| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Błażej Ruszczycki, Katarzyna Karolina Pels, Agnieszka Walczak, Katarzyna Zamłyńska, Michał Such, Andrzej Antoni Szczepankiewicz, Małgorzata Hanna Hall, Adriana Magalska, Marta Magnowska, Artur Wolny, Grzegorz Bokota, Subhadip Basu, Ayan Pal, Dariusz Plewczynski, Grzegorz Marek Wilczyńsk. Three-Dimensional Segmentation and Reconstruction of Neuronal Nuclei in Confocal Microscopic Images. Frontiers in neuroanatomy. vol 13. 2020-10-01. PMID:31481881. |
an essential prerequisite to any quantification is the segmentation of the nuclei which are typically tightly packed in the tissue, the extreme being the hippocampal dentate gyrus (dg), in which nuclei frequently appear to overlap due to limitations in microscope resolution. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiang Cheng, Haoming Li, Heyan Zhao, Wen Li, Jianbing Qin, Guohua Ji. Function and mechanism of long non-coding RNA Gm21284 in the development of hippocampal cholinergic neurons. Cell & bioscience. vol 9. 2020-10-01. PMID:31485323. |
our previous studies have demonstrated that enhanced cholinergic neurogenesis occurs in the subgranular zone (sgz) of the hippocampal dentate gyrus (dg) after cholinergic denervation, which is closely associated with the core transcription factor lhx8. |
2020-10-01 |
2023-08-13 |
Not clear |
| Akihiro Yamauchi, Takahiro Tone, Koji Sugimoto, Hong Seok Lim, Taiichi Kaku, Chihiro Tohda, Takayuki Shindo, Koji Tamada, Yoichi Mizukami, Eiichi Hiran. Porcine placental extract facilitates memory and learning in aged mice. Food science & nutrition. vol 7. issue 9. 2020-10-01. PMID:31572593. |
the numbers of nissl-positive cells in the hippocampal cornu ammonis 3 (ca3) and dentate gyrus (dg) regions were increased in sd-f-treated aged mice relative to controls. |
2020-10-01 |
2023-08-13 |
mouse |
| Omkar L Patkar, Arnauld Belmer, Kate Beecher, Angela Jacques, Selena E Bartlet. Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31849624. |
interestingly, studies have demonstrated that the development of alcohol-induced negative affective states is linked to disrupted neurogenesis in the dentate gyrus (dg) region of the hippocampus in alcohol-dependent animals. |
2020-10-01 |
2023-08-13 |
mouse |
| Yu Rong Guo, Zi Wei Liu, Shuang Peng, Meng Yun Duan, Jing Wei Feng, Wei Feng Wang, Yan Hua Xu, Xi Tang, Xiang Zhi Zhang, Bo Xu Ren, Feng Ru Tan. The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis. Dose-response : a publication of International Hormesis Society. vol 17. issue 4. 2020-10-01. PMID:31903069. |
the radioprotective effect of amitriptyline, an inhibitor of acid sphingomyelinase (asmase), on radiation-induced impairment of hippocampal neurogenesis, loss of interneuron, and animal weight changes was investigated in balb/c mice by immunostaining of biomarkers for cell division (ki67), immature neurons (doublecortin or dcx), and interneurons (parvalbumin or pv) in the dentate gyrus (dg) of hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Marie Yokoyama, Naoki Matsu. Loss of Ensemble Segregation in Dentate Gyrus, but not in Somatosensory Cortex, during Contextual Fear Memory Generalization. Frontiers in behavioral neuroscience. vol 10. 2020-09-30. PMID:27872586. |
in the hippocampal dentate gyrus (dg), exclusively separated ensemble reactivation was observed when mice were exposed to a novel context. |
2020-09-30 |
2023-08-13 |
mouse |
| Marie Yokoyama, Naoki Matsu. Loss of Ensemble Segregation in Dentate Gyrus, but not in Somatosensory Cortex, during Contextual Fear Memory Generalization. Frontiers in behavioral neuroscience. vol 10. 2020-09-30. PMID:27872586. |
our results suggest that the alternations in the ensemble representation within the dg, or in upstream structures that link the sensory cortex to the hippocampus, may underlie generalized contextual fear memory expression. |
2020-09-30 |
2023-08-13 |
mouse |
| Tingting Zheng, Jiali Pu, Yanxing Chen, Yanfang Mao, Zhangyu Guo, Hongyu Pan, Ling Zhang, Heng Zhang, Binggui Sun, Baorong Zhan. Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer's Disease. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28203202. |
we found that injected exosomes can spread from the dentate gyrus (dg) to other regions of hippocampus and to the cortex. |
2020-09-30 |
2023-08-13 |
mouse |
| Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D'Onofrio, Antonino Cattane. ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28232789. |
later, we observe a regional- and cellular-selective parvalbumin interneuron and perineuronal net (pnn) depletion in the dentate gyrus (dg), but not in other hippocampal regions of tgprongf#3 mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D'Onofrio, Antonino Cattane. ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28232789. |
