Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
R G Steen, X Xiong, R K Mulhern, J W Langston, W C Wan. Subtle brain abnormalities in children with sickle cell disease: relationship to blood hematocrit. Annals of neurology. vol 45. issue 3. 1999-03-29. PMID:10072041. |
our objective was to test a hypothesis that subtle brain abnormality can be present in pediatric sickle cell disease (scd) patients who are clinically free of stroke. |
1999-03-29 |
2023-08-12 |
Not clear |
R G Steen, X Xiong, R K Mulhern, J W Langston, W C Wan. Subtle brain abnormalities in children with sickle cell disease: relationship to blood hematocrit. Annals of neurology. vol 45. issue 3. 1999-03-29. PMID:10072041. |
our findings suggest that chronic hypoxia of brain tissue can occur in scd patients free of clinical stroke. |
1999-03-29 |
2023-08-12 |
Not clear |
S A Zimmerman, R E War. Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease. American journal of hematology. vol 59. issue 4. 1998-12-14. PMID:9840906. |
thrombosis may play an important role in the pathophysiology of certain complications of sickle cell disease (scd), including stroke and avascular necrosis (avn). |
1998-12-14 |
2023-08-12 |
Not clear |
S A Zimmerman, R E War. Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease. American journal of hematology. vol 59. issue 4. 1998-12-14. PMID:9840906. |
we hypothesized that some patients with scd have an inherited hypercoagulable state that results in an increased risk of developing stroke or avn. |
1998-12-14 |
2023-08-12 |
Not clear |
S A Zimmerman, R E War. Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease. American journal of hematology. vol 59. issue 4. 1998-12-14. PMID:9840906. |
we analyzed genomic dna from 86 children and adults with scd, including 16 patients with a history of a clinical stroke and 14 patients with avn, for the presence of these mutations. |
1998-12-14 |
2023-08-12 |
Not clear |
S A Zimmerman, R E War. Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease. American journal of hematology. vol 59. issue 4. 1998-12-14. PMID:9840906. |
although each of these mutations is relatively common in patients with scd, neither is independently associated with an increased risk of developing stroke or avn. |
1998-12-14 |
2023-08-12 |
Not clear |
R G Steen, W E Reddick, R K Mulhern, J W Langston, R J Ogg, A A Bieberich, P B Kingsley, W C Wan. Quantitative MRI of the brain in children with sickle cell disease reveals abnormalities unseen by conventional MRI. Journal of magnetic resonance imaging : JMRI. vol 8. issue 3. 1998-08-27. PMID:9626865. |
conventional mri (cmri) has shown that brain abnormalities without clinical stroke can manifest in patients with sickle cell disease (scd). |
1998-08-27 |
2023-08-12 |
Not clear |
P E Houston, S Rana, S Sekhsaria, E Perlin, K S Kim, O L Castr. Homocysteine in sickle cell disease: relationship to stroke. The American journal of medicine. vol 103. issue 3. 1997-10-23. PMID:9316551. |
the risk factors and pathophysiology of stroke and other serious complications of sickle cell disease (scd) are poorly defined. |
1997-10-23 |
2023-08-12 |
Not clear |
P E Houston, S Rana, S Sekhsaria, E Perlin, K S Kim, O L Castr. Homocysteine in sickle cell disease: relationship to stroke. The American journal of medicine. vol 103. issue 3. 1997-10-23. PMID:9316551. |
hyperhomocysteinemia has recently been identified as a risk factor for stroke and other vascular diseases in the general population, however its role in scd has not been investigated. |
1997-10-23 |
2023-08-12 |
Not clear |
R G Steen, J W Langston, W E Reddick, R Ogg, G Chen, W C Wan. Quantitative MR imaging of children with sickle cell disease: striking T1 elevation in the thalamus. Journal of magnetic resonance imaging : JMRI. vol 6. issue 1. 1996-12-06. PMID:8851433. |
nonparametric kruskal-wallis analysis of variance of control subjects, of scd patients without stroke, and of scd patients with stroke showed that t1 increased with disease severity in the thalamus, frontal white matter, genu, and occipital white matter. |
1996-12-06 |
2023-08-12 |
human |
R G Steen, J W Langston, W E Reddick, R Ogg, G Chen, W C Wan. Quantitative MR imaging of children with sickle cell disease: striking T1 elevation in the thalamus. Journal of magnetic resonance imaging : JMRI. vol 6. issue 1. 1996-12-06. PMID:8851433. |
