| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Hosseini, H R Sadeghnia, A Rajabia. Protective effects of peel and seed extracts of Citrus aurantium on glutamate-induced cytotoxicity in PC12 cell line. Folia neuropathologica. vol 54. issue 3. 2017-04-13. PMID:27764519. |
oxidative stress and apoptosis contribute to neuronal degeneration in many neurodegenerative diseases such as alzheimer's disease. |
2017-04-13 |
2023-08-13 |
rat |
| Wen-Xuan Yu, Chen-Qiang Lin, Qing Zhao, Xin-Jian Lin, Xiao-Li Don. Neuroprotection against hydrogen peroxide-induced toxicity by Dictyophora echinovolvata polysaccharide via inhibiting the mitochondria-dependent apoptotic pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-27. PMID:28135600. |
neuronal apoptosis caused by toxic stimuli such as oxidative stress is believed to be one of the major reasons in the pathologenesis of neurodegenerative diseases. |
2017-03-27 |
2023-08-13 |
Not clear |
| Hongbo Li, Chunhui Zhu, Baoying Wang, Wenhua Zhu, Yan Feng, Fangying Du, Shaolan Wang, Chenghu Hu, Jie Ma, Xiaorui Y. 17β-Estradiol Protects the Retinal Nerve Cells Suppressing TLR2 Mediated Immune-Inflammation and Apoptosis from Oxidative Stress Insult Independent of PI3K. Journal of molecular neuroscience : MN. vol 60. issue 2. 2017-03-23. PMID:27596287. |
the excessive apoptosis of retinal nerve cells (rncs) could cause a variety of retinal neurodegenerative diseases which could result in the irreversible blindness. |
2017-03-23 |
2023-08-13 |
rat |
| Jagatheesan Nataraj, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohammed Ess. Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress. Nutritional neuroscience. vol 19. issue 6. 2017-03-10. PMID:25730317. |
mitochondrial dysfunction and oxidative stress-mediated apoptosis plays an important role in various neurodegenerative diseases including huntington's disease, parkinson's disease (pd) and alzheimer's disease (ad). |
2017-03-10 |
2023-08-13 |
human |
| Meizhu Zheng, Chunming Liu, Yajun Fan, Dongfang Shi, Yuchi Zhan. Protective Effects of Paeoniflorin Against MPP(+)-induced Neurotoxicity in PC12 Cells. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:27053303. |
pf has neuroprotective effects on mpp(+)-induced apoptosis in pc12 cells via regulating mitochondrial membrane potential and bcl-2/bax/caspase-3 signaling pathways, and this new insight will help develop a pf-based therapeutic strategy for treatmenting neurodegenerative diseases and injury. |
2017-03-06 |
2023-08-13 |
rat |
| Yu Xiong, Hong-Pei Ji, Wei-Tao Song, Ye-Wei Yin, Chao-Hua Xia, Bei Xu, Yi Xu, Xiao-Bo Xi. N-methyl-N-nitrosourea induces retinal degeneration in the rat via the inhibition of NF-κB activation. Cell biochemistry and function. vol 34. issue 8. 2017-01-31. PMID:27862073. |
retinitis pigmentosa (rp) is a group of inherited neurodegenerative diseases characterized by the loss of photoreceptor cells through apoptosis. |
2017-01-31 |
2023-08-13 |
rat |
| Maria Derksen, Christian Vorwerk, Detlef Sieme. Calpeptin, not calpain, directly inhibits an ion channel of the inner mitochondrial membrane. Protoplasma. vol 253. issue 3. 2016-12-14. PMID:26108743. |
the permeability transition pore (ptp) of inner mitochondrial membranes is a large conductance pathway for ions up to 1500 da which opening is responsible for ion equilibration and loss of membrane potential in apoptosis and thus in several neurodegenerative diseases. |
2016-12-14 |
2023-08-13 |
rat |
| Ye Tao, Tao Chen, Wei Fang, Guanghua Peng, Liqiang Wang, Limin Qin, Bei Liu, Yi Fei Huan. The temporal topography of the N-Methyl- N-nitrosourea induced photoreceptor degeneration in mouse retina. Scientific reports. vol 5. 2016-12-13. PMID:26685797. |
retinitis pigmentosa (rp) is a group of inherited neurodegenerative diseases characterized by the progressive photoreceptors apoptosis. |
2016-12-13 |
2023-08-13 |
mouse |
| Kyoung Joo Cho, So Young Cheon, Gyung Whan Ki. Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q. Scientific reports. vol 6. 2016-12-13. PMID:26728245. |
apoptosis signal-regulating kinase-1 (ask1), an early signaling element in the cell death pathway, has been hypothesized to participate in the pathology of neurodegenerative diseases. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ankit Shah, Naveen K Vaidya, Hari K Bhat, Anil Kuma. HIV-1 gp120 induces type-1 programmed cell death through ER stress employing IRE1α, JNK and AP-1 pathway. Scientific reports. vol 6. 2016-12-13. PMID:26740125. |
the er stress-mediated apoptosis has been implicated in several neurodegenerative diseases; however, its role in hiv/neuroaids remains largely unexplored. |
2016-12-13 |
2023-08-13 |
mouse |
