| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Morrison, K Williamson, K Arthur, G J Price, P W Hamilton, P Maxwel. Phenotypic changes in mitochondrial membrane potential (Delta psi(m)) during valinomycin-induced depolarisation and apoptosis. Cellular oncology : the official journal of the International Society for Cellular Oncology. vol 27. issue 4. 2007-04-13. PMID:16308472. |
in conclusion this study illustrates the potential of texture analysis as a novel and additional technique for quantifying jc-1 aggregation and revealing the spectrum of collapse of delta psi(m) during apoptosis. |
2007-04-13 |
2023-08-12 |
Not clear |
| Robert T M Boudreau, David M Conrad, David W Hoski. Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase. Cellular signalling. vol 19. issue 1. 2007-04-10. PMID:16844342. |
jurkat and ccrf-cem t leukemia cells treated with the pp2a-selective inhibitor okadaic acid (oa) showed a dose- and time-dependent induction of apoptosis, as indicated by loss of mitochondrial transmembrane potential (delta psi(m)), cleavage-induced activation of caspase-3, -8, and -9, and dna fragmentation. |
2007-04-10 |
2023-08-12 |
Not clear |
| Robert T M Boudreau, David M Conrad, David W Hoski. Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase. Cellular signalling. vol 19. issue 1. 2007-04-10. PMID:16844342. |
although p38 mapk activation usually promotes apoptosis, pharmacologic inhibition of p38 mapk exacerbated oa-induced dna fragmentation and loss of delta psi(m) in t leukemia cells, suggesting that, in this instance, the p38 mapk signaling pathway promoted cell survival. |
2007-04-10 |
2023-08-12 |
Not clear |
| Abdullah Baysan, Leman Yel, Sastry Gollapudi, Houfen Su, Sudhir Gupt. Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells. International journal of oncology. vol 30. issue 2. 2007-04-09. PMID:17203211. |
as2o3-induced apoptosis is associated with reduced mitochondrial transmembrane potential (delta psi), enhanced generation of intracellular reactive oxygen species (ros), release of cytochrome c and apoptosis-inducing factor (aif) from mitochondria into cytoplasm, activation of caspases, and upregulation of bax and bim expression. |
2007-04-09 |
2023-08-12 |
human |
| Jue Tu, Hong-Xiang Sun, Yi-Ping Y. 3 Beta-hydroxyolean-12-en-27-oic acid: a cytotoxic, apoptosis-inducing natural drug against COLO-205 cancer cells. Chemistry & biodiversity. vol 3. issue 1. 2007-03-23. PMID:17193218. |
these results indicate that 1 induces efficient cell apoptosis through down-regulating bcl-2 expression, up-regulating bax expression, lowering delta psi(m), and by activating the caspase-3 pathway. |
2007-03-23 |
2023-08-12 |
human |
| Quan-Fang Zheng, Hong-Xiang Sun, Qiao-Jun He, Yi-Ping Y. Induction of apoptosis in HeLa cells by 3beta-hydroxyurs-12-en-27-oic acid. Chemistry & biodiversity. vol 3. issue 7. 2007-03-22. PMID:17193306. |
these results indicate that 1 induces efficient cell apoptosis through down-regulating bcl-2 expression, up-regulating bax expression, lowering delta psi(m), and by activating the caspase-3 pathway. |
2007-03-22 |
2023-08-12 |
human |
| James M Haughian, Twila A Jackson, David M Koterwas, Andrew P Bradfor. Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta. Endocrine-related cancer. vol 13. issue 4. 2007-03-01. PMID:17158769. |
endometrial cancer cell survival and apoptosis is regulated by protein kinase c alpha and delta. |
2007-03-01 |
2023-08-12 |
human |
| James M Haughian, Twila A Jackson, David M Koterwas, Andrew P Bradfor. Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta. Endocrine-related cancer. vol 13. issue 4. 2007-03-01. PMID:17158769. |
to determine the functional roles of pkcalpha and delta in apoptosis in endometrial cancer, ishikawa cells were treated with selective pkc inhibitors or adenoviral constructs encoding wild-type or isoform-specific, dominant-negative mutants. |
2007-03-01 |
2023-08-12 |
human |
| Wellington K Ayensu, Paul B Tchounwo. Microarray analysis of mercury-induced changes in gene expression in human liver carcinoma (HepG2) cells: importance in immune responses. International journal of environmental research and public health. vol 3. issue 2. 2007-02-07. PMID:16823088. |
these genes are categorized as control and regulatory genes for metabolic pathways involving the cell cycle (cyclin-dependent kinases), apoptosis, cytokine expression, na+/k+ atpase, stress responses, g-protein signal transduction, transcription factors, dna repair as well as metal-regulatory transcription factor 1, mtf1 hgnc, chondroitin sulfate proteoglycan 5 (neuroglycan c), atp-binding cassette, sub-family g (white), cytochrome b-561 family protein, cdc-like kinase 1 (clk1 hgnc) (protein tyrosine kinase sty), na+/h+ exchanger regulatory factor (nherf hgnc), potassium voltage-gated channel subfamily h member 2 (kcnh2), putative mapk activating protein (pm20, pm21), ras homolog gene family, polymerase (dna directed), delta regulatory subunit (50 kda), leptin receptor involved in hematopoietin/interferon-class (d200- domain) cytokine receptor activity and thymidine kinase 2, mitochondrial tk2 hgnc and related genes. |
