| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Efthalia Angelopoulou, Yam Nath Paudel, Christina Piper. miR-124 and Parkinson's disease: A biomarker with therapeutic potential. Pharmacological research. vol 150. 2020-08-24. PMID:31707035. |
accumulating pre-clinical evidence shows that mir-124 may act through calpain 1/p25/cyclin-dependent kinases 5 (cdk5), nuclear factor-kappa b (nf-κb), signal transducer and activator of transcription 3 (stat3), bcl-2-interacting mediator of cell death (bim), 5' adenosine monophosphate-activated protein kinase (ampk) and extracellular signal-regulated kinase (erk)-mediated pathways to regulate cell survival, apoptosis, autophagy, mitochondrial dysfunction, oxidative damage and neuroinflammation in pd. |
2020-08-24 |
2023-08-13 |
Not clear |
| Can Zhao, Beibei Zhang, Jing Jiang, Yongliang Wang, Yongquan W. Up-regulation of ANXA1 suppresses polymorphonuclear neutrophil infiltration and myeloperoxidase activity by activating STAT3 signaling pathway in rat models of myocardial ischemia-reperfusion injury. Cellular signalling. vol 62. 2020-08-20. PMID:31132398. |
following this, the anxa1 vector, sirna-anxa1, and stattic (inhibitor of stat3 signaling pathway) were utilized for analyzing the regulatory role of anxa1 in physiological indexes, hemodynamic parameters, inflammatory factors, myocardial infarct size, mpo activity, pmn infiltration, and apoptosis of pmns. |
2020-08-20 |
2023-08-13 |
rat |
| Xiang Lu Ji, Ming H. Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma. Aging. vol 11. issue 15. 2020-08-19. PMID:31422383. |
we found that sc repressed cell viability and migration and induced apoptosis in vitro, while combined sc and erlotinib treatment enhanced osteosarcoma growth suppression by preventing feedback activation of stat3. |
2020-08-19 |
2023-08-13 |
mouse |
| Yunan Liu, Wei Ga. [Interleukin-37 inhibits proliferation, migration and induces apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) by inhibiting STAT3]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 3. 2020-08-13. PMID:32389171. |
[interleukin-37 inhibits proliferation, migration and induces apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (rafls) by inhibiting stat3]. |
2020-08-13 |
2023-08-13 |
Not clear |
| Yunan Liu, Wei Ga. [Interleukin-37 inhibits proliferation, migration and induces apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) by inhibiting STAT3]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 3. 2020-08-13. PMID:32389171. |
conclusion il-37 can inhibit the proliferation and migration of rafls and induces cell apoptosis by inhibiting the stat3 pathway. |
2020-08-13 |
2023-08-13 |
Not clear |
| Issa Tajmohammadi, Jamal Mohammadian, Mehdi Sabzichi, Shiva Mahmuodi, Mina Ramezani, Marjan Aghajani, Fatemeh Ramezan. Identification of Nrf2/STAT3 axis in induction of apoptosis through sub-G Journal of cellular biochemistry. vol 120. issue 8. 2020-08-12. PMID:30993753. |
identification of nrf2/stat3 axis in induction of apoptosis through sub-g we investigated the role of stattic as an adjuvant molecule to increase the cytotoxicity of 5-fluorouracil (5-fu) through specific inhibition of molecular targets, signal transducer and activator of transcription 3 (stat3) and nuclear factor erythroid 2-related factor 2 (nrf2) in ht-29 colon cancer cells. |
2020-08-12 |
2023-08-13 |
Not clear |
| Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Li. Effects of inflammatory responses, apoptosis, and STAT3/NF-κB- and Nrf2-mediated oxidative stress on benign prostatic hyperplasia induced by a high-fat diet. Aging. vol 11. issue 15. 2020-08-10. PMID:31412319. |
this study determined whether or not benign prostatic hyperplasia (bph) induced by a high-fat diet (hfd) is involved in inflammatory responses, apoptosis, and the signal transducer and activator of transcription (stat3)/nuclear factor-kappa b (nf-κb)- and nuclear factor erythroid 2-related factor 2 (nrf2)-mediated oxidative stress pathways. |
2020-08-10 |
2023-08-13 |
rat |
| Yi-Xin Du, Lin-Xin Guo, Han-Song Pan, Yi-Min Liang, Xiang L. Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion. Human cell. vol 33. issue 1. 2020-08-04. PMID:31667786. |
when cotransfected with circ_ankib1 sirna and mir-19b mimics or socs3 sirna, the cell proliferation, apoptosis, and invasion levels did not change significantly, suggesting that circ_ankib1 could affect the stat3 pathway and osteosarcoma cell growth and invasion by enhancing the regulation of mir-19b on the downstream target gene socs3. |
2020-08-04 |
2023-08-13 |
Not clear |
| Chang-Qing Jiang, Ling-Ling Ma, Zhen-Dong Lv, Fan Feng, Zhi Chen, Zu-De Li. Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells. Journal of natural medicines. vol 74. issue 3. 2020-07-27. PMID:32222939. |
polydatin induces apoptosis and autophagy via stat3 signaling in human osteosarcoma mg-63 cells. |
2020-07-27 |
2023-08-13 |
human |
| Chang-Qing Jiang, Ling-Ling Ma, Zhen-Dong Lv, Fan Feng, Zhi Chen, Zu-De Li. Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells. Journal of natural medicines. vol 74. issue 3. 2020-07-27. PMID:32222939. |
