| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
the dentate gyrus (dg), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the alzheimer's type due to alzheimer's disease (dat-ad), but less is known about the susceptibility of the dg to other tauopathies. |
2023-01-03 |
2023-08-14 |
human |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
we conclude that the dg is differentially vulnerable to pathologic tau accumulation, raising intriguing questions about the structural integrity and functional significance of hippocampal circuits in neurodegenerative dementias. |
2023-01-03 |
2023-08-14 |
human |
| Shirley Jaqueline Szriber, Leonardo Santana Novaes, Nilton Barreto Dos Santos, Carolina Demarchi Munhoz, Deise Carla Almeida Leite-Dellov. Imbalance in the ratio between mineralocorticoid and glucocorticoid receptors and neurodegeneration in the dentate gyrus of aged dogs. Veterinary world. vol 15. issue 11. 2023-01-02. PMID:36590120. |
given the aging changes in dogs' dentate gyrus (dg) and the possible involvement of cortisol receptors in this process, this study aimed to evaluate the expression of mr and gr and neuronal degeneration in this hippocampal region of aged dogs. |
2023-01-02 |
2023-08-14 |
Not clear |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway. Ecotoxicology and environmental safety. vol 250. 2022-12-31. PMID:36586168. |
consistent with these changes, we also observed that dlan-bl reduced the number of neurons in the ca1, ca3 and dg regions of the hippocampus, up-regulated the mrna expression levels of bax, down-regulated the mrna expression levels of bcl-2, bcl-xl and the protein expression level of pirs1, pakt, pgsk3β, β-catenin in the hippocampus. |
2022-12-31 |
2023-08-14 |
mouse |
| Azahara Oliva, Antonio Fernandez-Ruiz, Lindsay A Karab. CA2 orchestrates hippocampal network dynamics. Hippocampus. 2022-12-28. PMID:36575880. |
the hippocampus is composed of various subregions: ca1, ca2, ca3, and the dentate gyrus (dg). |
2022-12-28 |
2023-08-14 |
Not clear |
| Eu-Gene Kim, Wonseok Chang, SangYep Shin, Anjana Silwal Adhikari, Geun Hee Seol, Dae-Yong Song, Sun Seek Mi. Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 27. issue 1. 2022-12-28. PMID:36575939. |
gad67-positive neurons were increased in the hippocampal regions we observed: dentate gyrus (dg), ca3, ca1, subiculum, presubiculum, and parasubiculum. |
2022-12-28 |
2023-08-14 |
mouse |
| Youri G Bolsius, Pim R A Heckman, Camilla Paraciani, Sophia Wilhelm, Frank Raven, Elroy L Meijer, Martien J H Kas, Steve Ramirez, Peter Meerlo, Robbert Haveke. Recovering object-location memories after sleep deprivation-induced amnesia. Current biology : CB. 2022-12-28. PMID:36577400. |
here, we show that hippocampal object-location memories formed under sleep deprivation conditions can be successfully retrieved multiple days following training, using optogenetic dentate gyrus (dg) memory engram activation or treatment with the clinically approved phosphodiesterase 4 (pde4) inhibitor roflumilast. |
2022-12-28 |
2023-08-14 |
mouse |
| Alyssa M Ash, Elena Regele-Blasco, Désirée R Seib, Erin Chahley, Patrick D Skelton, Bryan W Luikart, Jason S Snyde. Adult-born Neurons Inhibit Developmentally-born Neurons during Spatial Learning. Neurobiology of learning and memory. 2022-12-26. PMID:36572174. |
ongoing neurogenesis in the dentate gyrus (dg) subregion of the hippocampus results in a heterogenous population of neurons. |
2022-12-26 |
2023-08-14 |
rat |
| Maria Kawalec, Piotr Wojtyniak, Ewelina Bielska, Anita Lewczuk, Anna Boratyńska-Jasińska, Małgorzata Beręsewicz-Haller, Małgorzata Frontczak-Baniewicz, Magdalena Gewartowska, Barbara Zabłock. Mitochondrial dynamics, elimination and biogenesis during post-ischemic recovery in ischemia-resistant and ischemia-vulnerable gerbil hippocampal regions. Biochimica et biophysica acta. Molecular basis of disease. 2022-12-25. PMID:36566873. |
our research revealed a significantly greater mtdna/ndna ratio in ca2-3, dg hippocampal regions (5.8 ± 1.4 vs 3.6 ± 0.8 in ca1) that corresponded to a neuronal resistance to i/r. |
2022-12-25 |
2023-08-14 |
Not clear |
| Yue Li, S Thameem Dheen, Fengru Tang, Yumin Luo, Ran Meng, Tay Sam Wah Samuel, Lan Zhan. Stage- and Subfield-Associated Hippocampal miRNA Expression Patterns after Pilocarpine-Induced Status Epilepticus. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551767. |
to investigate microrna (mirna) expression profiles before and after pilocarpine-induced status epilepticus (se) in the cornu ammonis (ca) and dentated gyrus (dg) areas of the mouse hippocampus, and to predict the downstream proteins and related pathways based on bioinformatic analysis. |
