| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dylan A Goodin, Eric Chau, Junjun Zheng, Cailin O'Connell, Anjana Tiwari, Yitian Xu, Polly Niravath, Shu-Hsia Chen, Biana Godin, Hermann B Frieboe. Characterization of the Breast Cancer Liver Metastasis Microenvironment via Machine Learning Analysis of the Primary Tumor Microenvironment. Cancer research communications. vol 4. issue 10. 2024-10-31. PMID:39373616. |
matched primary and metastatic human breast cancer samples were analyzed by imaging mass cytometry, identifying 20 shared marker clusters denoting macrophages (cd68, cd163, and cd206), monocytes (cd14), immune response (cd56, cd4, and cd8a), programmed cell death protein 1, pd-l1, tumor tissue (ki-67 and phosphorylated erk), cell adhesion (e-cadherin), hypoxia (hypoxia-inducible factor-1α), vascularity (cd31), and extracellular matrix (alpha smooth muscle actin, collagen, and matrix metalloproteinase 9). |
2024-10-31 |
2024-11-02 |
human |
| Weslay Rodrigues da Silva, Ana Paula Veras Sobral, Kaline Romeiro, Cleiton Rone Dos Santos Lima, Marina da Cunha Isaltino, Christianne Tavares Velozo Telles, Diana Santana de Albuquerqu. Proteins Associated with Persistent Apical Periodontitis: A Scoping Review. Iranian endodontic journal. vol 19. issue 4. 2024-10-29. PMID:39469511. |
a total of 12 biomarkers were identified, forkhead box p3, cluster of differentiation (cd)3, cd8, cd450, cd68, transforming growth factor alpha, transforming growth factor-beta1, matrix metalloproteinase-9, receptor activator of nuclear factor kappa beta ligand, osteoprotegerin, cd90 and sex-determining region y-box 2; categorized according to their applicability. |
2024-10-29 |
2024-10-31 |
Not clear |
| Anne Gomez-Mascard, Nathalie Van Acker, Guillaume Cases, Anthony Mancini, Sofia Galanou, François Xavier Frenois, Pierre Brousset, Jérôme Sales de Gauzy, Thibaud Valentin, Marie-Pierre Castex, Cécile Vérité, Sylvie Lorthois, Michel Quintard, Pascal Swider, Marie Faruch, Pauline Assema. Intra-tumoral heterogeneity assessment of the extracellular bone matrix and immune microenvironment in osteosarcoma using digital imaging to predict therapeutic response. Laboratory investigation; a journal of technical methods and pathology. 2024-08-04. PMID:39098628. |
we studied the interactions between tumor cells, immune cells (lymphocytes, histiocytes, osteoclasts), and bone extracellular matrix (ecm) in 18 surgical resection samples of osteosarcoma using multiplex and conventional immunohistochemistry (cd8, cd163, cd68, satb2), combined with multi-scale characterization approaches in territories of good and poor response (grt/prt) to treatment. |
2024-08-04 |
2024-08-07 |
Not clear |
| Victoria Stefanelli, Jared Lombardi, Joselito Ferrer, Maryellen Sando. Vascularization of Human Acellular Dermal Matrices: A Comparative Study in a Nonhuman Primate Model. Tissue engineering. Part A. 2024-07-23. PMID:39041614. |
immunohistochemical and histological assessments were conducted on biopsies from each hadm at 1, 3, and 6 months post-implantation to assess vascularization (hematoxylin and eosin [h&e], cd31, alpha smooth muscle actin [αsma], collagen iv), inflammatory/immune response (h&e, cd3, cd20, cd68), and collagen turnover (h&e, matrix metalloproteinase-9 [mmp-9]). |
2024-07-23 |
2024-07-25 |
human |
| Ziwei Chen, Jiarui Cui, Zejun Chen, Jiamin Wang, Hui Li, Nan Ouyang, Qiang Shi, Xueping L. Pulmo-protection of long-term swimming exercise via improving insulin sensitivity in monocrotaline-induced pulmonary hypertensive rats. Biochemical and biophysical research communications. vol 723. 2024-06-22. PMID:38815488. |
assessment of pulmonary substrate in pah rats indicated a prominent pro-inflammatory substrate, evidenced by macrophage accumulation through quantitative immunohistological analysis of macrophage-like cell expression (cd68), and extracellular matrix remodeling, evaluated by masson staining. |
2024-06-22 |
2024-06-25 |
rat |
| Bin Zhang, Kuan Zeng, Rui-Cong Guan, Hui-Qi Jiang, Yong-Jia Qiang, Qing Zhang, Mo Yang, Bao-Ping Deng, Yan-Qi Yan. Single-Cell RNA-Seq Analysis Reveals Macrophages Are Involved in the Pathogenesis of Human Sporadic Acute Type A Aortic Dissection. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830768. |
finally, immunohistochemistry, immunofluorescence, and western blot experiments confirmed the overexpression of macrophage marker genes (cd68 and cd163) and matrix metalloproteinases (mmp9 and mmp2) in ataad tissue. |
2023-02-25 |
2023-08-14 |
human |
