| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shan Ye, Li Fang, Shiyi Xie, Yan Hu, Shijia Chen, Nashwa Amin, Marong Fang, Zhiying H. Resveratrol alleviates postpartum depression-like behavior by activating autophagy via SIRT1 and inhibiting AKT/mTOR pathway. Behavioural brain research. 2022-11-10. PMID:36356720. |
in recent years, studies have suggested the sirt1 gene to be involved in the pathogenesis of depression. |
2022-11-10 |
2023-08-14 |
Not clear |
| Zsuzsanna Nemeth, Eva Kiss, Istvan Takac. The Role of Epigenetic Regulator SIRT1 in Balancing the Homeostasis and Preventing the Formation of Specific "Soil" of Metabolic Disorders and Related Cancers. Frontiers in bioscience (Landmark edition). vol 27. issue 9. 2022-10-12. PMID:36224002. |
several other diseases such as metabolic disease, obesity, diabetes, alzheimer's disease, cardiovascular disease or depression are related to chronic inflammation and similarly show decreased sirt1 level. |
2022-10-12 |
2023-08-14 |
Not clear |
| Hetao Bian, Ling Xiao, Liang Liang, Yinping Xie, Huiling Wang, Mark Slevin, Wen-Jun Tu, Gaohua Wan. Polydatin Prevents Neuroinflammation and Relieves Depression via Regulating Sirt1/HMGB1/NF-κB Signaling in Mice. Neurotoxicity research. 2022-08-20. PMID:35986876. |
treatment with polydatin increased the expression of the sirt1 but decreased the expression of the hmgb1, p-nf-κb, il-1b, and tnf-α in the lps-induced depression mice. |
2022-08-20 |
2023-08-14 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
[effects of jiaotai pills on cums-induced depression model in mice based on changes of sirt1 expression in hippocampus]. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
in conclusion, the results showed that jiaotai pills could improve the depression behaviors of model mice with cums-induced depression, and the underlying mechanism was related to the up-regulation of sirt1 in the hippocampus of mice to exert anti-inflammatory and anti-oxidative stress effects. |
2022-01-07 |
2023-08-13 |
mouse |
| Hao Guo, Cuola Deji, Han Peng, Jinyu Zhang, Yuanyuan Chen, Yulei Zhang, Yunpeng Wan. The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice. Genes, brain, and behavior. vol 20. issue 8. 2021-11-11. PMID:34355499. |
however, epigenetic mechanisms in the bla under the regulation of sirt1 in the depression are largely uncharacterized. |
2021-11-11 |
2023-08-13 |
mouse |
| Wei Guo, Xi Xiao, Yu-Tao Tian, Jia-Jia Yan. [The role and mechanism of SIRT1 gene in depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 5. 2021-10-29. PMID:34708240. |
[the role and mechanism of sirt1 gene in depression]. |
2021-10-29 |
2023-08-13 |
Not clear |
| Wei Guo, Xi Xiao, Yu-Tao Tian, Jia-Jia Yan. [The role and mechanism of SIRT1 gene in depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 5. 2021-10-29. PMID:34708240. |
therefore, this review mainly summarizes the relevant research progress on the role and mechanism of sirt1 gene in the hippocampus, prefrontal cortex, amygdala, hypothalamic suprachiasmatic nucleus, and nucleus accumbens in depression, in order to provide new ideas for exploring the mechanism and prevention of depression. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yunhai Tao, Kerun Gao, Bianhong Shen, Kaiyuan Zhang, Zhiwen Zhang, Chengpeng Wan. MicroRNA-135b-5p Downregulation Causes Antidepressant Effects by Regulating SIRT1 Expression. Biochemical genetics. vol 59. issue 6. 2021-10-28. PMID:33999341. |
the present study explored and clarified whether microrna (mir)-135b-5p could play a role in depression by regulating the expression of sirt1. |
2021-10-28 |
2023-08-13 |
mouse |
| b' Miranda Stiernborg, Paschalis Efstathopoulos, Andreas Lennartsson, Catharina Lavebratt, Aleksander A Math\\xc3\\xa. Acta neuropsychiatrica. 2021-10-20. PMID:34666848.' |
since the nad+-dependent histone deacetylases sirtuin-1 (sirt1) and sirtuin-2 (sirt2) are critically involved in epigenetics, endocrinology and immunology and affect the longevity in model organisms, we investigated their expression in brains of 3 month old and 14-15 month old rat model of depression flinders sensitive line (fsl) and control flinders resistant line (frl) rats. |
2021-10-20 |
2023-08-13 |
rat |
| Yuqing Zhang, Shailendra Anoopkumar-Dukie, Andrew Keith Dave. SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression? Biomolecules. vol 11. issue 3. 2021-09-28. PMID:33669121. |
sirt1 and sirt2 modulators: potential anti-inflammatory treatment for depression? |
2021-09-28 |
2023-08-13 |
Not clear |
