| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Wang, Lili Su, Silu Liu, Zhongmei He, Jianming Li, Ying Zong, Weijia Chen, Rui D. Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684254. |
the mechanism of pf for depression was assessed by the sirt1 selective inhibitor ex-527. |
2024-12-17 |
2024-12-21 |
mouse |
| Xue Wang, Lili Su, Silu Liu, Zhongmei He, Jianming Li, Ying Zong, Weijia Chen, Rui D. Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684254. |
additionally, the selective inhibition of sirt1 attenuated the therapeutic effect of pf on depression. |
2024-12-17 |
2024-12-21 |
mouse |
| Weijia Chen, Pengli Guo, Lili Su, Xiangjuan Guo, Meiling Shi, Jianan Geng, Ying Zong, Yan Zhao, Rui Du, Zhongmei H. Combining Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Total Ginsenoside Ginseng Root and Its Impact on Antidepressant Effects. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684318. |
in summary, total ginsenosides may regulate the ampk signaling pathway and activate the sirtuin 1 (sirt1) peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (pgc-1α) pathway to have therapeutic effects on depression. |
2024-12-17 |
2024-12-21 |
mouse |
| Yingxia He, Qinqin Wu, Ziwei Yin, Yi Zeng, Ningyu Xia, Hong Zh. Exploring the link between SIRT1 gene variants and depression comorbidity in type 2 diabetes. Medicine. vol 103. issue 48. 2024-11-29. PMID:39612426. |
exploring the link between sirt1 gene variants and depression comorbidity in type 2 diabetes. |
2024-11-29 |
2024-12-02 |
human |
| Yingxia He, Qinqin Wu, Ziwei Yin, Yi Zeng, Ningyu Xia, Hong Zh. Exploring the link between SIRT1 gene variants and depression comorbidity in type 2 diabetes. Medicine. vol 103. issue 48. 2024-11-29. PMID:39612426. |
this study aims to (1) analyze the clinical characteristics and risk factors of patients with type 2 diabetes and comorbid depression and (2) explore the association between sirt1 gene single-nucleotide polymorphism sites and this comorbidity. |
2024-11-29 |
2024-12-02 |
human |
| Yingxia He, Qinqin Wu, Ziwei Yin, Yi Zeng, Ningyu Xia, Hong Zh. Exploring the link between SIRT1 gene variants and depression comorbidity in type 2 diabetes. Medicine. vol 103. issue 48. 2024-11-29. PMID:39612426. |
the sirt1 mrna level was significantly reduced in type 2 diabetes comorbid depression patients. |
2024-11-29 |
2024-12-02 |
human |
| Yingxia He, Qinqin Wu, Ziwei Yin, Yi Zeng, Ningyu Xia, Hong Zh. Exploring the link between SIRT1 gene variants and depression comorbidity in type 2 diabetes. Medicine. vol 103. issue 48. 2024-11-29. PMID:39612426. |
the sirt1 gene had 3 sites: rs12415800, rs3758391, and rs932658, which were related to the patient's type 2 diabetes comorbid depression. |
2024-11-29 |
2024-12-02 |
human |
| Yingxia He, Qinqin Wu, Ziwei Yin, Yi Zeng, Ningyu Xia, Hong Zh. Exploring the link between SIRT1 gene variants and depression comorbidity in type 2 diabetes. Medicine. vol 103. issue 48. 2024-11-29. PMID:39612426. |
numerous factors influence the presence of depression in patients with type 2 diabetes, with the sirt1 gene playing a significant role, serving as a potential biomarker for this comorbidity. |
2024-11-29 |
2024-12-02 |
human |
| Hubin Yu, Xinping Li, Bo Ning, Lanshuan Feng, Yaolong Ren, Shilin Li, Yalong Kang, Jing Ma, Mingjun Zha. SIRT1: A Potential Therapeutic Target for Coronary Heart Disease Combined with Anxiety or Depression. Journal of drug targeting. 2024-10-29. PMID:39470049. |
sirt1: a potential therapeutic target for coronary heart disease combined with anxiety or depression. |
2024-10-29 |
2024-10-31 |
Not clear |
| Hubin Yu, Xinping Li, Bo Ning, Lanshuan Feng, Yaolong Ren, Shilin Li, Yalong Kang, Jing Ma, Mingjun Zha. SIRT1: A Potential Therapeutic Target for Coronary Heart Disease Combined with Anxiety or Depression. Journal of drug targeting. 2024-10-29. PMID:39470049. |
current research suggests that silent information regulatory factor 1 (sirt1) may serve as a potential biomarker for the comorbidity mechanism and treatment of chd with anxiety or depression. |
2024-10-29 |
2024-10-31 |