| Zenaida Ceauşu, Manuela Popa, Bogdan Socea, Gabriel Petre Gorecki, Mariana Costache, Mihai Ceauş. Influence of the microenvironment dynamics on extracellular matrix evolution under hypoxic ischemic conditions in the myocardium. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-07. PMID:35126702. |
tissue samples were taken from the myocardium of the left ventricle (anterior and lateral walls), and multiple series of histological sections were produced and analyzed using immunohistochemistry for collagen type i (col-1), tenascin c (tn-c), matrix metalloproteinase 9, cd34, and cd68. |
2022-02-07 |
2023-08-13 |
Not clear |
| Zaroug Jaleel, Elizabeth Blasberg, Chelsea Troiano, Paige Montanaro, Sarah Mazzilli, Hans Peter Gertje, Nicholas A Crossland, Michael Platt, Jeffrey Spiege. Association of vaping with decreased vascular endothelial growth factor expression and decreased microvessel density in cutaneous wound healing tissue in rats. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 29. issue 6. 2021-11-08. PMID:34129265. |
after 30 days, random pattern flaps were raised and healed for 2 weeks after which skin punch biopsies of flap and non-flap tissues were collected for quantitative-reverse transcription-polymerase chain reaction of three selected wound healing genes (transforming growth factor β [tgf-β], vascular endothelial growth factor [vegf], matrix metalloproteinase-1 [mmp-1]); then, immunohistochemistry for cd68 expression, α-smooth muscle actin looking at microvessel density (mvd) and in situ hybridization to localize vegf production were undertaken. |
2021-11-08 |
2023-08-13 |
rat |
| b' Tibor Teplick\\xc3\\xbd, Anton Matea\\xc5\\xa1\\xc3\\xadk, Zuzana Bal\\xc3\\xa1zsiov\\xc3\\xa1, Karol Kajo, Miroslava Vallov\\xc3\\xa1, Barbora Filov\\xc3\\xa1, Michal Trnka, Beata \\xc4\\x8cunderl\\xc3\\xadkov\\xc3\\xa. Phenotypical modifications of immune cells are enhanced by extracellular matrix. Experimental cell research. vol 405. issue 2. 2021-10-11. PMID:34174319.' |
moreover, even chemically uninduced monocytic thp-1 cells were present in a minor fraction as cd68 positive cell population in collagen type i matrix indicating their partial differentiation to macrophages. |
2021-10-11 |
2023-08-13 |
Not clear |
| Yifeng Luo, Hui Yi, Xinyan Huang, Gengpeng Lin, Yukun Kuang, Yubiao Guo, Canmao Xi. Inhibition of macrophage migration inhibitory factor (MIF) as a therapeutic target in bleomycin-induced pulmonary fibrosis rats. American journal of physiology. Lung cellular and molecular physiology. vol 321. issue 1. 2021-10-04. PMID:33881353. |
the results showed that mif inhibition attenuated lung injury and extracellular matrix deposition; significantly reduced the levels of cytokines including transforming growth factor-β1 (tgf-β1), tumor necrosis factor-α (tnf-α), interleukin-17 (il-17), hydroxyproline (hyp), fibroblast growth factor 23 (fgf23), and secreted phosphoprotein 1 (spp1); and inhibited the expression of cd68, f4/80, and α-smooth muscle actin (α-sma) protein. |
2021-10-04 |
2023-08-13 |
rat |
| Fernando Corvillo, Pilar Nozal, Alberto López-Lera, María P De Miguel, Juan Alberto Piñero-Fernández, Raúl De Lucas, María D García-Concepción, María J Beato, David Araújo-Vilar, Margarita López-Trascas. Evidence of ongoing complement activation on adipose tissue from an 11-year-old girl with Barraquer-Simons syndrome. The Journal of dermatology. vol 47. issue 12. 2021-05-14. PMID:32890433. |
adipose tissue from the patient showed atrophied and dead adipocytes, an abnormal production of extracellular matrix, and a remarkable accumulation of infiltrating cd68 macrophages and adipocyte precursors (marked by c-kit positiveness). |
2021-05-14 |
2023-08-13 |
Not clear |
| A P Burlaka, I I Ganusevich, A V Vovk, A A Burlaka, M R Gafurov, S N Luki. Redox state of adipose tissue for patients with gastric cancer and its connection with the body mass index and distance from the tumor. Obesity research & clinical practice. vol 14. issue 1. 2021-01-22. PMID:31711773. |
superoxide generation rate, activity of complex i in electron transport chain of mitochondria, activity of matrix metalloproteinase (mmp-2 and 9) of adipose tissues (at) of patients with gastric cancer in at located adjacent to tumor (atat) and at a distance of 3 cm (atd) are measured to follow the connection of the redox state with some of the microenvironment indicators (hif-1α, cd68, plin5), body mass index (bmi) and cancer metastasis. |
2021-01-22 |
2023-08-13 |
Not clear |