these results demonstrate that, in the hippocampus, the dg is selectively vulnerable to altered prongf/ngf signaling. |
2020-09-30 |
2023-08-13 |
mouse |
| Yasuhisa Tamura, Yosky Kataok. PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28243610. |
neural stem cells are present in 2 neurogenic regions, the subventricular zone (svz) and the subgranular zone (sgz) of the hippocampal dentate gyrus (dg), and continue to generate new neurons throughout life. |
2020-09-30 |
2023-08-13 |
human |
| Vanessa M Machado, Ana Sofia Lourenço, Cláudia Florindo, Raquel Fernandes, Caetana M Carvalho, Inês M Araúj. Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28386216. |
selected cognitive tests were performed on the 3rd and 8th week after ka-induced lesion, and cell proliferation, migration and differentiation in the dentate gyrus (dg) of the hippocampus of adult mice were analyzed using specific markers. |
2020-09-30 |
2023-08-13 |
mouse |
| Gustavo R Morel, Micaela López León, Maia Uriarte, Paula C Reggiani, Rodolfo G Goy. Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28405590. |
in rats, learning and memory performance decline during normal aging, which is paralleled by a severe reduction of the levels of neurogenesis in the hippocampal dentate gyrus (dg). |
2020-09-30 |
2023-08-13 |
rat |
| Gustavo R Morel, Micaela López León, Maia Uriarte, Paula C Reggiani, Rodolfo G Goy. Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28405590. |
the dg is thought to be the main hippocampal structure involved in pattern separation memory and there is evidence that the level of neurogenesis in the dg is directly related to pattern separation performance in rodents. |
2020-09-30 |
2023-08-13 |
rat |
| Luis E B Bettio, Joana Gil-Mohapel, Anna R Patten, Natasha F O'Rourke, Ronan P Hanley, Karthik Gopalakrishnan, Jeremy E Wulff, Brian R Christi. Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives. Neurogenesis (Austin, Tex.). vol 4. issue 1. 2020-09-30. PMID:28656155. |
within this context, isoxazole 9 (isx-9) has been shown to strongly induce cell proliferation and neuronal differentiation in the subgranular zone (sgz) of the hippocampal dentate gyrus (dg), while also improving hippocampal function in healthy mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Daniele Lana, Filippo Ugolini, Daniele Nosi, Gary L Wenk, Maria G Giovannin. Alterations in the Interplay between Neurons, Astrocytes and Microglia in the Rat Dentate Gyrus in Experimental Models of Neurodegeneration. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28955220. |
the differential expression/activation of astroglia and the alteration of their intercommunication may be responsible for the different susceptibility of the dg in comparison to the ca1 and ca3 hippocampal areas to neurodegeneration during aging and inflammation. |
2020-09-30 |
2023-08-13 |
rat |
| Marita G Hansen, Litsa N Ledri, Deniz Kirik, Merab Kokaia, Marco Ledr. Preserved Function of Afferent Parvalbumin-Positive Perisomatic Inhibitory Synapses of Dentate Granule Cells in Rapidly Kindled Mice. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29375319. |
here, using selective optogenetic activation of pv cells in the hippocampus, we show that seizures, induced by rapid kindling (rk) stimulations, enhance gamma-aminobutyric acid (gaba) release from pv cells onto dentate gyrus (dg) granule cells (gc). |
2020-09-30 |
2023-08-13 |
mouse |
| Catherine-Alexandra Grégoire, Stephanie Tobin, Brianna L Goldenstein, Éric Samarut, Andréanne Leclerc, Anne Aumont, Pierre Drapeau, Stephanie Fulton, Karl J L Fernande. RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29706867. |
here, we show that running and running-independent ee differentially affect the hippocampal dentate gyrus (dg), a brain region critical for learning and memory. |
2020-09-30 |
2023-08-13 |
mouse |
| Hongjie Wu, Jing Li, Dongxiao Xu, Qiansheng Zhang, Tao Cu. Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury. Frontiers in neurology. vol 9. 2020-09-30. PMID:30083129. |
we utilized a controlled cortical impact to establish a mouse tbi model, and then stereotaxically administered 25 or 100 ng gdf-5 into the bilateral hippocampal dentate gyrus (dg) of each of the animals. |
2020-09-30 |
2023-08-13 |
mouse |
| Hongjie Wu, Jing Li, Dongxiao Xu, Qiansheng Zhang, Tao Cu. Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury. Frontiers in neurology. vol 9. 2020-09-30. PMID:30083129. |
as a result, we found that post-injury stereotaxical administration of gdf-5 can improve neural stem cell proliferation and differentiation in the dg of the hippocampus, evidenced by the increase in brdu, sox-2, and dcx-labeled cells, as well as the improvement in dendrite arborization and newborn neuron activation in response to gdf-5 treatment. |
2020-09-30 |
2023-08-13 |
mouse |