t1 was significantly longer in scd patients without stroke (n = 13) than in control subjects (n = 21) in the thalamus and frontal white matter. |
1996-12-06 |
2023-08-12 |
human |
R G Steen, J W Langston, W E Reddick, R Ogg, G Chen, W C Wan. Quantitative MR imaging of children with sickle cell disease: striking T1 elevation in the thalamus. Journal of magnetic resonance imaging : JMRI. vol 6. issue 1. 1996-12-06. PMID:8851433. |
in addition, t1 values were significantly longer in scd patients with stroke than in patients without stroke in the genu and frontal white matter. |
1996-12-06 |
2023-08-12 |
human |
R G Steen, J W Langston, W E Reddick, R Ogg, G Chen, W C Wan. Quantitative MR imaging of children with sickle cell disease: striking T1 elevation in the thalamus. Journal of magnetic resonance imaging : JMRI. vol 6. issue 1. 1996-12-06. PMID:8851433. |
abnormality of the thalamus was identified by qmri in a substantial fraction of patients read as normal by both cmri and mra, suggesting that it may be possible to use t1 elevation to identify a subset of patients with scd who are at elevated risk for stroke. |
1996-12-06 |
2023-08-12 |
human |
S Hayashi, H Toyoshima, N Tanabe, K Miyanish. Daily peaks in the incidence of sudden cardiac death and fatal stroke in Niigata Prefecture. Japanese circulation journal. vol 60. issue 4. 1996-11-21. PMID:8726167. |
we concluded that 1) a circadian variation with two peak incidences, one between 6 and 8 am, and one between 6 and 8 pm, was characteristic of scd in general, 2) there was a primary peak between 4 and 6 am for scd due to ami in males, and 3) there was a peak between 6 and 8 pm in the incidence of fatal stroke for both men and women. |
1996-11-21 |
2023-08-12 |
Not clear |
R B Franci. Large-vessel occlusion in sickle cell disease: pathogenesis, clinical consequences, and therapeutic implications. Medical hypotheses. vol 35. issue 2. 1991-10-11. PMID:1890982. |
large-vessel cerebral arterial disease (intimal hyperplasia with superimposed thrombosis) has clearly been established as the most important cause of stroke in scd, and considerable evidence suggests that pulmonary arterial thrombosis/embolism is a major cause of pulmonary infarction and hypertension. |
1991-10-11 |
2023-08-11 |
human |
L M Hariman, E R Griffith, A L Hurtig, M T Keeh. Functional outcomes of children with sickle-cell disease affected by stroke. Archives of physical medicine and rehabilitation. vol 72. issue 7. 1991-08-01. PMID:2059123. |
the nature and degree of functional recovery after stroke in children with sickle-cell disease (scd) has not been extensively investigated. |
1991-08-01 |
2023-08-11 |
human |
L M Hariman, E R Griffith, A L Hurtig, M T Keeh. Functional outcomes of children with sickle-cell disease affected by stroke. Archives of physical medicine and rehabilitation. vol 72. issue 7. 1991-08-01. PMID:2059123. |
the purpose of this study was to evaluate retrospectively the functional status of 14 scd children who had had strokes and to compare them with age-matched and gender-matched scd children who had not had strokes. |
1991-08-01 |
2023-08-11 |
human |
L M Hariman, E R Griffith, A L Hurtig, M T Keeh. Functional outcomes of children with sickle-cell disease affected by stroke. Archives of physical medicine and rehabilitation. vol 72. issue 7. 1991-08-01. PMID:2059123. |
by doing so, we would be able to quantify the eventual physical and cognitive functional outcomes of survivors of stroke secondary to scd and assess the impact of stroke on these patients. |
1991-08-01 |
2023-08-11 |
human |
L M Hariman, E R Griffith, A L Hurtig, M T Keeh. Functional outcomes of children with sickle-cell disease affected by stroke. Archives of physical medicine and rehabilitation. vol 72. issue 7. 1991-08-01. PMID:2059123. |
these children (five boys and nine girls) with scd and stroke(s) were 11.6 +/- 4.3 years of age (range five to 18 years). |
1991-08-01 |
2023-08-11 |
human |
L M Hariman, E R Griffith, A L Hurtig, M T Keeh. Functional outcomes of children with sickle-cell disease affected by stroke. Archives of physical medicine and rehabilitation. vol 72. issue 7. 1991-08-01. PMID:2059123. |
intelligence quotient of the children with scd-stroke(s) was significantly lower than those of age-matched and gender-matched nonstroke scd children, suggesting that stroke caused an adverse effect on the cognitive functioning of these children. |
1991-08-01 |
2023-08-11 |
human |