| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuqi Li, Wenhao Li, Xiaonan Zhu, Nuo Xu, Qinyu Meng, Wenguo Jiang, Lei Zhang, Meizi Yang, Fang Xu, Yana L. VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathway. Journal of translational medicine. vol 22. issue 1. 2024-10-29. PMID:39468621. |
here, we investigated vegfb as a main target to regulate insulin resistance and metabolic syndrome. |
2024-10-29 |
2024-10-31 |
Not clear |
| Yuqi Li, Wenhao Li, Xiaonan Zhu, Nuo Xu, Qinyu Meng, Wenguo Jiang, Lei Zhang, Meizi Yang, Fang Xu, Yana L. VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathway. Journal of translational medicine. vol 22. issue 1. 2024-10-29. PMID:39468621. |
vegfb ameliorates insulin resistance in nafld via the pi3k/akt signal pathway. |
2024-10-29 |
2024-10-31 |
Not clear |
| Rui Shang, Chae Syng Lee, Hualin Wang, Roger Dyer, Christophe Noll, André Carpentier, Ibrahim Sultan, Kari Alitalo, Robert Boushel, Bahira Hussein, Brian Rodrigue. Reduction in Insulin Uncovers a Novel Effect of VEGFB on Cardiac Substrate Utilization. Arteriosclerosis, thrombosis, and vascular biology. vol 44. issue 1. 2023-12-27. PMID:38150518. |
reduction in insulin uncovers a novel effect of vegfb on cardiac substrate utilization. |
2023-12-27 |
2023-12-30 |
Not clear |
| Yu-Qi Li, Lu-Yang Zhang, Yu-Chi Zhao, Fang Xu, Zhi-Yong Hu, Qi-Hao Wu, Wen-Hao Li, Ya-Nuo L. Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion. World journal of diabetes. vol 14. issue 11. 2023-12-11. PMID:38077805. |
recently, vascular endothelial growth factor b (vegfb) has been demonstrated to play a positive role in improving glucose metabolism and insulin sensitivity. |
2023-12-11 |
2023-12-17 |
mouse |
| Yuqi Li, Rongrong Li, Xu Luo, Fang Xu, Meizi Yang, Lanhui Zheng, Qihao Wu, Wenguo Jiang, Yana L. Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2 Molecular medicine reports. vol 28. issue 4. 2023-09-08. PMID:37681454. |
thus, the present study aimed to discuss the effect of vegfb on regulating insulin secretion in t2dm development, and its underlying mechanism. |
2023-09-08 |
2023-10-07 |
mouse |
| Yuqi Li, Rongrong Li, Xu Luo, Fang Xu, Meizi Yang, Lanhui Zheng, Qihao Wu, Wenguo Jiang, Yana L. Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2 Molecular medicine reports. vol 28. issue 4. 2023-09-08. PMID:37681454. |
vascular endothelial growth factor b regulates insulin secretion in β cells of type 2 diabetes mellitus mice via plcγ and the ip3r‑evoked ca2 vascular endothelial growth factor b (vegfb) plays a crucial role in glucolipid metabolism and is highly associated with type 2 diabetes mellitus (t2dm). |
2023-09-08 |
2023-10-07 |
mouse |
| Yuqi Li, Rongrong Li, Xu Luo, Fang Xu, Meizi Yang, Lanhui Zheng, Qihao Wu, Wenguo Jiang, Yana L. Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2 Molecular medicine reports. vol 28. issue 4. 2023-09-08. PMID:37681454. |
the decrement of insulin secretion in islet β cell of t2dm mice were aggravated and blood glucose remained at a high level after vegfb knockout (ko). |
2023-09-08 |
2023-10-07 |
mouse |
| Yuqi Li, Rongrong Li, Xu Luo, Fang Xu, Meizi Yang, Lanhui Zheng, Qihao Wu, Wenguo Jiang, Yana L. Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2 Molecular medicine reports. vol 28. issue 4. 2023-09-08. PMID:37681454. |
the role of vegfb in the insulin secretion of β cells remains unverified. |
2023-09-08 |
2023-10-07 |
mouse |
| Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu, Yana L. Reducing VEGFB accelerates NAFLD and insulin resistance in mice via inhibiting AMPK signaling pathway. Journal of translational medicine. vol 20. issue 1. 2022-07-30. PMID:35907871. |
this study investigated the involvement of vegfb in lipid metabolism and insulin resistance via the ampk signaling pathway in nafld. |
2022-07-30 |
2023-08-14 |
mouse |
| Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu, Yana L. Reducing VEGFB accelerates NAFLD and insulin resistance in mice via inhibiting AMPK signaling pathway. Journal of translational medicine. vol 20. issue 1. 2022-07-30. PMID:35907871. |
reducing vegfb accelerates nafld and insulin resistance in mice via inhibiting ampk signaling pathway. |
2022-07-30 |
2023-08-14 |
mouse |
| Xu Luo, Rong-Rong Li, Yu-Qi Li, Han-Pu Yu, Hai-Ning Yu, Wen-Guo Jiang, Ya-Na L. Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1. Molecular medicine reports. vol 26. issue 3. 2022-07-27. PMID:35894135. |
the present study used systemic vegfb gene‑knockout mice to investigate the effects of downregulation of the vegfb gene on lipid metabolism and insulin secretion, and to explore the mechanism of the vegfb pathway involved in the regulation of glucose and lipid metabolism. |
