| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ram Prajit, Nataya Sritawan, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welba. Chrysin alleviates the impeded neurogenesis in accelerated brain aging by D-galactose in rats. Biogerontology. vol 26. issue 2. 2025-03-14. PMID:40085327. |
aged-related cognitive impairments are associated with molecular neurodegenerations and impeded neurogenesis in the dentate gyrus (dg) of the damaged hippocampus. |
2025-03-14 |
2025-03-17 |
rat |
| Ane Rodríguez-Bodero, Paolo Bonifazi, Jan Tønnesen, Juan Manuel Encinas-Pére. Picrotoxin-Induced Epileptogenic Hippocampal Organotypic Slice Cultures (hOTCs). Methods in molecular biology (Clifton, N.J.). vol 2899. 2025-03-11. PMID:40067635. |
this model offers significant advantages over traditional in vitro methods, as they allow the examination of mid to long-term manipulations while preserving the structure of the dentate gyrus (dg) in the hippocampus. |
2025-03-11 |
2025-03-14 |
mouse |
| Anne-Sophie Sack, Esperanza Garcia, Terrance P Snutc. Maturational Stage Dependent Contributions of the Cav3.2 T-type Calcium Channel to Dentate Gyrus Granule Cell Excitability. eNeuro. 2025-03-11. PMID:40068874. |
cav3.2 channels are highly expressed in the dentate gyrus (dg) of the hippocampus, and mice lacking cav3.2 (ko) exhibit impairments in hippocampal dependent learning and memory tasks, as well as attenuated development of pilocarpine induced epilepsy. |
2025-03-11 |
2025-03-14 |
mouse |
| Stefania Bartoletti, Federica Raimondi, Beatrice Casadei Garofani, Elisa Ren, Francesca Ciarpella, Arianna Capodiferro, Gemma Palazzolo, Antonietta Vilella, Giuseppina Leo, Michele Zoli, Ilaria Decimo, Giulia Curi. Two minimally invasive strategies to implant guide cannulas for multiple injections in deep brain areas. Methods (San Diego, Calif.). 2025-03-10. PMID:40064209. |
to overcome this problem, we developed, in tle adult rats, two novel approaches to implant guide cannulas more superficially: the "above dentate gyrus (dg)" and the "above hippocampus (hpc)" strategies. |
2025-03-10 |
2025-03-13 |
rat |
| Lisa Traunmüller, Erin E Duffy, Hanqing Liu, Stella Sanalidou, Elena G Assad, Senmiao Sun, Naeem S Pajarillo, Nancy Niu, Eric C Griffith, Michael E Greenber. Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus. bioRxiv : the preprint server for biology. 2025-03-10. PMID:40060638. |
we employed single- nucleus multiomics (snrna- and atac-seq) and bulk rna-seq of the hippocampal dg, ca3, and ca1 regions to characterize the temporal evolution of cell-type-specific chromatin accessibility and gene expression changes that occur in 14 different cell types of the hippocampus upon exposure of mice to a novel environment. |
2025-03-10 |
2025-03-12 |
mouse |
| Kin Pong U, Lin Gao, Huan Zhang, Zeyuan Ji, Jiacheng Lin, Shenyi Peng, Xiaohu Zhang, Shaolong Xue, Weifeng Qin, Lai Ling Tsang, Yonglun Kong, Yin Xia, Patrick Ming-Kuen Tang, Tao Wang, Wayne Yuk Wai Lee, Gang Li, Xiaohua Jian. KDM3A controls postnatal hippocampal neurogenesis via dual regulation of the Wnt/β-catenin signaling pathway. Cell death and differentiation. 2025-03-03. PMID:40033066. |
hippocampal neurogenesis, the generation of new neurons in the dentate gyrus (dg) of mammalian hippocampus, is essential for cognitive and emotional processes. |
2025-03-03 |
2025-03-06 |
mouse |
| Weijia Zhi, Jiale Tang, Mingzhao Zhang, Yong Zou, Simo Qiao, Lizhen Ma, Ji Dong, Binwei Yao, Xuelong Zhao, Zhenqi Yang, Zhongwu Lin, Xiangjun Hu, Lifeng Wan. Mechanistic insights into microwave radiation induced cognitive impairments: The role of m Ecotoxicology and environmental safety. vol 292. 2025-02-25. PMID:39999628. |