| Heejei Yoon, Seung-Il Choi, Eung Kweon Ki. Uptake of cell debris and enhanced expression of inflammatory factors in response to dead cells in corneal fibroblast cells. Experimental eye research. vol 194. 2020-12-15. PMID:32217186. |
the corneal fibroblasts strongly expressed extracellular matrix molecules (fn and col1a1) and low or medium levels of macrophage markers (cd14, cd68, and cd36), inflammatory cytokines (il1a, il1b, and il6), and chemokines (il8 and ccl2), but not cd11b, suggesting that corneal fibroblasts are macrophage-like fibroblasts. |
2020-12-15 |
2023-08-13 |
Not clear |
| Hui Li, Jingjing Sun, Hefeng Yang, Xue Han, Xiangyou Luo, LiJun Liao, Bo Yang, Tian Zhu, Fangjun Huo, Weihua Guo, Weidong Tia. Recruited CD68 Bioactive materials. vol 6. issue 4. 2020-10-28. PMID:33102946. |
recruited cd68 successful regenerative medicine strategies of xenogeneic extracellular matrix need a synergistic balance among inflammation, fibrosis, and remodeling process. |
2020-10-28 |
2023-08-13 |
Not clear |
| Shukui Zhou, Ying Wang, Kaile Zhang, Nailong Cao, Ranxing Yang, Jianwen Huang, Weixin Zhao, Mahbubur Rahman, Hong Liao, Qiang F. The Fabrication and Evaluation of a Potential Biomaterial Produced with Stem Cell Sheet Technology for Future Regenerative Medicine. Stem cells international. vol 2020. 2020-09-28. PMID:32104186. |
then, acellular matrix was transplanted onto subcutaneous tissue for 1 week or 3 weeks; h&e staining and immunohistochemical analysis of cd68 expression and quantitative real-time pcr (qpcr) were performed to evaluate the immunogenicity and biocompatibility. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lande Xue, Linwang Su, Jianli Xie, Yanmei Du, Xijiao Y. EMMPRIN-CypA contributes to the inflammatory processes in human periodontitis through infiltrating CD68 International journal of clinical and experimental pathology. vol 11. issue 8. 2020-01-21. PMID:31949770. |
emmprin-cypa contributes to the inflammatory processes in human periodontitis through infiltrating cd68 extracellular matrix metalloproteinase inducer (emmprin) and its ligand cyclophilin a (cypa) levels increase in human inflammatory diseases, but emmprin-cypa interactions and cell types expressing emmprin and cypa in the pathogenesis of periodontitis are uncertain. |
2020-01-21 |
2023-08-13 |
human |
| Sara Bravaccini, Roberta Malton. CD68, CD163, and matrix metalloproteinase 9 (MMP-9) in breast tumor microenvironment to predict breast cancer survival: are they enough? Breast cancer research : BCR. vol 21. issue 1. 2019-09-18. PMID:30944011. |
cd68, cd163, and matrix metalloproteinase 9 (mmp-9) in breast tumor microenvironment to predict breast cancer survival: are they enough? |
2019-09-18 |
2023-08-13 |
Not clear |
| Vasiliki Pelekanou, Franz Villarroel-Espindola, Kurt A Schalper, Lajos Pusztai, David L Rim. CD68, CD163, and matrix metalloproteinase 9 (MMP-9) co-localization in breast tumor microenvironment predicts survival differently in ER-positive and -negative cancers. Breast cancer research : BCR. vol 20. issue 1. 2019-06-06. PMID:30558648. |
cd68, cd163, and matrix metalloproteinase 9 (mmp-9) co-localization in breast tumor microenvironment predicts survival differently in er-positive and -negative cancers. |
2019-06-06 |
2023-08-13 |
Not clear |
| Shawna S Kim, Georgia Nikoloudaki, Mark Darling, Michael J Rieder, Douglas W Hamilto. Phenytoin activates Smad3 phosphorylation and periostin expression in drug-induced gingival enlargement. Histology and histopathology. vol 33. issue 12. 2019-03-13. PMID:29916554. |
human pige tissues were assessed using masson's trichrome, with cell infiltration and changes in extracellular matrix composition characterized through labeling with antibodies to periostin, phospho-smad 3, tgf-β, as well as the macrophage markers cd68 and rm3/1. |
2019-03-13 |
2023-08-13 |
human |
| Therése Lindsten, Alexander Hedbrant, Anna Ramberg, Jonny Wijkander, Anja Solterbeck, Margareta Eriksson, Dick Delbro, Ann Erlandsso. Effect of macrophages on breast cancer cell proliferation, and on expression of hormone receptors, uPAR and HER-2. International journal of oncology. vol 51. issue 1. 2018-07-17. PMID:28498427. |
in this study, we examined the immunoreactivity of the macrophage markers cd68 and cd163 as well as the hormone receptors estrogen receptor α (erα), progesterone receptor (pr), estrogen receptor β1 (erβ1), human epidermal growth factor receptor 2 (her-2), matrix metalloproteinase 9 (mmp‑9), urokinase-type plasminogen activator receptor (upar) and the proliferations marker ki67 in 17 breast cancer biopsies. |
2018-07-17 |
2023-08-13 |
human |