| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Szilvia Benkő, Ádám Déne. Microglial inflammatory mechanisms in stroke: the jury is still out. Neuroscience. 2024-02-16. PMID:38364965. |
because extensive review articles discussing the role of inflammatory mechanisms in different forms of acute brain injury are available, here we focus on some specific pathways that appear to be important for stroke pathophysiology with assumed contribution by microglia. |
2024-02-16 |
2024-02-19 |
Not clear |
| Zifu Li, Tianxiang Gao, Jing Wang, Xiaoxi Zhang, Yongxin Zhang, Lei Zhang, Pengfei Yang, Jianmin Li. Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke. Journal of neurochemistry. 2024-02-12. PMID:38344886. |
in this study, we investigated the potential involvement of tnfsf9 in reperfusion injury associated with ferroptosis in acute ischaemic stroke patients, mouse models and bv2 microglia. |
2024-02-12 |
2024-02-15 |
mouse |
| Zifu Li, Tianxiang Gao, Jing Wang, Xiaoxi Zhang, Yongxin Zhang, Lei Zhang, Pengfei Yang, Jianmin Li. Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke. Journal of neurochemistry. 2024-02-12. PMID:38344886. |
we first examined tnfsf9 changes in peripheral blood from stroke patients with successful reperfusion, and constructed oxygen-glucose deprivation-reperfusion (ogd-r) on bv2 microglia, oxygen-glucose deprivation for 6 h followed by reoxygenation and re-glucose for 24 h, and appropriate over-expression or knockdown of tnfsf9 manipulation on bv2 cells and found that in the case of bv2 cells encountering ogd-r over-expression of tnfsf9 resulted in increased bv2 apoptosis. |
2024-02-12 |
2024-02-15 |
mouse |
| Rehnuma Islam, Jan-Eric Ahlfors, Ricky Siu, Humna Noman, Roya Akbary, Cindi M Morshea. Inhibition of Apoptosis in a Model of Ischemic Stroke Leads to Enhanced Cell Survival, Endogenous Neural Precursor Cell Activation and Improved Functional Outcomes. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339065. |
furthermore, acute nwl283 administration is neuroprotective at the stroke injury site, decreasing neuronal cell death and reducing microglia activation. |
2024-02-10 |
2024-02-12 |
mouse |
| Bing Han, Shunheng Zhou, Yuan Zhang, Sina Chen, Wen Xi, Chenchen Liu, Xu Zhou, Mengqin Yuan, Xiaoyu Yu, Lu Li, Yu Wang, Hui Ren, Jian Xie, Bin Li, Minzi Ju, You Zhou, Ziqi Liu, Zhongli Xiong, Ling Shen, Yuan Zhang, Ying Bai, Jun Chen, Wei Jiang, Honghong Ya. Integrating spatial and single-cell transcriptomics to characterize the molecular and cellular architecture of the ischemic mouse brain. Science translational medicine. vol 16. issue 733. 2024-02-07. PMID:38324639. |
analysis of ligand-receptor interactions in cell communication revealed galectin-9 to cell-surface glycoprotein cd44 (lgals9-cd44) as a critical signaling pathway after ischemic injury and identified microglia and macrophages as the main source of galectins after stroke. |
2024-02-07 |
2024-02-10 |
mouse |
| Kimberly Prescott, Alexandra E Münch, Evan Brahms, Maya K Weigel, Kenya Inoue, Marion S Buckwalter, Shane A Liddelow, Todd C Peterso. Blocking of microglia-astrocyte proinflammatory signaling is beneficial following stroke. Frontiers in molecular neuroscience. vol 16. 2024-01-19. PMID:38240014. |
microglia and astrocytes play an important role in the neuroinflammatory response and contribute to both the destruction of neighboring tissue as well as the resolution of inflammation following stroke. |
2024-01-19 |
2024-01-21 |
Not clear |
| Peng Zhou, Zhe-Cheng Yu, Cong Cao, Huai-Rui Cui, Mao-Chao Ding, Chao-Xian Yang, Min Lia. Pyruvate maintains and enhances the pro-inflammatory response of microglia caused by glucose deficiency in early stroke. Journal of cellular biochemistry. 2024-01-16. PMID:38226453. |
pyruvate maintains and enhances the pro-inflammatory response of microglia caused by glucose deficiency in early stroke. |
2024-01-16 |
2024-01-18 |
mouse |
| Mingzhu Gao, Yan Li, William Ho, Chen Chen, Qijing Chen, Fengshi Li, Maoping Tang, Qiuyue Fan, Jieqing Wan, Weifeng Yu, Xiaoyang Xu, Peiying Li, Xue-Qing Zhan. Targeted mRNA Nanoparticles Ameliorate Blood-Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization. ACS nano. 2024-01-16. PMID:38227975. |
targeted mrna nanoparticles ameliorate blood-brain barrier disruption postischemic stroke by modulating microglia polarization. |
2024-01-16 |
2024-01-19 |
Not clear |
| Yiwei Feng, Lishan Lin, Tengteng Wu, Yukun Feng, Fengyin Liang, Ge Li, Yongchao Li, Yalun Guan, Shuhua Liu, Yu Zhang, Guangqing Xu, Zhong Pe. Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity. Cell death & disease. vol 15. issue 1. 2024-01-12. PMID:38216560. |
the results showed that microinfarcts led to trained immunity in microglia, which worsened the pro-inflammatory response and ischemic injury in the secondary photothrombotic stroke. |
2024-01-12 |
2024-01-15 |