2007-02-07 |
2023-08-12 |
human |
| Wen Tang, Jian-Wen Liu, Wei-Ming Zhao, Dong-Zhi Wei, Jian-Jiang Zhon. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life sciences. vol 80. issue 3. 2007-02-02. PMID:17007887. |
moreover, reduction of mitochondria membrane potential (delta psi(m)) and release of cytochrome c were observed during the induced apoptosis. |
2007-02-02 |
2023-08-12 |
mouse |
| Leonid A Sitailo, Shalini S Tibudan, Mitchell F Dennin. The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis. The Journal of biological chemistry. vol 281. issue 40. 2006-11-30. PMID:16901898. |
the protein kinase c delta catalytic fragment targets mcl-1 for degradation to trigger apoptosis. |
2006-11-30 |
2023-08-12 |
Not clear |
| Leonid A Sitailo, Shalini S Tibudan, Mitchell F Dennin. The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis. The Journal of biological chemistry. vol 281. issue 40. 2006-11-30. PMID:16901898. |
proteolytic cleavage and subsequent activation of protein kinase c (pkc) delta is required for apoptosis induced by a variety of genotoxic agent, including uv radiation. |
2006-11-30 |
2023-08-12 |
Not clear |
| Meenakshi Tiwari, Ashok Kumar, Rohit Anthony Sinha, Ashutosh Shrivastava, Anil Kumar Balapure, Ramesh Sharma, Virendra Kumar Bajpai, Kalyan Mitra, Satish Babu, Madan Madhav Godbol. Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress. Carcinogenesis. vol 27. issue 10. 2006-11-13. PMID:16675469. |
4-hpr-induced apoptosis is associated with hydroperoxide production and loss of mitochondrial membrane potential (delta psi(m)). |
2006-11-13 |
2023-08-12 |
Not clear |
| Won Ho Kim, June Woo Lee, Bin Gao, Myeong Ho Jun. Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway. Cellular signalling. vol 17. issue 12. 2006-10-04. PMID:15908180. |
using pancreatic beta-cell line min6n8 cells, co-treatment with tnf-alpha and ifn-gamma, but neither cytokine alone, synergistically induced apoptosis, correlated with the activation of the jnk/sapk, which resulted in the production of reactive oxidative species (ros) and loss of mitochondrial transmembrane potential (delta psi m). |
2006-10-04 |
2023-08-12 |
Not clear |
| Won Ho Kim, June Woo Lee, Bin Gao, Myeong Ho Jun. Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway. Cellular signalling. vol 17. issue 12. 2006-10-04. PMID:15908180. |
additionally, cells transfected with wild-type jnk1 became more susceptible to apoptosis induced by tnf-alpha/ifn-gamma through ros production and loss of delta psi m, while cascading apoptotic events were prevented in dominant-negative jnk1-transfected or jnk inhibitor sp600125-treated cells. |
2006-10-04 |
2023-08-12 |
Not clear |
| Han-Jung Chae, Hyung-Ryong Kim, Wan-Goo Lee, Yong-Keun Kwak, Woo-Hyun Kim, Seong-Tshool Hong, Gwang-Hyun Cho, Jung-Soo Kim, Soo-Wan Cha. Radiation protects adriamycin-induced apoptosis. Immunopharmacology and immunotoxicology. vol 27. issue 2. 2006-09-28. PMID:16114506. |
this study shows that irradiation inhibited apoptosis by enhancing bcl-2, attenuating bax induction, and preventing collapse of mitochondrial membrane potential (delta psi), cytochrome c release into cytoplasm and caspase-3, -6 and -9 activations. |
2006-09-28 |
2023-08-12 |
rat |
| María M Caffarel, David Sarrió, José Palacios, Manuel Guzmán, Cristina Sánche. Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer research. vol 66. issue 13. 2006-09-07. PMID:16818634. |
here, we show that delta(9)-tetrahydrocannabinol (thc), through activation of cb(2) cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis. |
2006-09-07 |
2023-08-12 |
human |
| Arkaitz Carracedo, Meritxell Gironella, Mar Lorente, Stephane Garcia, Manuel Guzmán, Guillermo Velasco, Juan L Iovann. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer research. vol 66. issue 13. 2006-09-07. PMID:16818650. |
knockdown experiments using selective small interfering rnas showed the involvement of p8 via its downstream endoplasmic reticulum stress-related targets activating transcription factor 4 (atf-4) and trb3 in delta(9)-tetrahydrocannabinol-induced apoptosis. |
2006-09-07 |
2023-08-12 |
human |
| Matthieu Pesant, Stéphanie Sueur, Patrick Dutartre, Mireille Tallandier, Paul A Grimaldi, Luc Rochette, Jean-Louis Conna. Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis. Cardiovascular research. vol 69. issue 2. 2006-08-18. PMID:16337160. |
peroxisome proliferator-activated receptor delta (ppardelta) activation protects h9c2 cardiomyoblasts from oxidative stress-induced apoptosis. |
2006-08-18 |
2023-08-12 |
Not clear |
| E Domingo-Gil, M Esteba. Role of mitochondria in apoptosis induced by the 2-5A system and mechanisms involved. Apoptosis : an international journal on programmed cell death. vol 11. issue 5. 2006-08-18. PMID:16532271. |
the onset of apoptosis elicits the disruption of mitochondrial membrane potential (delta psi m), as well as the generation of reactive oxygen species (ros). |
2006-08-18 |
2023-08-12 |
human |