| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carl R Lupica, Arthur C Riegel, Alexander F Hoffma. Marijuana and cannabinoid regulation of brain reward circuits. British journal of pharmacology. vol 143. issue 2. 2005-04-22. PMID:15313883. |
marijuana and cannabinoid regulation of brain reward circuits. |
2005-04-22 |
2023-08-12 |
Not clear |
| Carl R Lupica, Arthur C Riegel, Alexander F Hoffma. Marijuana and cannabinoid regulation of brain reward circuits. British journal of pharmacology. vol 143. issue 2. 2005-04-22. PMID:15313883. |
the psychoactive properties of marijuana are mediated by the active constituent, delta(9)-thc, interacting primarily with cb1 cannabinoid receptors in a large number of brain areas. |
2005-04-22 |
2023-08-12 |
Not clear |
| Carl R Lupica, Arthur C Riegel, Alexander F Hoffma. Marijuana and cannabinoid regulation of brain reward circuits. British journal of pharmacology. vol 143. issue 2. 2005-04-22. PMID:15313883. |
in addition, we compare the effects of delta(9)-thc with those of other commonly abused drugs on these reward circuits, and we discuss the roles that endogenous cannabinoids may play within these brain pathways, and their possible involvement in regulating ongoing brain function, independently of marijuana consumption. |
2005-04-22 |
2023-08-12 |
Not clear |
| Sachin Patel, Benjamin F Cravatt, Cecilia J Hillar. Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 3. 2005-04-21. PMID:15280883. |
these data suggest the cea is an important neural substrate subserving the interactions between cannabinoids and environmental stress, and could be relevant to understanding the context-dependent emotional and affective changes induced by marijuana intoxication and the role of endocannabinoid signaling in the modulation of amygdalar activity. |
2005-04-21 |
2023-08-12 |
mouse |
| Sami Sarfaraz, Farrukh Afaq, Vaqar M Adhami, Hasan Mukhta. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer research. vol 65. issue 5. 2005-04-19. PMID:15753356. |
cannabinoids, the active components of cannabis sativa linnaeus (marijuana) and their derivatives have received renewed interest in recent years due to their diverse pharmacologic activities such as cell growth inhibition, anti-inflammatory effects and tumor regression. |
2005-04-19 |
2023-08-12 |
human |
| Gabrielle L McLemore, Reed Z B Cooper, Kimberlei A Richardson, Ariel V Mason, Cathleen Marshall, Frances J Northington, Estelle B Gaud. Cannabinoid receptor expression in peripheral arterial chemoreceptors during postnatal development. Journal of applied physiology (Bethesda, Md. : 1985). vol 97. issue 4. 2005-04-18. PMID:15358754. |
to determine whether marijuana could potentially affect the activity of peripheral arterial chemoreceptors during early postnatal development, we used in situ hybridization histochemistry to characterize the pattern and level of mrna expression for cannabinoid type 1 receptor (cb1r) in the carotid body, superior cervical ganglia (scg), and nodose-petrosal-jugular ganglia (ng-pg-jg) complex in newborn rats. |
2005-04-18 |
2023-08-12 |
rat |
| F Rodríguez De Fonseca, M A Gorriti, A Bilbao, L Escuredo, L M García-Segura, D Piomelli, M Navarr. Role of the endogenous cannabinoid system as a modulator of dopamine transmission: implications for Parkinson's disease and schizophrenia. Neurotoxicity research. vol 3. issue 1. 2005-04-12. PMID:15111259. |
this system is the target of natural cannabinoids, the psychoactive constituents of cannabis sativa preparations (marijuana, hashish). |
2005-04-12 |
2023-08-12 |
rat |
| A A M Stolker, J van Schoonhoven, A J de Vries, I Bobeldijk-Pastorova, W H J Vaes, R van den Ber. Determination of cannabinoids in cannabis products using liquid chromatography-ion trap mass spectrometry. Journal of chromatography. A. vol 1058. issue 1-2. 2005-04-12. PMID:15595662. |
determination of cannabinoids in cannabis products using liquid chromatography-ion trap mass spectrometry. |
2005-04-12 |
2023-08-12 |
Not clear |
| A A M Stolker, J van Schoonhoven, A J de Vries, I Bobeldijk-Pastorova, W H J Vaes, R van den Ber. Determination of cannabinoids in cannabis products using liquid chromatography-ion trap mass spectrometry. Journal of chromatography. A. vol 1058. issue 1-2. 2005-04-12. PMID:15595662. |
the cannabinoids were extracted from the grinded cannabis samples with a mixture of methanol-chloroform and analysed using liquid chromatography with ion-trap-mass-spectrometry (lc-it-msn). |
2005-04-12 |
2023-08-12 |
Not clear |
| Kazuhide Hayakawa, Kenichi Mishima, Kohji Abe, Nobuyoshi Hasebe, Fumie Takamatsu, Hiromi Yasuda, Tomoaki Ikeda, Keiichiro Inui, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. vol 15. issue 15. 2005-04-08. PMID:15640760. |
