| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antje Grosche, Jens Grosche, Alexei Verkhratsk. Physiology and pathophysiology of the retinal neuroglia. Handbook of clinical neurology. vol 210. 2025-03-27. PMID:40148047. |
neuroglia of the retina are represented by müller glia, parenchymal astrocytes, microglia and oligodendrocytes mainly associated with the optic nerve. |
2025-03-27 |
2025-03-30 |
Not clear |
| Zhenhao Zhang, He Wang, Wei Li, Ya Liu, Lin Xu, Jianjun Li. Regeneration of Retinal Ganglion Cell-Like Cells and Reconstruction of Visual Neural Circuits in mice with Glaucoma. Experimental eye research. 2025-03-09. PMID:40058721. |
microglia are a type of glial cells that regulate the immune response in the retina and central nervous system (cns), whether they have pluripotency and be reversed into rgcs remains unclear and challenging. |
2025-03-09 |
2025-03-12 |
mouse |
| Olivia B Taylor, Nicholas DeGroff, Heithem M El-Hodiri, Chengyu Gao, Andy J Fische. Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells. eLife. vol 13. 2025-03-06. PMID:40047533. |
finally, we show that tgfβ/smad3 signaling in the resting retina maintains s1pr1 expression in mg. we conclude that the s1p signaling is dynamically regulated in mg and mgpcs in the chick retina, and activation of s1p signaling depends, in part, on signals produced by reactive microglia. |
2025-03-06 |
2025-03-08 |
chicken |
| Andrew I Jobling, Ursula Greferath, Michael A Dixon, Pialuisa Quiriconi, Belinda Eyar, Anna K van Koeverden, Samuel A Mills, Kirstan A Vessey, Bang V Bui, Erica L Fletche. Microglial regulation of the retinal vasculature in health and during the pathology associated with diabetes. Progress in retinal and eye research. 2025-02-28. PMID:40020909. |
work in the brain and retina has recently indicated that microglia can directly regulate the local vasculature. |
2025-02-28 |
2025-03-04 |
Not clear |
| Andrew I Jobling, Ursula Greferath, Michael A Dixon, Pialuisa Quiriconi, Belinda Eyar, Anna K van Koeverden, Samuel A Mills, Kirstan A Vessey, Bang V Bui, Erica L Fletche. Microglial regulation of the retinal vasculature in health and during the pathology associated with diabetes. Progress in retinal and eye research. 2025-02-28. PMID:40020909. |
in the healthy retina, microglia make extensive contact with blood vessels, as well as neuronal synapses, and are important in vascular patterning during development. |
2025-02-28 |
2025-03-04 |
Not clear |
| Sarah J Karlen, Kaitryn E Ronning, Marie E Burn. Progress in Assessing Retinal Microglia Using Single-Cell RNA Sequencing. Advances in experimental medicine and biology. vol 1468. 2025-02-10. PMID:39930187. |
here, we compare two common methods of retinal cell preparation (collagenase digestion with immune cell enrichment by facs; col/facs vs papain digestion of the whole retina without enrichment; pap/whole) and three different algorithms for database integration (cca, rpca, and harmony) to examine microglia in healthy retinas. |
2025-02-10 |
2025-02-13 |
Not clear |
| Kaitryn E Ronning, Marie E Burns, Florian Sennlau. Monocytes in Retinal Degeneration: Little Cells with a Big Impact. Advances in experimental medicine and biology. vol 1468. 2025-02-10. PMID:39930185. |
microglia are the only immune cells in the retina during normal function, but during damage and disease, monocytes are able to invade the retina. |
2025-02-10 |
2025-02-13 |
Not clear |
| Nathaniel Ghena, Sarah R Anderson, Jacqueline M Roberts, Emmalyn Irvin, Joon Schwakopf, Alejandra Bosco, Monica L Vette. CD11c-Expressing Microglia Are Transient, Driven by Interactions With Apoptotic Cells. Glia. 2025-01-20. PMID:39828972. |
in the developing retina, we previously found a significant proportion of microglia express cd11c (integrin αx, itgax, subunit of complement receptor 4) which has also been reported in other developmental and disease contexts. |
2025-01-20 |
2025-01-23 |
Not clear |
| Nathaniel Ghena, Sarah R Anderson, Jacqueline M Roberts, Emmalyn Irvin, Joon Schwakopf, Alejandra Bosco, Monica L Vette. CD11c-Expressing Microglia Are Transient, Driven by Interactions With Apoptotic Cells. Glia. 2025-01-20. PMID:39828972. |
we found that cd11c+ microglia track with prominent waves of neuronal apoptosis in postnatal retina. |
2025-01-20 |
2025-01-23 |
Not clear |
| Verena Behnke, Anne Wolf, Mandy Hector, Thomas Langman. C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model. Investigative ophthalmology & visual science. vol 66. issue 1. 2025-01-08. PMID:39775695. |
in the aging retina, persistent activation of microglia is known to play a key role in retinal degenerative diseases like age-related macular degeneration (amd). |
2025-01-08 |
2025-01-31 |
mouse |
