| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karsten Spiekermann, Michael Pau, Ruth Schwab, Karin Schmieja, Sabine Franzrahe, Wolfgang Hiddeman. Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells. Experimental hematology. vol 30. issue 3. 2002-05-03. PMID:11882364. |
in hematopoietic and epithelial cells, activation of stat 1 induces apoptosis and growth arrest, whereas activation of stat3 and stat5 transduces growth-promoting signals. |
2002-05-03 |
2023-08-12 |
Not clear |
| J Wan, J Wang, H Cheng, Y Yu, G Xing, Z Oiu, X Qian, F H. Proteomic analysis of apoptosis initiation induced by all-trans retinoic acid in human acute promyelocytic leukemia cells. Electrophoresis. vol 22. issue 14. 2002-04-08. PMID:11565797. |
also at that time point, the positive regulators of apoptosis such as stat3 increased at protein level, whereas negative regulators (bcl-2 and p-stat3) decreased. |
2002-04-08 |
2023-08-12 |
human |
| M M Oshiro, T H Landowski, R Catlett-Falcone, L A Hazlehurst, M Huang, R Jove, W S Dalto. Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 7. issue 12. 2002-03-27. PMID:11751528. |
inhibition of this pathway by the jak selective kinase inhibitor ag490 or dominant-negative stat3 protein results in down-regulation of bcl-x(l) expression and enhanced sensitivity to fas-mediated apoptosis. |
2002-03-27 |
2023-08-12 |
human |
| Jiayuh Lin, Xiaohong Jin, Kori Rothman, Huey-Jen Lin, Huaijing Tang, William Burk. Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells. Cancer research. vol 62. issue 2. 2002-02-15. PMID:11809683. |
wt p53 also induced significant apoptosis in breast cancer cell lines that express constitutively active stat3. |
2002-02-15 |
2023-08-12 |
human |
| A Rebbaa, P M Chou, B L Mirki. Factors secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and inhibiting apoptosis. Molecular medicine (Cambridge, Mass.). vol 7. issue 6. 2002-02-01. PMID:11474132. |
factors secreted by human neuroblastoma mediated doxorubicin resistance by activating stat3 and inhibiting apoptosis. |
2002-02-01 |
2023-08-12 |
human |
| A Rebbaa, P M Chou, B L Mirki. Factors secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and inhibiting apoptosis. Molecular medicine (Cambridge, Mass.). vol 7. issue 6. 2002-02-01. PMID:11474132. |
the transcription factor stat3 has been reported to play a key role in protecting cells against apoptosis by up-regulating expression of the anti-apoptotic gene bcl-xl. |
2002-02-01 |
2023-08-12 |
human |
| A Rebbaa, P M Chou, B L Mirki. Factors secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and inhibiting apoptosis. Molecular medicine (Cambridge, Mass.). vol 7. issue 6. 2002-02-01. PMID:11474132. |
this investigation analyzes the relationship between the development of resistance to doxorubicin-mediated apoptosis in neuroblastoma cells (skn-sh) and activation of the stat3 signaling pathway. |
2002-02-01 |
2023-08-12 |
human |
| W M Burke, X Jin, H J Lin, M Huang, R Liu, R K Reynolds, J Li. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene. vol 20. issue 55. 2002-01-10. PMID:11753675. |
further, ag490 induced significant apoptosis in ovarian and breast cancer cell lines expressing high levels of constitutively active stat3 but had a less profound effect on normal cells lacking constitutively active stat3. |
2002-01-10 |
2023-08-12 |
mouse |
| C J Watso. Stat transcription factors in mammary gland development and tumorigenesis. Journal of mammary gland biology and neoplasia. vol 6. issue 1. 2001-12-20. PMID:11467447. |
in contrast, stat3 is an essential mediator of apoptosis and post-lactational regression. |
2001-12-20 |
2023-08-12 |
mouse |
| M Narimatsu, H Maeda, S Itoh, T Atsumi, T Ohtani, K Nishida, M Itoh, D Kamimura, S J Park, K Mizuno, J Miyazaki, M Hibi, K Ishihara, K Nakajima, T Hiran. Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells. Molecular and cellular biology. vol 21. issue 19. 2001-09-27. PMID:11533249. |
t lymphocytes from the stat3(msbe/msbe) mice were more susceptible to apoptosis despite the presence of il-6 than those from wild-type mice. |
2001-09-27 |
2023-08-12 |
mouse |
