| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young Yun Jung, Ninh The Son, Chakrabhavi Dhananjaya Mohan, Jairo Kenupp Bastos, Nguyen Dinh Luyen, Le Mai Huong, Kwang Seok Ah. Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP-1 expression, and the STAT3 pathway. IUBMB life. 2024-05-06. PMID:38708996. |
kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ros production, shp-1 expression, and the stat3 pathway. |
2024-05-06 |
2024-05-08 |
Not clear |
| Hirotaka Fuchizawa, Kiyohiro Ando, Noriko Motoi, Toshihiko Iizuka, Masaharu Inoue, Kouki Mitani, Yuta Sano, Hisanori Takenobu, Masayuki Haruta, Ritsuko Onuki, Yoh Matsuoka, Takehiko Kamijo, Yukio Kageyam. STAT3 Contributes a Favorable Response to Pembrolizumab Through IFN-γ-induced Apoptosis in Urothelial Cancer. Anticancer research. vol 44. issue 5. 2024-04-27. PMID:38677727. |
stat3 contributes a favorable response to pembrolizumab through ifn-γ-induced apoptosis in urothelial cancer. |
2024-04-27 |
2024-04-30 |
Not clear |
| Rokeya Akter, Rackhyun Park, Soo Kyung Lee, Eun Ju Han, Kyu-Sang Park, Junsoo Park, Mee-Yon Ch. Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673975. |
jak2/stat3 inhibition decreased the levels of emr1, jak2, stat1, and stat3, significantly impeded the proliferation, migration, and mobility of cells, and increased the apoptosis of emr1 |
2024-04-27 |
2024-04-29 |
Not clear |
| Juan Liu, Ye Huang, Zhong Li. [Curcumin Combined with Thalidomide Inhibits Proliferation of KG-1 Cells and Its Related Mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 32. issue 2. 2024-04-25. PMID:38660846. |
to investigate the effects of curcumin combined with thalidomide on the proliferation and apoptosis of acute myeloid leukemia kg-1 cells, and its correlation with b-cell lymphoma-xl (bcl-xl), signal transducer and activator of transcription 3 (stat3). |
2024-04-25 |
2024-04-28 |
Not clear |
| Bashir Ahmad, Chuan Tian, Ji-Xin Tang, John Sieh Dumbuya, Wen Li, Jun L. Anticancer activities of natural abietic acid. Frontiers in pharmacology. vol 15. 2024-04-18. PMID:38633616. |
these natural products have complex structures due to which they work against cancer through different molecular pathways, stat3, nf-kb, pi3k/akt/mtor, cell cycle arrest, mitochondrial dependent pathway, extrinsic apoptosis pathway, autophagy, mitophagy and ferroptosis. |
2024-04-18 |
2024-04-20 |
Not clear |
| Xuejiao Li, Hua Peng, Jianshu Kang, Xiaomei Sun, Jian Li. IL-1β induced down-regulation of miR-146a-5p promoted pyroptosis and apoptosis of corneal epithelial cell in dry eye disease through targeting STAT3. BMC ophthalmology. vol 24. issue 1. 2024-03-30. PMID:38553670. |
il-1β induced down-regulation of mir-146a-5p promoted pyroptosis and apoptosis of corneal epithelial cell in dry eye disease through targeting stat3. |
2024-03-30 |
2024-04-01 |
Not clear |
| Jie Zeng, Wei-Wei Gao, Hao Yang, Ya-Nang Wang, Yang Mei, Ting-Ting Liu, Min Wang, Li Tang, Dong-Chuan Ma, Wei L. Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain. European journal of pharmacology. 2024-03-29. PMID:38552937. |
sts pretreatment inhibited lps-stimulated pro-inflammatory cytokine secretion, reduced stat3 pathway related-proteins and apoptosis, increased mir-125b-5p and proopiomelanocortin expression, and enhanced microglia transformation from m1 to m2 phenotype in bv-2 cells. |
2024-03-29 |
2024-04-01 |
rat |
