| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiale Gan, Xinyi Yang, Jianan Wu, Peian Liu, Zhaoyao Chen, Yue Hu, Wenlei Li, Yuan Zhu, Minghua W. Neuroprotective mechanisms of microglia in ischemic stroke: a review focused on mitochondria. Molecular biology reports. vol 52. issue 1. 2025-04-01. PMID:40167874. |
mitochondria participates in and influences the pathological processes of ischemic stroke, including oxidative stress, modulation of microglia phenotype, and axonal regenerative function, and is an essential and often overlooked target in the clinical management of stroke. |
2025-04-01 |
2025-04-03 |
Not clear |
| Zengli Zhang, Mengxue Zhang, Dan Li, Ruichen Shu, Qian Pan, Wangyuan Zou, Kaiyuan Wang, Yiqing Yi. Microglial Annexin A3 Downregulation Alleviates Ischemic Injury by Inhibiting NF-κB/NLRP3-mediated Inflammation. Inflammation. 2025-03-15. PMID:40087252. |
annexin a3 (anxa3) is expressed in microglia and plays a detrimental role in stroke. |
2025-03-15 |
2025-03-18 |
mouse |
| Ting-Ting Li, Xiao-Fan Guo, Yi-Jing Zhao, Ya-Hong Cheng, Dan-Qing Xin, Yan Song, De-Xiang Liu, Zhen Wan. Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice. Acta pharmacologica Sinica. 2025-03-13. PMID:40075146. |
in summary, stroke-induced abnormal neuronal activity reduces mir-128-3p levels in ischemic neurons and evs, leading to increased microglia activation and neuronal injury after a stroke. |
2025-03-13 |
2025-03-15 |
mouse |
| Li-da Du, Cheng Fang, Yue-Qing Wang, Zi-Ying Feng, Ogunleye Femi Abiola, Zhao-Lin Gao, Ju-Yang Huang, Yin-Zhong M. MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism. Acta pharmacologica Sinica. 2025-03-12. PMID:40069489. |
mmp-9 is predominantly secreted by inflammatory cells such as neutrophils, macrophages and microglia soon after stroke onset. |
2025-03-12 |
2025-03-14 |
mouse |
| Jun Qian, Xiaoming Guo, Qian Xu, Zhidong Huan. Therapeutic Potential of TPT-260 in Ischemic Stroke: An Investigation Into Its Anti-Inflammatory Effects and Impact on Microglial Activation. Journal of inflammation research. vol 18. 2025-03-06. PMID:40046681. |
inhibition of m1 microglia effectively alleviate neuronal damage in mild stroke. |
2025-03-06 |
2025-03-08 |
mouse |
| Ran Gao, Yaqi Xu, Min Zhang, Qi Zeng, Gaizhi Zhu, Wenting Su, Renxi Wan. From Gene Discovery to Stroke Risk: C5orf24's Pivotal Role Uncovered. Molecular neurobiology. 2025-03-04. PMID:40038197. |
the gene b230219d22rik and c5orf24 expressed in microglia was observed to have reduced expression in mouse and human cell stroke models, respectively. |
2025-03-04 |
2025-03-07 |
mouse |
| Yang An, Gang Su, Wei Chen, Jinyang Song, Miao Chai, Longni Zhu, Zhenchang Zhan. Research Progress on the Mechanisms of Microglial Extracellular Vesicles Affecting the Prognosis of Ischemic Stroke. Neurochemistry international. 2025-02-27. PMID:40015338. |
microglia play a complex and crucial role in stroke. |
2025-02-27 |
2025-03-02 |
Not clear |
| Yang An, Gang Su, Wei Chen, Jinyang Song, Miao Chai, Longni Zhu, Zhenchang Zhan. Research Progress on the Mechanisms of Microglial Extracellular Vesicles Affecting the Prognosis of Ischemic Stroke. Neurochemistry international. 2025-02-27. PMID:40015338. |
existing studies have shown that after a stroke occurs, microglia release extracellular vesicles containing proteins, nucleic acids, metabolites, etc. |
2025-02-27 |
2025-03-02 |
Not clear |
| Cuiling Ji, Lixinbei Sheng, Kaijun Han, Ping Yuan, Wei Li, Lu Chen, Yongyue Ga. Microglial intervention in ischemic stroke: roles and intervention strategies. Neural regeneration research. 2025-02-25. PMID:39995094. |
as the primary immune cells of the central nervous system, microglia play dual roles in neuroinflammation and tissue repair following a stroke. |
2025-02-25 |
2025-02-27 |
Not clear |
| Gab Seok Kim, Elisabeth Harmon, Manuel C Gutierrez, Sodam Kim, Lauren Vance, Haven Burrous, Jessica M Stephenson, Anjali Chauhan, Anik Banerjee, Zachary Wise, Andrea Doan, John Ahn, Ting Wu, Jesus Bautista-Garrido, Juneyoung Lee, Chunfeng Tan, Joo Eun Jung, Louise D McCullough, Joshua D Wythe, Sean P Marrell. Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice. Nature communications. vol 16. issue 1. 2025-02-14. PMID:39953063. |
to identify potential regulators of inflammation, we performed single-cell rna sequencing (scrna-seq) of young and aged mouse brains following stroke and found that interferon alpha-inducible protein 27 like 2 a (ifi27l2a) was significantly up-regulated, particularly in microglia of aged brain. |
2025-02-14 |
2025-02-18 |
mouse |
| Gab Seok Kim, Elisabeth Harmon, Manuel C Gutierrez, Sodam Kim, Lauren Vance, Haven Burrous, Jessica M Stephenson, Anjali Chauhan, Anik Banerjee, Zachary Wise, Andrea Doan, John Ahn, Ting Wu, Jesus Bautista-Garrido, Juneyoung Lee, Chunfeng Tan, Joo Eun Jung, Louise D McCullough, Joshua D Wythe, Sean P Marrell. Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice. Nature communications. vol 16. issue 1. 2025-02-14. PMID:39953063. |