| V N Ivanov, A Bhoumik, M Krasilnikov, R Raz, L B Owen-Schaub, D Levy, C M Horvath, Z Rona. Cooperation between STAT3 and c-jun suppresses Fas transcription. Molecular cell. vol 7. issue 3. 2001-08-30. PMID:11463377. |
the expression of dominant negative stat3 or c-jun in melanoma cells efficiently increased fas expression and sensitized cells to fasl-induced apoptosis. |
2001-08-30 |
2023-08-12 |
mouse |
| B Groner, L Hennighause. Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium. Breast cancer research : BCR. vol 2. issue 3. 2001-08-02. PMID:11250703. |
stat3 activation seems to be a driving force in the induction of apoptosis early in the involution period. |
2001-08-02 |
2023-08-12 |
mouse |
| J Turkson, R Jov. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene. vol 19. issue 56. 2001-07-26. PMID:11426647. |
block of constitutive stat3 signaling results in growth inhibition and apoptosis of stat3-positive tumor cells in vitro and in vivo. |
2001-07-26 |
2023-08-12 |
human |
| R Garcia, T L Bowman, G Niu, H Yu, S Minton, C A Muro-Cacho, C E Cox, R Falcone, R Fairclough, S Parsons, A Laudano, A Gazit, A Levitzki, A Kraker, R Jov. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene. vol 20. issue 20. 2001-07-05. PMID:11420660. |
in addition, transfection of a dominant-negative form of stat3 leads to growth inhibition involving apoptosis of breast cancer cells. |
2001-07-05 |
2023-08-12 |
human |
| J Zhang, B Shen, Y Li, Y Su. STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells. Leukemia research. vol 25. issue 6. 2001-06-28. PMID:11337018. |
interleukin-6 (il-6), a pleiotropic cytokine, induces a robust and sustained activation of stat3 in m1 acute myeloid leukemia cells, which in turn undergo growth arrest, terminal differentiation and apoptosis in response to il-6. |
2001-06-28 |
2023-08-12 |
Not clear |
| J Zhang, B Shen, Y Li, Y Su. STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells. Leukemia research. vol 25. issue 6. 2001-06-28. PMID:11337018. |
on the other hand, stat3 antisense cdna augmented il-6-induced apoptosis of m1 cells, which was supported by the cell cycle assay, dna fragmentation assay and detection of the p17 active fragment of caspase 3. |
2001-06-28 |
2023-08-12 |
Not clear |
| H Yoshikawa, K Matsubara, G S Qian, P Jackson, J D Groopman, J E Manning, C C Harris, J G Herma. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nature genetics. vol 28. issue 1. 2001-05-31. PMID:11326271. |
this growth suppression was caused by apoptosis and was reproduced by ag490, a specific, chemical jak2 inhibitor that reversed constitutive phosphorylation of stat3 in socs-1 inactivated cells. |
2001-05-31 |
2023-08-12 |
human |
| K W Eriksen, K Kaltoft, G Mikkelsen, M Nielsen, Q Zhang, C Geisler, M H Nissen, C Röpke, M A Wasik, N Odu. Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Leukemia. vol 15. issue 5. 2001-05-31. PMID:11368440. |
we show that (1) stat3 (a transcription factor known to regulate il-2ralpha transcription) is constitutively tyrosine-phosphorylated in ss tumor cells, but not in non-malignant t cells; (2) stat3 binds constitutively to a stat-binding sequence in the promotor of the il-2ralpha gene; (3) the janus kinase inhibitor, tyrphostine ag490, inhibits stat3 activation, stat3 dna binding, and il-2ralpha mrna and protein expression in parallel; and (4) tyrphostine ag490 inhibits il-2 driven mitogenesis and triggers apoptosis in ss tumor cells. |
2001-05-31 |
2023-08-12 |
Not clear |
| G Niu, K H Shain, M Huang, R Ravi, A Bedi, W S Dalton, R Jove, H Y. Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest. Cancer research. vol 61. issue 8. 2001-05-10. PMID:11309279. |
here, we provide evidence that blocking stat3 signaling in b16 cells results in release of soluble factors that are capable of inducing apoptosis and cell cycle arrest of nontransfected b16 cells. |
2001-05-10 |
2023-08-12 |
Not clear |
| Y Shen, G Devgan, J E Darnell, J F Bromber. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11171987. |
constitutively activated stat3 protects fibroblasts from serum withdrawal and uv-induced apoptosis and antagonizes the proapoptotic effects of activated stat1. |
2001-04-19 |
2023-08-12 |
Not clear |