| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Dan Lewis, Ashley Winter, Thomas F Murphy, Snehlata Tripathi, Virendra N Pandey, Beverly E Barto. STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566225. |
we conclude that truncating the 5' end left intact enough of the canonical stat3 binding site for effective hybridization to the genome, whereas truncation of the 3' end, which is outside the canonical binding site, may have affected binding of required cofactors essential for stat3 activity, thereby reducing the capacity of this modified oligonucleotide to induce apoptosis. |
2008-08-22 |
2023-08-12 |
Not clear |
| Wenwen Ren, Yanhong Duan, Yang Yang, Yonghua Ji, Fuxue Che. Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer. Neurological research. vol 30. issue 3. 2008-08-01. PMID:17716392. |
down-regulation of stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer. |
2008-08-01 |
2023-08-12 |
human |
| Feng Huang, Xiaoyun Tong, Liangqing Fu, Ronghua Zhan. Knockdown of STAT3 by shRNA inhibits the growth of CAOV3 ovarian cancer cell line in vitro and in vivo. Acta biochimica et biophysica Sinica. vol 40. issue 6. 2008-07-21. PMID:18535750. |
in addition, stat3 knockdown inhibited anchorage-independent growth and induced apoptosis in caov3 cells, and decreased tumor growth in nude mice implanted with ovarian cancer cells. |
2008-07-21 |
2023-08-12 |
mouse |
| Jeffrey A Alten, Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PloS one. vol 3. issue 2. 2008-07-15. PMID:18270592. |
pre-treatment of rats with a selective inhibitor of stat3, t40214, reduced the il-6-mediated increase in cardiac stat3 activity, blocked successful resuscitation by il-6 and reversed il-6-mediated protection from cardiac apoptosis. |
2008-07-15 |
2023-08-12 |
mouse |
| Jeffrey A Alten, Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PloS one. vol 3. issue 2. 2008-07-15. PMID:18270592. |
the hearts of mice deficient in the naturally occurring dominant negative isoform of stat3, stat3beta, were completely resistant to hs-induced apoptosis. |
2008-07-15 |
2023-08-12 |
mouse |
| Jeffrey A Alten, Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PloS one. vol 3. issue 2. 2008-07-15. PMID:18270592. |
thus, cardiac dysfunction, cardiomyocyte apoptosis and induction of apoptosis pathway genes are important components of hcc; il-6 administration prevented hcc by blocking cardiomyocyte apoptosis and induction of apoptosis pathway genes via stat3 and warrants further study as a resuscitation adjuvant for prevention of hcc and death in trauma patients. |
2008-07-15 |
2023-08-12 |
mouse |
| Marloes S van Kester, Jacoba J Out-Luiting, Peter A von dem Borne, Rein Willemze, Cornelis P Tensen, Maarten H Vermee. Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells. The Journal of investigative dermatology. vol 128. issue 7. 2008-06-24. PMID:18200050. |
cucurbitacin i inhibits stat3 and induces apoptosis in sézary cells. |
2008-06-24 |
2023-08-12 |
Not clear |
| Amanda L Boehm, Malabika Sen, Raja Seethala, William E Gooding, Maria Freilino, Silvia Man Yan Wong, Shaomeng Wang, Daniel E Johnson, Jennifer Rubin Grandi. Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck. Molecular pharmacology. vol 73. issue 6. 2008-06-10. PMID:18326051. |
the triple combination of erlotinib, stat3 decoy, and gossypol further enhanced cell growth inhibition and apoptosis in vitro, and it down-regulated signaling molecules further downstream of the egfr-stat3 signaling pathway, such as cyclin d1. |
2008-06-10 |
2023-08-12 |
Not clear |
| Gerardo G Mackenzie, Nina Queisser, Manuel L Wolfson, Cesar G Fraga, Ana M Adamo, Patricia I Oteiz. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386790. |
curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active nf-kappab and stat3 pathways in hodgkin's lymphoma cells. |
2008-06-02 |
2023-08-12 |
Not clear |
| Gerardo G Mackenzie, Nina Queisser, Manuel L Wolfson, Cesar G Fraga, Ana M Adamo, Patricia I Oteiz. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386790. |
therefore, the current goal in hl treatment is to find new therapies that specifically target the deregulated signaling cascades, such as nf-kappab and stat3, which cause hodgkin and reed-sternberg (h-rs) cell proliferation and resistance of apoptosis. |
