| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Pistis, Luca Ferraro, Luigi Pira, Giovanna Flore, Sergio Tanganelli, Gian Luigi Gessa, Paola Devot. Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383968. |
cannabinoid modulation of prefrontal cortex and hippocampus neuronal functioning has been correlated to the disruptive action of marijuana on memory tasks. |
2002-10-30 |
2023-08-12 |
rat |
| David M Wilson, Joanne Peart, Billy R Martin, D Troy Bridgen, Peter R Byron, Aron H Lichtma. Physiochemical and pharmacological characterization of a Delta(9)-THC aerosol generated by a metered dose inhaler. Drug and alcohol dependence. vol 67. issue 3. 2002-10-22. PMID:12127197. |
further development of a delta(9)-thc mdi could provide an appropriate delivery device for the therapeutic use of cannabinoids, thereby reducing the need for medicinal marijuana. |
2002-10-22 |
2023-08-12 |
mouse |
| Sophie Parmentier-Batteur, Kunlin Jin, Lin Xie, Xiao Ou Mao, David A Greenber. DNA microarray analysis of cannabinoid signaling in mouse brain in vivo. Molecular pharmacology. vol 62. issue 4. 2002-10-11. PMID:12237329. |
to identify novel genes involved in cannabinoid receptor-mediated signaling, we used cdna microarrays to detect changes in mrna expression in the forebrains of mice 12 h after they were given a single intraperitoneal dose of the naturally-occurring cannabis sativa alkaloid delta(9)-tetrahydrocannabinol (delta(9)-thc) or the synthetic cannabinoid receptor agonist (r)-(+)-2,3-dihydro-5-methyl-3-[(morpholinyl)methyl] pyrrolo[1,2,3-de]-1,4-benzoxazin-yl-1-naphtalenylmethanone mesylate [r(+)-win 55,212-2]. |
2002-10-11 |
2023-08-12 |
mouse |
| Sean M Bagshaw, Neil A Hage. Medical efficacy of cannabinoids and marijuana: a comprehensive review of the literature. Journal of palliative care. vol 18. issue 2. 2002-10-02. PMID:12164099. |
medical efficacy of cannabinoids and marijuana: a comprehensive review of the literature. |
2002-10-02 |
2023-08-12 |
Not clear |
| Anna Porcella, Giorgio Marchese, Maria Antonietta Casu, Antonio Rocchitta, Maria Letizia Lai, Gian Luigi Gessa, Luca Pan. Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid. European journal of endocrinology. vol 147. issue 2. 2002-09-24. PMID:12153749. |
previous reports have shown that the delta(9)-tetrahydrocannabinol (delta(9)tch), the major psychoactive cannabinoid components of marijuana, is able [corrected] to inhibit thyroid hormonal activity. |
2002-09-24 |
2023-08-12 |
rat |
| Zoltán Járai, György Kúno. [Cardiovascular effects of cannabinoids]. Orvosi hetilap. vol 143. issue 26. 2002-08-21. PMID:12140859. |
the psychoactive properties of cannabinoids, the biologically active constituents of the marijuana plant, have long been recognized. |
2002-08-21 |
2023-08-12 |
mouse |
| Neil T Smit. A review of the published literature into cannabis withdrawal symptoms in human users. Addiction (Abingdon, England). vol 97. issue 6. 2002-08-13. PMID:12084124. |
research also continues to be published into the physiological effects of cannabis on animals via self-administration paradigms and the use of cannabinoid antagonists. |
2002-08-13 |
2023-08-12 |
human |
| Emmanuel S Onaivi, Claire M Leonard, Hiroki Ishiguro, Ping Wu Zhang, Zhicheng Lin, Babatunde E Akinshola, George R Uh. Endocannabinoids and cannabinoid receptor genetics. Progress in neurobiology. vol 66. issue 5. 2002-08-12. PMID:12015198. |
this review presents the remarkable advances that have been achieved in marijuana (cannabinoid) research, with the discovery of specific receptors and the existence of naturally occurring cannabis-like substances in the human body and brain. |
2002-08-12 |
2023-08-12 |
mouse |
| Emmanuel S Onaivi, Claire M Leonard, Hiroki Ishiguro, Ping Wu Zhang, Zhicheng Lin, Babatunde E Akinshola, George R Uh. Endocannabinoids and cannabinoid receptor genetics. Progress in neurobiology. vol 66. issue 5. 2002-08-12. PMID:12015198. |
the last decade has seen more rapid progress in marijuana research than any time in the thousands of years that marijuana has been used by humans, particularly in cannabinoid genomics. |
2002-08-12 |
2023-08-12 |
mouse |
| Fiona J Couper, Melissa Pemberton, Anjanette Jarvis, Marty Hughes, Barry K Loga. Prevalence of drug use in commercial tractor-trailer drivers. Journal of forensic sciences. vol 47. issue 3. 2002-07-03. PMID:12051337. |
the second most frequently encountered drug class were the cannabinoids, with 4.3% of drivers testing positive for marijuana metabolites. |
2002-07-03 |
2023-08-12 |
Not clear |