| Xiangcheng Tang, Wei Liu, Jia Liang, Xingfei Zhu, Xiangyu Ge, Dong Fang, Lirong Ling, Fanglan Yuan, Kun Zeng, Qingshan Chen, Guoming Zhang, Lili Gong, Shaochong Zhan. Correction to: Triamcinolone Acetonide Protects Against Light-Induced Retinal Degeneration by Activating Anti-Inflammatory STAT6/Arg1 Signaling in Microglia. Inflammation. 2024-12-28. PMID:39730973. |
these results reveal a new mechanism by which ta protects the retina from ld by shifting microglia toward an anti-inflammatory state through the stat6/arg1 axis. |
2024-12-28 |
2024-12-30 |
mouse |
| Bilin Rao, Xiaoqing Liu, Jiayi Xiao, Xiaotian Wu, Fang He, Qingwen Yang, Wenna Zhao, Xin Lin, Jun Zhan. Microglia heterogeneity during neuroinflammation and neurodegeneration in the mouse retina. Brain structure & function. vol 230. issue 1. 2024-12-25. PMID:39720969. |
microglia heterogeneity during neuroinflammation and neurodegeneration in the mouse retina. |
2024-12-25 |
2024-12-27 |
mouse |
| Bilin Rao, Xiaoqing Liu, Jiayi Xiao, Xiaotian Wu, Fang He, Qingwen Yang, Wenna Zhao, Xin Lin, Jun Zhan. Microglia heterogeneity during neuroinflammation and neurodegeneration in the mouse retina. Brain structure & function. vol 230. issue 1. 2024-12-25. PMID:39720969. |
microglia play important roles in maintaining homeostasis and immunoreactive defense in the central nervous system including retina. |
2024-12-25 |
2024-12-27 |
mouse |
| Wissam B Nassrallah, Hao Ran Li, Lyden Irani, Printha Wijesinghe, Peter William Hogg, Lucy Hui, Jean Oh, Ian R Mackenzie, Veronica Hirsch-Reinshagen, Ging-Yuek Robin Hsiung, Wellington Pham, Sieun Lee, Joanne A Matsubar. 3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer's disease via machine learning. Acta neuropathologica communications. vol 12. issue 1. 2024-12-24. PMID:39719599. |
in contrast, there was no difference in either size or shape for cd68- microglia between the two groups, suggesting an important difference in the active states of cd68 + microglia in ad retina. |
2024-12-24 |
2024-12-27 |
Not clear |
| Wissam B Nassrallah, Hao Ran Li, Lyden Irani, Printha Wijesinghe, Peter William Hogg, Lucy Hui, Jean Oh, Ian R Mackenzie, Veronica Hirsch-Reinshagen, Ging-Yuek Robin Hsiung, Wellington Pham, Sieun Lee, Joanne A Matsubar. 3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer's disease via machine learning. Acta neuropathologica communications. vol 12. issue 1. 2024-12-24. PMID:39719599. |
overall, this study reveals unique differences in the size and activity of the retinal microglia, which may relate to their potential chronic activation due to increased levels of aβs in the ad retina. |
2024-12-24 |
2024-12-27 |
Not clear |
| Jordan E Rumford, Ailis Grieshaber, Samantha Lewiston, Jordan L Reed, Samuel S Long, Diana M Mitchel. Forced MyD88 signaling in microglia impacts the production and survival of regenerated retinal neurons. Frontiers in cell and developmental biology. vol 12. 2024-12-05. PMID:39633708. |
despite such findings, direct connection of microglia-specific inflammatory factors as drivers of regenerative responses in the retina are still not defined, and intracellular pathways activated to stimulate such signals from microglia are currently unknown. |
2024-12-05 |
2024-12-07 |
Not clear |
| Hasan U Banna, Mary Slayo, James A Armitage, Blanca Del Rosal, Loretta Vocale, Sarah J Spence. Imaging the eye as a window to brain health: frontier approaches and future directions. Journal of neuroinflammation. vol 21. issue 1. 2024-11-30. PMID:39614308. |
in this review, we discuss the gross anatomy of the eye, focusing on the sensory and non-sensory cells of the retina, especially microglia, that lend themselves to diagnosing brain disease by imaging the retina. |
2024-11-30 |
2024-12-02 |
Not clear |
| Chen Lu, Xiying Mao, Songtao Yua. Decoding physiological and pathological roles of innate immune cells in eye diseases: the perspectives from single-cell RNA sequencing. Frontiers in immunology. vol 15. 2024-11-15. PMID:39544948. |
notably, resident microglia and infiltrating neutrophils exhibit swift responses during the initial phase of injury, while peripheral monocyte-derived macrophages exhibit transcriptomic profiles akin to those of activated microglia, suggesting their potential for long-term residence within the retina. |
2024-11-15 |
2024-11-17 |
Not clear |
| Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei L. Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia. eLife. vol 12. 2024-11-08. PMID:39514271. |
human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia. |
2024-11-08 |
2024-11-16 |
mouse |
| Wenxin Ma, Lian Zhao, Biying Xu, Robert N Fariss, T Michael Redmond, Jizhong Zou, Wai T Wong, Wei L. Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia. eLife. vol 12. 2024-11-08. PMID:39514271. |
microglia exhibit both maladaptive and adaptive roles in the pathogenesis of neurodegenerative diseases and have emerged as a cellular target for central nervous system (cns) disorders, including those affecting the retina. |
2024-11-08 |
2024-11-16 |
mouse |