| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hajime Isomot. Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangio- carcinoma due to SOCS3 epigenetic silencing. Digestion. vol 79 Suppl 1. 2009-04-06. PMID:19153483. |
interleukin-6 (il-6)-mediated signal transducers and activators of transcription 3 (stat3) activation are aberrantly sustained in cca cells, resulting in resistance to apoptosis. |
2009-04-06 |
2023-08-12 |
Not clear |
| David J Tweardy, Naijie Jin. Enhancing or eliminating signals for cell survival to treat disease. Transactions of the American Clinical and Climatological Association. vol 117. 2009-04-02. PMID:18528463. |
we developed a rat model of severe hemorrhagic shock (hs) to assess the benefits of promoting stat3 activity in diseases marked by excessive apoptosis. |
2009-04-02 |
2023-08-12 |
mouse |
| David J Tweardy, Naijie Jin. Enhancing or eliminating signals for cell survival to treat disease. Transactions of the American Clinical and Climatological Association. vol 117. 2009-04-02. PMID:18528463. |
administration of the stat3-activating cytokine il-6 at the initiation of resuscitation from hs activated intra-cardiac stat3, reversed cardiac apoptosis, left ventricular dysfunction and hypovolemic circulatory collapse (hcc) and resulted in a 5-fold reduction in mortality; pre-treatment of rats with gq-odn prevented the reversal of cardiac apoptosis and hcc by il-6. |
2009-04-02 |
2023-08-12 |
mouse |
| David J Tweardy, Naijie Jin. Enhancing or eliminating signals for cell survival to treat disease. Transactions of the American Clinical and Climatological Association. vol 117. 2009-04-02. PMID:18528463. |
thus, targeting of stat3 may be a useful for treatment of multiple cancers; agents that activate stat3 may be beneficial in acute insults that cause apoptosis in organs critical for survival. |
2009-04-02 |
2023-08-12 |
mouse |
| Zhenfeng Duan, Rachel Y Ames, Meagan Ryan, Francis J Hornicek, Henry Mankin, Michael V Seide. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer chemotherapy and pharmacology. vol 63. issue 4. 2009-03-31. PMID:18587580. |
this inhibition of the il-6-stat3 pathway correlated with suppression of the anti-apoptotic stat3 target genes bcl-x(l), survivin, and mcl-1, and with apoptosis induction as measured by monitoring parp and its cleavage product, as well as by quantitative measurement of the apoptosis-associated ck18asp396. |
2009-03-31 |
2023-08-12 |
Not clear |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery. Journal of nephrology. vol 21. issue 6. 2009-03-24. PMID:19034877. |
effect of jak2 kinase inhibition on stat1 and stat3 activation and apoptosis of tubular epithelial cells induced by atp depletion/recovery. |
2009-03-24 |
2023-08-12 |
human |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery. Journal of nephrology. vol 21. issue 6. 2009-03-24. PMID:19034877. |
in an in vitro model of renal ischemia/reperfusion injury (iri), we investigated the role of jak2 kinase inhibition on signal transducer and activator of transcription 1 (stat1) and stat3 activations as well as apoptosis of human proximal tubular epithelial cells (hkcs) induced by adenosine triphosphate (atp) depletion/recovery. |
2009-03-24 |
2023-08-12 |
human |
| Qin Li, Rui Zhang, Yun-Liang Guo, Yuan-Wu Me. Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion. Journal of molecular neuroscience : MN. vol 37. issue 1. 2009-03-23. PMID:18633737. |
effect of neuregulin on apoptosis and expressions of stat3 and gfap in rats following cerebral ischemic reperfusion. |
2009-03-23 |
2023-08-12 |
rat |
| Qin Li, Rui Zhang, Yun-Liang Guo, Yuan-Wu Me. Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion. Journal of molecular neuroscience : MN. vol 37. issue 1. 2009-03-23. PMID:18633737. |
the aim is to investigate the effect of neuregulin-1beta (nrg-1beta) on the neuronal apoptosis and the expressions of signal transducer and activator of transcription (stat3) and glial fibrillary acidic protein (gfap) in rats following cerebral ischemia/reperfusion. |
2009-03-23 |
2023-08-12 |
rat |
| Banibrata Sen, Babita Saigal, Nila Parikh, Gary Gallick, Faye M Johnso. Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding. Cancer research. vol 69. issue 5. 2009-03-20. PMID:19223541. |
to determine the biological significance of stat3 activation, we combined specific stat3 depletion with a pharmacologic sfk inhibitor and observed increased cell cycle arrest and apoptosis. |
