| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyejin Ko, Jong Hyun Lee, Hyun Su Kim, Taewoo Kim, Young Taek Han, Young-Ger Suh, Jaemoo Chun, Yeong Shik Kim, Kwang Seok Ah. Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer. Biomolecules. vol 9. issue 5. 2020-01-30. PMID:31058868. |
moreover, sg-1721 not only inhibited nuclear translocation and dna binding of stat3 but also induced apoptosis, and decreased expression of diverse oncogenic proteins. |
2020-01-30 |
2023-08-13 |
Not clear |
| Haijing Liang, Guifang Wang, Yuanyuan Liu, Guiqiu Zhao, Jiangdong Du, Xue Zha. Targeting STAT3 induces apoptosis and suppresses cell growth and invasion by inactivation of Slug signaling in retinoblastoma. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938117. |
targeting stat3 induces apoptosis and suppresses cell growth and invasion by inactivation of slug signaling in retinoblastoma. |
2020-01-19 |
2023-08-13 |
human |
| Jia-Ru Wang, Ying-Hua Luo, Xian-Ji Piao, Yi Zhang, Yu-Chao Feng, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hui Xue, Wen-Zhong Wang, Long-Kui Cao, Cheng-Hao Ji. Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest via ROS-mediated MAPK/STAT3/NF-κB pathways in human hepatocellular carcinoma cells. Drug development research. vol 80. issue 4. 2020-01-17. PMID:30698296. |
taken together, the findings of this study indicate that isl induced hepg2 cell apoptosis via ros-mediated mapk, stat3, and nf-κb signaling pathways. |
2020-01-17 |
2023-08-13 |
human |
| T Lei, S Zhou, Q Meng, M Zhan. STAT3 signaling pathway in drug-resistant bladder cancer cell line. Journal of biological regulators and homeostatic agents. vol 33. issue 5. 2020-01-14. PMID:31912690. |
stat3 signaling pathway is related to the proliferation, apoptosis and metastasis of tumor cells. |
2020-01-14 |
2023-08-13 |
Not clear |
| Zhuoying Wang, Chongren Wang, Dongqing Zuo, Tao Zhang, Fei Yin, Zifei Zhou, Hongsheng Wang, Jing Xu, Min Mao, Gangyang Wang, Yingqi Hua, Wei Sun, Zhengdong Ca. Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A. International journal of biological sciences. vol 15. issue 3. 2020-01-13. PMID:30745853. |
attenuation of stat3 phosphorylation promotes apoptosis and chemosensitivity in human osteosarcoma induced by raddeanin a. osteosarcoma (os) is the most common primary bone malignancy in adolescents. |
2020-01-13 |
2023-08-13 |
human |
| Narjes Hendouei, Fatemeh Saghafi, Faezeh Shadfar, Seyed Jalal Hosseinimeh. Molecular mechanisms of anti-psychotic drugs for improvement of cancer treatment. European journal of pharmacology. vol 856. 2020-01-13. PMID:31108054. |
besides their medical applications, anti-psychotic drugs have other pharmacological properties which are involved in multiple intracellular functions including metabolism, cell stress, cell-cycle regulation, survival and apoptosis through modulation of cellular signaling pathways such as pi3k/akt/gsk-3β, stat3 and wingless (wnt)-related intracellular signaling. |
2020-01-13 |
2023-08-13 |
Not clear |
| Hao Wang, Ying-Hua Luo, Gui-Nan Shen, Xian-Ji Piao, Wan-Ting Xu, Yi Zhang, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hui Xue, Hong-Xing Wang, Chang-Yuan Wang, Cheng-Hao Ji. Two novel 1,4‑naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species‑mediated MAPK/Akt/STAT3 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322207. |
bq and oq induced apoptosis by upregulating the protein expression of p38 and jnk and downregulating the levels of erk and stat3. |
2020-01-13 |
2023-08-13 |
human |