the neuroprotective effects of delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by sr141716, a cannabinoid cb1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. |
2005-04-08 |
2023-08-12 |
mouse |
| Boris Julien, Pascale Grenard, Fatima Teixeira-Clerc, Jeanne Tran Van Nhieu, Liying Li, Meliha Karsak, Andreas Zimmer, Ariane Mallat, Sophie Lotersztaj. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology. vol 128. issue 3. 2005-04-06. PMID:15765409. |
cannabinoids are the active components of marijuana and act via 2 g-protein-coupled receptors, cb1 and cb2. |
2005-04-06 |
2023-08-12 |
Not clear |
| P Alexander Arguello, J David Jentsc. Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat. Psychopharmacology. vol 177. issue 1-2. 2005-03-23. PMID:15290005. |
cb1 receptors (cb1rs) mediate many of the psychoactive effects of cannabinoids, and marijuana intoxication can produce neurocognitive deficits with a similarity to those seen in schizophrenia, including impairments of attention. |
2005-03-23 |
2023-08-12 |
rat |
| Ying-Ching Liang, Chiung-Chun Huang, Kuei-Sen Hs. Therapeutic potential of cannabinoids in trigeminal neuralgia. Current drug targets. CNS and neurological disorders. vol 3. issue 6. 2005-03-23. PMID:15578967. |
currently there is growing amount of evidence to suggest that the psychoactive ingredient in cannabis and individual cannabinoids may be effective in alleviating neuropathic pain and hyperalgesia. |
2005-03-23 |
2023-08-12 |
Not clear |
| A Busuttil, J O Obafunwa, S Bulgi. Passive inhalation of cannabis smoke: a novel defence strategy? Journal of clinical forensic medicine. vol 3. issue 2. 2005-02-28. PMID:15335617. |
defence lawyers sometimes argue that the presence of cannabinoid metabolites in the defendant's blood or urine resulted from passive unintentional inhalation of environmental cannabis smoke. |
2005-02-28 |
2023-08-12 |
Not clear |
| Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono, Ikuo Yamamot. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology. vol 206. issue 3. 2005-02-24. PMID:15588936. |
testosterone 6beta- and 16alpha-hydroxylase activities together with androstenedione formation from testosterone in rat liver microsomes were also significantly inhibited by the crude marijuana extracts and the cannabinoids. |
2005-02-24 |
2023-08-12 |
rat |
| Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono, Ikuo Yamamot. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology. vol 206. issue 3. 2005-02-24. PMID:15588936. |
crude marijuana extracts (1 and 10 microg/ml) of thca strain stimulated the proliferation of mcf-7 cells, although the purified cannabinoids (thc, cbd and cbn) did not show significant effects, such as the extract at the concentration of 0.01-1000 nm. |
2005-02-24 |
2023-08-12 |
rat |
| Kazuhito Watanabe, Erina Motoya, Naoki Matsuzawa, Tatsuya Funahashi, Toshiyuki Kimura, Tamihide Matsunaga, Koji Arizono, Ikuo Yamamot. Marijuana extracts possess the effects like the endocrine disrupting chemicals. Toxicology. vol 206. issue 3. 2005-02-24. PMID:15588936. |
these results indicate that there are some metabolic interactions between cannabinoid and steroid metabolism and that the constituents showing estrogen-like activity exist in marijuana. |
2005-02-24 |
2023-08-12 |
rat |
| Aaron B Ilan, Michael E Smith, Alan Gevin. Effects of marijuana on neurophysiological signals of working and episodic memory. Psychopharmacology. vol 176. issue 2. 2005-02-17. PMID:15502936. |
the primary psychoactive constituent of marijuana, delta9-thc, activates cannabinoid receptors, which are especially abundant in the frontal cortex and hippocampus. |
2005-02-17 |
2023-08-12 |
Not clear |
| Matthew J McFarland, Eric L Barke. Anandamide transport. Pharmacology & therapeutics. vol 104. issue 2. 2005-02-17. PMID:15518883. |
n-arachidonylethanolamine (anandamide) is an endogenous agonist of the cannabinoid cb1 and cb2 receptors and displays many of the same receptor-mediated physiological effects as delta9-tetrahydrocannabinol (delta9-thc), the active component of marijuana. |
2005-02-17 |
2023-08-12 |
Not clear |
| P-W Zhang, H Ishiguro, T Ohtsuki, J Hess, F Carillo, D Walther, E S Onaivi, T Arinami, G R Uh. Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. Molecular psychiatry. vol 9. issue 10. 2005-02-15. PMID:15289816. |
the cb1/cnr1 receptor is the major brain site at which cannabinoid marijuana constituents are psychoactive as well as the principal brain receptor for endogenous anandamide ligands. |
2005-02-15 |
2023-08-12 |
mouse |