2022-12-23 |
2023-08-14 |
mouse |
| Anita Lewczuk, Barbara Zablocka, Malgorzata Beresewicz-Halle. Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4,DG Region? Molecular neurobiology. 2022-12-22. PMID:36547847. |
is nrf2 behind endogenous neuroprotection of the hippocampal ca2-4,dg region? |
2022-12-22 |
2023-08-14 |
Not clear |
| Anita Lewczuk, Barbara Zablocka, Malgorzata Beresewicz-Halle. Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4,DG Region? Molecular neurobiology. 2022-12-22. PMID:36547847. |
an example of endogenous neuroprotection is ischemia-resistance of the hippocampal regions comprising the ca2, ca3, ca4 and dentate gyrus subfields (here abbreviated to ca2-4,dg) which can be contrasted with the ischemia-vulnerable ca1 region. |
2022-12-22 |
2023-08-14 |
Not clear |
| Anita Lewczuk, Barbara Zablocka, Malgorzata Beresewicz-Halle. Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4,DG Region? Molecular neurobiology. 2022-12-22. PMID:36547847. |
our results therefore suggest that high nrf2 activity in ca2-4,dg may guarantee resistance of this region to i/r, potentially explaining the differential sensitivities of the hippocampal regions. |
2022-12-22 |
2023-08-14 |
Not clear |
| Longjie Zhang, Lan Luo, Lifen Xue, Dongzhi Ran, Fang Yang, Qiang Tang, Wengao Jian. RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG. Experimental neurology. 2022-12-15. PMID:36521778. |
rage signaling pathway is involved in cus-induced depression-like behaviors by regulating the expression of nr2a and nr2b in rat hippocampus dg. |
2022-12-15 |
2023-08-14 |
rat |
| Longjie Zhang, Lan Luo, Lifen Xue, Dongzhi Ran, Fang Yang, Qiang Tang, Wengao Jian. RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG. Experimental neurology. 2022-12-15. PMID:36521778. |
cus decreased the expression of rage, nr2a, and nr2b, inhibited the phosphorylation of transcript factor erk and creb in rat hippocampus dg. |
2022-12-15 |
2023-08-14 |
rat |
| Longjie Zhang, Lan Luo, Lifen Xue, Dongzhi Ran, Fang Yang, Qiang Tang, Wengao Jian. RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG. Experimental neurology. 2022-12-15. PMID:36521778. |
rage knockdown in hippocampus dg by rage shrna lentiviral particles induced depressive-like behaviors, reduced the mrna and protein expression of nr2a and nr2b, and inhibited the phosphorylation of erk and creb. |
2022-12-15 |
2023-08-14 |
rat |
| Longjie Zhang, Lan Luo, Lifen Xue, Dongzhi Ran, Fang Yang, Qiang Tang, Wengao Jian. RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG. Experimental neurology. 2022-12-15. PMID:36521778. |
rage over-expression in hippocampus dg by rage adenovirus particles reversed the effects of cus on depressive-like behaviors, erk and creb phosphorylation, and nr2a and nr2b expression. |
2022-12-15 |
2023-08-14 |
rat |
| Kıymet Kübra Tüfekci, Elfide Gizem Bakirhan, Funda Terz. A Maternal High-Fat Diet Causes Anxiety-Related Behaviors by Altering Neuropeptide Y1 Receptor and Hippocampal Volumes in Rat Offspring: the Potential Effect of N-Acetylcysteine. Molecular neurobiology. 2022-12-11. PMID:36502431. |
stereological data indicated significant decreases in the total volume of the hippocampus and ca1 and dentate gyrus (dg) regions in the obese (ob) group (p < 0.01). |
2022-12-11 |
2023-08-14 |
rat |
| Meng-Ying Liu, Lu-Lu Wei, Xian-Hui Zhu, Hua-Chen Ding, Xiang-Hu Liu, Huan Li, Yuan-Yuan Li, Zhou Han, Lian-Di Li, Zi-Wei Du, Ya-Ping Zhou, Jing Zhang, Fan Meng, Yu-Lin Tang, Xiao Liu, Chun Wang, Qi-Gang Zho. Prenatal stress modulates HPA axis homeostasis of offspring through dentate TERT independently of glucocorticoids receptor. Molecular psychiatry. 2022-12-09. PMID:36481932. |
we found that the level of tert in the dentate gyrus (dg) of the hippocampus during the developmental stage determines the responses of the hpa axis to stressful events in adulthood through modulating the excitability of the dentate granular cells (dgcs) rather than the expression of gr. |
2022-12-09 |
2023-08-14 |
mouse |
| Li Zhang, Bijia Song, Xuan Zhang, Mu Jin, Lixin An, Tiandong Han, Fan Liu, Zhiyao Wan. Resveratrol Ameliorates Trigeminal Neuralgia-Induced Cognitive Deficits by Regulating Neural Ultrastructural Remodelling and the CREB/BDNF Pathway in Rats. Oxidative medicine and cellular longevity. vol 2022. 2022-12-08. PMID:36478990. |
ultrastructures of the hippocampal dg region and infraorbital nerve were observed by transmission electron microscopy. |
2022-12-08 |
2023-08-14 |
rat |