| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J G van Amsterdam, J W van der Laan, J L Slange. [Cognitive and psychotic effects after cessation of chronic cannabis use]. Nederlands tijdschrift voor geneeskunde. vol 142. issue 10. 1998-07-02. PMID:9623095. |
establishment of residual cognitive and psychotic effects (effects present at the time that all active cannabinoids are eliminated from the body) putatively produced by prolonged heavy cannabis use is difficult, because of many confounding variables like slow elimination of active cannabinoids, lack of supervision during abstinence, poor use of well-matched control groups and the presence of withdrawal symptoms. |
1998-07-02 |
2023-08-12 |
Not clear |
| J Axelrod, C C Felde. Cannabinoid receptors and their endogenous agonist, anandamide. Neurochemical research. vol 23. issue 5. 1998-06-19. PMID:9566594. |
cannabinoids are a class of compound found in marijuana which have been known for their therapeutic and psychoactive properties for at least 4000 years. |
1998-06-19 |
2023-08-12 |
Not clear |
| M Fellermeier, M H Zen. Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol. FEBS letters. vol 427. issue 2. 1998-06-18. PMID:9607329. |
a new enzyme, geranylpyrophosphate:olivetolate geranyltransferase (got), the first enzyme in the biosynthesis of cannabinoids could be detected in extracts of young leaves of cannabis sativa. |
1998-06-18 |
2023-08-12 |
Not clear |
| T W Klein, H Friedman, S Specte. Marijuana, immunity and infection. Journal of neuroimmunology. vol 83. issue 1-2. 1998-06-12. PMID:9610678. |
the influence of marijuana cannabinoids on immune function has been examined extensively over the last 25 yr. |
1998-06-12 |
2023-08-12 |
human |
| T W Klein, H Friedman, S Specte. Marijuana, immunity and infection. Journal of neuroimmunology. vol 83. issue 1-2. 1998-06-12. PMID:9610678. |
various experimental models have been used employing drug-abusing human subjects, experimental animals exposed to marijuana smoke or injected with cannabinoids, and in vitro models employing immune cell cultures treated with various cannabinoids. |
1998-06-12 |
2023-08-12 |
human |
| B F Thomas, A F Gilliam, D F Burch, M J Roche, H H Seltzma. Comparative receptor binding analyses of cannabinoid agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 285. issue 1. 1998-05-12. PMID:9536023. |
a series of alternatively halogenated analogs of sr141716a were synthesized and tested in rat brain membrane binding assays along with the classical cannabinoids, delta9-tetrahydrocannabinol, cannabinol, cannabidiol, the nonclassical cannabinoid cp-55,940, the aminoalkylindole win55212-2 and the endogenous fatty acid ethanolamide, anandamide. |
1998-05-12 |
2023-08-12 |
rat |
| B F Thomas, A F Gilliam, D F Burch, M J Roche, H H Seltzma. Comparative receptor binding analyses of cannabinoid agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 285. issue 1. 1998-05-12. PMID:9536023. |
these results suggest that cp-55,940, win55212-2 and other agonists interact with cannabinoid binding sites within the brain which are distinguishable from the population of binding sites for sr141716a, its analogs and cannabidiol. |
1998-05-12 |
2023-08-12 |
rat |
| G L Gessa, M Melis, A L Muntoni, M Dian. Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489854. |
these findings support the contention that cannabinoids regulate mesolimbic dopamine transmission and may help to explain the addictive properties of marijuana. |
1998-04-29 |
2023-08-12 |
rat |
| K R Müller-Vahl, H Kolbe, R Dengle. [Gilles de la Tourette syndrome. Effect of nicotine, alcohol and marihuana on clinical symptoms]. Der Nervenarzt. vol 68. issue 12. 1998-04-01. PMID:9465342. |
we suggest that marijuana influences an assumed interaction between cannabinoid and dopamine receptors and, by this, influences the dopaminergic processes in basal ganglia and motor activity. |
1998-04-01 |
2023-08-12 |
Not clear |
| A Linacre, J Thorp. Detection and identification of cannabis by DNA. Forensic science international. vol 91. issue 1. 1998-04-01. PMID:9493346. |