| Hao Wang, Ying-Hua Luo, Gui-Nan Shen, Xian-Ji Piao, Wan-Ting Xu, Yi Zhang, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hui Xue, Hong-Xing Wang, Chang-Yuan Wang, Cheng-Hao Ji. Two novel 1,4‑naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species‑mediated MAPK/Akt/STAT3 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322207. |
these results demonstrated that bq and oq induced apoptosis and cell cycle arrest at the g2/m phase in ags cells by stimulating ros generation, which caused subsequent activation of mapk, akt and stat3 signaling pathways. |
2020-01-13 |
2023-08-13 |
human |
| Yen-Po Cheng, Shiming Li, Wan-Ling Chuang, Chia-Hsuan Li, Guan-Jun Chen, Ching-Chin Chang, Chi-Hung R Or, Ping-Yi Lin, Chia-Che Chan. Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-Acetyloxy-6,7,8,4'-Tetra-Methoxyflavone, a Tangeretin Derivative, on Human Glioblastoma Multiforme Cells. International journal of molecular sciences. vol 20. issue 13. 2020-01-13. PMID:31323961. |
notably, ectopic expression of dominant-active stat3 impeded 5-actmf-induced suppression of viability and clonogenicity plus apoptosis induction in gbm cells, confirming the prerequisite of stat3 blockage for the inhibitory action of 5-actmf on gbm cell survival and growth. |
2020-01-13 |
2023-08-13 |
human |
| Gui-Xiang Tan, Xin-Ning Wang, Yun-Yun Tang, Wan-Jing Cen, Zhen-Hua Li, Guo-Cai Wang, Jian-Wei Jiang, Xi-Cheng Wan. PP-22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma cell line CNE-2 by inducing endoplasmic reticulum stress, downregulating STAT3 signaling, and modulating the MAPK pathway. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30191969. |
pp-22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma cell line cne-2 by inducing endoplasmic reticulum stress, downregulating stat3 signaling, and modulating the mapk pathway. |
2020-01-09 |
2023-08-13 |
Not clear |
| Gui-Xiang Tan, Xin-Ning Wang, Yun-Yun Tang, Wan-Jing Cen, Zhen-Hua Li, Guo-Cai Wang, Jian-Wei Jiang, Xi-Cheng Wan. PP-22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma cell line CNE-2 by inducing endoplasmic reticulum stress, downregulating STAT3 signaling, and modulating the MAPK pathway. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30191969. |
a further study showed that pp-22 also induced apoptosis by downregulating the signal transducers and activators of transcription 3 (stat3) pathway, and the inhibitory effect was also confirmed by stat3 small interfering rna. |
2020-01-09 |
2023-08-13 |
Not clear |
| Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J Linton, Pierluigi Di Sebastiano, Xi Chen, Adam B Keeton, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Gary A Piazza, Vincenzo De Laurenzi, Gianluca Sala, Marco Falasc. Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer. Journal of experimental & clinical cancer research : CR. vol 38. issue 1. 2020-01-09. PMID:31378204. |
abcc3-mediated regulation of pdac cell proliferation and tumour growth in vivo was demonstrated and was shown to be conferred by upregulation of stat3 signalling and regulation of apoptosis. |
2020-01-09 |
2023-08-13 |
Not clear |
| Jiajun Chen, Yue Zhou, Xiangyu Zhou, Jia Li, Feng Liu, Qingwei Zho. Inhibitory effects of plasmid small interfering RNA targeting signal transducer and activator of transcription‑3 in C6 glioma cells. Molecular medicine reports. vol 20. issue 3. 2020-01-06. PMID:31322201. |
the current study investigated the effect of plasmid small interfering rna (psirna)‑mediated silencing of signal transducer and activator of transcription‑3 (stat3) on the invasion, apoptosis, and expression levels of cyclin d1, caspase‑3 and b‑cell lymphoma‑2 (bcl‑2) in c6 glioma cells. |