2009-03-20 |
2023-08-12 |
Not clear |
| Manoj K Pandey, Bokyung Sung, Kwang Seok Ahn, Bharat B Aggarwa. Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Molecular pharmacology. vol 75. issue 3. 2009-03-16. PMID:19103760. |
consistent with these results, overexpression of constitutive active stat3 significantly reduced the butein-induced apoptosis. |
2009-03-16 |
2023-08-12 |
Not clear |
| Paul G Tiffen, Nader Omidvar, Nuria Marquez-Almuina, Dawn Croston, Christine J Watson, Richard W E Clarkso. A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo. Molecular endocrinology (Baltimore, Md.). vol 22. issue 12. 2009-03-06. PMID:18927239. |
this resulted in sustained stat3 activity, increased epithelial apoptosis, and enhanced clearance of epithelial structures during the remodeling phase of mammary involution. |
2009-03-06 |
2023-08-12 |
mouse |
| Zohar Yagil, Gillian Kay, Hovav Nechushtan, Ehud Razi. A specific epitope of protein inhibitor of activated STAT3 is responsible for the induction of apoptosis in rat transformed mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 4. 2009-03-04. PMID:19201870. |
a specific epitope of protein inhibitor of activated stat3 is responsible for the induction of apoptosis in rat transformed mast cells. |
2009-03-04 |
2023-08-12 |
rat |
| Zohar Yagil, Gillian Kay, Hovav Nechushtan, Ehud Razi. A specific epitope of protein inhibitor of activated STAT3 is responsible for the induction of apoptosis in rat transformed mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 4. 2009-03-04. PMID:19201870. |
we have characterized the biological role of a 23-aa domain derived from pias3 that induces apoptosis in these cells by inhibiting the transcriptional activity of both mitf and stat3. |
2009-03-04 |
2023-08-12 |
rat |
| Ajaikumar B Kunnumakkara, Asha S Nair, Bokyung Sung, Manoj K Pandey, Bharat B Aggarwa. Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1. Molecular cancer research : MCR. vol 7. issue 1. 2009-02-26. PMID:19147543. |
consistent with these results, overexpression of constitutive active stat3 significantly reduced the akba-induced apoptosis. |
2009-02-26 |
2023-08-12 |
human |
| Juxiang Li, Xi-Lin Niu, Nageswara R Madamanch. Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18854310. |
pp2, a fyn-specific inhibitor, blocked jak2, stat3, and p38 mapk activation and significantly attenuated apoptosis induced by h(2)o(2). |
2009-02-04 |
2023-08-12 |
mouse |
| Juxiang Li, Xi-Lin Niu, Nageswara R Madamanch. Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18854310. |
ag490, a jak2-specific inhibitor, significantly attenuated h(2)o(2)-induced apoptosis, and blocked h(2)o(2)-induced activation of stat3, but not p38 mapk in both wild-type and lar(-/-) vsmcs. |
2009-02-04 |
2023-08-12 |
mouse |
| Eun Soo Kim, Sung Yi Hong, Hye Kyung Lee, Seung Won Kim, Min Ji An, Tae Il Kim, Kyoung Ryul Lee, Won Ho Kim, Jae Hee Cheo. Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. Oncology reports. vol 20. issue 6. 2009-02-04. PMID:19020709. |
the results of this study suggest that guggulsterone not only induces apoptosis, but also inhibits angiogenesis and metastasis in colon cancer cells by blocking stat3 and vegf expression, suggesting its therapeutic potential in the treatment of colorectal cancer. |
2009-02-04 |
2023-08-12 |
human |
| Alexander Sainz-Perez, Hélène Gary-Gouy, Françoise Gaudin, Ghyath Maarof, Anne Marfaing-Koka, Thierry de Revel, Ali Dallou. IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 9. 2009-01-21. PMID:18941194. |
il-24 induces apoptosis of chronic lymphocytic leukemia b cells engaged into the cell cycle through dephosphorylation of stat3 and stabilization of p53 expression. |
2009-01-21 |
2023-08-12 |
Not clear |
| Joelle Hillion, Surajit Dhara, Takita Felder Sumter, Mita Mukherjee, Francescopaolo Di Cello, Amy Belton, James Turkson, Souyma Jaganathan, Linzhao Cheng, Zhaohui Ye, Richard Jove, Peter Aplan, Ying-Wei Lin, Kelsey Wertzler, Ray Reeves, Ossama Elbahlouh, Jeanne Kowalski, Raka Bhattacharya, Linda M S Resa. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? Cancer research. vol 68. issue 24. 2009-01-15. PMID:19074878. |
blocking stat3 function induced apoptosis in the transgenic leukemia cells but not in controls. |
2009-01-15 |
2023-08-12 |
mouse |