current methods of cannabis identification involve the use of techniques such as hplc and gc to identify cannabinoids. |
1998-04-01 |
2023-08-12 |
Not clear |
| J M Kirk, P Doty, H De Wi. Effects of expectancies on subjective responses to oral delta9-tetrahydrocannabinol. Pharmacology, biochemistry, and behavior. vol 59. issue 2. 1998-03-31. PMID:9476972. |
thirty-five regular marijuana users were assigned to one of two groups: one group was told that they may receive a cannabinoid or placebo and a second group was told that they may receive a drug from one of several classes of drugs (e.g., stimulant, sedative, antiemetic) or placebo. |
1998-03-31 |
2023-08-12 |
human |
| E Schlicker, J Timm, J Zentner, M Göther. Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in the human and guinea-pig hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 5. 1998-02-19. PMID:9402037. |
in conclusion, cannabinoid receptors of the cb1 subtype occur in the human hippocampus, where they may contribute to the psychotropic effects of cannabis, and in the guinea-pig hippocampus, cerebellum, cerebral cortex and hypothalamus. |
1998-02-19 |
2023-08-12 |
mouse |
| S J Gatley, R Lan, N D Volkow, N Pappas, P King, C T Wong, A N Gifford, B Pyatt, S L Dewey, A Makriyanni. Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422389. |
imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid cb1 receptors in vivo. |
1998-02-02 |
2023-08-12 |
mouse |
| S J Gatley, R Lan, N D Volkow, N Pappas, P King, C T Wong, A N Gifford, B Pyatt, S L Dewey, A Makriyanni. Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422389. |
the major active ingredient of marijuana, (-)-delta9-tetrahydrocannabinol, exerts its psychoactive effects via binding to cannabinoid cb1 receptors, which are widely distributed in the brain. |
1998-02-02 |
2023-08-12 |
mouse |
| D R Compton, B R Marti. The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. The Journal of pharmacology and experimental therapeutics. vol 283. issue 3. 1998-01-15. PMID:9399986. |
anandamide is an putative endogenous cannabinoid ligand that produces pharmacological effects similar to those of delta9-tetrahydrocannabinol, the principle psychoactive constituent in marijuana. |
1998-01-15 |
2023-08-12 |
mouse |
| T Lehmann, F Sager, R Brenneise. Excretion of cannabinoids in urine after ingestion of cannabis seed oil. Journal of analytical toxicology. vol 21. issue 5. 1997-12-29. PMID:9288590. |
excretion of cannabinoids in urine after ingestion of cannabis seed oil. |
1997-12-29 |
2023-08-12 |
human |
| J A Wagner, K Varga, E F Ellis, B A Rzigalinski, B R Martin, G Kuno. Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. Nature. vol 390. issue 6659. 1997-12-22. PMID:9394002. |
anandamide, an endogenous cannabinoid ligand, binds to cb1 cannabinoid receptors in the brain and mimics the neurobehavioural actions of marijuana. |
1997-12-22 |
2023-08-12 |
rat |
| M E Brewster, E Pop, R L Foltz, S Reuschel, W Griffith, S Amselem, A Biego. Clinical pharmacokinetics of escalating i.v. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers. International journal of clinical pharmacology and therapeutics. vol 35. issue 9. 1997-11-18. PMID:9314087. |
these data are similar to those reported for naturally occurring cannabinoids such as delta 9-tetrahydrocannabinol and cannabidiol. |
1997-11-18 |
2023-08-12 |
human |
| Y Mikawa, S Matsuda, T Kanagawa, T Tajika, N Ueda, Y Mimur. Ocular activity of topically administered anandamide in the rabbit. Japanese journal of ophthalmology. vol 41. issue 4. 1997-10-27. PMID:9304433. |
marijuana and its psychoactive constituents, cannabinoids, reduce intraocular pressure (iop) in humans and animals. |
1997-10-27 |
2023-08-12 |
rabbit |
| J Brodkin, J M Moerschbaeche. SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 3. 1997-10-17. PMID:9316868. |
neither injections of the centrally inactive cannabinoid, cannabidiol (3.2-100 mg/kg i.p. |
1997-10-17 |
2023-08-12 |
rat |