| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Ludovic Croxfor. Therapeutic potential of cannabinoids in CNS disease. CNS drugs. vol 17. issue 3. 2003-03-31. PMID:12617697. |
the use of nonpsychoactive cannabinoids such as cannabidiol and dexanabinol may allow the dissociation of unwanted psychoactive effects from potential therapeutic benefits. |
2003-03-31 |
2023-08-12 |
Not clear |
| Giulia Di Carlo, Angelo A Izz. Cannabinoids for gastrointestinal diseases: potential therapeutic applications. Expert opinion on investigational drugs. vol 12. issue 1. 2003-03-26. PMID:12517253. |
delta(9)-tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, cb(1) and cb(2) receptors. |
2003-03-26 |
2023-08-12 |
Not clear |
| Takayuki Sugiura, Keizo Wak. Cannabinoid receptors and their endogenous ligands. Journal of biochemistry. vol 132. issue 1. 2003-03-25. PMID:12097154. |
delta9-tetrahydrocannabinol, a major psychoactive component of marijuana, has been shown to interact with specific cannabinoid receptors, thereby eliciting a variety of pharmacological responses in experimental animals and human. |
2003-03-25 |
2023-08-12 |
human |
| Satish Kathuria, Silvana Gaetani, Darren Fegley, Fernando Valiño, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Giovanna La Rana, Antonio Calignano, Arcangela Giustino, Maria Tattoli, Maura Palmery, Vincenzo Cuomo, Daniele Piomell. Modulation of anxiety through blockade of anandamide hydrolysis. Nature medicine. vol 9. issue 1. 2003-03-18. PMID:12461523. |
the psychoactive constituent of cannabis, delta(9)-tetrahydrocannabinol, produces in humans subjective responses mediated by cb1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion. |
2003-03-18 |
2023-08-12 |
rat |
| Maurice R Elphick, Yutaka Satou, Nori Sato. The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalis. Gene. vol 302. issue 1-2. 2003-03-14. PMID:12527200. |
the g-protein coupled cannabinoid receptors cb(1) and cb(2) are activated by delta(9)-tetrahydrocannabinol, the psychoactive ingredient of cannabis, and mediate physiological effects of endogenous cannabinoids ('endocannabinoids'). |
2003-03-14 |
2023-08-12 |
human |
| Stephen Sidne. Cardiovascular consequences of marijuana use. Journal of clinical pharmacology. vol 42. issue S1. 2003-03-12. PMID:12412838. |
this review describes what is known about effects of marijuana and cannabinoids in relation to human physiological and disease outcomes. |
2003-03-12 |
2023-08-12 |
human |
| Stephen Sidne. Cardiovascular consequences of marijuana use. Journal of clinical pharmacology. vol 42. issue S1. 2003-03-12. PMID:12412838. |
research directions might include more studies of cardiovascular disease outcomes and relationships of marijuana with cardiovascular risk factors, studies of metabolic and physiologic effects of chronic marijuana use that may affect cardiovascular disease risk, increased understanding of the role of the cannabinoid receptor system in cardiovascular regulation, and studies to determine if there is a therapeutic role for cannabinoids in blood pressure control or for neuroprotection after stroke. |
2003-03-12 |
2023-08-12 |
human |
| Barry M Bredt, Dana Higuera-Alhino, Starley B Shade, Samuel J Hebert, Joseph M McCune, Donald I Abram. Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients. Journal of clinical pharmacology. vol 42. issue S1. 2003-03-12. PMID:12412840. |
cannabinoids, including smoked marijuana and delta9-tetrahydrocannabinol (thc) (dronabinol, marinol), have been used to treat human immunodeficiency virus-1 (hiv)-associated anorexia and weight loss. |
2003-03-12 |
2023-08-12 |
human |
| Herbert Schuel, Lani J Burkman, Jack Lippes, Kent Crickard, Mary C Mahony, Andrea Giuffrida, Robert P Picone, Alexandros Makriyanni. Evidence that anandamide-signaling regulates human sperm functions required for fertilization. Molecular reproduction and development. vol 63. issue 3. 2003-03-10. PMID:12237954. |