2020-01-06 |
2023-08-13 |
Not clear |
| Tae-Rin Min, Hyun-Ji Park, Ki-Tae Ha, Gyoo-Yong Chi, Yung-Hyun Choi, Shin-Hyung Par. Suppression of EGFR/STAT3 activity by lupeol contributes to the induction of the apoptosis of human non‑small cell lung cancer cells. International journal of oncology. vol 55. issue 1. 2019-12-20. PMID:31115519. |
the constitutive activation of stat3 by stat3 y705d overexpression suppressed lupeol‑induced apoptosis, demonstrating that the inhibition of stat3 activity contributed to the induction of apoptosis. |
2019-12-20 |
2023-08-13 |
human |
| Senthil Kumaran Satyanarayanan, Driss El Kebir, Soaad Soboh, Sergei Butenko, Meriem Sekheri, Janan Saadi, Neta Peled, Simaan Assi, Amira Othman, Sagie Schif-Zuck, Yonatan Feuermann, Dalit Barkan, Noa Sher, János G Filep, Amiram Arie. IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation. Nature communications. vol 10. issue 1. 2019-12-16. PMID:31375662. |
stat3 signalling in response to ifn-β promotes apoptosis of human pmns. |
2019-12-16 |
2023-08-13 |
mouse |
| Wenda Zhang, Wenying Yu, Guiping Cai, Jiawen Zhu, Chao Zhang, Shanshan Li, Jianpeng Guo, Guoping Yin, Chen Chen, Lingyi Kon. A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy. Cell death & disease. vol 9. issue 11. 2019-12-10. PMID:30368518. |
a stat3 plasmid transfecting assay suggested that kyz3 induced tumor cell apoptosis mainly by targeting stat3. |
2019-12-10 |
2023-08-13 |
Not clear |
| Deok Yong Sim, Hyo-Jung Lee, Ji Hoon Jung, Eunji Im, Jisung Hwang, Dong Sub Kim, Sung-Hoon Ki. Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid. International journal of molecular sciences. vol 20. issue 12. 2019-12-10. PMID:31248140. |
overall, these findings suggest that la induced apoptosis via the mirna-134 mediated inhibition of stat3 and rela/p65 acetylation. |
2019-12-10 |
2023-08-13 |
Not clear |
| Xinlin Sun, Jihui Wang, Min Huang, Taoliang Chen, Jiansheng Chen, Fabing Zhang, Huijun Zeng, Zhimin Xu, Yiquan K. STAT3 promotes tumour progression in glioma by inducing FOXP1 transcription. Journal of cellular and molecular medicine. vol 22. issue 11. 2019-12-09. PMID:30134017. |
this paper investigated the effects of stat3 through promoting foxp1 transcription on proliferation, apoptosis and invasion in glioma cells. |
2019-12-09 |
2023-08-13 |
Not clear |
| Jia-Ru Wang, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Yi Zhang, Hao Wang, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Shi-Nong Wang, Tong Zhang, Hui Xue, Long-Kui Cao, Cheng-Hao Ji. 2-(4-methoxyphenylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK and STAT3 signaling pathway in human gastric cancer cells. Journal of chemotherapy (Florence, Italy). vol 31. issue 4. 2019-12-09. PMID:31074342. |
2-(4-methoxyphenylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ros-mediated mapk and stat3 signaling pathway in human gastric cancer cells. |
2019-12-09 |
2023-08-13 |
human |
| Jia-Ru Wang, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Yi Zhang, Hao Wang, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Shi-Nong Wang, Tong Zhang, Hui Xue, Long-Kui Cao, Cheng-Hao Ji. 2-(4-methoxyphenylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK and STAT3 signaling pathway in human gastric cancer cells. Journal of chemotherapy (Florence, Italy). vol 31. issue 4. 2019-12-09. PMID:31074342. |
these findings showed that mptdmnq induced ags cell apoptosis via ros-mediated mapk and stat3 signaling pathways. |
2019-12-09 |
2023-08-13 |
human |