| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuqing Li, Li Wang, Xinwang Ying, Yujun Zheng, Qianqian Tan, Xiaolan Yu, Jiahong Gong, Ming Li, Xiaofeng Deng, Guanhu Yang, Shengcun Li, Songhe Jian. Electroacupuncture pre-treatment alleviates sepsis-induced cardiac inflammation and dysfunction by inhibiting the calpain-2/STAT3 pathway. Frontiers in physiology. vol 13. 2022-09-26. PMID:36160853. |
additionally, inhibition of calpain-2 expression using the corresponding sirna decreased the phosphorylation of stat3,pro-inflammatory factors and apoptosis in lipopolysaccharide- treated cardiomyocytes, confirming that calpain-2 activated p-stat3 participate in septic cardiomyopathy. |
2022-09-26 |
2023-08-14 |
mouse |
| Antonella Di Sotto, Marco Gullì, Marco Minacori, Romina Mancinelli, Stefania Garzoli, Ester Percaccio, Alessio Incocciati, Donatella Romaniello, Gabriela Mazzanti, Margherita Eufemi, Silvia Di Giacom. β-Caryophyllene Counteracts Chemoresistance Induced by Cigarette Smoke in Triple-Negative Breast Cancer MDA-MB-468 Cells. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140359. |
β-caryophyllene was found to be able to increase the csc-induced death of mda-mb-468 cells, likely triggering oxidative stress, cell cycle arrest and apoptosis; moreover, it hindered cell recovery, autophagy activation and cell migration; at last, a marked inhibition of the signal transducer and activator of transcription 3 (stat3) activation was highlighted: this could represent a key mechanism of the chemoprevention by β-caryophyllene. |
2022-09-23 |
2023-08-14 |
human |
| Arshad Husain Rahmani, Mohammed A Alsahli, Ahmad Almatroudi, Mashael Abdullah Almogbel, Amjad Ali Khan, Shehwaz Anwar, Saleh A Almatrood. The Potential Role of Apigenin in Cancer Prevention and Treatment. Molecules (Basel, Switzerland). vol 27. issue 18. 2022-09-23. PMID:36144783. |
moreover, the anti-cancer potential of apigenin is confirmed through its ability to modulate various cell signalling pathways, including tumor suppressor genes, angiogenesis, apoptosis, cell cycle, inflammation, apoptosis, pi3k/akt, nf-κb, mapk/erk and stat3 pathways. |
2022-09-23 |
2023-08-14 |
Not clear |
| Qi-Bing Liu, Ren-Hui Zhou, Chong-Mei Li. TLR9/FCRL3 regulates B cell viability, apoptosis, and antibody and IL-10 production through ERK1/2, p38, and STAT3 signaling pathways. In vitro cellular & developmental biology. Animal. 2022-09-19. PMID:36121575. |
tlr9/fcrl3 regulates b cell viability, apoptosis, and antibody and il-10 production through erk1/2, p38, and stat3 signaling pathways. |
2022-09-19 |
2023-08-14 |
Not clear |
| Qi-Bing Liu, Ren-Hui Zhou, Chong-Mei Li. TLR9/FCRL3 regulates B cell viability, apoptosis, and antibody and IL-10 production through ERK1/2, p38, and STAT3 signaling pathways. In vitro cellular & developmental biology. Animal. 2022-09-19. PMID:36121575. |
these results indicate that tlr9 activation affects b cell proliferation, apoptosis, antibody production, and il-10 secretion by upregulating fcrl3 expression, and is associated with erk1/2, p38, and stat3 pathways. |
2022-09-19 |
2023-08-14 |
Not clear |
| Manal Alfwuaires, Hany Elsawy, Azza Sedk. Acacetin Inhibits Cell Proliferation and Induces Apoptosis in Human Hepatocellular Carcinoma Cell Lines. Molecules (Basel, Switzerland). vol 27. issue 17. 2022-09-09. PMID:36080130. |
we used a functional proteomics tumor pathway technology platform and multiple hcc cell lines to investigate the effects of acacetin (acn) on stat3 activation, protein kinases, phosphatases, products of stat3-regulated genes, and apoptosis. |
