| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Po-Fu Yueh, Yuan-Hao Lee, Chun-Yu Fu, Chun-Bin Tung, Fei-Ting Hsu, Keng-Li La. Magnolol Induces the Extrinsic/Intrinsic Apoptosis Pathways and Inhibits STAT3 Signaling-Mediated Invasion of Glioblastoma Cells. Life (Basel, Switzerland). vol 11. issue 12. 2021-12-24. PMID:34947930. |
magnolol induces the extrinsic/intrinsic apoptosis pathways and inhibits stat3 signaling-mediated invasion of glioblastoma cells. |
2021-12-24 |
2023-08-13 |
Not clear |
| Yong Xia, Xing Wang, Yan Liu, Ellen Shapiro, Herbert Lepor, Moon-Shong Tang, Tung-Tien Sun, Xue-Ru W. PKM2 is essential for bladder cancer growth and maintenance. Cancer research. 2021-12-14. PMID:34903602. |
the reduction in nuclear stat3 in the absence of pkm2 also correlated with decreased autophagy and increased apoptosis. |
2021-12-14 |
2023-08-13 |
mouse |
| Zhaoyan Lin, Qingqing Li, Ying Zhao, Zixiang Lin, Nan Cheng, Di Zhang, Gang Liu, Jiahao Lin, Hong Zhang, Degui Li. Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer. Frontiers in oncology. vol 11. 2021-12-13. PMID:34900688. |
the results showed that af and icg-001 synergistically depressed the growth and invasion of human colon cancer cells by inhibiting the phosphorylation of signal transducer and activator of transcription 3 (stat3) and its downstream mediator b-cell lymphoma-2-like 1 (bcl-xl) and inducing caspase-3-dependent apoptosis. |
2021-12-13 |
2023-08-13 |
mouse |
| Hongwu Meng, Ruowen Niu, Hongmei You, Ling Wang, Rui Feng, Cheng Huang, Jun L. Interleukin-9 attenuates inflammatory response and hepatocyte apoptosis in alcoholic liver injury. Life sciences. vol 288. 2021-12-11. PMID:34843736. |
furthermore, macrophage-derived il-9 can reduce hepatocyte apoptosis by inhibiting the activation of the stat3 pathway. |
2021-12-11 |
2023-08-13 |
mouse |
| Zunwei Liu, Bo Wang, Qihang Gu. MiR-26b-5p-modified hUB-MSCs derived exosomes attenuate early brain injury during subarachnoid hemorrhage via MAT2A-mediated the p38 MAPK/STAT3 signaling pathway. Brain research bulletin. vol 175. 2021-12-10. PMID:34284075. |
oxyhb treated pc cells incubated with exosomes were transfected with mir-26b-5p inhibitor alone or together with si-mat2a, respectively, and it was observed that exosomes decreased the phosphorylation levels of p38 mapk and stat3 proteins, inhibited cell apoptosis and inflammatory mediator expression, and mir-26b-5p inhibitor abrogated the effects of exosomes, while transfection of si-mat2a reversed the effects of mir-26b-5p inhibitor. |
2021-12-10 |
2023-08-13 |
human |
| Yiwen Huang, Yuanyuan Wang, Xiaobin Liu, Yingjun Ouyan. Silencing lncRNA HOTAIR improves the recovery of neurological function in ischemic stroke via the miR-148a-3p/KLF6 axis. Brain research bulletin. vol 176. 2021-12-10. PMID:34391823. |
to summarize, this study demonstrated that lncrna hotair absorbed mir-148a-3p and up-regulated klf6 expression through cerna mechanism, and inhibited stat3 pathway, promoted apoptosis and inflammation, and aggravated neurological injury post-is. |
2021-12-10 |
2023-08-13 |
Not clear |
| Shenglin Wang, Yunqing Wang, Zhen Huang, Hongxiang Wei, Xinwen Wang, Rongkai Shen, Wenbin Lan, Guangxian Zhong, Jianhua Li. Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway. Acta biochimica et biophysica Sinica. vol 53. issue 12. 2021-12-10. PMID:34693451. |
combined treatment with gefitinib and stattic, an inhibitor for stat3 phosphorylation, engenders more evident inhibitory effects on cell proliferation, migration, and invasion and promotive effects on cell apoptosis and g1 phase arrest in os, compared with the single exposure to gefitinib or stattic. |
2021-12-10 |
2023-08-13 |
Not clear |
| Chunliu Mi, Xiangxiang Cao, Kai Ma, Mian Wei, Wenjing Xu, Yan Lin, Jihong Zhang, Tian-Yun Wan. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34717917. |
digitoxin promotes apoptosis and inhibits proliferation and migration by reducing hif-1α and stat3 in kras mutant human colon cancer cells. |
2021-12-10 |
2023-08-13 |
mouse |