in conclusion, these data demonstrated that polydatin induced mg-63 cell death through inducing apoptosis, and autophagy which was mediated via the stat3 signaling. |
2020-07-27 |
2023-08-13 |
human |
| Jong Hyun Lee, Chulwon Kim, Jeong-Hyeon Ko, Young Yun Jung, Sang Hoon Jung, Eunok Kim, Moonkyoo Kong, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Gautam Sethi, Kwang Seok Ah. Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-15. PMID:30520154. |
casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of stat3 signaling cascade. |
2020-07-15 |
2023-08-13 |
human |
| Bin Zhu, Caiping Ren, Ke Du, Hecheng Zhu, Yong Ai, Fenghua Kang, Yi Luo, Weidong Liu, Lei Wang, Yang Xu, Xingjun Jiang, Yihua Zhan. Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31541631. |
in the present study, it was demonstrated that a novel synthesized oa family compound, olean-28,13b-olide 2 (olo-2), synergistically enhanced cisplatin (cddp)-mediated apoptosis, led to the activation of caspase-3 and the generation of reactive oxygen species (ros), induced dna damage, and inhibited the activation of the extracellular-signal-regulated kinase (erk), signal transducer and activator of transcription 3 (stat3), akt and nuclear factor-κb (nf-κb) pathways in human multidrug-resistant a549/cddp lung adenocarcinoma cells. |
2020-07-01 |
2023-08-13 |
human |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
methotrexate significantly induces apoptosis by inhibiting stat3 activation in npm-alk-positive alcl cells. |
2020-07-01 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
in the present study, we found that low-dose methotrexate significantly induced apoptosis in transformed ba/f3 cells expressing npm-alk by inhibiting the activation of signal transducer and activator of transcription factor 3 (stat3), a critical downstream molecule of npm-alk. |
2020-07-01 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
a co-treatment with folinic acid prevented the methotrexate-induced inhibition of stat3 activation and induction of apoptosis, suggesting that methotrexate exerts its cytotoxic effects by depleting tetrahydrofolate (thf) in transformed cells by npm-alk. |
2020-07-01 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
furthermore, methotrexate induced the down-regulation of the anti-apoptotic protein, mcl-1, dna damage, and the activation of a p53 tumor suppressor, leading to apoptosis through the inhibition of stat3. |
2020-07-01 |
2023-08-13 |
Not clear |
| Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Zubair, Khizar Samiullah, Iqra Sarfraz, Muqaddas Masood, Farhat Jabeen, Tayyaba Sultana, Salma Sultan. Eriocalyxin B induces apoptosis in human triple negative breast cancer cells via inhibiting STAT3 activation and mitochondrial dysfunction. Pakistan journal of pharmaceutical sciences. vol 32. issue 6(Supplementary). 2020-07-01. PMID:32024623. |
eriocalyxin b induces apoptosis in human triple negative breast cancer cells via inhibiting stat3 activation and mitochondrial dysfunction. |
2020-07-01 |
2023-08-13 |
human |
| Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Zubair, Khizar Samiullah, Iqra Sarfraz, Muqaddas Masood, Farhat Jabeen, Tayyaba Sultana, Salma Sultan. Eriocalyxin B induces apoptosis in human triple negative breast cancer cells via inhibiting STAT3 activation and mitochondrial dysfunction. Pakistan journal of pharmaceutical sciences. vol 32. issue 6(Supplementary). 2020-07-01. PMID:32024623. |
here, we have probed the molecular mechanism of erib-induced apoptosis in tnbc (mda-mb231) cells to check whether its anticancer activity is mediated by modulation of stat3 and nf-ϰb. |
2020-07-01 |
2023-08-13 |
human |
| Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Zubair, Khizar Samiullah, Iqra Sarfraz, Muqaddas Masood, Farhat Jabeen, Tayyaba Sultana, Salma Sultan. Eriocalyxin B induces apoptosis in human triple negative breast cancer cells via inhibiting STAT3 activation and mitochondrial dysfunction. Pakistan journal of pharmaceutical sciences. vol 32. issue 6(Supplementary). 2020-07-01. PMID:32024623. |
erib induced apoptosis in mda-mb231 cells via inhibiting nf-ϰbp65, stat3 phosphorylation, increasing bax/bcl-2 ratio, mmp dissipation, and activation of caspase-3. |
2020-07-01 |
2023-08-13 |
human |
| Federica Laudisi, Fabio Cherubini, Antonio Di Grazia, Vincenzo Dinallo, Davide Di Fusco, Eleonora Franzè, Angela Ortenzi, Illari Salvatori, Silvia Scaricamazza, Ivan Monteleone, Naoya Sakamoto, Giovanni Monteleone, Carmine Stolf. Progranulin sustains STAT3 hyper-activation and oncogenic function in colorectal cancer cells. Molecular oncology. vol 13. issue 10. 2020-06-29. PMID:31361391. |
progranulin physically interacts with stat3 in crc cells, and its knockdown with a specific antisense oligonucleotide (aso) inhibits stat3 activation and restrains the expression of stat3-related oncogenic proteins, thus causing cell cycle arrest and apoptosis. |
2020-06-29 |
2023-08-13 |
human |