| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guanghua Xiong, Hongmei Hu, Haiyan Zhang, Jun'e Zhang, Zigang Cao, Huiqiang Lu, Xinjun Lia. Cyhalofop-butyl exposure induces the severe hepatotoxicity and immunotoxicity in zebrafish embryos. Fish & shellfish immunology. 2023-02-26. PMID:36842639. |
moreover, cyb induced zebrafish liver injury and increased hepatocyte apoptosis, which increased the protein expression levels of bax, tlr4, nf-kb p65 and stat3 in zebrafish. |
2023-02-26 |
2023-08-14 |
cat |
| Juan Huang, Chunhua Lv, Baoyu Zhao, Zhongqian Ji, Zhenran Ga. SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-02-14. PMID:36785765. |
in conclusion, scara5 inhibited the proliferation and emt and induced the apoptosis of oscc cells through the inhibition of stat3 and pi3k/akt signaling pathways, thereby exerting a tumor suppressor effect. |
2023-02-14 |
2023-08-14 |
human |
| Jiaqi Wu, Danrui Xiao, Kaiwen Yu, Kudureti Shalamu, Ben He, Min Zhan. The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy. Acta biochimica et biophysica Sinica. 2023-02-14. PMID:36786072. |
our results demonstrate that mots-c treatment reduces the mrna levels of inflammatory cytokines ( il-1β, il-4, il-6, and tnfα) in cardiomyocytes and the levels of circulating myocardial injury markers, such as ck-mb and tnt, alleviates cardiomyocyte mitochondrial dysfunction and oxidative stress, reduces cardiomyocyte apoptosis, activates cardioprotection-related signaling pathways, including ampk, akt, and erk, and inhibits the inflammation-related signaling pathways jnk and stat3. |
2023-02-14 |
2023-08-14 |
Not clear |
| Young Song, Joseph Leem, Mehul Dhanani, M Dan McKirnan, Yasuhiro Ichikawa, Julie Braza, Elizabeth O Harrington, H Kirk Hammond, David M Roth, Hemal H Pate. Impact of blood factors on endothelial cell metabolism and function in two diverse heart failure models. PloS one. vol 18. issue 2. 2023-02-13. PMID:36780477. |
apoptosis and necrosis were increased in cells incubated with dauno-hf plasma for 24 h. down-regulation of voltage-dependent anion-selective channel (vdac)-1, translocase of outer membrane 20 (tom20), and mitochondrial fission factor (mff) in cells exposed to dauno-hf plasma and mitochondrial signal transducer and activator of transcription 3 (stat3) and mff in cells exposed to mi-hf plasma were observed. |
2023-02-13 |
2023-08-14 |
mouse |
| Hanwen Yang, Pengpeng Zhang, Qiang Wang, Ke Cheng, Yujun Zha. The research development of STAT3 in hepatic ischemia-reperfusion injury. Frontiers in immunology. vol 14. 2023-02-10. PMID:36761734. |
stat3 influences the mitochondria through multiple pathways and is also involved in apoptosis and other forms of programmed cell death. |
2023-02-10 |
2023-08-14 |
Not clear |
| Haoying Huang, Xiaohan Yi, Qingyun Wei, Mengyuan Li, Xueting Cai, Yan Lv, Ling Weng, Yujie Mao, Weiwei Fan, Mengmeng Zhao, Zhongpei Weng, Qing Zhao, Kewei Zhao, Meng Cao, Jing Chen, Peng Ca. Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer. Journal of nanobiotechnology. vol 21. issue 1. 2023-02-05. PMID:36740689. |
intriguingly, the systemic administration of stat3/ekevs significantly suppressed subcutaneous pc9-gr4-azd1 tumor xenografts in nude mice by stat3 mediated apoptosis. |
2023-02-05 |
2023-08-14 |
mouse |
| Xueying Wang, Jiling Feng, Rong Wu, Jiaqi Tan, Qing Huang, Yeelin Phang, Li Zhang, Wenwei Fu, Hongxi Xu, Changwu Zhen. Garcinol and its analogues: Synthesis, cytotoxic activity and mechanistic investigation. Bioorganic chemistry. vol 133. 2023-02-02. PMID:36731298. |
