| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yinan Wang, Chuanhe Yang, Michelle M Sims, Joshua R Sacher, Mithun Raje, Hemantkumar Deokar, Peibin Yue, James Turkson, John K Buolamwini, Lawrence M Pfeffe. SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. Cancer letters. 2022-03-04. PMID:35245627. |
ss-4 strongly and selectively inhibited stat3 tyrosine (y)-705 phosphorylation in mt330 and ln229 gbm cells and inhibited their proliferation and induced apoptosis with an ic |
2022-03-04 |
2023-08-13 |
Not clear |
| Naohiro Yanagimura, Shinji Takeuchi, Koji Fukuda, Sachiko Arai, Azusa Tanimoto, Akihiro Nishiyama, Naohisa Ogo, Hiroyuki Takahashi, Akira Asai, Satoshi Watanabe, Toshiaki Kikuchi, Seiji Yan. STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis. NPJ precision oncology. vol 6. issue 1. 2022-03-01. PMID:35228642. |
stat3 inhibition suppresses adaptive survival of alk-rearranged lung cancer cells through transcriptional modulation of apoptosis. |
2022-03-01 |
2023-08-13 |
Not clear |
| Naohiro Yanagimura, Shinji Takeuchi, Koji Fukuda, Sachiko Arai, Azusa Tanimoto, Akihiro Nishiyama, Naohisa Ogo, Hiroyuki Takahashi, Akira Asai, Satoshi Watanabe, Toshiaki Kikuchi, Seiji Yan. STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis. NPJ precision oncology. vol 6. issue 1. 2022-03-01. PMID:35228642. |
stat3 inhibition effectively suppressed the adaptive survival of alk-rearranged lung cancer cells by enhancing alk inhibition-induced apoptosis. |
2022-03-01 |
2023-08-13 |
Not clear |
| Jixiu Wang, Qianhui Sun, Guowen Wang, Huanling Wang, Hong Li. The effects of blunt snout bream (Megalobrama amblycephala) IL-6 trans-signaling on immunity and iron metabolism via JAK/STAT3 pathway. Developmental and comparative immunology. 2022-02-26. PMID:35217123. |
the enrichment analysis of go and kegg showed that mail-6 trans-signaling is mainly involved in stress and inflammation response, and the activation of stat3 is mainly related to cell proliferation, apoptosis and immune regulation. |
2022-02-26 |
2023-08-13 |
Not clear |
| Wenbo Shao, Cunxin Zhang, Kang Li, Ziang Lu, Zihao Zhao, Kai Gao, Chaoliang L. Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury. Brain research. 2022-02-24. PMID:35202619. |
wogonin inhibits inflammation and apoptosis through stat3 signal pathway to promote the recovery of spinal cord injury. |
2022-02-24 |
2023-08-13 |
rat |
| Wenbo Shao, Cunxin Zhang, Kang Li, Ziang Lu, Zihao Zhao, Kai Gao, Chaoliang L. Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury. Brain research. 2022-02-24. PMID:35202619. |
western blot, tunel staining, and immunofluorescence were used to detect changes in the neuronal inflammation, apoptosis, and stat3 signal pathway. |
2022-02-24 |
2023-08-13 |
rat |
| Wenbo Shao, Cunxin Zhang, Kang Li, Ziang Lu, Zihao Zhao, Kai Gao, Chaoliang L. Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury. Brain research. 2022-02-24. PMID:35202619. |
experimental results in vivo and in vitro showed that wogonin could promote the recovery of motor function, improve the histopathological morphology, inhibit the activation of the stat3 signal pathway, and reduce the neuronal inflammation and apoptosis in the rats with sci. |
2022-02-24 |
2023-08-13 |
rat |
| Wenbo Shao, Cunxin Zhang, Kang Li, Ziang Lu, Zihao Zhao, Kai Gao, Chaoliang L. Wogonin inhibits inflammation and apoptosis through STAT3 signal pathway to promote the recovery of spinal cord injury. Brain research. 2022-02-24. PMID:35202619. |
therefore, wogonin could inhibit inflammation and apoptosis by inhibiting the stat3 signal pathway and promote the functional recovery of rats with sci. |
2022-02-24 |
2023-08-13 |
rat |
| Tao Zhao, Nan Hu, Xiaojuan Yu, Tao S. Case Report: Endocapillary Glomerulopathy Associated With Large Granular T Lymphocyte Leukemia. Frontiers in immunology. vol 12. 2022-02-11. PMID:35145513. |
the clonal proliferation of t cells, which is related to stat3 gene mutation and abnormal fas-mediated apoptosis pathway after cell activation, plays a major role in disease progression. |
2022-02-11 |
2023-08-13 |
Not clear |
| You-Shan Tsai, Yen-Po Chen, Shih-Wei Lin, Yen-Lien Chen, Chin-Chu Chen, Guan-Jhong Huan. Lactobacillus rhamnosus GKLC1 ameliorates cisplatin-induced chronic nephrotoxicity by inhibiting cell inflammation and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 147. 2022-02-08. PMID:35131657. |
an llc-pk1 kidney cell assay revealed that l. rhamnosus gklc1 suppressed the nephrotoxicity of cisplatin by reducing the inflammation via the mapks/nf-ĸb/cox-2 pathway, inhibiting apoptosis via the p53/bax/caspase-3 pathway, and ameliorating fibrosis via the stat3 pathway. |
2022-02-08 |
2023-08-13 |
mouse |