2022-09-09 |
2023-08-14 |
human |
| Wei Li, Tao Huang, Shenghan Xu, Bangwei Che, Ying Yu, Wenjun Zhang, Kaifa Tan. Molecular Mechanism of Tanshinone against Prostate Cancer. Molecules (Basel, Switzerland). vol 27. issue 17. 2022-09-09. PMID:36080361. |
several studies have shown that tanshinone can target various molecular pathways of pca, including the signal transducer and activator of transcription 3 (stat3) pathway, androgen receptor (ar) pathway, phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) pathway, and mitogen-activated protein kinase (mapk) pathway, which will affect the release of pro-inflammatory cytokines and affect cell proliferation, apoptosis, tumor metabolism, genomic stability, and tumor drug resistance. |
2022-09-09 |
2023-08-14 |
Not clear |
| Pengyu Zhang, Qiang Zhang, Zhenxia Sha. Silence of S1PR4 Represses the Activation of Fibroblast-like Synoviocytes by Regulating IL-17/STAT3 Signaling Pathway. Inflammation. 2022-09-06. PMID:36068391. |
the silence of s1pr4 decreases the proliferation, migration, proinflammation, and promotes the apoptosis of ra-flss, accompanied with repressing interleukin-17 (il-17)/signal transducer and activator of transcription 3 (stat3) signal pathway. |
2022-09-06 |
2023-08-14 |
human |
| Mateo Ruiz-Conca, Jaume Gardela, Teresa Mogas, Manel López-Béjar, Manuel Álvarez-Rodrígue. Apoptosis and glucocorticoid-related genes mRNA expression is modulated by coenzyme Q10 supplementation during in vitro maturation and vitrification of bovine oocytes and cumulus cells. Theriogenology. vol 192. 2022-09-05. PMID:36063671. |
we also studied the mrna expression of nr3c1-related genes belonging to the gc regulation pathway, such as hydroxysteroid dehydrogenases (hsd11b1; hsd11b2), immunophilins (fkbp4; fkbp5), signal transducers and activators of transcription (stat3; stat5a), the mineralocorticoid receptor (nr3c2), and to the apoptosis pathway, such as the anti- (bcl2) and pro-apoptotic (bax) mrna transcripts in oocytes and cumulus cells 1) after ivm, and 2) after vitrification, both in presence or absence of q10 supplementation during ivm. |
2022-09-05 |
2023-08-14 |
cattle |
| Yue Xie, Zhao-Wei Zheng, Hao-Ting He, Zhi-Bo Chan. LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer. The Kaohsiung journal of medical sciences. 2022-09-02. PMID:36054559. |
furthermore, adam28 overexpression attenuated mir-128-3p overexpression-induced apoptosis and autophagy inhibition in nsclc by increasing the phosphorylation of jak2 and stat3. |
2022-09-02 |
2023-08-14 |
mouse |
| Sabrina Manni, Maria Pesavento, Zaira Spinello, Lara Saggin, Arash Arjomand, Anna Fregnani, Laura Quotti Tubi, Greta Scapinello, Carmela Gurrieri, Gianpietro Semenzato, Livio Trentin, Francesco Piazz. Protein Kinase CK2 represents a new target to boost Ibrutinib and Venetoclax induced cytotoxicity in mantle cell lymphoma. Frontiers in cell and developmental biology. vol 10. 2022-08-29. PMID:36035991. |
ck2 promotes cancer cell growth and clonal expansion, sustaining pivotal survival signaling cascades, such as the ones dependent on akt, nf-κb, stat3 and others, counteracting apoptosis through a "non-oncogene" addiction mechanism. |
2022-08-29 |
2023-08-14 |
Not clear |
| Li Pan, Xiang Chen, Feyruz Virgilia Rassool, Chenglong Li, Jiayuh Li. LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009550. |
lll12b, a novel small-molecule stat3 inhibitor, induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells. |
2022-08-26 |
2023-08-14 |
mouse |