| Xiaofan Gu, Shanshan Lu, Meng Fan, Shuang Xu, Guangyu Lin, Yun Zhao, Weili Zhao, Xuan Liu, Xiaochun Dong, Xiongwen Zhan. Compound Z526 alleviates chemotherapy-induced cachectic muscle loss by ameliorating oxidative stress-driven protein metabolic imbalance and apoptosis. European journal of pharmacology. 2024-03-29. PMID:38552940. |
the pharmacological effects of z526 were based on its potency in reducing oxidative stress in cachectic myocytes and muscle tissues, which inhibited the activation of nf-κb and stat3 to decrease atrogin-1-mediated protein degradation, activated the akt/mtor signaling pathway to promote protein synthesis, regulated bcl-2/bax ratio to reduce caspase-3-triggered apoptosis. |
2024-03-29 |
2024-04-01 |
mouse |
| Anqi Fan, Mengxiang Gao, Xuhuan Tang, Mengya Jiao, Chenchen Wang, Yingying Wei, Quan Gong, Jixin Zhon. HMGB1/RAGE axis in tumor development: unraveling its significance. Frontiers in oncology. vol 14. 2024-03-26. PMID:38529373. |
this axis is instrumental in tumor progression, promoting tumor cell proliferation, autophagy, metastasis, and angiogenesis while inhibiting apoptosis, through pivotal signaling pathways, including mapk, nf-κb, pi3k/akt, erk, and stat3. |
2024-03-26 |
2024-03-28 |
Not clear |
| Jiang Cao, Xiao Yu, Jingcheng Liu, Jiaju Fu, Binyu Wang, Chaoqin Wu, Sheng Zhang, Hongtao Chen, Zi Wang, Yinyang Xu, Tao Sui, Jie Chang, Xiaojian Ca. Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury. Neural regeneration research. vol 19. issue 11. 2024-03-25. PMID:38526286. |
additionally, in glutamate-induced excitotoxicity astrocytes, ruxolitinib restored eaat2 expression and increased glutamate uptake by inhibiting the activation of stat3, thereby reducing glutamate-induced neurotoxicity, calcium influx, oxidative stress, and cell apoptosis, and increasing the complexity of dendritic branching. |
2024-03-25 |
2024-03-27 |
mouse |
| Zhipan Liang, Qiuyun Chen, Liuying Pan, Xiaowei She, Tengfei Che. Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer. Journal of thoracic disease. vol 16. issue 2. 2024-03-20. PMID:38505087. |
mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated stat3 signaling downregulation in non-small cell lung cancer. |
2024-03-20 |
2024-03-23 |
Not clear |
| Saleh A Almatroodi, Ahmad Almatroudi, Hajed Obaid A Alharbi, Amjad Ali Khan, Arshad Husain Rahman. Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules. Molecules (Basel, Switzerland). vol 29. issue 5. 2024-03-13. PMID:38474604. |
the studies have confirmed that luteolin can inhibit cancer-cell survival and proliferation, angiogenesis, invasion, metastasis, mtor/pi3k/akt, stat3, wnt/β-catenin, and cell-cycle arrest, and induce apoptosis. |
2024-03-13 |
2024-03-15 |
Not clear |
| Min-Yung Kuo, Wen-Chyi Dai, Jie-Li Chang, Jo-Shu Chang, Tse-Min Lee, Chia-Che Chan. Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL-xL signaling axis. Environmental toxicology. 2024-03-06. PMID:38444163. |
notably, ectopic expression of stat3-c, a dominant-active stat3 mutant, abolished fucoxanthin-elicited melanoma cell apoptosis and clonogenicity inhibition, supporting the pivotal role of stat3 blockage in fucoxanthin's melanoma cytotoxicity. |
2024-03-06 |
2024-03-08 |
human |
| Ying Fu, Yu Xiang, Jie Zha, Guochun Chen, Zheng Don. Enhanced STAT3/PIK3R1/mTOR Signaling Triggers Tubular Cell Inflammation and Apoptosis in Septic-Induced Acute Kidney Injury: Implications for Therapeutic Intervention. Clinical science (London, England : 1979). 2024-02-27. PMID:38411015. |