this study has potential medical and public policy ramifications because of the incidence of marijuana abuse by adults in our society, previously documented reproductive effects of marijuana, and the ongoing debate about medicinal use of marijuana and cannabinoids. |
2003-03-10 |
2023-08-12 |
human |
| Allan J Flac. Delta-9-tetrahydrocannabinol (THC) in the treatment of end-stage open-angle glaucoma. Transactions of the American Ophthalmological Society. vol 100. 2003-03-03. PMID:12545695. |
therefore, the research advisory panel of california instituted the cannabis therapeutic research program to permit compassionate access to cannabinoid derivatives. |
2003-03-03 |
2023-08-12 |
Not clear |
| Paul F Smit. Cannabinoids in the treatment of pain and spasticity in multiple sclerosis. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 6. 2003-02-26. PMID:12137404. |
there is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-thc), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances. |
2003-02-26 |
2023-08-12 |
Not clear |
| Paul F Smit. Cannabinoids in the treatment of pain and spasticity in multiple sclerosis. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 6. 2003-02-26. PMID:12137404. |
whether or not cannabinoids do have therapeutic potential in the treatment of ms, a further issue will be whether synthetic cannabinoids should be used in preference to cannabis itself. |
2003-02-26 |
2023-08-12 |
Not clear |
| b' Mauro Maccarrone, Alessandro Finazzi-Agr\\xc3\\xb. Endocannabinoids and their actions. Vitamins and hormones. vol 65. 2003-01-10. PMID:12481549.' |
anandamide (i) and 2-arachidonoylglycerol (ii) are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of delta 9-tetrahydrocannabinol (iii), the active principle of cannabis sativa preparations such as hashish and marijuana. |
2003-01-10 |
2023-08-12 |
human |
| E Nocerino, M Amato, A A Izz. Cannabis and cannabinoid receptors. Fitoterapia. vol 71 Suppl 1. 2003-01-01. PMID:10930707. |
cannabis and cannabinoid receptors. |
2003-01-01 |
2023-08-12 |
Not clear |
| E Nocerino, M Amato, A A Izz. Cannabis and cannabinoid receptors. Fitoterapia. vol 71 Suppl 1. 2003-01-01. PMID:10930707. |
cannabis and cannabinoids exert many of their biological functions through receptor-mediated mechanisms. |
2003-01-01 |
2023-08-12 |
Not clear |
| Jimok Kim, Masako Isokawa, Catherine Ledent, Bradley E Alge. Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 23. 2002-12-23. PMID:12451119. |
endogenous cannabinoids (endocannabinoids) are endogenous compounds that resemble the active ingredient of marijuana and activate the cannabinoid receptor in the brain. |
2002-12-23 |
2023-08-12 |
rat |
| Ismael Galve-Roperh, Daniel Rueda, Teresa Gómez del Pulgar, Guillermo Velasco, Manuel Guzmá. Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Molecular pharmacology. vol 62. issue 6. 2002-12-09. PMID:12435806. |
cannabinoids, the active components of marijuana and their endogenous counterparts, exert many of their actions in brain through the seven-transmembrane receptor cb(1). |
2002-12-09 |
2023-08-12 |
human |
| R Mechoula. Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052029. |
the unexpected production of aggression by cannabis and cannabinoids under stressful conditions, published mainly in the past, is summarized. |
2002-12-06 |
2023-08-12 |
Not clear |
| Sean D McAllister, Michelle Glas. CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052033. |
the discovery that the major psychoactive component of marijuana activated two g-protein coupled receptors prompted the search for the endogenous cannabinoid ligands now termed endocannabinoids. |
2002-12-06 |
2023-08-12 |
Not clear |
| B S Basavarajappa, B L Hungun. Neuromodulatory role of the endocannabinoid signaling system in alcoholism: an overview. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052043. |
the identification of a g-protein-coupled receptor, namely, the cannabinoid receptor (cb1 receptor) that was activated by delta(9)-tetrahydrocannabinol (delta(9)-thc), the major psychoactive component of marijuana, led to the discovery of endogenous cannabinoid agonists. |
2002-12-06 |
2023-08-12 |
mouse |