using a combination of cell culture, experimental stroke models in mice, and human autopsy brain samples, we demonstrated that induction of ifi27l2a occurs in microglia in response to aging, ischemic stroke, and pro-inflammatory molecules. |
2025-02-14 |
2025-02-18 |
mouse |
| Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huan. Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2. Neurobiology of disease. 2025-02-08. PMID:39921112. |
microglia trpc1 sumoylation drives neuroinflammation after stroke by modulating nlrp3 activity via increasing trpc1 interaction with arrb2. |
2025-02-08 |
2025-02-11 |
mouse |
| Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huan. Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2. Neurobiology of disease. 2025-02-08. PMID:39921112. |
mice with a loss of trpc1 sumoylation in microglia exhibited improved stroke outcomes including reduced behavior deficits, infarct volume, blood brain barrier damage as well as neuronal apoptosis. |
2025-02-08 |
2025-02-11 |
mouse |
| Ermei Lu, Peng Zhou, Yuanyuan Li, Jiale Chen, Kexin Zhang, Kecheng Zho. Long Noncoding RNA ISA1 Protects Against Ischemic Brain Damage by Promoting the Transformation of Microglia Toward Anti-inflammatory Phenotype via the SOCS3/JAK2/STAT3 Pathway. Neurochemical research. vol 50. issue 2. 2025-02-01. PMID:39891829. |
the shift of microglia towards an anti-inflammatory phenotype has been shown to decrease neuroinflammation, improve neurological function, and is considered a potential therapeutic approach for stroke. |
2025-02-01 |
2025-02-04 |
mouse |
| Huiran Zhang, Yanfei Tian, Yan Zhang, Yan Wang, Jinlong Qi, Xiangyu Wang, Yi Yuan, Rong Chen, Yupeng Zhao, Chang Liu, Najing Zhou, Lanxin Liu, Han Hao, Xiaona Du, Hailin Zhan. Neuroprotective Effects, Mechanisms of Action and Therapeutic Potential of the Kv7/KCNQ Channel Opener QO-83 in Ischemic Stroke. Translational stroke research. 2025-01-24. PMID:39853651. |
solitary dose of qo-83 contributes to the microglia inhibition and fibrotic scar mitigation post stroke. |
2025-01-24 |
2025-01-27 |
mouse |
| Conelius Ngwa, Afzal Misrani, Kanaka Valli Manyam, Yan Xu, Shaohua Qi, Romana Sharmeen, Juneyoung Lee, Long-Jun Wu, Louise McCullough, Fudong Li. Escape of Kdm6a from X Chromosome Is Detrimental to Ischemic Brains via IRF5 Signaling. Translational stroke research. 2025-01-03. PMID:39752046. |
we hypothesized that kdm6a/5c demethylate h3k27me3/h3k4me3 in microglia, respectively, and mediate the transcription of interferon regulatory factor 5 (irf5) and irf4, leading to microglial pro-inflammatory responses and exacerbated stroke injury. |
2025-01-03 |
2025-01-05 |
mouse |
| Zhiruo Liu, Qin Qin, Shisi Wang, Xinmei Kang, Yuxin Liu, Lei Wei, Zhengqi Lu, Wei Cai, Mengyan H. STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions. CNS neuroscience & therapeutics. vol 30. issue 12. 2024-12-19. PMID:39698742. |
monocyte-derived macrophages and microglia initially adopt an anti-inflammatory phenotype following stroke but later transition to a pro-inflammatory state. |
2024-12-19 |
2024-12-21 |
Not clear |
| Zhiruo Liu, Qin Qin, Shisi Wang, Xinmei Kang, Yuxin Liu, Lei Wei, Zhengqi Lu, Wei Cai, Mengyan H. STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions. CNS neuroscience & therapeutics. vol 30. issue 12. 2024-12-19. PMID:39698742. |
this study investigates the activation dynamics of molecular signaling pathways in macrophages and microglia after stroke. |
2024-12-19 |
2024-12-21 |
Not clear |
| Alessandra Maria Testa, Livia Vignozzi, Diana Corallo, Sanja Aveic, Antonella Viola, Manuela Allegra, Roberta Angion. Hypoxic Human Microglia Promote Angiogenesis Through Extracellular Vesicle Release. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684220. |
microglia, the brain-resident immune cells, orchestrate neuroinflammatory responses and are crucial in the progression of neurological diseases, including ischemic stroke (is), which accounts for approximately 85% of all strokes worldwide. |
2024-12-17 |
2024-12-21 |
mouse |
| Ruiqi Cheng, Xiaoqin Luo, Xiaohui Wu, Zijie Wang, Ziqun Chen, Shaoru Zhang, Hongmei Xiao, Jiaju Zhong, Rongrong Zhang, Yang Cao, Xinyue Qi. Artificial Microglia Nanoplatform Loaded With Anti-RGMa in Acoustic/Magnetic Feld for Recanalization and Neuroprotection in Acute Ischemic Stroke. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-10-30. PMID:39475454. |
hence, an artificial nanoplatform loaded with anti-repulsive guidance molecule a monoclonal antibody (anti-rgma) and coated with microglia membrane (micm) is reported for stroke treatment, namely micm@plga/anti-rgma/fe |
2024-10-30 |
2024-11-02 |
Not clear |