2008-06-02 |
2023-08-12 |
Not clear |
| Gerardo G Mackenzie, Nina Queisser, Manuel L Wolfson, Cesar G Fraga, Ana M Adamo, Patricia I Oteiz. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386790. |
curcumin is incorporated into h-rs cells and acts inhibiting both nf-kappab and stat3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. |
2008-06-02 |
2023-08-12 |
Not clear |
| Yalai Bai, Usman Ahmad, Yinong Wang, Jie H Li, Jonathan C Choy, Richard W Kim, Nancy Kirkiles-Smith, Stephen E Maher, James G Karras, C Frank Bennett, Alfred L M Bothwell, Jordan S Pober, George Tellide. Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18192275. |
interferon-gamma induces x-linked inhibitor of apoptosis-associated factor-1 and noxa expression and potentiates human vascular smooth muscle cell apoptosis by stat3 activation. |
2008-05-20 |
2023-08-12 |
mouse |
| Yalai Bai, Usman Ahmad, Yinong Wang, Jie H Li, Jonathan C Choy, Richard W Kim, Nancy Kirkiles-Smith, Stephen E Maher, James G Karras, C Frank Bennett, Alfred L M Bothwell, Jordan S Pober, George Tellide. Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18192275. |
stat3 activation by ifn-gamma sensitized vsmcs to apoptosis triggered by both death receptor- and mitochondrial-mediated pathways. |
2008-05-20 |
2023-08-12 |
mouse |
| Hui-Fang Xie, Ru-Xiang Xu, Ji-Peng Wei, Xiao-Dan Jiang, Zhen-Hua Li. [P-JAK2 and P-STAT3 protein expression and cell apoptosis following focal cerebral ischemia-reperfusion injury in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 27. issue 2. 2008-05-15. PMID:17355939. |
to investigate the changes in phosphorylated jak2 and stat3 protein expression of and cell apoptosis following focal cerebral ischemia-reperfusion injury in rats. |
2008-05-15 |
2023-08-12 |
rat |
| Shigetoshi Sano, Keith Syson Chan, John DiGiovann. Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. Journal of dermatological science. vol 50. issue 1. 2008-04-22. PMID:17601706. |
it was shown that stat3 activation contributed to skin wound healing, keratinocyte migration, hair follicle growth, and resistance to uv irradiation-induced apoptosis. |
2008-04-22 |
2023-08-12 |
mouse |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. STAT3 inhibits apoptosis of human renal tubular epithelial cells induced by ATP depletion/recovery. Nephron. Experimental nephrology. vol 108. issue 1. 2008-04-14. PMID:18097150. |
stat3 inhibits apoptosis of human renal tubular epithelial cells induced by atp depletion/recovery. |
2008-04-14 |
2023-08-12 |
human |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. STAT3 inhibits apoptosis of human renal tubular epithelial cells induced by ATP depletion/recovery. Nephron. Experimental nephrology. vol 108. issue 1. 2008-04-14. PMID:18097150. |
in the in vitro model of renal ischemic injury, we explored the role of the stat3, a major component of the stat family, in apoptosis of human proximal tubular epithelial cell (hkc) induced by atp depletion/recovery. |
2008-04-14 |
2023-08-12 |
human |
| Corina Borghouts, Christian Kunz, Natalia Delis, Bernd Grone. Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Molecular cancer research : MCR. vol 6. issue 2. 2008-04-09. PMID:18314488. |
we show that treatment of glioblastoma cells, expressing constitutively activated stat3, with the purified peptide aptamers strongly inhibits stat3 signaling, causing cell growth arrest and inducing apoptosis. |
2008-04-09 |
2023-08-12 |
human |
| Rebecka Hellsten, Martin Johansson, Anna Dahlman, Nishtman Dizeyi, Olov Sterner, Anders Bjartel. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. The Prostate. vol 68. issue 3. 2008-04-01. PMID:18163422. |
stat3 signaling may be an interesting target for cancer therapy since inhibition of this pathway mediates growth inhibition and apoptosis of these cells. |
2008-04-01 |
2023-08-12 |
Not clear |
| B Belinda Ding, J Jessica Yu, Raymond Y-L Yu, Lourdes M Mendez, Rita Shaknovich, Yonghui Zhang, Giorgio Cattoretti, B Hilda Y. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood. vol 111. issue 3. 2008-03-26. PMID:17951530. |
most importantly, inactivating stat3 by either ag490 or small interference rna in abc-dlbcl cells inhibits cell proliferation and triggers apoptosis. |
2008-03-26 |
2023-08-12 |
Not clear |