based on previous studies, we hypothesize that microwave-induced cognitive impairments and vulnerability in the hippocampal dentate gyrus (dg) region are due to abnormal synaptic plasticity regulated by both newborn and mature neurons derived from neural stem cells (nscs). |
2025-02-25 |
2025-02-28 |
human |
| Yuanyuan Hou, Yao Zuo, Shaofei Song, Tong Zhan. Long-term variable photoperiod exposure impairs hippocampal synapse involving of the glutamate system and leads to memory deficits in male Wistar rats. Experimental neurology. 2025-02-19. PMID:39971149. |
to investigate the impact of circadian misalignment on hippocampal function, we measured various field excitatory postsynaptic potentials (fepsp) and golgi staining in the ca1 and dentate gyrus (dg) regions in wistar rats. |
2025-02-19 |
2025-02-23 |
human |
| Xiao-Jie Li, Shuo Wu, Zi-Han Liu, An-An Liu, Hui-Sheng Peng, Yu-Jun Wang, Ye-Xiang Chen, Jing-Gen Liu, Chi X. CXCR2 modulates chronic pain comorbid depression in mice by regulating adult neurogenesis in the ventral dentate gyrus. Acta pharmacologica Sinica. 2025-02-19. PMID:39972170. |
research shows that chronic pain may induce depression-like behaviors through impairing adult hippocampal neurogenesis (ahn) in the ventral dentate gyrus (dg), whereas restoration of ahn may effectively alleviate depression. |
2025-02-19 |
2025-02-23 |
mouse |
| David J Horovitz, Laura A Askins, Grace M Regnier, Joseph A McQuai. Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions. Neurobiology of aging. vol 148. 2025-02-15. PMID:39954409. |
higher levels of the vesicular gaba transporter (vgat) were associated with better spatial learning in older rats, across several synaptic zones of the dorsal hippocampus, including the outer molecular layer of the dentate gyrus (dg), and the so, sr, slm, and pyramidal cell layers of both ca3 and ca1. |
2025-02-15 |
2025-02-18 |
rat |
| Yue Li, Li-Li Zhang, Can Zhao, Hong-Mei Zhao, Yan Wang, Jin-Lei Fu, Jie Zhang, Ning Zhang, Hong-Dan X. [Effect of Eucommiae Cortex extract mediated by ERβ/JNK pathway on learning and memory ability of APP/PS1 double-transgenic mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929610. |
the histomorphological and cellular ultrastructural features of the hippocampal region of the mice were observed by hematoxylin-eosin(he) staining and transmission electron microscopy(tem); the molecular docking validation of the key active ingredients and the key targets was performed by using autodock vina software, and the immunohistochemical method(ihc) was used to detect the erβ expression in the dentate gyrus(dg) area of mouse hippocampus. |
2025-02-10 |
2025-02-13 |
mouse |
| Yue Li, Li-Li Zhang, Can Zhao, Hong-Mei Zhao, Yan Wang, Jin-Lei Fu, Jie Zhang, Ning Zhang, Hong-Dan X. [Effect of Eucommiae Cortex extract mediated by ERβ/JNK pathway on learning and memory ability of APP/PS1 double-transgenic mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929610. |
tem results showed that some neuronal nuclei in the hippocampal area had a consolidated state, slightly thickened and aberrant nuclear membranes, and fewer intracytoplasmic nidus bodies; the ihc results showed that the expression of erβ in the hippocampal dg area of the mice was reduced. |
2025-02-10 |
2025-02-13 |
mouse |
| Yue Li, Li-Li Zhang, Can Zhao, Hong-Mei Zhao, Yan Wang, Jin-Lei Fu, Jie Zhang, Ning Zhang, Hong-Dan X. [Effect of Eucommiae Cortex extract mediated by ERβ/JNK pathway on learning and memory ability of APP/PS1 double-transgenic mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929610. |
the pyramidal cells tended to be arranged in an orderly manner; the nuclei of neurons in the hippocampal area were in a better state; the expression of erβ in the hippocampal dg area of the mice was elevated; the expression of erβ in the hippocampal tissue was elevated, and the level of p-jnk/jnk was reduced. |
2025-02-10 |
2025-02-13 |
mouse |