cambogin and 21' were shown to have a greater capacity to cause apoptosis in pancreatic cancer bxpc3 cells, and the suppression of bxpc3 cells by 21' might be attributed to the target of stat3 signaling. |
2023-02-02 |
2023-08-14 |
Not clear |
| Chunxiao Li, Yu Xu, Tengjiao Gao, Shunyao Zhang, Zhe Lin, Shaobo Gu, Yi Fang, Xin Yuan, Siyi Yu, Qi Jiang, Zhongze Lou, Xiuming Zhang, Jie Zhang, Qiaoyan Wu, Mengli Gu, Xiaoyun Ding, Jing Sun, Yi Che. Ruxolitinib Alleviates Inflammation, Apoptosis, and Intestinal Barrier Leakage in Ulcerative Colitis via STAT3. Inflammatory bowel diseases. 2023-02-01. PMID:36721335. |
ruxolitinib alleviates inflammation, apoptosis, and intestinal barrier leakage in ulcerative colitis via stat3. |
2023-02-01 |
2023-08-14 |
Not clear |
| Yumeng Jiang, Zhuangzhuang Li, Qiang Ma, Wenqi Dong, Qingxiu Yao, Dongzhen Y. Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway. Biochemical pharmacology. 2023-01-31. PMID:36720354. |
inhibition of the stat3 signaling pathway with the inhibitor s3i-201 or sirna disrupted the protective effects of aucubin on cisplatin-induced apoptosis. |
2023-01-31 |
2023-08-14 |
mouse |
| Mustafa M M Elbakry, Nermeen M ElBakary, Sanaa A Hagag, Eman H A Hemid. Pomegranate Peel Extract Sensitizes Hepatocellular Carcinoma Cells to Ionizing Radiation, Induces Apoptosis and Inhibits MAPK, JAK/STAT3, β-Catenin/NOTCH, and SOCS3 Signaling. Integrative cancer therapies. vol 22. 2023-01-30. PMID:36710483. |
as a key player in tumor proliferation, and inflammatory cascade induction, the down-regulation of stat3 following treatment of irradiated and non-irradiated hepg2 cells with ppe as recorded in the present work resulted in reduction of tumor growth, via modulating inflammatory response manifested by (down-regulation of tlr4 expression and nfkb level), suppressing survival markers expressed by reduction of jak, notch1, β-catenin, socs3, and enhancing apoptosis (induction of tumor ppar-γ and caspase-3) followed by changes in redox tone (expressed by increase in nrf-2, sod and catalase activities, and decrease in mda concentration). |
2023-01-30 |
2023-08-14 |
Not clear |
| Wei Sun, Nai-Dan Zhang, Tong Zhang, Yan-Nan Li, Hui Xue, Jing-Long Cao, Wen-Shuang Hou, Jian Liu, Ying Wang, Cheng-Hao Ji. Cyanidin-3-O-Glucoside Induces the Apoptosis of Human Gastric Cancer MKN-45 Cells through ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677726. |
in conclusion, c3g caused mkn-45 cells to undergo apoptosis; arrested the cell cycle in the g2/m phase; hindered cell migration; and activated the mapk, stat3, and nf-κb signaling pathways, by inducing an increase in ros levels. |
2023-01-21 |
2023-08-14 |
human |
| Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Mouludi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najaf. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways. Mini reviews in medicinal chemistry. 2023-01-20. PMID:36658710. |
it seems that apigenin enhances apoptosis by inducing anticancer immunity and tumor suppressor genes, like p53 and pten, and also by inhibiting stat3 and nf-κb signaling pathways. |
2023-01-20 |
2023-08-14 |
Not clear |
| Minxiao Chen, Chenchen Qian, Bo Jin, Chenghong Hu, Lingxi Zhang, Minshan Wang, Bin Zhou, Wei Zuo, Lijiang Huang, Yi Wan. Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma. Cancer biology & therapy. vol 24. issue 1. 2023-01-16. PMID:36647192. |
treatment of wz26 increased reactive oxygen species (ros) generation, subsequently decreased mitochondrial membrane potential and inhibited the phosphorylation of signal transducer and activator of transcription 3 (stat3), thereby inducing g2/m cell cycle arrest and cell apoptosis. |