| Linda A Parker, Raphael Mechoulam, Coralynne Schliever. Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats. Neuroreport. vol 13. issue 5. 2002-06-24. PMID:11973447. |
here we report that cannabidiol, a major non-psychoactive cannabinoid found in marijuana and its synthetic dimethylheptyl homolog interfere with nausea elicited by lithium chloride and with conditioned nausea elicited by a flavor paired with lithium chloride. |
2002-06-24 |
2023-08-12 |
rat |
| L Nong, C Newton, H Friedman, T W Klei. CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types. Advances in experimental medicine and biology. vol 493. 2002-05-20. PMID:11727770. |
marijuana cannabinoid receptors (cbr), cb1 and cb2, are g protein-coupled receptors reported to be expressed in brain as well as cells of the periphery. |
2002-05-20 |
2023-08-12 |
human |
| Jenny L Wiley, Irina D Beletskaya, Edward W Ng, Zongmin Dai, Peter J Crocker, Anu Mahadevan, Raj K Razdan, Billy R Marti. Resorcinol derivatives: a novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists. The Journal of pharmacology and experimental therapeutics. vol 301. issue 2. 2002-05-13. PMID:11961073. |
the role of the oxygen of the benzopyran substituent of delta(9)-tetrahydrocannabinol in defining affinity for brain cannabinoid (cb(1)) receptors is not well understood; however, it is known that opening the pyran ring can result in either increased potency and affinity, as in cp 55,940 [(-)-cis-3-[2-hydroxy-4(1,1- dimethyl-heptyl)phenyl]-trans-4-(3-hydroxy-propyl)cyclohexanol], or in an inactive cannabinoid, as in cannabidiol. |
2002-05-13 |
2023-08-12 |
Not clear |
| Mareshige Kojoma, Osamu Iida, Yukiko Makino, Setsuko Sekita, Motoyoshi Satak. DNA fingerprinting of Cannabis sativa using inter-simple sequence repeat (ISSR) amplification. Planta medica. vol 68. issue 1. 2002-05-08. PMID:11842329. |
chemical analysis of cannabinoid, and inter-simple sequence repeat (issr) fingerprinting of dna were used to identify different samples of cannabis sativa l. for forensic purposes. |
2002-05-08 |
2023-08-12 |
Not clear |
| R Mechoulam, L Han. The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. Pain research & management. vol 6. issue 2. 2002-05-01. PMID:11854768. |
recent advances in the understanding of the molecular basis of cannabis action are explained, including the identification of the cannabinoid receptors cb(1) and cb(2), as well as the isolation of endogenous cannabinoids from the brain and periphery. |
2002-05-01 |
2023-08-12 |
Not clear |
| H Kalan. Medicinal use of cannabis: history and current status. Pain research & management. vol 6. issue 2. 2002-05-01. PMID:11854770. |
to provide an overview of the history and pharmacology of cannabis in relation to current scientific knowledge concerning actual and potential therapeutic uses of cannabis preparations and pure cannabinoids. |
2002-05-01 |
2023-08-12 |
Not clear |
| M J Wallace, J L Wiley, B R Martin, R J DeLorenz. Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. European journal of pharmacology. vol 428. issue 1. 2002-04-02. PMID:11779037. |
cannabinoid compounds like delta9-tetrahydrocannabinol and cannabidiol have been shown to be anticonvulsant in maximal electroshock, a model of partial seizure with secondary generalization. |
2002-04-02 |
2023-08-12 |
Not clear |
| M J Wallace, J L Wiley, B R Martin, R J DeLorenz. Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. European journal of pharmacology. vol 428. issue 1. 2002-04-02. PMID:11779037. |
we first show that the cannabinoid compounds delta9-tetrahydrocannabinol (ed50 = 42 mg/kg), cannabidiol (ed50 = 80 mg/kg), and win 55,212-2 (ed50 = 47 mg/kg) are anticonvulsant in maximal electroshock. |
2002-04-02 |
2023-08-12 |
Not clear |
| M J Wallace, J L Wiley, B R Martin, R J DeLorenz. Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. European journal of pharmacology. vol 428. issue 1. 2002-04-02. PMID:11779037. |
we further establish, using the cannabinoid cb1 receptor specific antagonist n-(piperidin-1-yl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamidehydrochloride (sr141716a) (ad50 = 2.5 mg/kg), that the anticonvulsant effects of delta9-tetrahydrocannabinol and win 55,212-2 are cannabinoid cb1 receptor-mediated while the anticonvulsant activity of cannabidiol is not. |
2002-04-02 |
2023-08-12 |
Not clear |
| R I Wilson, R A Nicol. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature. vol 410. issue 6828. 2002-03-21. PMID:11279497. |
marijuana affects brain function primarily by activating the g-protein-coupled cannabinoid receptor-1 (cb1), which is expressed throughout the brain at high levels. |
2002-03-21 |
2023-08-12 |
Not clear |