| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Justin Tanner, Gerrit Orthlieb, Stephen Helms Tiller. Effect of touch on proprioception: non-invasive trigeminal nerve stimulation suggests general arousal rather than tactile-proprioceptive integration. Frontiers in human neuroscience. vol 18. 2024-10-29. PMID:39469503. |
task attention and arousal are physiologically regulated by the reticular activating system (ras), a brainstem circuit including the locus coeruleus (lc). |
2024-10-29 |
2024-10-31 |
Not clear |
| Jiasheng Su, Kiran Thapaliya, Natalie Eaton-Fitch, Sonya M Marshall-Gradisnik, Leighton R Barnde. Connectivity between Salience and Default Mode Networks and subcortical nodes distinguishes between two classes of ME/CFS. Brain connectivity. 2022-11-10. PMID:36352819. |
sa connections to the hippocampus and brainstem reticular activation system (ras) differed from and were stronger than hc. |
2022-11-10 |
2023-08-14 |
human |
| Aida Quiroz, Cheyenne Camacho, Subburaj Kanna. Genesis of Antibiotic Resistance (AR) LXXIX: Turbulence Modeling of Hemodynamics in Simplified Severe Sepsis Protocol-2 (SSSP-2)-NCT01663701: Linear Correlation of CPPopt, GCS 3-8 and in hospital mortality (ihm). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556660. |
ddx: dysfxn of brainstem ras, thalamic relay nuclei, and/or b/l diffuse dysfxn of cerebral hemispheres (verbatim - nc-5-38). |
2022-05-13 |
2023-08-13 |
Not clear |
| N Kezunovic, C Simon, J Hyde, K Smith, P Beck, A Odle, E Garcia-Ril. AROUSAL FROM SLICES TO HUMANS: Translational studies on sleep-wake control. Translational neuroscience. vol 1. issue 1. 2021-10-21. PMID:22639732. |
one element of the reticular activating system (ras) is the pedunculopontine nucleus (ppn), which is the cholinergic arm of the ras, and projects to the thalamus to trigger thalamocortical rhythms and to the brainstem to modulate muscle tone and locomotion. |
2021-10-21 |
2023-08-12 |
human |
| T Bayasgalan, S Stupniki, A Kovács, A Csemer, P Szentesi, K Pocsai, L Dionisio, G Spitzmaul, B Pá. Alteration of Mesopontine Cholinergic Function by the Lack of KCNQ4 Subunit. Frontiers in cellular neuroscience. vol 15. 2021-08-13. PMID:34381336. |
in the central nervous system, kcnq4 expression is restricted to certain brainstem structures such as the ras nuclei. |
2021-08-13 |
2023-08-13 |
mouse |
| Leighton R Barnden, Zack Y Shan, Donald R Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep Bhut. Intra brainstem connectivity is impaired in chronic fatigue syndrome. NeuroImage. Clinical. vol 24. 2020-09-22. PMID:31671321. |
brainstem ras connectivity deficits can explain autonomic changes and diminish cortical oscillatory coherence which can impair attention, memory, cognitive function, sleep quality and muscle tone, all symptoms of me/cfs. |
2020-09-22 |
2023-08-13 |
Not clear |
| Leighton R Barnden, Zack Y Shan, Donald R Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep Bhut. Intra brainstem connectivity is impaired in chronic fatigue syndrome. NeuroImage. Clinical. vol 24. 2020-09-22. PMID:31671321. |
we selected limited brainstem reticular activation system (ras) regions-of-interest (rois) based on previous structural mri findings in a different me/cfs cohort (bilateral rostral medulla and midbrain cuneiform nucleus), the dorsal raphe nucleus, and two subcortical rois (hippocampus subiculum and thalamus intralaminar nucleus) reported to have rich brainstem connections. |
2020-09-22 |
2023-08-13 |
Not clear |
| Dhanush Haspula, Michelle A Clar. Neuroinflammation and sympathetic overactivity: Mechanisms and implications in hypertension. Autonomic neuroscience : basic & clinical. vol 210. 2018-10-04. PMID:29361405. |
hyperactive brain renin angiotensin system (ras), oxidative stress and neuroinflammation in brainstem cardiovascular centers and other brain regions are implicated as key factors in augmenting sympathetic activity in hypertension and other cardiovascular abnormalities. |
2018-10-04 |
2023-08-13 |
rat |
| Edgar Garcia-Rill, Christen Simon, Kristen Smith, Nebosja Kezunovic, James Hyd. The pedunculopontine tegmental nucleus: from basic neuroscience to neurosurgical applications: arousal from slices to humans: implications for DBS. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 10. 2012-01-25. PMID:20936418. |
one element of the reticular activating system (ras) is the pedunculopontine nucleus (ppn), which projects to the thalamus to trigger thalamocortical rhythms and the brainstem to modulate muscle tone and locomotion. |
2012-01-25 |
2023-08-12 |
human |
| Adolfo E Cuadra, Zhiying Shan, Colin Sumners, Mohan K Raizad. A current view of brain renin-angiotensin system: Is the (pro)renin receptor the missing link? Pharmacology & therapeutics. vol 125. issue 1. 2010-03-01. PMID:19723538. |
based on decades of research it is clear that angiotensin ii (ang ii), the major bioactive product of the ras, mediates these actions largely via its ang ii type 1 receptor (at1r), located within hypothalamic and brainstem control centers. |
2010-03-01 |
2023-08-12 |
Not clear |