| Li Pan, Xiang Chen, Feyruz Virgilia Rassool, Chenglong Li, Jiayuh Li. LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009550. |
in addition, targeting stat3 with lll12b induced apoptosis, reduced colony formation ability, and inhibited cell migration in tnbc cells. |
2022-08-26 |
2023-08-14 |
mouse |
| Wenjing Xiang, Wanchen Qi, Huayu Li, Jia Sun, Chao Dong, Haojie Ou, Bing Li. Palbociclib Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells via RB-Independent STAT3 Phosphorylation. Current oncology (Toronto, Ont.). vol 29. issue 8. 2022-08-25. PMID:36005200. |
palbociclib induces the apoptosis of lung squamous cell carcinoma cells via rb-independent stat3 phosphorylation. |
2022-08-25 |
2023-08-14 |
human |
| Wenjing Xiang, Wanchen Qi, Huayu Li, Jia Sun, Chao Dong, Haojie Ou, Bing Li. Palbociclib Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells via RB-Independent STAT3 Phosphorylation. Current oncology (Toronto, Ont.). vol 29. issue 8. 2022-08-25. PMID:36005200. |
we found that palbociclib induced lusc cell apoptosis through inhibition of src tyrosine kinase/signal transducers and activators of transcription 3 (stat3). |
2022-08-25 |
2023-08-14 |
human |
| Ji Di, Bo Jiang, Hao Shang, Xin Yang, Chengwu Zhang, Xiali Shi, Yan Cha. Study on the Mechanism of Action of STAT3 in the Drug Resistance of Gastric Cancer Cells. Contrast media & molecular imaging. vol 2022. 2022-08-22. PMID:35992548. |
this research detected the expression of stat3 in gastric cancer tissues and adjacent tissues by western blot and immunohistochemical experiments and conducted corresponding basic experiments to explore the role of stat3 in inhibiting the proliferation of cisplatin-resistant gastric cancer cells and promoting their apoptosis, including the construction of cisplatin-resistant gastric cancer cell line, the knock-out stat3 in drug-resistant gastric cancer cells by crispr-cas9, and the comparison of the proliferation and apoptosis of drug-resistant cells and drug-resistant cells stat3(-). |
2022-08-22 |
2023-08-14 |
Not clear |
| Cheng-Chen Zhang, Ting Wu, Li Guan, Yu-Jue Wang, Rui-Qin Yao, Dian-Shuai Gao, Feng L. Effects of STAT3 Inhibitor BP-1-102 on The Proliferation, Invasiveness, Apoptosis and Neurosphere Formation of Glioma Cells in Vitro. Cell biochemistry and biophysics. 2022-08-22. PMID:35994220. |
effects of stat3 inhibitor bp-1-102 on the proliferation, invasiveness, apoptosis and neurosphere formation of glioma cells in vitro. |
2022-08-22 |
2023-08-14 |
Not clear |
| Xueyao Wang, Rui Hu, Zhenwei Song, Huajun Zhao, Zhaoyi Pan, Yujie Feng, Yating Yu, Qiuju Han, Jian Zhan. Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity. Cancer letters. 2022-08-18. PMID:35981569. |
sorafenib combined with stat3 knockdown triggers er stress-induced hcc apoptosis and cgas-sting-mediated anti-tumor immunity. |
2022-08-18 |
2023-08-14 |
Not clear |
| Xueyao Wang, Rui Hu, Zhenwei Song, Huajun Zhao, Zhaoyi Pan, Yujie Feng, Yating Yu, Qiuju Han, Jian Zhan. Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity. Cancer letters. 2022-08-18. PMID:35981569. |
our studies demonstrated that stat3 knockdown promoted sorafenib-induced er stress-induced apoptosis. |
2022-08-18 |
2023-08-14 |
Not clear |
| Cairu Liu, Haiqin Feng, Lihong Song, Shuirui Li, Yiping Wu, Liping Yan. Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer. Oncology reports. vol 48. issue 4. 2022-08-03. PMID:35920185. |
relative cell viability and apoptosis, as well as the mrna and protein levels of pi3k, akt, jak1 and stat3 were evaluated. |
2022-08-03 |
2023-08-14 |
Not clear |