| Chunliu Mi, Xiangxiang Cao, Kai Ma, Mian Wei, Wenjing Xu, Yan Lin, Jihong Zhang, Tian-Yun Wan. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34717917. |
moreover, digitoxin promoted apoptosis and inhibited proliferation and migration, which was potentially mediated by suppression of hif-1α and stat3. |
2021-12-10 |
2023-08-13 |
mouse |
| Wei Han, Desong Kong, Qin Lu, Wei Zhang, Zhimin Fa. Aloperine inhibits colorectal cancer cell proliferation and metastasis progress via regulating miR-296-5p/STAT3 axis. Tissue & cell. vol 74. 2021-12-09. PMID:34883316. |
up-regulation of mir-296-5p and alo treatment both suppressed stat3 expression, inhibited crc cell proliferation, migration, invasion as well as the expressions of bcl-2 and n-cadherin, but promoted apoptosis and expressions of bax and e-cadherin, which were all reversed by overexpressed stat3. |
2021-12-09 |
2023-08-13 |
Not clear |
| Lihong Yang, Xuehui Y. Naturally occurring Girinimbine alkaloid inhibits the proliferation, migration, and invasion of human breast cancer cells via induction of apoptosis and inhibition of MEK/ERK and STAT3 signalling pathways. Acta biochimica Polonica. vol 68. issue 4. 2021-12-07. PMID:34472799. |
naturally occurring girinimbine alkaloid inhibits the proliferation, migration, and invasion of human breast cancer cells via induction of apoptosis and inhibition of mek/erk and stat3 signalling pathways. |
2021-12-07 |
2023-08-13 |
human |
| Zixin Hou, Ji Chen, Huan Yang, Xiaoling Hu, Fengrui Yan. PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3. Cell death discovery. vol 7. issue 1. 2021-12-03. PMID:34857740. |
furthermore, mir-124 targeted and inversely modulated ezh2 and stat3, promoting the autophagy of schwann cells and inhibiting their apoptosis. |
2021-12-03 |
2023-08-13 |
mouse |
| Sony Maharjan, Mijeong Kang, Jinsoo Kim, Dongbum Kim, Sangkyu Park, Minyoung Kim, Kyeongbin Baek, Younghee Lee, Hyung-Joo Kwo. Apoptosis Enhances the Replication of Human Coronavirus OC43. Viruses. vol 13. issue 11. 2021-12-01. PMID:34835005. |
dephosphorylation of stat1 and stat3, induced by hcov-oc43 infection, was also associated with hcov-oc43-mediated apoptosis. |
2021-12-01 |
2023-08-13 |
human |
| Ming-Jie Yuan, Tao Wan. Advances of the interleukin-21 signaling pathway in immunity and angiogenesis. Biomedical reports. vol 5. issue 1. 2021-11-30. PMID:27330746. |
il-21-mediated human b cell and dendritic cells differentiation requires signal transducer and activator of transcription 3 (stat3), and also induces b-cell apoptosis dependents on the toll-like receptor signal. |
2021-11-30 |
2023-08-13 |
human |
| Chengwu Tang, Wenming Feng, Ying Bao, Huimin D. Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP). Bioengineered. vol 12. issue 1. 2021-11-30. PMID:34057016. |
additionally, Δ1-360 tincr overexpression did not affect hcc cell growth, apoptosis, migration, infiltration, and stat3 target genes expression. |
2021-11-30 |
2023-08-13 |
human |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
stat3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
using a streptozotocin-induced type 1 dm model, we showed enhanced hippocampal neuronal apoptosis that was associated with increased stat3 activation. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also demonstrated that stat3 activation in microglia increased tumor necrosis factor-α (tnf-α) expression; subsequently, tnf-α increased neuronal apoptosis by increasing reactive oxygen species (ros) levels in the neuronal cells. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also took advantage of mice lacking stat3 in microglia and demonstrated that depletion of microglial stat3 reduced neuronal apoptosis in the diabetic hippocampus. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
taken together, these results suggest that stat3 activation in microglia plays an important role in hyperglycemia-induced neuronal apoptosis in the diabetic hippocampus and provide a potential therapeutic benefit of stat3 inhibition in microglia for preventing diabetic neuronal lesions. |
2021-11-29 |
2023-08-13 |
mouse |