| Zhanyi Lin, Yanfang Chen, Wenfeng Zhang, Alex F Chen, Shuguang Lin, Mariana Morri. RNA interference shows interactions between mouse brainstem angiotensin AT1 receptors and angiotensin-converting enzyme 2. Experimental physiology. vol 93. issue 5. 2009-01-12. PMID:18310259. |
the study takes advantage of the bilateral brainstem expression of renin-angiotensin system (ras) markers. |
2009-01-12 |
2023-08-12 |
mouse |
| Zhanyi Lin, Yanfang Chen, Wenfeng Zhang, Alex F Chen, Shuguang Lin, Mariana Morri. RNA interference shows interactions between mouse brainstem angiotensin AT1 receptors and angiotensin-converting enzyme 2. Experimental physiology. vol 93. issue 5. 2009-01-12. PMID:18310259. |
gene silencing showed that there were interactions between brainstem ang at1a receptors and the ras regulatory enzyme, ace2. |
2009-01-12 |
2023-08-12 |
mouse |
| Merari F R Ferrari, Mohan K Raizada, Debora R Fior-Chad. Differential regulation of the renin-angiotensin system by nicotine in WKY and SHR glia. Journal of molecular neuroscience : MN. vol 35. issue 2. 2008-08-22. PMID:18369742. |
given that (1) the renin-angiotensin system (ras) is compartmentalized within the central nervous system in neurons and glia (2) the major source of brain angiotensinogen is the glial cells, (3) the importance of ras in the central control of blood pressure, and (4) nicotine increases the probability of development of hypertension associated to genetic predisposition; the objective of the present study was to evaluate the effects of nicotine on the ras in cultured glial cells from the brainstem and hypothalamus of wistar kyoto (wky) and spontaneously hypertensive (shr) rats. |
2008-08-22 |
2023-08-12 |
rat |
| Merari F R Ferrari, Mohan K Raizada, Debora R Fior-Chad. Nicotine modulates the renin-angiotensin system of cultured neurons and glial cells from cardiovascular brain areas of Wistar Kyoto and spontaneously hypertensive rats. Journal of molecular neuroscience : MN. vol 33. issue 3. 2008-02-04. PMID:17952638. |
considering the importance of the renin-angiotensin system (ras) for the central control of blood pressure and that nicotine increases the probability of development of hypertension associated to genetic predisposition, our aims are (1) to determine ras in cultured neurons and glia from the brainstem and hypothalamus of spontaneously hypertensive (shr) and wistar kyoto (wky) rats; (2) to analyze the possibility of nicotine to interact with brain ras; and (3) to hypothesize any contribution of nicotine and ras to the development of neurogenic hypertension. |
2008-02-04 |
2023-08-12 |
rat |
| Merari F R Ferrari, Mohan K Raizada, Debora R Fior-Chad. Nicotine modulates the renin-angiotensin system of cultured neurons and glial cells from cardiovascular brain areas of Wistar Kyoto and spontaneously hypertensive rats. Journal of molecular neuroscience : MN. vol 33. issue 3. 2008-02-04. PMID:17952638. |
our study also featured evidences of direct modulation of the ras by nicotine in neurons and glia of brainstem and hypothalamus, which seems to be differential between the two rat strains. |
2008-02-04 |
2023-08-12 |
rat |
| Merari F R Ferrari, Mohan K Raizada, Debora R Fior-Chad. Nicotine modulates the renin-angiotensin system of cultured neurons and glial cells from cardiovascular brain areas of Wistar Kyoto and spontaneously hypertensive rats. Journal of molecular neuroscience : MN. vol 33. issue 3. 2008-02-04. PMID:17952638. |
in conclusion, we demonstrated that neuronal and glial ras from the brainstem and hypothalamus of shr differ from wky rats and nicotine differentially modulates the brain ras in shr and wky. |
2008-02-04 |
2023-08-12 |
rat |
| Merari F R Ferrari, Mohan K Raizada, Debora R Fior-Chad. Nicotine modulates the renin-angiotensin system of cultured neurons and glial cells from cardiovascular brain areas of Wistar Kyoto and spontaneously hypertensive rats. Journal of molecular neuroscience : MN. vol 33. issue 3. 2008-02-04. PMID:17952638. |
this study demonstrated physiological differences in ras between cultured neuronal and glial cells from the brainstem and hypothalamus of shr and wky neonate rats. |
2008-02-04 |
2023-08-12 |
rat |
| C J Dickinso. Chronic fatigue syndrome--aetiological aspects. European journal of clinical investigation. vol 27. issue 4. 1997-06-26. PMID:9134372. |
many observations suggest that the syndrome could derive from residual damage to the reticular activating system (ras) of the upper brain stem and/or to its cortical projections. |
1997-06-26 |
2023-08-12 |
Not clear |
| C J Dickinso. Chronic fatigue syndrome--aetiological aspects. European journal of clinical investigation. vol 27. issue 4. 1997-06-26. PMID:9134372. |
in the well-known post-polio fatigue syndrome, lesions predominate in the ras of the brain stem. |
1997-06-26 |
2023-08-12 |
Not clear |
| H Jo, E K Yang, W J Lee, K Y Park, H J Kim, J S Par. Gene expression of central and peripheral renin-angiotensin system components upon dietary sodium intake in rats. Regulatory peptides. vol 67. issue 2. 1997-03-28. PMID:8958582. |
it also showed that the ras components in the brainstem and hypothalamus were differentially expressed upon sodium deprivation. |
1997-03-28 |
2023-08-12 |
rat |