor Mice. Inflammation. vol 44. issue 1. 2021-10-07. PMID:32918665. |
our results showed that clp-induced and lps-induced memory impairments were accompanied with increased expressions of hippocampal microglia iba1 and cd86 (m1 markers), but reduced expression of arg1 (m2 marker). |
2021-10-07 |
2023-08-13 |
mouse |
| Jinqiang Zhang, Peijing Rong, Lijuan Zhang, Hui He, Tao Zhou, Yonghua Fan, Li Mo, Qiuying Zhao, Yue Han, Shaoyuan Li, Yifei Wang, Wan Yan, Huafu Chen, Zili Yo. IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis. Science advances. vol 7. issue 12. 2021-06-25. PMID:33731342. |
we identified interleukin 4 (il4)-driven microglia characterized by high expression of arg1, which is critical in maintaining hippocampal neurogenesis and stress resistance. |
2021-06-25 |
2023-08-13 |
Not clear |
| Hyun-Sun Park, Min-Jung You, Bohyun Yang, Kyu Beom Jang, Jongman Yoo, Hyun Jin Choi, Sang-Hyuk Lee, Minji Bang, Min-Soo Kwo. Chronically infused angiotensin II induces depressive-like behavior via microglia activation. Scientific reports. vol 10. issue 1. 2021-05-03. PMID:33328497. |
chronic infusion of angii also induced microglial activation in the hippocampus with increase of il-1β mrna and decrease of arg1 mrna. |
2021-05-03 |
2023-08-13 |
mouse |
| Yue Han, Jiutai Wang, Qiuying Zhao, Xiaofang Xie, Rui Song, Ying Xiao, Xixi Kang, Lijuan Zhang, Yue Zhang, Cheng Peng, Zili Yo. Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32032783. |
levels of mrna encoding pro-inflammatory markers il-6, tnfα, and il-1β were higher in male msd offspring, whereas levels of anti-inflammatory markers arg1, il-4, and il-10 were lower, as was pparγ expression in the hippocampus. |
2021-04-27 |
2023-08-13 |
rat |
| Shouhong Zhou, Shanshan Chen, Wenxia Xie, Xiaoxiao Guo, Jianfeng Zha. Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. Neuropeptides. vol 81. 2021-02-12. PMID:31932110. |
double-labelling immunofluorescence co-localization showed that, compared with the cwirs + saline group, cwirs + apelin-13 group significantly inhibited the co-localization expression of iba-1 and inos, and promoted the co-localization expression of iba-1 and arg1 in hippocampus microglia. |
2021-02-12 |
2023-08-13 |
rat |
| Zhe Li, Xuezhao Cao, Hong Ma, Yong Cui, Xiaoqian Li, Na Wang, Yongjian Zho. Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. Journal of neuropathology and experimental neurology. vol 77. issue 8. 2019-10-03. PMID:29939299. |
hippocampal interleukin-1β, cx3cl1, cx3cr1, brain derived neurotrophic factor (bdnf), ionized calcium-binding adapter molecule 1 (iba-1), and arginase-1 (arg1) levels were measured. |
2019-10-03 |
2023-08-13 |
rat |
| Zhe Li, Fang Liu, Hong Ma, Paul F White, Roya Yumul, Yanhua Jiang, Na Wang, Xuezhao Ca. Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4. Brain research. vol 1665. 2018-03-22. PMID:28414034. |
brain derived neurotrophic factor (bdnf), synaptophysin, ionized calcium-binding adapter molecule 1 (iba-1), microglial m2 phenotype marker arg1, and cd200 were also examined in the hippocampus. |
2018-03-22 |
2023-08-13 |
rat |
| Alyssa Littlefield, Rachel A Kohma. Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice. Neuroscience. vol 343. 2017-11-08. PMID:27916728. |
in response to il-4/il-13 administration, aged mice showed increased hippocampal expression of the m2-related genes arg1, socs1, ym1, and cd206 relative to adult mice. |
2017-11-08 |
2023-08-13 |
mouse |
| Jerry B Hunt, Kevin R Nash, Devon Placides, Peter Moran, Maj-Linda B Selenica, Firas Abuqalbeen, Kevin Ratnasamy, Nina Slouha, Santiago Rodriguez-Ospina, Miloni Savlia, Yashobha Ranaweera, Patrick Reid, Chad A Dickey, Rodrigo Uricia, Clement G Y Yang, Leslie A Sandusky, Marcia N Gordon, Dave Morgan, Daniel C Le. Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 44. 2016-02-12. PMID:26538654. |
arg1 overexpression also mitigated hippocampal atrophy in tau transgenic mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Qiuying Zhao, Xiaofang Xie, Yonghua Fan, Jinqiang Zhang, Wei Jiang, Xiaohui Wu, Shuo Yan, Yubo Chen, Cheng Peng, Zili Yo. Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment. Scientific reports. vol 5. 2016-01-06. PMID:25830666. |
the classical microglial activation markers (m1 phenotype) il-1β, il-6, tnf-α, cd68 and inos were increased, while the alternative microglial activation markers (m2 phenotype) arg1, ym1, il-4, il-10 and cd206 were reduced in hippocampus of msd offspring. |
2016-01-06 |
2023-08-13 |
rat |
| Thong C Ma, Aline Campana, Philipp S Lange, Hsin-Hwa Lee, Kasturi Banerjee, J Barney Bryson, Lata Mahishi, Shabnam Alam, Roman J Giger, Stephen Barnes, Sidney M Morris, Dianna E Willis, Jeffrey L Twiss, Marie T Filbin, Rajiv R Rata. A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 2. 2010-02-01. PMID:20071539. |
to identify small molecules that capture arg1's protective and regenerative properties, we screened a hippocampal cell line stably expressing the proximal promoter region of the arginase 1 gene fused to a reporter gene against a library of compounds containing clinically approved drugs. |
2010-02-01 |
2023-08-12 |
Not clear |