| Min Wang, Yu-Jiao Li, Yi Ding, Hui-Nan Zhang, Ting Sun, Kun Zhang, Le Yang, Yan-Yan Guo, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei W. Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25561437. |
neuronal apoptosis and oxidative stress are involved in most of the neurodegenerative diseases, promoting neuron survival is critical for therapy. |
2016-11-14 |
2023-08-13 |
mouse |
| Garima Singh, Jingwen Zhang, Yilun Ma, Richard A Cerione, Marc A Antonya. The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability. The Journal of biological chemistry. vol 291. issue 17. 2016-11-03. PMID:26893378. |
these findings provide important insights into how ttg participates in the pathogenesis of neurodegenerative diseases, particularly with regard to the actions of a c-terminal truncated form of ttg (tg-short) that has been linked to such disorders and induces apoptosis by assuming an open-like conformation. |
2016-11-03 |
2023-08-13 |
human |
| Liang Chen, Lejin Sun, Zhene Liu, Hongxia Wang, Cunli X. Protection afforded by quercetin against H2O2-induced apoptosis on PC12 cells via activating PI3K/Akt signal pathway. Journal of receptor and signal transduction research. vol 36. issue 1. 2016-10-25. PMID:26414235. |
cell damage and apoptosis induced by oxidative stress have been involved in various neurodegenerative diseases. |
2016-10-25 |
2023-08-13 |
Not clear |
| Shuang Hu, Di Wang, Junrong Zhang, Mengyan Du, Yingkun Cheng, Yan Liu, Ning Zhang, Di Wang, Yi W. Mitochondria Related Pathway Is Essential for Polysaccharides Purified from Sparassis crispa Mediated Neuro-Protection against Glutamate-Induced Toxicity in Differentiated PC12 Cells. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821016. |
these results suggested that scwea protects against l-glu-induced neuronal apoptosis in dpc12 cells and may be a promising candidate for treatment against neurodegenerative disease. |
2016-10-19 |
2023-08-13 |
Not clear |
| J Hu, M Xu, J Yuan, B Li, S Entenman, H Yu, Q Y Zhen. Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice. Neuroscience. vol 316. 2016-10-18. PMID:26748055. |
tauroursodeoxycholic acid (tudca), a taurine-conjugated bile acid, has been used in experimental research and clinical applications related to liver disease, diabetes, neurodegenerative diseases, and other diseases associated with apoptosis. |
2016-10-18 |
2023-08-13 |
mouse |
| Ting Zhu, Deming Zhao, Zhiqi Song, Zhen Yuan, Chaosi Li, Yunsheng Wang, Xiangmei Zhou, Xiaomin Yin, Muhammad Farooque Hassan, Lifeng Yan. HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway. Neurobiology of aging. vol 37. 2016-09-26. PMID:26507311. |
histone deacetylase 6 (hdac6) controls several major cellular responses to stress that play a role in neurodegenerative diseases, including aggresome formation, autophagy, and apoptosis. |
2016-09-26 |
2023-08-13 |
Not clear |
| Danya Ben-Hail, Varda Shoshan-Barmat. VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis. Biochimica et biophysica acta. vol 1863. issue 7 Pt A. 2016-09-08. PMID:27064145. |
finally, inhibitors of apoptosis could serve in pathological conditions where enhanced apoptosis is found, such as neurodegenerative diseases. |
2016-09-08 |
2023-08-13 |
Not clear |
| Baoman Wang, Fei Yuan, Xiangyin Kong, Lan-Dian Hu, Yu-Dong Ca. Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network. Computational and mathematical methods in medicine. vol 2015. 2016-08-29. PMID:26543496. |
in addition, some diseases, such as obesity, cancer, and neurodegenerative diseases, can be cured through apoptosis, which produces few side effects. |
2016-08-29 |
2023-08-13 |
Not clear |
| Liang Zhou, Hongfeng Wang, Haigang Ren, Qingsong Hu, Zheng Ying, Guanghui Wan. Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease. Molecular neurobiology. vol 52. issue 3. 2016-08-08. PMID:25311206. |
b-cell lymphoma 2 (bcl-2) is a key regulator in autophagy, apoptosis, and mitochondria quality control in many cell types including neurons, and it plays important roles in the pathogenesis of neurodegenerative diseases mentioned above. |
2016-08-08 |
2023-08-13 |
Not clear |
| Sajjad Sisakhtnezhad, Leila Khosrav. Emerging physiological and pathological implications of tunneling nanotubes formation between cells. European journal of cell biology. vol 94. issue 10. 2016-07-04. PMID:26164368. |
moreover, the latest findings into their functional roles in physiological and pathological processes, such as signal transduction, micro and nano-particles delivery, immune responses, embryogenesis, cellular reprogramming, apoptosis, cancer, and neurodegenerative diseases initiation and progression and pathogens transfer, will be discussed. |
2016-07-04 |
2023-08-13 |
Not clear |