in these models, renal inflammation and tubular cell apoptosis were accompanied by the aberrant activation of the mechanistic target of rapamycin (mtor) and the signal transducer and activator of transcription 3 (stat3) signaling pathways. |
2024-02-27 |
2024-03-02 |
mouse |
| Ying Fu, Yu Xiang, Jie Zha, Guochun Chen, Zheng Don. Enhanced STAT3/PIK3R1/mTOR Signaling Triggers Tubular Cell Inflammation and Apoptosis in Septic-Induced Acute Kidney Injury: Implications for Therapeutic Intervention. Clinical science (London, England : 1979). 2024-02-27. PMID:38411015. |
pharmacological inhibition of either mtor or stat3 significantly improved renal function and reduced apoptosis and inflammation. |
2024-02-27 |
2024-03-02 |
mouse |
| Fan Cao, Mengru Li, Weijie Wang, Yi Yi, Ying Chen, Hongrui Li. A coumarin-furoxan hybrid as novel nitric oxide donor induced cell apoptosis and ferroptosis in NSCLC by promoting S-nitrosylation of STAT3 and negative regulation of JAK2-STAT3 pathway. Biochemical pharmacology. 2024-02-22. PMID:38387529. |
a coumarin-furoxan hybrid as novel nitric oxide donor induced cell apoptosis and ferroptosis in nsclc by promoting s-nitrosylation of stat3 and negative regulation of jak2-stat3 pathway. |
2024-02-22 |
2024-02-25 |
Not clear |
| Fan Cao, Mengru Li, Weijie Wang, Yi Yi, Ying Chen, Hongrui Li. A coumarin-furoxan hybrid as novel nitric oxide donor induced cell apoptosis and ferroptosis in NSCLC by promoting S-nitrosylation of STAT3 and negative regulation of JAK2-STAT3 pathway. Biochemical pharmacology. 2024-02-22. PMID:38387529. |
moreover, compound 9 inhibits jak2/stat3 protein phosphorylation and induces s-nitrosylation modification of stat3, ultimately resulting in endogenous apoptosis in nsclc. |
2024-02-22 |
2024-02-25 |
Not clear |
| Yiquan Wu, Victoria Wang, Robert Yarchoa. Pacritinib inhibits proliferation of primary effusion lymphoma cells and production of viral interleukin-6 induced cytokines. Scientific reports. vol 14. issue 1. 2024-02-20. PMID:38374336. |
pacritinib induced apoptosis in pel cells and inhibited stat3 and nf-κb activity as evidenced by reduced amount of phosphorylated moieties. |
2024-02-20 |
2024-02-22 |
human |
| Q Ye, L Ren, Z M Jiang, X Y Li, G Y Wei, Y F Ren, L H Re. Cryptanshinone extract of Salvia miltiorrhiza stimulates pediatric acute myeloid leukemia stem cell apoptosis and the anti-inflammatory mechanism via accelerating microRNA-211-5p to supress Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway activation. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 6. 2024-02-13. PMID:38345448. |
this study was designed to explore cryptanshinone (cpt) extract of salvia miltiorrhiza stimulating pediatric acute myeloid leukemia (aml) stem cell (lsc) apoptosis and anti-inflammatory mechanism via accelerating microrna (mir)-211-5p to restrain janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway activation. |
2024-02-13 |
2024-02-15 |
human |
| Ruyue Yang, Wenhui Yue, Dong Hu, Guidan Wang, Longfei Mao, Jiahe Huang, Huili Wang, Gaofeng Lian. Synthesis of compounds based on the active domain of cabotegravir and their application in inhibiting tumor cells activity. ChemistryOpen. 2024-02-05. PMID:38315083. |
we further demonstrated these derivatives induce cell apoptosis in kyse30 cells by inhibiting the expression of stat3 protein and smad2/3 protein. |
2024-02-05 |
2024-02-09 |
Not clear |