2022-07-27 |
2023-08-14 |
mouse |
| Xu Luo, Rong-Rong Li, Yu-Qi Li, Han-Pu Yu, Hai-Ning Yu, Wen-Guo Jiang, Ya-Na L. Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1. Molecular medicine reports. vol 26. issue 3. 2022-07-27. PMID:35894135. |
it was identified that downregulating vegfb improved lipid metabolism and insulin resistance. |
2022-07-27 |
2023-08-14 |
mouse |
| Xu Luo, Rong-Rong Li, Yu-Qi Li, Han-Pu Yu, Hai-Ning Yu, Wen-Guo Jiang, Ya-Na L. Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1. Molecular medicine reports. vol 26. issue 3. 2022-07-27. PMID:35894135. |
serum insulin secretion increased and homa‑ir decreased since vegfb was knocked down. |
2022-07-27 |
2023-08-14 |
mouse |
| Rui Shang, Nathaniel Lal, Chae Syng Lee, Yajie Zhai, Karanjit Puri, Oscar Seira, Robert C Boushel, Ibrahim Sultan, Markus Räsänen, Kari Alitalo, Bahira Hussein, Brian Rodrigue. Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart. American journal of physiology. Endocrinology and metabolism. vol 321. issue 6. 2021-12-03. PMID:34747201. |
we wanted to explore whether this influence of vegfb on cardiac metabolism involves regulation of lpl activity with consequent effects on lipotoxicity and insulin signaling. |
2021-12-03 |
2023-08-13 |
human |
| Rui Shang, Nathaniel Lal, Chae Syng Lee, Yajie Zhai, Karanjit Puri, Oscar Seira, Robert C Boushel, Ibrahim Sultan, Markus Räsänen, Kari Alitalo, Bahira Hussein, Brian Rodrigue. Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart. American journal of physiology. Endocrinology and metabolism. vol 321. issue 6. 2021-12-03. PMID:34747201. |
cardiac-specific vegfb overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart. |
2021-12-03 |
2023-08-13 |
human |
| Rui Shang, Nathaniel Lal, Chae Syng Lee, Yajie Zhai, Karanjit Puri, Oscar Seira, Robert C Boushel, Ibrahim Sultan, Markus Räsänen, Kari Alitalo, Bahira Hussein, Brian Rodrigue. Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart. American journal of physiology. Endocrinology and metabolism. vol 321. issue 6. 2021-12-03. PMID:34747201. |
in conclusion, the interrogation of vegfb function on cardiac metabolism uncovered an intriguing and previously unappreciated effect to lower lpl activity and prevent lipid metabolite accumulation to improve insulin action. |
2021-12-03 |
2023-08-13 |
human |
| Frank Chenfei Ning, Nina Jensen, Jiarui Mi, William Lindström, Mirela Balan, Lars Muhl, Ulf Eriksson, Ingrid Nilsson, Daniel Nyqvis. VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:31969592. |
we found that vegfb was ubiquitously expressed throughout the pancreas, and that β-cell vegfb deletion resulted in increased insulin gene expression. |
2020-11-30 |
2023-08-13 |
mouse |
| Annika Mehlem, Isolde Palombo, Xun Wang, Carolina E Hagberg, Ulf Eriksson, Annelie Falkeval. PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B. Diabetes. vol 65. issue 4. 2017-06-08. PMID:26822083. |
ablation of vegfb in mpgc-1αtg mice fed a high-fat diet (hfd) normalized glucose intolerance, insulin resistance, and dyslipidemia. |
2017-06-08 |
2023-08-13 |
mouse |
| Marius R Robciuc, Riikka Kivelä, Ian M Williams, Jan Freark de Boer, Theo H van Dijk, Harri Elamaa, Feven Tigistu-Sahle, Dmitry Molotkov, Veli-Matti Leppänen, Reijo Käkelä, Lauri Eklund, David H Wasserman, Albert K Groen, Kari Alital. VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications. Cell metabolism. vol 23. issue 4. 2016-12-30. PMID:27076080. |
mechanistically, the binding of vegfb to vegf receptor 1 (vegfr1, also known as flt1) activated the vegf/vegfr2 pathway and increased capillary density, tissue perfusion, and insulin supply, signaling, and function in adipose tissue. |
2016-12-30 |
2023-08-13 |
mouse |
| Lorna W Harries, Alexander D Fellows, Luke C Pilling, Dena Hernandez, Andrew Singleton, Stefania Bandinelli, Jack Guralnik, Jonathan Powell, Luigi Ferrucci, David Melze. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mechanisms of ageing and development. vol 133. issue 8. 2012-12-31. PMID:22813852. |
genes involved in insulin signaling (pten, pi3k, pdk1), ribosomal biogenesis (s6k), lipid metabolism (srebf1), cellular apoptosis (sgk1), angiogenesis (vegfb), insulin production and sensitivity (foxo), cellular stress response (hif1a) and cytoskeletal remodeling (pkc) were inversely correlated with age, whereas genes relating to inhibition of ribosomal components (4ebp1) and inflammatory mediators (stat3) were positively associated with age in one or both datasets. |
2012-12-31 |
2023-08-12 |
human |