| Gaopan Dong, Xiaohan Ye, Shumei Wang, Wenhua Li, Rong Cai, Lupei Du, Xiaodong Shi, Minyong L. Au-24 as a Potential Thioredoxin Reductase Inhibitor in Hepatocellular Carcinoma Cells. Pharmacological research. 2022-02-06. PMID:35124208. |
this compound can also affect the normal function of apoptosis, mapk, pi3k/akt/mtor, nf-κb, stat3 signaling pathways. |
2022-02-06 |
2023-08-13 |
Not clear |
| Jun Han, Jie Kan, Xinguo Wang, Qingling Yuan, Xiaoyan Song, Min Huang, Hao W. Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation. Translational cancer research. vol 9. issue 8. 2022-02-04. PMID:35117835. |
polyphyllin i suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation. |
2022-02-04 |
2023-08-13 |
Not clear |
| Yang Liu, Ying-Hua Luo, Shu-Mei Li, Gui-Nan Shen, Jia-Ru Wang, Yi Zhang, Yu-Chao Feng, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Hong-Xing Wang, Yang Cui, Ying Wang, Cheng-Hao Ji. 2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells. Drug and chemical toxicology. vol 45. issue 1. 2022-02-01. PMID:35100937. |
2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ros-mediated mapk, akt, and stat3 signaling pathways in hepg2 human hepatocellular carcinoma cells. |
2022-02-01 |
2023-08-13 |
human |
| Yang Liu, Ying-Hua Luo, Shu-Mei Li, Gui-Nan Shen, Jia-Ru Wang, Yi Zhang, Yu-Chao Feng, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Hong-Xing Wang, Yang Cui, Ying Wang, Cheng-Hao Ji. 2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells. Drug and chemical toxicology. vol 45. issue 1. 2022-02-01. PMID:35100937. |
taken together, these findings suggest that ntdmnq induces apoptosis via ros-mediated mapk, akt and stat3 signaling pathways in hepg2 cells, and may be a potent anticancer agent. |
2022-02-01 |
2023-08-13 |
human |
| Anna Markowska, Joanna Stanislawiak-Rudowicz, Tomasz Kasprzak, Janina Markowska, Monika Szarszewsk. Metformin in selected malignancies in women. Ginekologia polska. 2022-01-24. PMID:35072253. |
the mechanism of the antitumor action of metformin is pleiotropic and involves several signalling pathways, including ampk/mtor (mitogen activated protein kinase/mammalian target rapamycin), stat3 (signal transducer and activator of transcription) and numerous factors: nf-kb (nuclear factor kappa), hif-1 alpha (hypoxia inducible factor 1), igf-1 (insulin-like growth factor-1), which affect cell proliferation and apoptosis. |
2022-01-24 |
2023-08-13 |
Not clear |
| Targeting STAT3 induces apoptosis and suppresses cell growth and invasion by inactivation of Slug signaling in retinoblastoma [Retraction]. International journal of clinical and experimental pathology. vol 14. issue 12. 2022-01-14. PMID:35028000. |
targeting stat3 induces apoptosis and suppresses cell growth and invasion by inactivation of slug signaling in retinoblastoma [retraction]. |
2022-01-14 |
2023-08-13 |
Not clear |
| Banumathi, Ankith Sherapura, Vikas H Malojirao, Zabiulla, B S Sharath, Prabhu Thirusangu, Riaz Mahmood, N Suchetha Kumari, Shrinath M Baliga, Shaukath Ara Khanum, B T Prabhaka. Antiproliferative pharmacophore azo-hydrazone analogue BT-1F exerts death signalling pathway targeting STAT3 in solid tumour. Pharmacological reports : PR. 2022-01-10. PMID:35001321. |
the over expression of stat3 in these tumours results in an evasion of apoptosis and thereby pathogenesis. |
2022-01-10 |
2023-08-13 |
Not clear |
| Juan Dong, Changquan Guo, Shuo Zhou, An Zhao, Jian Li, Yuling Mi, Caiqiao Zhan. Leukemia inhibitory factor prevents chicken follicular atresia through PI3K/AKT and Stat3 signaling pathways. Molecular and cellular endocrinology. 2022-01-06. PMID:34990741. |
further investigation revealed that lif inhibited the gc autophagic apoptosis by activating pi3k/akt and stat3 pathways, reflecting an increase of bcl-2 expression but a decrease in becn1. |
2022-01-06 |
2023-08-13 |
chicken |
| Qu Zhang, Xiao-Mei Zhou, Shao-Zhong Wei, Dian-Sheng Cui, Kang-Li Deng, Gai Liang, Yan Luo, Bo Luo, Xin-Jun Lian. STAT3 as a target for sensitizing prostate cancer cells to irradiation. Journal of radiation research. 2021-12-31. PMID:34970978. |
we demonstrated that stat3 blockade with a stat3 inhibitor or sirna increased the radiosensitivity of pca cells and that radiation together with stat3 blockade induced more apoptosis and double-strand breaks (dsbs) than radiation alone in lncap cells. |
2021-12-31 |
2023-08-13 |
human |
| Futoon Abedrabbu Al-Rawashde, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Hamid Ali Nagi Al-Jama. Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 12. 2021-12-30. PMID:34967577. |
the present study aimed to evaluate the effect of tq on the expression of bcr abl, jak2, stat3, stat5a and stat5b genes and their consequences on the cell proliferation and apoptosis in k562 cml cells. |
2021-12-30 |
2023-08-13 |
Not clear |