Not clear |
| Yiwei Feng, Lishan Lin, Tengteng Wu, Yukun Feng, Fengyin Liang, Ge Li, Yongchao Li, Yalun Guan, Shuhua Liu, Yu Zhang, Guangqing Xu, Zhong Pe. Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity. Cell death & disease. vol 15. issue 1. 2024-01-12. PMID:38216560. |
furthermore, the knockout of nlrp3 in microglia alleviated the trained immunity and reduced the harmful effects of microinfarcts on recurrent stroke. |
2024-01-12 |
2024-01-15 |
Not clear |
| Huijie Duan, Junya Hu, Yang Deng, Junqing Zou, Wangli Ding, Qiang Peng, Rui Duan, Jianguo Sun, Junrong Zh. Berberine Mediates the Production of Butyrate to Ameliorate Cerebral Ischemia via the Gut Microbiota in Mice. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201839. |
in addition, butyric acid could inhibit the activation of the microglia and astrocytes in the brains of model mice, thereby inhibiting the generation of pro-inflammatory factors il-6, il-1β and tnf-α as well as improving stroke outcomes. |
2024-01-11 |
2024-01-13 |
mouse |
| Xiao-Li Min, Wen-Ji Jia, Li Guo, Rui Jing, Xiao-Hong Zhao, Jia-Yi Hu, Xu-Hui Li, Wei Liu, Tao Wang, Xing-Kui Do. Brain microvascular endothelial cell-derived exosomes transmitting circ_0000495 promote microglial M1-polarization and endothelial cell injury under hypoxia condition. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 2. 2024-01-09. PMID:38193649. |
however, the role of hbmvecs-derived exosomes in microglia polarization after stroke remains unknown. |
2024-01-09 |
2024-01-10 |
mouse |
| Anna M Plana. Role of microglia in stroke. Glia. 2024-01-04. PMID:38173414. |
role of microglia in stroke. |
2024-01-04 |
2024-01-06 |
human |
| Anna M Plana. Role of microglia in stroke. Glia. 2024-01-04. PMID:38173414. |
accurate profiling of microglia phenotypes, alongside with a more precise understanding of the associated post-ischemic tissue conditions, is a necessary step to serve as the potential foundation for focused interventions in human stroke. |
2024-01-04 |
2024-01-06 |
human |
| Huiya Li, Pinyi Liu, Bing Zhang, Zengqiang Yuan, Mengdi Guo, Xinxin Zou, Yi Qian, Shiji Deng, Liwen Zhu, Xiang Cao, Tao Tao, Shengnan Xia, Xinyu Bao, Yun X. Acute ischemia induces spatially and transcriptionally distinct microglial subclusters. Genome medicine. vol 15. issue 1. 2023-12-12. PMID:38082331. |
microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular injury after stroke. |
2023-12-12 |
2023-12-17 |
Not clear |
| Xin Gao, Gang Su, Miao Chai, Minghui Shen, Zhenzhen Hu, Wei Chen, Juan Gao, Ruixin Li, Tianfei Ma, Yang An, Zhenchang Zhan. Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia. Neurochemistry international. 2023-12-11. PMID:38081419. |
activated microglia participate in the pathological processes after stroke through polarization, autophagy, phagocytosis, pyroptosis, ferroptosis, apoptosis, and necrosis, thereby influencing the injury and repair following stroke. |
2023-12-11 |
2023-12-17 |
Not clear |
| Xin Gao, Gang Su, Miao Chai, Minghui Shen, Zhenzhen Hu, Wei Chen, Juan Gao, Ruixin Li, Tianfei Ma, Yang An, Zhenchang Zhan. Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia. Neurochemistry international. 2023-12-11. PMID:38081419. |
autophagy and phagocytosis in microglia following ischemia are dynamic processes, where moderate levels promote cell survival, while excessive responses may exacerbate neurofunctional deficits following stroke. |
2023-12-11 |
2023-12-17 |
Not clear |
| Jingwei Song, Syed Aqib Ali Zaidi, Liangge He, Shuai Zhang, Guangqian Zho. Integrative Analysis of Machine Learning and Molecule Docking Simulations for Ischemic Stroke Diagnosis and Therapy. Molecules (Basel, Switzerland). vol 28. issue 23. 2023-12-09. PMID:38067435. |
the rna velocity and pseudo time analysis showed that microglia subcluster 0 would develop toward subcluster 2 within 24 h from stroke onset. |
2023-12-09 |
2023-12-17 |
Not clear |
| Jingwei Song, Syed Aqib Ali Zaidi, Liangge He, Shuai Zhang, Guangqian Zho. Integrative Analysis of Machine Learning and Molecule Docking Simulations for Ischemic Stroke Diagnosis and Therapy. Molecules (Basel, Switzerland). vol 28. issue 23. 2023-12-09. PMID:38067435. |
az_628, which screened from cmap analysis, was found to have lower binding energy with mmp12, lgals3, fam20c, capg, pkm2, sdc4, and itga5 in microglia subcluster 2 and maybe a therapeutic agent for the poor development of microglia subcluster 2 after stroke. |
2023-12-09 |
2023-12-17 |
Not clear |
| Lu Yu, Zuohui Zhang, Hao Chen, Miao Wang, Wenqi Mao, Jinxia Hu, Dandan Zuo, Bingchen Lv, Weifeng Wu, Suhua Qi, Guiyun Cu. Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke. Bioengineering & translational medicine. vol 8. issue 6. 2023-12-01. PMID:38023701. |
remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating hgf after acute ischemia stroke. |
2023-12-01 |
2023-12-07 |
mouse |