| Xi Jiang, Ziwei Chen, Xuefeng Yu, Jin Chen, Chonglu Sun, Changfeng Jing, Lexing Xu, Fuhe Liu, Wenjuan Ni, Lei Che. Lipopolysaccharide-induced depression is associated with estrogen receptor-α/SIRT1/NF-κB signaling pathway in old female mice. Neurochemistry international. vol 148. 2021-09-08. PMID:34119591. |
by comparing the results of mechanism exploration in old male mice and old female mice and the different expression levels of e2, sirt1, nf-κb and inflammatory cytokines in young female mice and old female mice, we speculate that the age or gender-related depression difference may be associated with the different activation levels of the erα/sirt1/nf-κb signaling pathway. |
2021-09-08 |
2023-08-13 |
mouse |
| Jia Wang, Si-Fei Ma, Qi Yun, Wen-Jun Liu, Mei-Na Guo, Yong-Qiang Zhu, Zi-Zhong Liu, Jin-Jun Qian, Wei-Ning Zhan. Ameliorative effect of SIRT1 in postpartum depression mediated by upregulation of the glucocorticoid receptor. Neuroscience letters. vol 761. 2021-08-25. PMID:34265417. |
ameliorative effect of sirt1 in postpartum depression mediated by upregulation of the glucocorticoid receptor. |
2021-08-25 |
2023-08-13 |
Not clear |
| Chun-Mei Duan, Jian-Rong Zhang, Teng-Fei Wan, Yue Wang, Hui-Sheng Chen, Liang Li. SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31618623. |
taken together, these findings indicated that activation of sirt1 ameliorate cums-induced depressive-like behaviors via shifting microglial polarization toward the m2 phenotype, thereby providing a novel and beneficial therapeutic approach for depression that may be translatable to depression patients in the future. |
2021-04-29 |
2023-08-13 |
mouse |
| Dai Nan, Cheng Yuqi, Shen Zonglin, Dong Chenglong, Li Na, Liu Fang, Zhou Cong, Xu Xiufen. Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first-episode medication-naïve major depression. Psychiatry research. Neuroimaging. vol 301. 2020-11-30. PMID:32447184. |
association of a sirt1 polymorphism with changes of gray matter volume in patients with first-episode medication-naïve major depression. |
2020-11-30 |
2023-08-13 |
Not clear |
| Dai Nan, Cheng Yuqi, Shen Zonglin, Dong Chenglong, Li Na, Liu Fang, Zhou Cong, Xu Xiufen. Association of a SIRT1 polymorphism with changes of gray matter volume in patients with first-episode medication-naïve major depression. Psychiatry research. Neuroimaging. vol 301. 2020-11-30. PMID:32447184. |
a single nucleotide polymorphism (snp) rs12415800 of the silent mating type information regulation 2 homolog 1 gene (sirt1) has shown a genome-wide significant association with major depression disorder (mdd) in a recent gwas using a large sample. |
2020-11-30 |
2023-08-13 |
Not clear |
| Dandan Wang, Wei Tang, Junxiong Zhao, Weixing Fan, Yi Zhang, Chen Zhan. A Comprehensive Analysis of the Effect of SIRT1 Variation on the Risk of Schizophrenia and Depressive Symptoms. Frontiers in genetics. vol 11. 2020-09-28. PMID:32849821. |
rs3758391 is a functional locus of sirtuin (sirt1) involving depression etiology. |
2020-09-28 |
2023-08-13 |
Not clear |
| Weipeng Liu, Hao Yan, Danyang Zhou, Xin Cai, Yuyanan Zhang, Shiyi Li, Huijuan Li, Shiwu Li, Dong-Sheng Zhou, Xingxing Li, Chen Zhang, Yan Sun, Jia-Pei Dai, Jingmei Zhong, Yong-Gang Yao, Xiong-Jian Luo, Yiru Fang, Dai Zhang, Yina Ma, Weihua Yue, Ming Li, Xiao Xia. The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population. Translational psychiatry. vol 9. issue 1. 2020-09-21. PMID:31819045. |
the depression gwas risk allele predicts smaller cerebellar gray matter volume and reduced sirt1 mrna expression in chinese population. |
2020-09-21 |
2023-08-13 |
human |
| Chenghua Zhou, Yuqing Wu, Xiaobao Ding, Naihao Shi, Youqin Cai, Zhizhong Z Pa. SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKIIα Deacetylation in Central Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 11. 2020-09-08. PMID:32005763. |
we found that animals that were vulnerable to developing behaviors of anxiety and depression under the pain condition displayed reduced sirt1 protein levels in central amygdala, but not those animals resistant to the emotional disorders. |
2020-09-08 |
2023-08-13 |
mouse |
| Xinyu Fang, Yan Chen, Yewei Wang, Juanjuan Ren, Chen Zhan. Depressive symptoms in schizophrenia patients: A possible relationship between SIRT1 and BDNF. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-28. PMID:31247244. |
increasing evidence implicates that both sirt1 and bdnf closely related to the development of depression. |
2020-08-28 |
2023-08-13 |
Not clear |