2023-01-16 |
2023-08-14 |
mouse |
| Andra Fortner, Alexandra Chera, Antoanela Tanca, Octavian Bucu. Apoptosis regulation by the tyrosine-protein kinase CSK. Frontiers in cell and developmental biology. vol 10. 2022-12-29. PMID:36578781. |
as sfks play a vital role in apoptosis, cell proliferation and survival regulation, sfk inhibition by csk has a pro-apoptotic effect, which is mediated by the inhibition of cellular signaling cascades controlled by sfks, such as the mapk/erk, stat3 and pi3k/akt signaling pathways. |
2022-12-29 |
2023-08-14 |
Not clear |
| Yanan Wang, Jiapeng Lei, Song Zhang, Xiaomei Wang, Jiangbo Jin, Yufeng Liu, Mingxi Gan, Yi Yuan, Longhua Sun, Xiaolei Li, Tianyu Han, Jian-Bin Wan. 4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer. Cell death & disease. vol 13. issue 12. 2022-12-27. PMID:36575176. |
after that, 4ebp1 translocated to cytoplasm and interacted with stat3 by competing with jak and erk, leading to the inactivation of stat3 in the cytoplasm, resulting in apoptosis under glucose withdrawal conditions. |
2022-12-27 |
2023-08-14 |
Not clear |
| Erratum to "A novel 4'-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits EGFR/ERK1/2/ STAT3 pathways in non-small-cell lung cancer without any adverse effects in mice". FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 1. 2022-12-17. PMID:36527405. |
erratum to "a novel 4'-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits egfr/erk1/2/ stat3 pathways in non-small-cell lung cancer without any adverse effects in mice". |
2022-12-17 |
2023-08-14 |
mouse |
| Guojing Sun, Jingwei Lu, Zhenfang Wu, Xian Zhang, Yunfan T. STAT3 expression in patients with fragility fractures and its effect on the biological function of osteoblasts. Cell and tissue banking. 2022-12-12. PMID:36508120. |
we observed stat3 mrna expression in the patients with ffs and controls and altered stat3 mrna to detect changes in the proliferation, invasion, and apoptosis of osteoblasts. |
2022-12-12 |
2023-08-14 |
human |
| Guojing Sun, Jingwei Lu, Zhenfang Wu, Xian Zhang, Yunfan T. STAT3 expression in patients with fragility fractures and its effect on the biological function of osteoblasts. Cell and tissue banking. 2022-12-12. PMID:36508120. |
transfection of stat3 mrna mimics resulted in increased stat3 mrna expression, inhibited cell proliferation as detected by an mtt assay, and increased apoptosis rate, which was determined using flow cytometry with human fetal osteoblastic cell line 1.19 cells. |
2022-12-12 |
2023-08-14 |
human |
| Guojing Sun, Jingwei Lu, Zhenfang Wu, Xian Zhang, Yunfan T. STAT3 expression in patients with fragility fractures and its effect on the biological function of osteoblasts. Cell and tissue banking. 2022-12-12. PMID:36508120. |
regulating stat3 mrna can inhibit the proliferation and induce the osteoblasts apoptosis. |
2022-12-12 |
2023-08-14 |
human |
| Jinmei Jin, Yaping Wu, Zeng Zhao, Ye Wu, Yu-Dong Zhou, Sanhong Liu, Qingyan Sun, Guizhu Yang, Jiayi Lin, Dale G Nagle, Jiangjiang Qin, Zhiyuan Zhang, Hong-Zhuan Chen, Weidong Zhang, Shuyang Sun, Xin Lua. Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer. JCI insight. vol 7. issue 22. 2022-12-12. PMID:36509291. |
the following mechanistic investigation identifies the reduced expression of critical downstream stat3 effectors, through which tsm-1 promotes cell cycle arrest and apoptosis in tumor cells. |
2022-12-12 |
2023-08-14 |
Not clear |