| Yicheng Wu, Vladyslav I Korobeynyk, Margherita Zamboni, Felix Waern, John Darby Cole, Sarah Mundt, Melanie Greter, Jonas Frisén, Enric Llorens-Bobadilla, Sebastian Jessberge. Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus. Nature neuroscience. vol 28. issue 2. 2025-02-07. PMID:39762661. |
our data reveal the lifelong molecular dynamics of nscs and their surrounding neurogenic dg niche with age and provide a powerful resource to understand age-related molecular alterations in the aging hippocampus. |
2025-02-07 |
2025-02-09 |
Not clear |
| Joshua Jin, James Doan, Cassandra Fernandez, Samuel Nguyen, Cole Spencer, Alexander M Kleschevniko. Early postnatal GABAB antagonist treatment normalizes inhibitory/excitatory balance in neonatal Ts65Dn mice, a genetic model of down syndrome. Experimental neurology. vol 386. 2025-02-01. PMID:39889878. |
we observed that hippocampal girk2 levels are enhanced, gabab/girk2 signaling efficiency is increased, and intrinsic neuronal excitability of dentate gyrus (dg) granule cells is reduced in neonatal ts65dn mice. |
2025-02-01 |
2025-02-04 |
mouse |
| Xiaojing Chen, Ning Cheng, Cheng Wang, James J Knieri. Impaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model. Proceedings of the National Academy of Sciences of the United States of America. vol 122. issue 5. 2025-01-30. PMID:39883841. |
the hippocampal dentate gyrus (dg) is thought to orthogonalize inputs from the entorhinal cortex (pattern separation) and relay this information to the ca3 region. |
2025-01-30 |
2025-02-02 |
mouse |
| Peng Ren, Jing-Ya Wang, Meng-Jie Xu, Hong-Lei Chen, Jing-Yao Duan, Yun-Feng L. Enhancement of neurogenesis and antidepressant-like efficacy through combined activation of Sigma-1 and 5-HT1A receptors: focus on Sigma-1-5-HT1A heteroreceptor complex. Neurochemistry international. 2025-01-30. PMID:39884578. |
mechanistically, combined treatment with s1r and 5-ht1a agonists showed a synergistic effect on neurogenesis and plasticity in the dorsal dg region of the hippocampus in crs mice. |
2025-01-30 |
2025-02-02 |
mouse |
| Alberto Pauletti, Polina Gurlo, Edna Weiß, Ana Beatriz DePaula-Silva, Karen S Wilcox, Sonja Bröe. Viral encephalitis and seizures cause rapid depletion of neuronal progenitor cells and alter neurogenesis in the adult mouse dentate gyrus. Frontiers in cellular neuroscience. vol 18. 2025-01-29. PMID:39876841. |
given that epilepsy conventionally correlates with hippocampal sclerosis and neuronal degeneration, a potentially innovative avenue for therapeutic intervention involves fostering adult neurogenesis, a process primarily occurring within the subgranular zone of the dentate gyrus (dg) through the differentiation of neural stem cells (nsc). |
2025-01-29 |
2025-01-31 |
mouse |
| Ravi Kumar, Pratibha Kumari, Raj Kuma. Central Nervous System Response Against Ionizing Radiation Exposure: Cellular, Biochemical, and Molecular Perspectives. Molecular neurobiology. 2025-01-28. PMID:39875779. |
the hippocampus region, specifically the dentate gyrus (dg) and subventricular zone (svz), have been identified as a radiation-sensitive neurogenic niche. |
2025-01-28 |
2025-01-31 |
Not clear |
| Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuj. Repeated exposure to antibiotics exhibits anxiety-like behaviors with a reduction in neurogenesis in the ventral hippocampus of dentate gyrus. Neuroscience letters. 2025-01-22. PMID:39842766. |
disruption of gut microbiota balance is known to contribute to the development of anxiety; however, it remains unclear whether dysbiosis-induced anxiety involves the glycogen synthase kinase-3β (gsk-3β)/camp response element binding protein (creb)/brain-derived neurotrophic factor (bdnf) pathway and neurogenesis in the ventral hippocampal dentate gyrus (dg). |
2025-01-22 |
2025-01-25 |
mouse |