Not clear |
| Hubin Yu, Xinping Li, Bo Ning, Lanshuan Feng, Yaolong Ren, Shilin Li, Yalong Kang, Jing Ma, Mingjun Zha. SIRT1: A Potential Therapeutic Target for Coronary Heart Disease Combined with Anxiety or Depression. Journal of drug targeting. 2024-10-29. PMID:39470049. |
in addition, this article also summarizes the therapeutic potential of sirt1 as a potential biomarker in patients with chd combined with anxiety or depression. |
2024-10-29 |
2024-10-31 |
Not clear |
| Ye Zhang, Li Gui, Yan Yin, Xiaona Tong, Guobin Xia, Yuanyuan Wang, Jingting Yi, Chunyan Tian, Xiaobo Liu, Hongling Yan. Network Pharmacology Integrated with Pharmacological Evaluation for Investigating the Mechanism of Resveratrol in Perimenopausal Depression. Behavioural brain research. 2024-10-24. PMID:39447964. |
in vivo experiments demonstrated that res also significantly improved the depression behaviors, increased the levels of 5-ht1a and sirt1, and decreased levels of mao-a of depression rats. |
2024-10-24 |
2024-10-28 |
rat |
| Omar Gammoh, Aseel Ibrahim, Ala Yehya, Abdelrahim Alqudah, Esam Qnais, Sara Altaber, Osama Abo Alrob, Alaa A A Aljabali, Murtaza M Tambuwal. Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396638. |
the study of intercellular adhesion molecule-1 (icam-1) and sirt1, a member of the sirtuin family with nitric oxide (no), is emerging in depression and anxiety. |
2024-02-24 |
2024-02-26 |
mouse |
| Rashmi Patil, Urmila Aswar, Nishant Vya. Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling. Hormones and behavior. vol 161. 2024-02-14. PMID:38354494. |
pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male swiss albino mice and affects insulin resistance, inflammation, hpa axis dysfunction and sirt1 mediated leptin-ghrelin signaling. |
2024-02-14 |
2024-02-17 |
mouse |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
study on the mechanism for sirt1 during the process of exercise improving depression. |
2023-05-27 |
2023-08-14 |
Not clear |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
silent information regulator 1 (sirt1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa b (nf-κb), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β)), gene expression in the nucleus accumben (nac) and ca1 region of the hippocampus (e.g., nescient helix-loop-helix2 (nhlh2), monoamine oxidase (mao-a), and 5-hydroxyindole-3-acetic acid (5-hiaa)), and neuronal regeneration in the ca3 region of the hippocampus. |
2023-05-27 |
2023-08-14 |
Not clear |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
exercise is an important means to improve energy metabolism and depression, but it remains to be established how sirt1 acts during exercise and improves depression. |
2023-05-27 |
2023-08-14 |
Not clear |
| Cai-Yun Huang, Na-Na Chen, Fei Zhou, Hong-Mei Zhang, Xiao-Rong Yan. [Effects of SIRT1 in amygdala on chronic restraint stress-induced depression-like behaviors in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 5. 2023-04-23. PMID:37088752. |
to investigate the effects of silent information regulator 1 (sirt1) in amygdala on depression-like behaviors in rats using chronic restraint stress (crs) as a model of depression. |
2023-04-23 |
2023-08-14 |
rat |
| Lv Du, Lei Chen, Bang Luo, Yong-Jun Chen, Ping Zhang, Yi-Yun Tang, Jia-Mei Jiang, Wei Zo. Silent information regulator 1 mediates H2S-inhibited chronic restraint stress-induced depressive-like behaviors by regulating hippocampal autophagy. Neuroreport. 2023-02-02. PMID:36728843. |
silent information regulator 1 (sirt1), a deacetylase at the consumption of nad+ plays an important regulatory role in depression. |
2023-02-02 |
2023-08-14 |
rat |
| Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Y. Bergenin alleviates myocardial ischemia-reperfusion injury via SIRT1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-20. PMID:36538860. |
further studies showed that inhibiting sirt1 blocked bergenin's beneficial impact against apoptosis following si/r injury through excessive oxidative stress and depression of the bcl2 to bax ratio. |
2022-12-20 |
2023-08-14 |
mouse |